Genetic marker related to human bladder cancer, and detection method and application thereof

A genetic marker, bladder cancer technology, applied in the field of tumors, can solve the problem that p53 cannot be used as an independent prognostic indicator

Active Publication Date: 2019-04-26
吕兆洁
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, multivariate analysis proved that p53 can

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  • Genetic marker related to human bladder cancer, and detection method and application thereof
  • Genetic marker related to human bladder cancer, and detection method and application thereof
  • Genetic marker related to human bladder cancer, and detection method and application thereof

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Embodiment Construction

[0032] The present invention will be further described in detail below through specific embodiments in conjunction with the accompanying drawings. In the following implementation manners, many details are described for better understanding of the present application. However, those skilled in the art can readily recognize that some of the features can be omitted in different situations, or can be replaced by other elements, materials, and methods. In some cases, some operations related to the application are not shown or described in the description, this is to avoid the core part of the application being overwhelmed by too many descriptions, and for those skilled in the art, it is necessary to describe these operations in detail Relevant operations are not necessary, and they can fully understand the relevant operations according to the description in the specification and general technical knowledge in the field.

[0033] In this invention, through large-scale genome sequen...

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Abstract

The invention provides a genetic marker related to human bladder cancer, and a detection method and application thereof. The genetic marker is located in the ZNF83 gene sequence, gene mutation occursat the genetic marker, and the mutation site is selected from one or more of chr19:57808752T>A, chr19:57808761T>C and chr19:57808819G>T. Mutation of the ZNF83 gene is one of the indicators of poor prognosis of bladder cancer, and can be used as an auxiliary index for the diagnosis of bladder cancer. The ZNF83 gene can be used as a new effect target for the treatment of bladder cancer.

Description

technical field [0001] The invention relates to the technical field of tumors, in particular to a genetic marker related to human bladder cancer, a detection method and application thereof. Background technique [0002] Bladder cancer is the most common malignancy of the genitourinary system in various countries and regions around the world. An estimated 386,300 new cases and 150,200 deaths occurred in 2008 alone. Past studies have shown that bladder cancer is a highly heterogeneous disease with two different subtypes (superficial and invasive) with variable clinical manifestations and complex genetic background. Recently, we performed a study showing recurrent mutations in eight chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARIDIA, and CHD6) in bladder transitional cell carcinoma. However, at present, we still lack a systematic understanding of the somatic mutations in bladder cancer, and we know little about the key "driver genes" in the process of blad...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/118C12Q2600/156
Inventor 吕兆洁蔡志明
Owner 吕兆洁
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