Haemostatic wound dressing

Abstract

The invention discloses a haemostatic wound dressing and a preparation method thereof. The haemostatic wound dressing is prepared from the following raw materials in parts by weight: 15-35 parts of hydroxypropyl chitosan, 15-35 parts of chitosan, 10-20 parts of chitosan lactate, 5-12 parts of pectin, 3-12 parts of sodium carboxymethyl cellulose, 5-12 parts of alginate, 2-8 parts of an antibacterial agent, 2-8 parts of an antiphlogistic, 1-3 parts of Cu<2+> and 1-3 parts of Zn<2+>. The dressing disclosed by the invention is applicable to such aspects as performing rapid haemostasis, resisting bacterium, diminishing inflammation, inhibiting bacterium and promoting wound healing.

Description

technical field

[0001] The invention relates to a medical dressing, in particular to a hemostatic dressing and a preparation method thereof. Background technique

[0002] Chitosan (CTS) is a natural organic polymer polysaccharide derived from shrimp and crab shells. It has good biocompatibility and has the biological functions of both collagen in higher animal tissues and cellulose in higher plant tissues. , has good adaptability to animals and plants, and the affinity with organisms is reflected at the cellular level, and the possibility of producing antigens is very small. It has biological activities such as anti-inflammation, antibacterial, and promotion of wound repair, and plays a hemostatic effect through various channels.

[0003] At present, most of the hemostatic dressings commonly used in the medical field are cotton or gauze. Although these medical gauze or cotton have good air permeability, they have no antibacterial and bacteriostatic properties, and must be ...

Examples

Embodiment 1

[0016] Weigh 15 kg of hydroxypropyl chitin, 15 kg of chitosan, 10 kg of chitosan lactate, 3 kg of sodium carboxymethyl cellulose, 5 kg of sodium alginate, 2 kg of nano-zinc oxide, and cyclopropane Floxacin 2 kg, CuCl 2 3 kg, ZnCl 2 3 kg, put in the reactor, add 1% acetic acid aqueous solution, stir until fully dissolved; add 5 kg of pectin, continue to stir and heat at 60°C for 10 min; pour the mixed solution on the template for injection molding, Scraped and fully dried, stripped, sterilized and packaged individually. Obtain a dressing with a thickness of 25 µm.

Embodiment 2

[0018] Weigh 25 kg of hydroxypropyl chitin, 25 kg of chitosan, 15 kg of chitosan lactate, 8 kg of sodium carboxymethyl cellulose, 8 kg of sodium alginate, 6 kg of nano-zinc oxide, and Mycin 6 kg, CuSO 4 5 kg, ZnSO 4 5 kg, put in the reactor, add 1% acetic acid aqueous solution, stir until fully dissolved; add 8 kg of pectin, continue to stir and heat at 70°C for 15 min; pour the mixed solution on the template for injection molding, Scraped and fully dried, stripped, sterilized and packaged individually. Obtain a dressing with a thickness of 35 µm.

Embodiment 3

[0020] Weigh 35 kg of hydroxypropyl chitin, 35 kg of chitosan, 20 kg of chitosan lactate, 12 kg of sodium carboxymethyl cellulose, 12 kg of potassium alginate, 8 kg of ammonium dihydrogen phosphate, and Nitazole 8 kg, CuSO 4 6 kg, ZnSO 4 6 kg, put in the reactor, add 1.5% acetic acid aqueous solution, stir until fully dissolved; add 12 kg of pectin, continue to stir and heat at 80°C for 20 min; pour the mixed solution on the template for injection molding, Scraped and fully dried, stripped, sterilized and packaged individually. Obtain a dressing with a thickness of 55 µm.

technical field

[0001] The invention relates to a medical dressing, in particular to a hemostatic dressing and a preparation method thereof. Background technique

[0002] Chitosan (CTS) is a natural organic polymer polysaccharide derived from shrimp and crab shells. It has good biocompatibility and has the biological functions of both collagen in higher animal tissues and cellulose in higher plant tissues. , has good adaptability to animals and plants, and the affinity with organisms is reflected at the cellular level, and the possibility of producing antigens is very small. It has biological activities such as anti-inflammation, antibacterial, and promotion of wound repair, and plays a hemostatic effect through various channels.

[0003] At present, most of the hemostatic dressings commonly used in the medical field are cotton or gauze. Although these medical gauze or cotton have good air permeability, they have no antibacterial and bacteriostatic properties, and must be ...

Examples

Embodiment 1

[0016] Weigh 15 kg of hydroxypropyl chitin, 15 kg of chitosan, 10 kg of chitosan lactate, 3 kg of sodium carboxymethyl cellulose, 5 kg of sodium alginate, 2 kg of nano-zinc oxide, and cyclopropane Floxacin 2 kg, CuCl 2 3 kg, ZnCl 2 3 kg, put in the reactor, add 1% acetic acid aqueous solution, stir until fully dissolved; add 5 kg of pectin, continue to stir and heat at 60°C for 10 min; pour the mixed solution on the template for injection molding, Scraped and fully dried, stripped, sterilized and packaged individually. Obtain a dressing with a thickness of 25 µm.

Embodiment 2

[0018] Weigh 25 kg of hydroxypropyl chitin, 25 kg of chitosan, 15 kg of chitosan lactate, 8 kg of sodium carboxymethyl cellulose, 8 kg of sodium alginate, 6 kg of nano-zinc oxide, and Mycin 6 kg, CuSO 4 5 kg, ZnSO 4 5 kg, put in the reactor, add 1% acetic acid aqueous solution, stir until fully dissolved; add 8 kg of pectin, continue to stir and heat at 70°C for 15 min; pour the mixed solution on the template for injection molding, Scraped and fully dried, stripped, sterilized and packaged individually. Obtain a dressing with a thickness of 35 µm.

Embodiment 3

[0020] Weigh 35 kg of hydroxypropyl chitin, 35 kg of chitosan, 20 kg of chitosan lactate, 12 kg of sodium carboxymethyl cellulose, 12 kg of potassium alginate, 8 kg of ammonium dihydrogen phosphate, and Nitazole 8 kg, CuSO 4 6 kg, ZnSO 4 6 kg, put in the reactor, add 1.5% acetic acid aqueous solution, stir until fully dissolved; add 12 kg of pectin, continue to stir and heat at 80°C for 20 min; pour the mixed solution on the template for injection molding, Scraped and fully dried, stripped, sterilized and packaged individually. Obtain a dressing with a thickness of 55 µm.