Infrared spectroscopic analysis method of semisynthesis medicine

Abstract

The invention relates to a detection method of a semisynthesis medicine, an infrared spectrogram of the medicine and a chromatogram are associated, then a model is established, and the content of the relative components in the medicine can be analyzed and predicted. The method can integrally control the quality of the semisynthesis medicine.

Description

technical field [0001] The invention relates to the technical field of drug analysis, in particular to an infrared spectrum analysis method for semi-synthetic drugs. Background technique [0002] Semi-synthetic drugs refer to the general term for drugs obtained by compounding structural modifications on the basis of natural drug extracts. And the quality of natural medicine extract is crucial to the quality of final medicine. [0003] Natural medicine fingerprint is a comprehensive and quantifiable means of identification. It is based on the systematic research on the chemical components of natural medicines and is mainly used to evaluate the authenticity, goodness and stability of natural medicines and their extracts. . [0004] In recent years, with the rapid development of biotechnology, the intersection of life science and chromatographic separation technology has formed a new comprehensive technology-biochromatography, which opens up another way for the basic research...

AI Technical Summary

Problems solved by technology

In addition to the continuous use of the mobile phase and the reference substance in a short period of time, this method of determination must repeat the above three operations for each sample content determination. Therefore, the HPLC content determination method is cumbersome and has a long cycle, and it is impossible to quickly predict the content of the extract. The content of relevant ingredients in