Composition of flavonoids and preparation method thereof

A flavonoid compound and composition technology, which is applied in the direction of drug combination, non-active ingredients of polymer compounds, medical preparations of non-effective ingredients, etc. There are no problems such as development and application, increasing the economic burden of patients, etc., and achieve the effect of improving bioavailability, reducing cell damage, and reducing the binding rate

Active Publication Date: 2021-11-02
YUNNAN HEMPMON PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some flavonoids, such as geranyl flavone A, are insoluble in water and can only be dissolved in organic solvents such as ethanol, propylene glycol, ethyl acetate, etc., resulting in low bioavailability
Therefore, in order to achieve the effectiveness of the drug, it is necessary to administer large doses, and the use of large doses will inevitably bring compliance problems and increase the financial burden of patients; at the same time, taking large doses of drugs will also increase the burden on the liver and kidneys, resulting in unpredictable liver disease. kidney damage
In addition, in some practical experiments, geranyl flavone A has also shown certain cytotoxicity, so that this plant-derived compound has not been effectively developed and applied in the field of medicine.
[0004] At present, there are no solutions to the above problems at home and abroad.

Method used

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  • Composition of flavonoids and preparation method thereof
  • Composition of flavonoids and preparation method thereof
  • Composition of flavonoids and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] According to parts by weight, take by weighing 2.5 parts of geranyl flavone A, 1.5 parts of pectin, 12 parts of poloxamer 188, 2.5 parts of hydroxypropyl β-cyclodextrin, 0.5 parts of PEG4000, and 0.5 parts of potassium sorbate. 0.1 parts, purified water is 80.4 parts.

[0075] Mix geranyl flavone A, poloxamer 188, hydroxypropyl β-cyclodextrin, PEG4000 and potassium sorbate, grind them into a mixed powder, then add pectin and purified water to the mixed powder, stir, and mix thoroughly to obtain The liquid composition is recorded as prescription 1.

Embodiment 2

[0077] According to parts by weight, taking geranyl flavone A is 20 parts, edible gelatin is 5 parts, poloxamer 188 is 65 parts, hydroxypropyl beta cyclodextrin is 15 parts, and citric acid is 0.1 part. Put it in a mortar and grind it into a fine powder of 100 mesh to 200 mesh, and record it as prescription 2.

Embodiment 3

[0079] According to parts by weight, weigh 20 parts of geranyl flavone A, 5 parts of edible gelatin, 5 parts of dextran, 25 parts of medium-chain fatty acid powder, 40 parts of hydroxypropyl β-cyclodextrin, and 5 parts of PEG4000 , 0.01 parts of potassium sorbate, 0.2 parts of vitamin C. According to the solid content of 10wt%, the above-mentioned materials were dispersed in purified water, and after being uniformly dispersed, they were freeze-dried for 24 hours through a freeze dryer (model FD-1A-50) to obtain a fluffy fine powder of 80-100 mesh, which was recorded as prescription 3.

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PUM

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Abstract

The invention discloses a flavonoid compound composition and a preparation method thereof. The flavonoid compound composition comprises a flavonoid compound, an absorption slow-release substance and a solubilizer. The present invention forms a composition by adding absorption slow-release substances and solubilizers to the flavonoids, which improves the water solubility of the flavonoids and improves the bioavailability; at the same time, cell damage is reduced. The cell viability was increased by at least 1.17 times, indicating that the composition of the present invention can effectively reduce cytotoxicity.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical compositions, in particular to a composition of flavonoids and a preparation method thereof. Background technique [0002] More than 20 kinds of flavonoids in the whole cannabis plant have been reported, the common ones are apigenin, luteolin, quercetin, orientin, rutin, vitexin and so on. In addition, geranyl flavone A (Cannflavin A) and geranyl flavone B (Cannflavin B) are two unique flavonoids in cannabis plants. Flavonoids in cannabis have been proven to have various pharmacological activities. For example, Barrett et al. reported that geranyl flavonoids A / B in cannabis can greatly enhance anti-inflammatory effects, and have an effect on prostaglandin E- The inhibitory effect of 2 is 30 times that of aspirin (Barrett, M.L., A.M.Scutt, et al., "Cannflavin A and B, prenylated flavones from Cannabissativa". Experientia 42(4):(1986)452-453); Amany K et al. It has been reported that gerany...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K36/60A61K47/36A61K47/42A61K47/10A61K47/38A61P29/00A61P31/00A61P31/04A61P33/02A61P25/28A61P35/00
CPCA61K31/352A61K36/60A61K47/10A61K47/36A61K47/38A61K47/42A61P25/28A61P29/00A61P31/00A61P31/04A61P33/02A61P35/00
Inventor 柳旭高伟博李惠龙赵丽梅常坦然李如彦李庆中
Owner YUNNAN HEMPMON PHARMA CO LTD
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