Planar microneedle, microneedle patch, vertical shape and manufacturing equipment

A technology of microneedle stickers and microneedles, applied in the field of microneedles, can solve the problems that it is difficult to satisfy injection and fill the mold forming groove, it is difficult to accurately ensure the distribution of raw material liquid, and the precision of microneedle drug loading is low, so as to improve the yield of good products , Avoid breakage, reduce the effect of demoulding resistance

Active Publication Date: 2022-08-05
YOUWE ZHUHAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large depth and depth-to-length ratio of the forming groove of this mold, it is difficult to accurately ensure that the raw material liquid is only distributed in the needle tip groove when injecting the raw material liquid into the needle tip groove of the forming groove, resulting in low drug loading accuracy of the microneedle , and it is easy to cause the raw material liquid to be dried into microneedles, and it is difficult for the microneedles to be demoulded from the forming groove. At the same time, when the raw material liquid is an oil-water mixture or has a high viscosity, it is difficult to meet the requirement of injecting it into the forming groove of the mold

Method used

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  • Planar microneedle, microneedle patch, vertical shape and manufacturing equipment
  • Planar microneedle, microneedle patch, vertical shape and manufacturing equipment
  • Planar microneedle, microneedle patch, vertical shape and manufacturing equipment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] see figure 1 , this embodiment provides a plane microneedle, including a base layer 11 and a microneedle 12 , and the microneedle 12 is arranged on the base layer 11 . The microneedle 12 includes a needle tip 124 , a middle portion 125 and a needle seat 126 , the middle portion 125 connects the needle tip 124 and the needle seat 126 , and the direction of the needle tip 124 toward the needle seat 126 is substantially the same as the extending direction of the base layer 11 . The microneedles 12 are formed by the forming grooves 321 in the mold 32 .

[0098] see Figure 14 On the one hand, the direction of the needle tip groove 3212 for forming the needle tip 124 toward the needle seat groove 3214 for forming the needle seat 126 is substantially horizontal, which can reduce the depth of the forming groove 321 and reduce the maximum depth of the forming groove 321 The ratio of the maximum length to the needle tip groove 3212 of the forming groove 321 is convenient for a...

Embodiment 2

[0126] see Figure 2-11 And 34, on the basis of Embodiment 1, this embodiment provides a microneedle patch. Specifically, it includes the following two types:

[0127] see Figure 34 , when the microneedle sticker 2 is provided with the adhesive layer 21: after the microneedle 12 is vertical, the side of the base layer 11 away from the microneedle 12 and the third side wall 123 or the raised part 127 of the microneedle 12 are adhered to the adhesive layer 21 , to form a microneedle patch 2 with an adhesive layer 21 . The microneedle patch 2 can be stably adhered to the skin surface through the adhesive layer 21 exposed in the base through hole 112 after the microneedle 12 is inserted into the skin, so as to avoid extruding the microneedle 12 under the action of skin resilience and affecting the microneedle. Normal use of needle stick 2.

[0128] When the microneedle patch 2 is not provided with the adhesive layer 21 : the microneedle 12 contains components that are easily ...

Embodiment 3

[0132] On the basis of Embodiment 1, this embodiment provides a manufacturing equipment for flat microneedles, which includes a base 31 , a mold 32 and a panel 33 located above the base 31 .

[0133] Referring to 11-18, the top of the base 31 is provided with a groove 311 for accommodating the mold 32 . The top of the mold 32 is provided with a plurality of molding grooves 321 for molding the microneedles 12 . The forming groove 321 includes a needle tip groove 3212, a needle seat groove 3214 and a middle groove 3213. The middle groove 3213 communicates with the needle tip groove 3212 and the needle seat groove 3214. The needle tip groove 3212 of the forming groove 321 faces the needle seat groove 3214 in a horizontal direction. The panel 33 is provided with forming holes 331 for accommodating all the forming grooves 321 , and the forming holes 331 are used for forming the base layer 11 . The top of the mold 32 protrudes upward to form an isolation portion 322 , and the isola...

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Abstract

The invention relates to a planar microneedle. The planar microneedle comprises a substrate layer and a microneedle body. The microneedle comprises a needle tip, a middle part and a needle seat. The microneedle further comprises a first side wall, a circumferential side wall and a third side wall, the first side wall and the substrate layer are located on the same plane, the first side wall and the circumferential side wall are located in the circumferential direction of the microneedle, and the third side wall is located at the bottom of the microneedle. The third side wall comprises a first edge and a movable edge, and the first edge is connected with the substrate layer. The microneedle rotates around the first side until the included angle between the third side wall and the plane where the substrate layer is located is 0-+ / -10 degrees, and a substrate through hole is formed in the joint of the microneedle and the substrate layer. The invention also relates to a micro-needle patch, manufacturing equipment of a planar micro-needle, a preparation method of the planar micro-needle and a planar micro-needle standing device. The micro-needle has the advantages that the micro-needle only carries medicine at the needle point, the micro-needle is suitable for filling an oil-water mixture or raw material liquid with high viscosity into the forming groove, and the micro-needle is stable after standing.

Description

technical field [0001] The invention relates to the technical field of microneedles, in particular to a plane microneedle, a microneedle sticker and a vertical shape and manufacturing equipment. Background technique [0002] The micro-needle sticker is pressed into the skin by the micro-needle carrying the drug to realize the injection of the drug. Because the needle of the micro-needle is short, it is not easy to cause pain to the patient during use. Therefore, it has gradually begun to be widely used. [0003] At present, the forming method of microneedle stickers is generally as follows: inject raw material liquid into the forming groove of the mold, and integrally form microneedles extending in the direction perpendicular to the base layer. Due to the large depth and depth-to-length ratio of the forming groove of this kind of mold, when injecting the raw material liquid into the needle tip groove of the forming groove, it is difficult to accurately ensure that the raw ma...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0023A61M2037/0046A61M2037/0053A61M2037/0061
Inventor李成国冷钢陈锦永马永浩李燕芬
OwnerYOUWE ZHUHAI BIOTECH CO LTD