Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Formula and preparation process of escitalopram oxalate effervescent tablet

A technology for escitalopram oxalate and effervescent tablets, which is applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the effects of bioavailability and poor compliance of depressed patients To avoid adverse effects, low bioavailability and good taste

Active Publication Date: 2018-09-11
YANGTAI PHARMA SHANDONG
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the public patents and clinical application preparations of escitalopram oxalate mainly include ordinary tablets. Escitalopram oxalate tablets have already been marketed at home and abroad. Carrying and other characteristics, but the ordinary tablets that have been on the market have poor compliance for patients with dysphagia and depression, and the bioavailability is also affected by the dissolution rate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Formula and preparation process of escitalopram oxalate effervescent tablet
  • Formula and preparation process of escitalopram oxalate effervescent tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of escitalopram oxalate effervescent tablet, its component by weight percentage is: escitalopram oxalate is 3.34g, anhydrous citric acid 17.75g, sodium bicarbonate 29.75g, sucrose 26.62g, orange flavor Flavor 5.74g, Aspartame 8.87g, Macrogol-6000 7.83g, PVPK 30 0.1g;

[0026] Preparation:

[0027] ① Grind escitalopram oxalate, sodium bicarbonate, anhydrous citric acid, sucrose, and orange flavor to 80 meshes, and sieve aspartame and polyethylene glycol-6000 80 meshes;

[0028] ②Weigh the prescribed amount of escitalopram oxalate, anhydrous citric acid, aspartame, and orange flavor, mix well, and add 38% of the total mass of PVPK 30 Ethanol solution, making soft materials, granulating with a 20-mesh sieve, drying at 60°C until the moisture content of the granules is ≤1.0%, and sizing with a 18-mesh sieve to obtain granule a;

[0029] ③Weigh the prescribed amount of sodium bicarbonate and sucrose, mix evenly, add PVPK with a total mass of 62% 30 Ethanol solutio...

Embodiment 2

[0034] A kind of escitalopram oxalate effervescent tablet, its component by weight percentage is: escitalopram oxalate is 3.34g, anhydrous citric acid 20g, sodium bicarbonate 30g, sucrose 29.56g, orange essence 4g , Aspartame 7g, Macrogol-6000 6g, PVPK 30 0.1g;

[0035] Preparation:

[0036] ① Grind escitalopram oxalate, sodium bicarbonate, anhydrous citric acid, sucrose, and orange flavor to 80 meshes, and sieve aspartame and polyethylene glycol-6000 80 meshes;

[0037] ②Weigh the prescribed amount of escitalopram oxalate, anhydrous citric acid, aspartame, and orange flavor, mix well, and add 38% of the total mass of PVPK 30 Ethanol solution, making soft materials, granulating with a 20-mesh sieve, drying at 60°C until the moisture content of the granules is ≤1.0%, and sizing with a 18-mesh sieve to obtain granule a;

[0038] ③Weigh the prescribed amount of sodium bicarbonate and sucrose, mix evenly, add PVPK with a total mass of 62% 30 Ethanol solution, making soft mater...

Embodiment 3

[0043] A kind of escitalopram oxalate effervescent tablet, its component by weight percentage is: escitalopram oxalate is 3.34g, anhydrous citric acid 18.56g, sodium bicarbonate 30g, sucrose 28g, orange essence 5g , Aspartame 8g, Macrogol-6000 7g, PVPK 30 0.1g;

[0044] Preparation:

[0045] ① Grind escitalopram oxalate, sodium bicarbonate, anhydrous citric acid, sucrose, and orange flavor to 80 meshes, and sieve aspartame and polyethylene glycol-6000 80 meshes;

[0046] ②Weigh the prescribed amount of escitalopram oxalate, anhydrous citric acid, aspartame, and orange flavor, mix well, and add 38% of the total mass of PVPK 30 Ethanol solution, making soft materials, granulating with a 20-mesh sieve, drying at 65°C until the moisture content of the granules is ≤1.0%, and sizing with a 18-mesh sieve to obtain granule a;

[0047]③Weigh the prescribed amount of sodium bicarbonate and sucrose, mix evenly, add PVPK with a total mass of 62% 30 Ethanol solution, making soft materi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical category of pharmaceutical preparations. The main drug escitalopram oxalate is suitable for treating depression and panic disorder with or without agoraphobia. The Escitalopram Oxalate Effervescent Tablet adopts a tableting process in which the main drug, a disintegrant and a fragrance are formulated, and the acidic disintegrant and the alkaline disintegrant are granulated separately. The formula and process are easy to operate, the product quality is controllable, the taste is good and the cost is low.

Description

technical field [0001] The invention belongs to the technical category of pharmaceutical preparations, and in particular relates to the formula and preparation process of escitalopram oxalate effervescent tablets. Background technique [0002] Escitalopram oxalate is clinically used for the treatment of major depressive disorder and generalized anxiety disorder. It belongs to the class of selective serotonin reuptake inhibitors (SSRIs) that selectively inhibit the reuptake of serotonin from the synaptic cleft into nerve cells. Escitalopram oxalate has a highly selective inhibitory effect on the reuptake of serotonin (5-HT), with little effect on the reuptake of norepinephrine and dopamine. It increases the concentration of 5-hydroxytryptamine (5-HT) in the synaptic cleft by preventing the reabsorption of 5-hydroxytryptamine (5-HT), thereby producing an antidepressant effect. At present, the public patents and clinical application preparations of escitalopram oxalate mainly...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K31/343A61K47/12A61K47/04A61K47/26A61K47/18A61K47/10A61K47/32A61P25/22
Inventor 张汝德于云涛冯永斌
Owner YANGTAI PHARMA SHANDONG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com