Antisense oligomers for controlling candida albicans infections

A technology of Candida albicans and oligomers, which is applied in the field of inhibiting the morphological transformation of Candida albicans from yeast to filament, and treating or treating Candida albicans infection, which can solve the problems of rare application and underutilization

Pending Publication Date: 2021-10-15
UNIVERSITY OF MINHO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite the fact that ASOs for the control of bacterial growth have been developed over the past decad

Method used

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  • Antisense oligomers for controlling candida albicans infections
  • Antisense oligomers for controlling candida albicans infections
  • Antisense oligomers for controlling candida albicans infections

Examples

Experimental program
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Embodiment Construction

[0048] The present disclosure relates to the use of ASO to target specific genes involved in the morphological transformation of Candida albicans from yeast to filaments.

[0049] The present disclosure further describes the use of ASO in the inhibition of morphological transformation of Candida albicans from yeast to filament by AST.

[0050] In one embodiment, ASOs targeting three different genes were designed and synthesized to ensure complete blockade of C. albicans filamentous formation. Considering each gene's high specificity to the C. albicans genome and low specificity to the Homo sapiens genome, high specificity to the genome and low specificity to the Homo sapiens genome were selected from each gene, and from each gene Select the target area. The regions selected were (5'-ACAATAACGGTATGCC-3'), (5'CGCTTATTACATGTTATCA 3') and (5'GCTTACTCTCAACC 3') for EFG1, HWP1 and HYR1, respectively.

[0051] In one embodiment, the target region selected for methylation is:

[00...

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Abstract

The present disclosure relates to the use of antisense oligomers in the treatment or therapy of Candida albicans infections. The present disclosure further describes the use of antisense oligomers in antisense therapy to inhibit the morphological transition of Candida albicans from yeast to filamentous form.

Description

technical field [0001] The present disclosure relates to the use of antisense oligomers in the treatment or therapy of Candida albicans infection. In particular, antisense oligomers were used to target specific genes involved in the morphological transformation of C. albicans from yeast to filamentous form. [0002] The present disclosure further describes the use of antisense oligomers in antisense therapy to inhibit the morphological transformation of Candida albicans from yeast to filaments. Background technique [0003] Candida species generally exist as commensal microorganisms, but they can also act as opportunistic pathogens with the ability to cause superficial and systemic infections. The incidence of Candida infection has increased significantly over the past few years due to the increasing number of elderly populations and immunocompromised patients, as well as the widespread use of indwelling medical devices. Candida albicans infection remains the most prevalen...

Claims

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Application Information

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IPC IPC(8): C12N15/113A61F13/20A61F2/00A61P31/10A61K31/712A61K31/7125
CPCC12N15/113C12N2310/11C12N2310/315C12N2310/341C12N2310/346C12N2320/31A61F13/00063A61F13/8405C12N2310/321C12N2310/3521C09D5/14C09D199/00
Inventor 索尼亚·卡丽娜·莫赖斯·达·席尔瓦丹妮拉·埃拉·阿林助努诺·米格尔·莫赖斯·阿泽维多玛丽安娜·孔滕特·兰热尔·亨里克斯卡丽娜·曼努埃拉·费尔南德斯·阿尔梅达
Owner UNIVERSITY OF MINHO
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