A kind of ionization method and device

An ionization and ion source technology, applied in the field of mass spectrometry, can solve problems such as complex sample analysis steps, and achieve the effect of wide application range, easy implementation and remarkable practicability

Active Publication Date: 2017-12-19
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these atmospheric pressure ionization methods simplify the analysis steps, these ionization methods still need the assistance of auxiliary gas, laser, voltage, etc., which complicates the analysis steps of the sample.

Method used

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  • A kind of ionization method and device
  • A kind of ionization method and device
  • A kind of ionization method and device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Will figure 1 The flame ionization device shown is combined with a mass spectrometer (mass analyzer is Fourier transform ion cyclotron resonance), for liquid sample methyl salicylate (Methyl salicylate, MW=152): Perform mass spectrometry:

[0071] Use n-butane as fuel to make it burn to produce flame 1;

[0072] Spray a sample of methyl salicylate over or around the flame;

[0073] Keep the flame burning continuously, and the mass analyzer is always in the collection state;

[0074] image 3 For the mass spectrum obtained by image 3 The mass spectrum shown can be seen: the ion peak related to methyl salicylate appears in the spectrum [M+H] + =153, indicating that the device and method of the present invention can achieve good ionization efficiency.

Embodiment 2

[0076] Will figure 1 The ionization device shown is combined with a mass spectrometer (the mass analyzer is Fourier transform ion cyclotron resonance), and for the liquid sample dimethyl sulfoxide (Dimethyl sulfoxide, MW=78): Perform mass spectrometry:

[0077] Use n-butane as fuel to make it burn to produce flame 1;

[0078] Keep containers of DMSO open near flames;

[0079] Keep the flame burning continuously, and the mass analyzer is always in the collection state;

[0080] Figure 4 For the mass spectrum obtained by Figure 4 The mass spectrum shown can be seen: the ion peak related to dimethyl sulfoxide appears in the spectrum [2M+H] + =157, indicating that the device and method of the present invention can achieve good ionization efficiency.

Embodiment 3

[0082] Will figure 1 The ionization device shown is combined with a mass spectrometer (the mass analyzer is Fourier transform ion cyclotron resonance), and for the liquid sample diethylene glycol dimethyl ether (2-Methoxyethyl ether, MW=134): Perform mass spectrometry:

[0083] Use n-butane as fuel to make it burn to produce flame 1;

[0084] Keep the container of diethylene glycol dimethyl ether open near the flame;

[0085] Keep the flame burning continuously, and the mass analyzer is always in the collection state;

[0086] Figure 5 For the mass spectrum obtained by Figure 5 The mass spectrum shown can be seen: the ion peak [M+H] related to diethylene glycol dimethyl ether appears in the spectrum + =135, indicating that the device and method of the present invention can achieve good ionization efficiency.

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Abstract

The invention discloses an ionization method and device. The ionization method includes an ion source, a sample and a mass spectrometer sampling channel, and is characterized in that the ion source is a flame. The ionization technology described in the present invention, by using the flame as the ion source, is not only easy to implement, simple to operate, and greatly reduces the analysis cost, but also has strong compatibility, can meet the ionization analysis temperature requirements of compounds with different molecular weights, and can It has good ionization efficiency for gaseous, liquid, solid samples and actual samples, not only has high sensitivity, but also can directly analyze actual samples, and can well realize polar, highly polar, non-polar, metal organic The ionization of compounds and other substances has a wide range of applications, and can be used in conjunction with portable mass spectrometers to achieve more convenient in-situ analysis of natural states, which has significant practical value.

Description

technical field [0001] The invention relates to an ionization method and device, belonging to the technical field of mass spectrometry. Background technique [0002] Mass spectrometry (MS) is a powerful tool for the analysis of complex mixtures, providing information about the molecular weight and chemical structure of the analyte. In recent years, with the continuous innovation and improvement of ionization technology and mass analyzers, mass spectrometry has become one of the fastest-growing analytical technologies. At present, mass spectrometry technology is widely used in chemistry and chemical engineering, biology and life science, medicine, pharmacy, Applications in environmental protection and other fields are becoming more and more extensive. [0003] Common ionization methods include electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and matrix-assisted laser desorption ionization (MALDI) commonly used in solids. The above-mentioned io...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/18H01J49/26
CPCH01J49/18H01J49/26G01N27/623
Inventor 郭寅龙刘小潘王昊阳涂奇奇
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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