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1‑o‑alkyl‑2‑acylglycerophosphorylcholine (pc‑o) 40:1 as a biomarker of healthy aging

A technology of acylglycerophosphocholine and PC-O, which is applied in the field of improvement, can solve the problems that the comprehensive description of the molecular mechanism has not been reported, and the lack of research on the metabolic phenotype of longevity

Inactive Publication Date: 2017-07-07
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite these findings, a comprehensive delineation of the molecular mechanisms influencing the aging process has yet to be reported
Furthermore, metabolic phenotype studies on longevity are still lacking

Method used

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  • 1‑o‑alkyl‑2‑acylglycerophosphorylcholine (pc‑o) 40:1 as a biomarker of healthy aging
  • 1‑o‑alkyl‑2‑acylglycerophosphorylcholine (pc‑o) 40:1 as a biomarker of healthy aging
  • 1‑o‑alkyl‑2‑acylglycerophosphorylcholine (pc‑o) 40:1 as a biomarker of healthy aging

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Experimental program
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Embodiment

[0169] Subjects and Study Groups

[0170] Each individual and their family gave informed consent for the study to be conducted. In total, 541 subjects belonging to different age groups were enrolled for this study in northern Italy (including Bologna, Florence, Parma, Milan). The centenarian group consisted of 156 individuals (125 females and 31 males), the older group consisted of 363 individuals (205 females and 158 males), and the young adult group consisted of 22 individuals (10 women and 12 men).

[0171] The study protocol was approved by the ethics committee of the Sant'Orsola-Malpighi University Faculty of Medicine (Bologna, Italy). Resulting biological samples (serum and urine) were stored at -80°C until metabolomic analysis.

[0172] clinical chemistry

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Abstract

Using NMR / MS-based metabolomics and targeted lipidomics approaches, the inventors studied the metabolic phenotypes of aging and longevity in a cohort including centenarians, older adults, and young adults. The present inventors identified biomarkers of reduced risk of developing age-related chronic inflammatory disorders, proposing a method of using PC-040:1 as a biomarker to diagnose a lifestyle that allows delaying and / or avoiding age-related chronic inflammatory disorders.

Description

technical field [0001] The present invention generally relates to healthy lifestyles and the prevention of aging-related chronic conditions. In particular, the invention relates to biomarkers and their use in detecting lifestyle improvements. Thus, the present invention provides, for example, 1-O-alkyl-2-acylglycerophosphorylcholine (PC-O) 40:1 as a biomarker and also provides Glycerophosphorylcholine (PC-O) 40:1 Method for diagnosing a lifestyle that allows delaying and / or avoiding chronic inflammatory conditions associated with aging. Background technique [0002] Aging is defined as a time-dependent decline in functional capacity and stress resistance, associated with increased risk of morbidity and mortality. Furthermore, the human aging phenotype is very heterogeneous and can be described as a complex mosaic resulting from the interaction of various environmental, stochastic and genetic-epigenetic variables. Decades of aging research have uncovered hundreds of genes ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68G01N33/92
CPCG01N33/49G01N33/492G01N33/493G01N33/6848G01N33/6893G01N33/92G01N2405/06G01N2570/00G01N2800/04G01N2800/50G01N2800/7042G01N2800/7095G09B19/00G09B19/0092
Inventor S·科里诺I·蒙托柳 鲁拉F-P·马丁P·A·盖S·A·D·莱兹
Owner NESTEC SA
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