A kind of TPBG antibody and its preparation method, its conjugate and application

An immunoconjugate and antibody technology, applied in the field of TPBG antibody and its preparation, can solve the problems of non-cancerous cell damage and limited killing effect.
CN106916227BActive Publication Date: 2019-12-13KAIHUI SCI & TECH DEV SHANGHAI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
KAIHUI SCI & TECH DEV SHANGHAI
Publication Date
2019-12-13

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Abstract

The invention discloses a TPBG antibody, its preparation method, its conjugate and application. The TPBG antibody includes one or more of the heavy chain variable region heavy chain CDR1, heavy chain CDR2 and heavy chain CDR3 of the TPBG antibody, and / or, the light chain variable region light chain CDR1, light chain CDR1 of the TPBG antibody One or more of CDR2 and light chain CDR3, the amino acid sequences of which are respectively described in the present invention. The TPBG antibody is a humanized antibody with high affinity, and the conjugate prepared after coupling with the small-molecule drug toxin MMAF can have a cytotoxic killing effect on TPBG-positive cells, so it is used in the preparation of drugs for treating tumors and the like middle.
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Description

technical field

[0001] The present invention relates to the field of antibodies, in particular to a TPBG antibody, its preparation method, its conjugate and its application. Background technique

[0002] A cell surface molecule, trophoblast-specific glycoprotein (TPBG, also known as 5T4), was found to be a specific protein expressed by embryonic trophoblasts when comparing embryonic stem cell trophoblasts with cancer cells. The human TPBG protein has a molecular weight of about 72kDa and contains 420 amino acids. Its N-terminal oligosaccharide structure has diversity, which can prevent proteolysis and interact with other molecules in the process of cell membrane signal transduction. The TPBG protein contains seven repeating leucine domains (LRRs), which can participate in protein-protein interactions.

[0003] The trophoblast is a layer of special embryonic stem cells between the placenta and the fetus, and TPBG is widely expressed in various trophoblast cells during embryo...

Claims

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