Application of chicoric acid in preparing drug for preventing respiratory syncytial virus
An anti-respiratory and syncytial virus technology, applied in the directions of antiviral agents, carboxylate preparation, respiratory diseases, etc., can solve problems such as cichoric acid that have not yet been seen
Active Publication Date: 2017-08-18
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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In the prior art, there have been no related reports about the anti-respiratory syncytial virus of cichoric acid
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[0020] The present invention will be further described below in conjunction with embodiment.
[0021] The instruments, reagents, materials, etc. involved in the following examples, unless otherwise specified, are conventional instruments, reagents, materials, etc. in the prior art, and can be obtained through formal commercial channels. The experimental methods, detection methods, etc. involved in the following examples, unless otherwise specified, are conventional experimental methods, detection methods, etc. in the prior art.
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The invention discloses a novel application of chicoric acid, namely an application of chicoric acid in preparing a drug for preventing respiratory syncytial virus (RSV). The inventor of the invention screens antiviral components in an echinacea plant by applying a traditional Chinese medicine chemical method and finds the optimum antiviral active ingredient, chicoric acid, through an in vitro antiviral pharmacological experiment and finds that the in vitro antiviral activity of chicoric acid on RSV is the strongest, and is superior to that of a reference drug, ribavirin, so that chicoric acid can be used for preparing the drug for preventing RSV as an active ingredient. In specific application, a pharmaceutically acceptable matrix or auxiliary material can be properly added to chicoric acid, and chicoric acid can be also combined with proper drugs in application.
Description
technical field [0001] The invention relates to the application of cichoric acid in the preparation of medicines against respiratory syncytial virus. Background technique [0002] Echinacea, also known as Echinacea, purple coneflower, is a perennial herb belonging to the genus Echinacea in the family Asteraceae. In the 1970s, Echinacea was introduced into my country and cultivated as an ornamental plant; in the 1990s, Academician Xiao Peigen first introduced Echinacea as an immunomodulator to China, and various parts of the country began to introduce it as a medicinal plant, and gradually put it into GAP standardized production , so as to ensure the safety of raw materials for research and development. In recent years, several echinacea preparations have been developed and applied clinically in China, such as "Jinpingfeng Capsule" (Zhejiang Zhengda Qingchunbao Pharmaceutical Co., Ltd.), "Zihuangjing" (Chengdu Di'ao Pharmaceutical Group Co., Ltd.), etc., all of which are Echi...
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Login to View More IPC IPC(8): A61K31/235C07C67/56C07C69/732A61P11/00A61P31/12
CPCA61K31/235A61K36/28C07C67/56C07C69/732
Inventor 李峰李健李娜
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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