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Formula and preparation process of escitalopram oxalate effervescent tablet

A technology of escitalopram oxalate and effervescent tablets, which is applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the effects of bioavailability and poor compliance of depressed patients To avoid adverse effects, low bioavailability and good taste

Active Publication Date: 2016-02-24
YANGTAI PHARMA SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new product has several benefits compared to regular medication forms like pills that they cannot easily ingest due to their size and shape. It also provides an easy-to-use liquid dosage format which makes them easier to use by individuals without having trouble chewing on them themselves. Additionally, this medicine may be given through drinks instead of directly into your mouth because there're no problem getting ridged up when eaten alone.

Problems solved by technology

The technical problem addressed in this patented text relates to improving the patient's ability to take medicine safely due to its low solubility or difficulty swallowing while still being effective against symptoms like panic attacks caused by stressors such as those associated with neurology treatments.

Method used

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  • Formula and preparation process of escitalopram oxalate effervescent tablet
  • Formula and preparation process of escitalopram oxalate effervescent tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of escitalopram oxalate effervescent tablet, its component by weight percentage is: escitalopram oxalate is 3.34g, anhydrous citric acid 17.75g, sodium bicarbonate 29.75g, sucrose 26.62g, orange flavor Flavor 5.74g, Aspartame 8.87g, Macrogol-60007.83g, PVPK 30 0.1g;

[0026] Preparation:

[0027] ① Grind escitalopram oxalate, sodium bicarbonate, anhydrous citric acid, sucrose, and orange flavor to 80 mesh, and sieve aspartame and polyethylene glycol-600 to 80 mesh;

[0028] ②Weigh the prescribed amount of escitalopram oxalate, anhydrous citric acid, aspartame, and orange flavor, mix well, and add 38% of the total mass of PVPK 30 Ethanol solution, making soft materials, granulating with a 20-mesh sieve, drying at 60°C until the moisture content of the granules is ≤1.0%, and sizing with a 18-mesh sieve to obtain granule a;

[0029] ③Weigh the prescribed amount of sodium bicarbonate and sucrose, mix evenly, add PVPK with a total mass of 62% 30 Ethanol solution, ...

Embodiment 2

[0034] A kind of escitalopram oxalate effervescent tablet, its component by weight percentage is: escitalopram oxalate is 3.34g, anhydrous citric acid 20g, sodium bicarbonate 30g, sucrose 29.56g, orange essence 4g , Aspartame 7g, Macrogol-60006g, PVPK 30 0.1g;

[0035] Preparation:

[0036] ① Grind escitalopram oxalate, sodium bicarbonate, anhydrous citric acid, sucrose, and orange flavor to 80 mesh, and sieve aspartame and polyethylene glycol-600 to 80 mesh;

[0037] ②Weigh the prescribed amount of escitalopram oxalate, anhydrous citric acid, aspartame, and orange flavor, mix well, and add 38% of the total mass of PVPK 30 Ethanol solution, making soft materials, granulating with a 20-mesh sieve, drying at 60°C until the moisture content of the granules is ≤1.0%, and sizing with a 18-mesh sieve to obtain granule a;

[0038] ③Weigh the prescribed amount of sodium bicarbonate and sucrose, mix evenly, add PVPK with a total mass of 62% 30 Ethanol solution, making soft material...

Embodiment 3

[0043] A kind of escitalopram oxalate effervescent tablet, its component by weight percentage is: escitalopram oxalate is 3.34g, anhydrous citric acid 18.56g, sodium bicarbonate 30g, sucrose 28g, orange essence 5g , Aspartame 8g, Macrogol-60007g, PVPK 30 0.1g;

[0044] Preparation:

[0045] ① Grind escitalopram oxalate, sodium bicarbonate, anhydrous citric acid, sucrose, and orange flavor to 80 mesh, and sieve aspartame and polyethylene glycol-600 to 80 mesh;

[0046] ②Weigh the prescribed amount of escitalopram oxalate, anhydrous citric acid, aspartame, and orange flavor, mix well, and add 38% of the total mass of PVPK 30 Ethanol solution, making soft materials, granulating with a 20-mesh sieve, drying at 65°C until the moisture content of the granules is ≤1.0%, and sizing with a 18-mesh sieve to obtain granule a;

[0047]③Weigh the sodium bicarbonate and sucrose of the recipe quantity, mix well, add PVPK of 62% of the total mass 30 Ethanol solution, making soft material,...

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PUM

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Abstract

The invention belongs to the technical field of a medicinal preparation. Escitalopram oxalate, as a main drug, is suitable for treating depression and for treating panic disorder accompanies with or not accompanied with agoraphobe. An escitalopram oxalate effervescent tablet adopts a formula which consists of the main drug, a disintegrant, an aromatic and the like, and is subject to a tabletting process that an acid disintegrant and an alkaline disintegrant are respectively granulated. The escitalopram oxalate effervescent tablet, through the formula and the process, is easy to operate, controllable in product quality, good in taste of taking and low in cost.

Description

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Claims

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Application Information

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Owner YANGTAI PHARMA SHANDONG
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