Alzheimer's disease detection marker and detection method thereof

A detection method and marker technology, applied in the field of disease detection, can solve problems such as detection delay or misdiagnosis, and achieve the effect of improving objectivity

Active Publication Date: 2016-10-12
SHENZHEN UNIV
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Problems solved by technology

[0004] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a detection marker for Alzheimer's disea

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  • Alzheimer's disease detection marker and detection method thereof
  • Alzheimer's disease detection marker and detection method thereof

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Embodiment 1

[0024] Serum from patients with Alzheimer's disease and healthy controls were collected separately, and then the serum from patients with Alzheimer's disease and healthy controls were compared and analyzed by high-throughput proteomics methods. The results obtained: Compared with the control healthy serum, 26 serum differential proteins were obtained in the serum of patients with Alzheimer's disease, of which 6 expressed proteins were up-regulated and 20 expressed proteins were down-regulated. Then, the enzyme-linked immunosorbent technique was used to detect the 26 serum differential proteins one by one, or the protein chip technology was used to detect the 26 serum differential proteins simultaneously, and the concentration changes of the detected serum differential proteins were determined. The present invention uses high-throughput proteomics method to compare and analyze the serum of patients with Alzheimer's disease and the serum of healthy controls. Compared with the con...

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Abstract

The invention discloses an Alzheimer's disease detection marker and a detection method thereof. A group of serum difference proteins provided by the invention can be used to detect the Alzheimer's disease, and when the group of serum difference proteins is used in the Alzheimer's disease detection, the group of serum difference proteins can improve the specificity and the accuracy of detection, has certain objectivity, and is better than single disease markers. 26 Serum difference proteins are obtained through comparing Alzheimer's disease patient's serum and heavy contrast serum by adopting high-flux proteomics, and a result of comparison with contrast shows that the number of expression up-regulation proteins is 6, and the number of expression down-regulation proteins is 20. All above proteins are detected one by one through ELISA, or are detected one by one or simultaneously through adopting a protein chip technology in order to determine the concentration change of the detected serum difference proteins, and the concentration change can be used as a basis for diagnosing the Alzheimer's disease. The detection method disclosed in the invention has higher specificity, sensitivity and accuracy than present Alzheimer's disease detection measuring scales.

Description

technical field [0001] The invention relates to the technical field of disease detection, in particular to a detection marker for Alzheimer's disease and a detection method thereof. Background technique [0002] Alzheimer's disease (AD), commonly known as senile dementia, is a neurodegenerative disease with insidious onset and progressive development. And accompanied by various neuropsychiatric symptoms and behavioral disturbances. The etiology of the disease has not been clarified so far, and the incidence rate is increasing year by year, becoming one of the main diseases that seriously threaten the physical and mental health of the elderly. At present, the diagnosis of Alzheimer's disease is mainly based on the neuropsychological assessment scale, clinical symptoms, clinical experience of clinicians, etc., which has a certain degree of subjectivity, and the diagnosis can only be made by the senile plaques (SPs) and nerve plaques (SPs) in the brain of the patient after dea...

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6896
Inventor 沈立明刘琼廖利萍倪嘉缵
Owner SHENZHEN UNIV
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