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Low-glycerin formulations for HIV treatment and prevention

A preparation, glycerin technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, suppository delivery, etc., can solve the problems of affecting the patient's rectum and the absence of fully effective preparations for HIV

Inactive Publication Date: 2015-12-23
EASTERN VIRGINIA MEDICAL SCHOOL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, there is no formulation that is completely effective against HIV
Furthermore, most known formulations have high levels of glycerol which can adversely affect the patient's rectum when such formulations are administered rectally

Method used

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  • Low-glycerin formulations for HIV treatment and prevention
  • Low-glycerin formulations for HIV treatment and prevention

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Embodiment Construction

[0013] Reference will now be made in detail to certain embodiments of the methods and compositions disclosed herein. While the compositions and methods will be described in conjunction with the enumerated embodiments, it will be understood that they are not intended to limit the invention to those embodiments. On the contrary, the disclosed methods and compositions are merely examples of alternatives, modifications and equivalents, which may be included within the scope of the claims.

[0014] 1. definition

[0015] Unless otherwise stated, the following terms and phrases used herein are intended to have the following meanings:

[0016] The term "physiologically functional derivative" refers to a pharmaceutically active compound having the same or close to the same physiological function as a given NRTI. The term "physiologically functional derivative" as used herein includes any: physiologically acceptable salts, ethers, esters, prodrugs, solvates, stereoisomers, including...

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Abstract

The present invention relates to formulations of nucleotide reverse transcriptase inhibitors (NRTIs), preferably [2-(6-Amino-purin-9-yl)-1-methyl-ethoxymethy]-phosphonic acid (tenofivir, PMPA), or a physiologically functional derivative thereof, wherein the formulations contain a low level of glycerin. Human immunodeficiency vims (HIV) infection and related diseases are a major public health problem worldwide. One approach to the problem of HIV / AIDS is to reduce the risk of transmission of HIV and thus reduce the number of individuals who become newly infected.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Patent Application No. 61 / 793,745, entitled "Low-Glycerin Formulations for HIV Treatment and Prevention," filed March 15, 2013, which is expressly incorporated by reference in its entirety This article. technical field [0003] The present invention generally relates to formulations of compounds having antiviral activity and more particularly anti-HIV properties. Background technique [0004] Human immunodeficiency virus (HIV) infection and related diseases are a major public health problem worldwide. One approach to the HIV / AIDS problem is to reduce the risk of HIV transmission and thus reduce the number of newly infected individuals. Even if a treatment or cure is available, preventing infection will likely remain the first line of defense in the first instance. For medical, psychological and economic reasons, prevention of initial infection is preferred over...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00
CPCA61K47/38A61K9/0031A61K9/0034A61K9/06A61K47/10A61K31/675A61P31/18A61K9/02
Inventor D·R·弗兰德
Owner EASTERN VIRGINIA MEDICAL SCHOOL
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