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A kind of preparation method of intercalation type metal oxide antibacterial agent

A technology of oxides and antibacterial agents, applied in the field of preparation of intercalated metal oxide antibacterial agents, can solve the problems of poor biological safety, high sterilization dosage, low toxic and side effects, etc., and achieves long durability, broad-spectrum sterilization, Low usage effect

Active Publication Date: 2021-06-11
INST OF EARTH ENVIRONMENT CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although metal cations have shown application potential in the field of antibacterial, traditional metal cation antibacterial agents have high dosage for sterilization and poor biological safety.
Therefore, it is still a big challenge to construct antibacterial agents with low toxic and side effects.

Method used

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  • A kind of preparation method of intercalation type metal oxide antibacterial agent

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preparation example Construction

[0022] A kind of preparation method of intercalation type metal oxide antibacterial agent of the present invention comprises the following steps:

[0023] (1) Two-dimensional metal oxide synthesis: add 1mol / L~3mol / L manganese salt, tungsten salt or molybdenum salt solution into the autoclave, add reducing agent solution (reducing agent is glutathione, cysteine acid, cysteine ​​hydrochloride, hydrogen peroxide, the concentration of the reducing agent solution is 3mol / L~6mol / L), mix well, adjust the pH value to 4-8 with acetic acid or ammonia water, and then Hydrothermal reaction at 120°C-250°C for 6-18 hours, centrifugal separation, drying at 25°C-100°C to obtain a two-dimensional metal oxide. Wherein, the volume ratio of the manganese salt, tungsten salt or molybdenum salt solution to the reducing agent solution is 1:1.

[0024] (2) Preparation of antibacterial agent: disperse the two-dimensional metal oxide in the mixed solution of water and organic solvent, then add 0.1mmol...

Embodiment 1

[0029] (1) Mix 100mL of 1mol / L ammonium molybdate solution and 100mL of 3mol / L glutathione aqueous solution, use acetic acid to adjust pH=4, react in water at 120°C for 18h, centrifugally wash, and dry at 25°C to obtain MoO x .

[0030] (2) MoO in step (1) x Disperse in water to form a 50mL 10mg / mL dispersion, add 1mL 0.1mmol / L copper nitrate solution and 1mL 0.1mg / mL ELB solution, peel off mechanically at 0-10°C for 0.5h, remove the sample and dry it at 80°C, Preparation of Cu@ELB@MoO x It is an intercalated metal oxide antibacterial agent.

Embodiment 2

[0032] (1) Mix 100mL 3mol / L ammonium molybdate aqueous solution and 100mL 6mol / L cysteine ​​aqueous solution, adjust the pH to 4 with acetic acid, react in water at 250°C for 6h, centrifugally wash, and dry at 100°C to obtain MoO x .

[0033] (2) MoO in step (1) x Disperse in water to form a 50mL 10mg / mL dispersion, add 1mL 1mmol / L zinc nitrate solution and 1mL 10mg / mL ELB solution, peel off mechanically at 0-10°C for 5h, remove the sample and dry it at 80°C to obtain Zn @ELB @MoO x .

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Abstract

The invention discloses a preparation method of an intercalation type metal oxide antibacterial agent. Add a reducing agent solution to manganese salt, tungsten salt or molybdenum salt solution, mix evenly, adjust the pH value to 4-8, and then set the pH value at 120-250 React at ℃ for 6h-18h, separate and dry to obtain a two-dimensional metal oxide; disperse the two-dimensional metal oxide in a mixed solution of water and an organic solvent, and then add bacterial nutrient extract solution and soluble metal salt solution, 0 Ultrasonic stripping is carried out at ℃~10℃ for 0.5~6 hours, the supernatant is filtered off, centrifuged and dried to obtain an intercalated metal oxide antibacterial agent. The intercalated metal oxide antibacterial agent prepared by the present invention has the function of actively targeting and adsorbing microorganisms in the air, and completely kills Gram-positive and Gram-negative bacteria by slow-release metal cations, and its antibacterial performance is efficient and effective Durable, broad application prospects in the field of antibacterial.

Description

technical field [0001] The invention belongs to the field of ion-disinfecting antibacterial agents, in particular to a preparation method of an intercalation type metal oxide antibacterial agent. Background technique [0002] Bacterial infections have caused many health problems and even killed millions of people around the world. In particular, the overuse of traditional antibiotics has led to widespread bacterial resistance to antibiotics, life-threatening infections and increased economic burden. The rising danger of drug-resistant bacteria creates an urgent need for new antimicrobial therapeutics. However, the traditional disinfection and sterilization technology has disadvantages such as easy to cause secondary pollution, strong toxic and side effects, and incomplete killing. [0003] Metal cations (Ag, Cu, Zn) have broad-spectrum antibacterial effects and are widely used in the field of antibacterial. Patent CN202010268064.5 provides an antibacterial PE shrink film,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N59/16A01N59/20A01P1/00
CPCA01N59/16A01N59/20
Inventor 黄宇高琴姜柳王震宇曹军骥
Owner INST OF EARTH ENVIRONMENT CHINESE ACAD OF SCI
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