A sample testing device and method for inhaled suspension

Abstract

The present application discloses a sample testing device and method for inhaled suspension, which relates to the field of liquid medicine testing, and includes a storage mechanism for storing suspension and protection, a magnetic stirrer for mixing and stirring the suspension is fixed at the lower end of the glass barrel, and a magnetic stirrer adapted to the magnetic stirrer is arranged in the glass barrel; a discharge mechanism for storing the suspension and making the suspension flow slowly and evenly is arranged in the storage mechanism, and a driving mechanism for driving the discharge mechanism to rotate and discharge is arranged in the storage mechanism; a test mechanism for filtering and testing particles in the suspension is arranged on the lower side of the driving mechanism inside the storage mechanism. The device is designed in an integrated manner, and multiple tests can be detected at one time, making the structure of the device more compact, effectively saving the test time, and at the same time, improving the test efficiency.

Description

Technical Field

[0001] The present application relates to the field of drug liquid testing, and in particular to a sample testing device and method for inhaled suspension. Background Art

[0002] Inhalation suspension (such as budesonide suspension for inhalation) is an important drug for the treatment of respiratory diseases and has a highly effective local anti-inflammatory effect. Therefore, the testing device for inhalation suspension is a device specifically used to test the performance of inhalation suspension. The suspension needs to be tested for physical and chemical properties, quality characteristics, stability, etc.

[0003] For example, the suspension particle detection device disclosed in publication number CN215768129U still has the following shortcomings in actual use:

[0004] The above patent uses a circular plate to squeeze the suspension through the filter element when testing the particles inside the suspension. This method will cause some large particles to pass through the filter element under the applied pressure and will also damage the filter element, resulting in inaccurate suspension test results.

[0005] Meanwhile, the above device can only perform one test on the suspension, and other test devices are required to test the suspension, which reduces the test efficiency. Summary of the invention

[0006] In order to improve the problem of low testing efficiency, the present application provides a sample testing device and method for inhaled suspension.

[0007] The present application provides a sample testing device and method for inhaled suspension using the following technical solutions:

[0008] A sample testing device for inhaled suspension, comprising a storage mechanism for storing suspension and protection, the storage mechanism comprising a laser transmitter, a laser receiver and a visual detection camera rotatably arranged outside a glass barrel and used for detecting the particle distribution of the suspension, a magnetic stirrer for mixing and stirring the suspension is fixed at the lower end of the glass barrel, and a magnetic stirrer adapted to the magnetic stirrer is arranged in the glass barrel;

[0009] The storage mechanism is provided with a discharge mechanism for storing the suspension and making the suspension flow slowly and evenly, and the storage mechanism is provided with a driving mechanism for driving the discharge mechanism to rotate and discharge;

[0010] A testing mechanism for filtering and testing particles in the suspension is provided inside the storage mechanism and located at the lower side of the driving mechanism;

[0011] The bottom surface of the outer wall of the glass barrel is provided with scale lines.

[0012] By adopting the above technical solution, the storage mechanism can fix various test devices and structures and store the suspension, thereby forming a complete test device. At the same time, the storage mechanism, unloading mechanism, driving mechanism and testing mechanism cooperate with each other to realize various tests of the suspension.

[0013] Preferably, the storage mechanism also includes a middle barrel detachably plugged into the upper end of the glass barrel, the middle barrel and the upper barrel are fixed by a connecting frame, a plurality of connecting frames are provided and arranged around the upper barrel, and annular grooves are provided in the middle of the side walls of the lower end of the upper barrel and the upper end of the middle barrel.

[0014] By adopting the above technical solution, the setting of the connecting frame can connect and fix the upper barrel and the middle barrel and reserve a space between the upper barrel and the middle barrel for installing the outer gear ring.

[0015] Preferably, a limiting ring is fixedly provided on the inner wall of the middle barrel near the lower port, a silicone ring is fixedly sleeved on the outer surface of the glass barrel, a ring plate is fixedly provided on the outer side of the silicone ring, and ear plates for fixing the laser transmitter, laser receiver and visual detection camera are fixedly provided on the outer surface of the ring plate.

[0016] By adopting the above technical solution, the setting of the limiting ring can support and limit the movable turntable so that the rotation of the movable turntable is more stable and smooth. At the same time, the setting of the silicone ring can increase the friction with the surface of the glass barrel so that the laser transmitter, laser receiver and visual inspection camera can be moved to any position to test the suspension.

[0017] Preferably, the laser transmitter corresponds to the laser receiver, and the visual inspection camera is arranged vertically to the laser transmitter.

[0018] By adopting the above technical solution, the laser emitted by the laser transmitter is refracted by the suspension particles, received by the laser receiver and converted into data and transmitted to the computer for calculation and processing. At the same time, the visual inspection camera can record the optical path of the laser and then record the particle distribution in the suspension.

[0019] Preferably, the driving mechanism includes an annular groove rotatably arranged at the lower end of the upper barrel and an outer gear ring inside the annular groove at the upper end of the middle barrel, a reduction motor is fixed to the upper end of the outer wall of the middle barrel, the output shaft of the reduction motor is fixed with a driving gear meshing with the outer gear ring, a connecting rod is fixed on one side of the outer gear ring located inside the middle barrel, and a roller is rotatably arranged on the lower side of the connecting rod away from the end of the outer gear ring.

[0020] By adopting the above technical solution, the reduction motor provides power for the rotation of the connecting rod, and the reduction motor is controlled by an external control device. The tester can control the reduction motor in real time and adjust parameters such as rotation.

[0021] Preferably, the unloading mechanism comprises a bent rod fixedly mounted on the upper side of one end of the connecting rod away from the outer gear ring, one end of the bent rod is fixedly provided with a storage cone barrel for storing the suspension to be tested, and the longitudinal axis centerline of the storage cone barrel coincides with the longitudinal axis centerline of the upper barrel.

[0022] By adopting the above technical solution, the bent rod supports the storage cone barrel so that there is a gap between the guide plate at the lower end of the storage cone barrel and the filter paper to avoid contact with the suspension and affect the filtering effect.

[0023] Preferably, a guide plate for guiding the suspension is obliquely fixedly provided at the outlet end of the lower end of the storage cone barrel, and a plurality of flow equalizing plates of different lengths are arranged in an array on the upper surface of the guide plate.

[0024] By adopting the above technical solution, the guide plate can adjust the flow direction of the suspension and cooperate with the flow equalizing plate to evenly distribute the suspension on the surface of the filter paper, effectively improving the test effect.

[0025] Preferably, the testing mechanism includes a movable swivel seat rotatably arranged in the middle of the limiting ring, a filter barrel is fixedly arranged in the middle of the inner cavity of the movable swivel seat, the upper end side wall of the filter barrel is in contact with the roller, and a movable gap is left between the outer periphery of the movable swivel seat and the inner wall of the middle barrel; under normal conditions, the movable swivel seat is in an inclined state.

[0026] By adopting the above technical solution, the filter barrel has a certain height for storing the suspension to prevent it from flowing out. At the same time, the roller can make the movable swivel seat rotate more smoothly and reduce friction. The movable swivel seat, the filter barrel and the filter paper are all in an inclined state, and the inclination angle is set at 3-6 degrees. It should be noted that the friction between the limiting ring and the movable swivel seat is much greater than the friction between the roller and the filter barrel, so that the filter barrel will not rotate about its own longitudinal center axis when the connecting rod rotates.

[0027] Preferably, a mounting groove is formed between the lower end surface of the filter barrel and the lower end surface of the movable swivel seat, filter paper for filtering the suspension is laid in the mounting groove, a clamping ring plate for fixing the filter paper is inserted and fixed in the mounting groove, and the filter surface diameter of the filter paper is the same as the inner wall diameter of the middle barrel.

[0028] By adopting the above technical solution, the inside of the installation groove can cooperate with the clamping ring plate to install filter papers of various shapes and different filtration precisions, so as to test different types of suspensions. The clamping ring plate is connected and fixed with the movable swivel seat by friction.

[0029] A method for using a sample testing device for an inhaled suspension, applied to the above-mentioned sample testing device for an inhaled suspension, comprises the following steps;

[0030] S01, inserting the middle barrel into the upper end of the glass barrel so that the upper end of the glass barrel is abutted and fixed against the limiting ring, and the lower end of the movable rotating seat is completely located inside the glass barrel;

[0031] S02. Then, the tester starts the reduction motor and drives the outer gear ring to rotate slowly. The outer gear ring drives the storage cone barrel to rotate through the connecting rod and the bent rod. Then, an equal amount of the suspension to be tested in the test tube is poured into the storage cone barrel. The suspension to be tested will flow to the surface of the guide plate. Through the setting of multiple flow equalizing plates, the suspension to be tested is guided to different positions of the filter paper radius;

[0032] S03. When the tester observes that the suspension flows down the filter paper, the timer starts timing, and the timing is stopped when the suspension on the upper end of the filter paper flows into the glass barrel and stops flowing. The Class A test data of this time is retained and compared with the flow time of the standard suspension to obtain the difference, thereby determining whether the size of the particles in the suspension to be tested is consistent. The quality of the suspension to be tested can also be determined by comparing the time of collecting an equal amount of test suspension;

[0033] S04. When the suspension to be tested flows down from the filter paper after being filtered, the tester can observe whether the flow of the suspension is in the form of drops or lines to preliminarily judge the viscosity of the suspension. During the filter paper filtering process, the roller rolls on the upper end of the filter barrel under the action of the connecting rod, thereby driving the movable rotating seat to rotate in a circle on the limiting ring, so that the suspension evenly enters the glass barrel and gathers, so that the particles inside the filtered suspension are more evenly distributed in the glass barrel;

[0034] S05. Then, the suspension can be subjected to a sedimentation test, and the time required for sedimentation can be recorded by a timer. The thickness of the sediment of particles inside the suspension can be recorded by a scale line and calculated by a formula to obtain the mass of the suspension.

[0035] S06. At the same time, when the suspension enters the glass barrel and stabilizes for a period of time, the tester moves the positions of the laser transmitter, the laser receiver and the visual inspection camera to detect the distribution or particle size of the particles inside the suspension. The laser transmitter emits laser to irradiate the suspension and the laser receiver receives the laser and then calculates through an external computing device. At the same time, the visual inspection camera can collect the particle distribution state of the suspension under normal conditions and after being irradiated by the laser;

[0036] S07. After obtaining the data A of the first suspension precipitation, then, remove the middle barrel and place the magnetic stirrer in the glass barrel. Then, the magnetic stirrer is rotated rapidly by the action of the magnetic stirrer to break up the precipitated particles and restore the suspension to a mixed state. Then, repeat the step of S05 to record the precipitation type B data and increase the test data.

[0037] In summary, the present application includes at least one of the following beneficial technical effects:

[0038] 1. The storage mechanism can store, mix and stir the suspension to be tested, and detect the particle distribution and viscosity of the suspension, effectively integrating multiple tests together to achieve an integrated design, so that one suspension can be tested for multiple tests at the same time, effectively improving the test effect and accuracy;

[0039] 2. The setting of the driving mechanism can make the suspension flow evenly to the surface of the filter paper, avoiding the large particles in the suspension from gathering in one place and affecting the filtration flow of the suspension, effectively avoiding the increase of test errors, and thus improving the accuracy of the test data.

[0040] 3. The setting of the test mechanism can make the suspension flow evenly on the filter paper and make the filter paper swing in a circular motion so that the filtered suspension can flow evenly into the glass barrel. The viscosity of the suspension can be observed during the swinging process, which can help the tester make a preliminary judgment on the viscosity of the suspension.

[0041] In summary, the device is designed to be integrated and can detect multiple tests at one time, making the structure of the device more compact, effectively saving test time and improving test efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] Figure 1 It is an overall isometric schematic diagram of a sample testing device and method for inhaled suspension of the present application;

[0043] Figure 2 A front view schematic diagram of a sample testing device and method for inhaled suspension of the present application;

[0044] Figure 3 It is an overall isometric exploded schematic diagram of a sample testing device and method for inhalation suspension of the present application;

[0045] Figure 4 A schematic diagram of the positions of the driving mechanism and the unloading mechanism of the sample testing device and method for inhaled suspension of the present application;

[0046] Figure 5 A schematic diagram of the separation of the middle barrel, the restriction ring and the movable swivel seat of the sample testing device and method for inhaled suspension of the present application;

[0047] Figure 6 A schematic diagram of the movable rotating seat, filter paper and snap ring plate separation of the sample testing device and method for inhaled suspension of the present application;

[0048] Figure 7 A schematic diagram of a magnetic stirrer and a magnetic stirring bar for a sample testing device and method for inhaled suspension of the present application;

[0049] Figure 8 This is a schematic diagram of the separation of the outer gear ring and the ring groove of the sample testing device and method for inhaled suspension of the present application;

[0050] Fig. 9 This is a schematic diagram of the unloading mechanism of the sample testing device and method for inhaled suspension of the present application.

[0051] Reference numerals: 100, storage mechanism; 101, upper barrel; 102, middle barrel; 103, glass barrel; 104, ear plate; 105, laser receiver; 106, laser transmitter; 107, magnetic stirrer; 108, ring plate; 109, silicone ring; 110, visual inspection camera; 111, ring groove; 112, limiting ring; 113, magnetic stirrer;

[0052] 200, driving mechanism; 201, driving gear; 202, reduction motor; 203, outer gear ring; 204, connecting rod; 205, roller;

[0053] 300, unloading mechanism; 301, bending rod; 302, storage cone barrel; 303, guide plate; 304, flow equalizing plate;

[0054] 400, testing mechanism; 401, filter barrel; 402, movable swivel seat; 403, filter paper; 404, mounting groove; 405, snap ring plate;

[0055] 500, connecting frame; 600, scale line. DETAILED DESCRIPTION

[0056] The following is combined with Figure 1 - Fig. 9 This application is described in further detail.

[0057] The embodiments of the present application disclose a sample testing device and method for inhaled suspension.

[0058] Reference Figure 1 - Figure 3, a sample testing device for inhaled suspension, including a storage mechanism 100 for storing suspension and protection, the storage mechanism 100 includes a laser transmitter 106, a laser receiver 105 and a visual detection camera 110 rotatably arranged on the outside of a glass barrel 103, the laser transmitter 106, the laser receiver 105 and the visual detection camera 110 are used to detect the particle distribution of the suspension, a magnetic stirrer 107 for mixing and stirring the suspension is fixed at the lower end of the glass barrel 103, the size of the magnetic stirrer 107 is much larger than the diameter of the glass barrel 103 to achieve a stable effect, a magnetic stirrer 113 adapted to the magnetic stirrer 107 is arranged in the glass barrel 103, the magnetic stirrer 113 is arranged at the induction end of the magnetic stirrer 107, and the size of the magnetic stirrer 113 includes but is not limited to the size shown in the accompanying drawings according to Customization is required. At the same time, a micro temperature sensor can be integrated inside the magnetic stirrer 113 and a wireless transmission module can be used to enable the magnetic stirrer 113 to detect the temperature of the suspension. In order to prevent the metal shell of the magnetic stirrer 113 from interfering with signal transmission, plastic material is reserved on the shell of the magnetic stirrer 113. The storage mechanism 100 also includes a middle barrel 102 that can be detachably plugged into the upper end of the glass barrel 103. When plugged in, the inner wall of the middle barrel 102 fits with the outer wall of the glass barrel 103 to achieve sealing. A plurality of connecting frames 500 are fixed around the surface of the middle barrel 102, and one end of the plurality of connecting frames 500 is fixed to the surface of the upper barrel 101, thereby fixing the upper barrel 101 and the middle barrel 102. An annular groove 111 is provided in the middle of the side wall at the lower end of the upper barrel 101 and the middle of the side wall at the upper end of the middle barrel 102, and the structural dimensions of the two annular grooves 111 are equal.

[0059] A barrel cover may also be provided at the upper opening of the upper barrel 101, and may be provided according to actual needs. The barrel cover is not shown in the prior art diagram.

[0060] After the suspension in the glass barrel 103 is precipitated, the tester powers on the magnetic stirrer 107 and turns on the switch, then places the magnetic stirrer 113 in the suspension in the glass barrel 103, then the magnetic stirrer 113 rotates under the drive of the magnetic force to remix the layered suspension, and then reprecipitates to increase the test data, thereby improving the accuracy of the test result. The specific operation is to measure the ratio of the height of the sediment to the original height of the suspension F=VU / VO or F=HU / HO;

[0061] Where VU is the volume of the sediment, VO is the original volume of the suspension; HU is the height of the sediment, and HO is the original height of the suspension. The larger the F value, the closer the height of the sediment is to the height of the suspension, and the more stable the suspension is.

[0062] During the laser detection process, the laser transmitter 106 will emit laser beams, which will interact with the inhalable suspension being tested. Then, the laser receiver 105 will receive and process these laser signals after the interaction, thereby obtaining information about the properties of the suspension such as particle size, concentration, etc., and then transmit it to the processing equipment through cables, and then display it on the monitor after being processed by a computer, so that the data can be displayed more intuitively.

[0063] Reference Figure 1 - Figure 5 The inner wall of the middle barrel 102 is integrally formed with the outer wall of the limiting ring 112 near the lower port. The inner edge of the limiting ring 112 gradually closes from top to bottom and the inclined surface is set to an arc shape and fits the outer surface of the movable rotating seat 402 to achieve the limiting effect. The silicone ring 109 is provided with an inner wall and an outer side. The outer surface of the glass barrel 103 is fixedly sleeved with the inner wall of the silicone ring 109. The outer side of the silicone ring 109 is fixedly glued and fixed to the surface of the ring plate 108. The friction force of the silicone ring 109 can make the ring plate 108 08 is fixed on the surface of the glass barrel 103, and the outer surface of the ring plate 108 is integrally formed with an ear plate 104 for fixing the laser transmitter 106, the laser receiver 105 and the visual inspection camera 110. The surface of the ear plate 104 is provided with a plurality of threaded holes so that other inspection devices, such as a "heating block or a cooling sheet" can be installed. The emitting end of the laser transmitter 106 corresponds to the receiving end of the laser receiver 105, and the visual inspection camera 110 is vertically arranged to the laser transmitter 106.

[0064] When the middle barrel 102 is plugged and fixed with the glass barrel 103, the lower end surface of the limiting ring 112 abuts against the upper end surface of the glass barrel 103 and achieves sealing, and the diameter of the filter paper 403 is much smaller than the barrel mouth diameter of the glass barrel 103, thereby preventing the suspension filtered by the filter paper 403 from contacting the barrel wall of the glass barrel 103 when the movable rotating seat 402 rotates. When testing the suspension inside the glass barrel 103, the tester moves the ring plate 108 by hand, and the ring plate 108 moves up and down on the surface of the glass barrel 103 to be fixed under the action of the silicone ring 109. The ring plate 108 can drive multiple ear plates 104 to move and then drive the laser transmitter 106, the laser receiver 105 and the visual inspection camera 110 to move, so that different positions of the suspension can be tested and detected, effectively improving the effect of the suspension test and improving the accuracy of the test.

[0065] The visual inspection camera 110 can record the suspension and the particle distribution inside it, and at the same time, can record the precipitation process of the suspension in real time, etc. It can be used according to the specific needs of the test.

[0066] Reference Figure 1 - Figure 4 , Figure 8 , Fig. 9 The storage mechanism 100 is provided with a discharge mechanism 300 for storing the suspension and making the suspension flow slowly and evenly. The discharge mechanism 300 includes a bent rod 301 fixedly arranged on the upper side of one end of the connecting rod 204 away from the outer gear ring 203. A storage cone barrel 302 is fixedly arranged at one end of the bent rod 301. The storage cone barrel 302 is used to store the suspension to be tested. The cone mouth of the storage cone barrel 302 is downward and its center coincides with the center of the filter barrel 401. The longitudinal axis of the storage cone barrel 302 coincides with the longitudinal axis of the upper barrel 101. A guide plate 303 for guiding the suspension is fixedly arranged at the outlet end of the lower end of the storage cone barrel 302. The guide plate 303 is tilted at an angle of 5-30 degrees. At the same time, the upper surface of the guide plate 303 The surface is provided with an inclined surface, and the inclination angle of the inclined surface is set at 3-5 degrees, and the inclination direction of the inclined surface can be set on any side of the left and right sides of the guide plate 303. A plurality of equalizing plates 304 of different lengths are arranged in an array on the inclined surface on the upper surface of the guide plate 303. A plurality of short equalizing plates 304 are gradually distributed and lengthened from the side of the guide plate 303 close to the storage cone barrel 302. At the same time, one end of the plurality of equalizing plates 304 of different lengths is flush with the lowest side of the inclined surface, and the end of the longer equalizing plate 304 at the other end protrudes from the end of the equalizing plate 304 arranged on the upper side, and the protruding distance is 3-5 mm. The end of the guide plate 303 away from the storage cone barrel 302 extends to near the inner wall of the filter barrel 401.

[0067] The tester pours the suspension to be tested in the test tube into the storage cone barrel 302, and the suspension flows to the guide plate 303 through the lower port of the storage cone barrel 302. The suspension first spreads on the surface of the guide plate 303, and then flows along the inclined surface and under the action of gravity and falls on the filter paper 403. The suspension flows from top to bottom and fills and flows between multiple equalizing plates 304 of different lengths. The suspension flowing out of the shorter equalizing plate 304 flows to the center of the filter paper 403, and the suspension flowing out of the longer equalizing plate 304 flows to the periphery of the filter paper 403, and then covers the radius of the filter paper 403, so that the suspension can evenly cover the surface of the filter paper 403, effectively improving the effect of the filtration test, while increasing the filtration area to effectively increase the filtration flow rate, and at the same time, it also ensures the consistency of each test of the particles in the suspension, thereby improving the consistency with the standard suspension test, and making the comparison result more accurate.

[0068] Reference Figure 1 - Figure 4The storage mechanism 100 is provided with a driving mechanism 200 for driving the unloading mechanism 300 to rotate and unload. The driving mechanism 200 includes a ring groove 111 rotatably arranged at the lower end of the upper barrel 101, which is plugged into the lower side of the outer gear ring 203 and rotates. The inner side of the ring groove 111 at the upper end of the middle barrel 102 is plugged into the upper side of the outer gear ring 203 and rotates. The upper and lower side surfaces of the outer gear ring 203 are both in contact with the inner wall of the ring groove 111 at the lower end of the upper barrel 101 and the inner wall of the ring groove 111 at the upper end of the middle barrel 102 to achieve limiting and prevent the outer gear ring 203 from shaking in a virtual position. The tooth portion of the outer gear ring 203 is located between the upper barrel 101 and the middle barrel 10 2, the upper end of the outer wall of the middle barrel 102 is fixed to the mounting end of the reduction motor 202 by bolts, the output shaft of the reduction motor 202 is fixed with a driving gear 201, the driving gear 201 is meshed with the outer gear ring 203, and the outer gear ring 203 is located on one side of the middle barrel 102 and is fixed with a connecting rod 204, the width of one end of the connecting rod 204 is smaller than the tooth height of the outer gear ring 203, and a rectangular notch is provided on the lower side of the connecting rod 204 away from the end of the outer gear ring 203, and a roller 205 is rotatably arranged in the notch, and the surface of the roller 205 is always in contact with the upper side wall of the filter barrel 401 and realizes pressure to keep the filter barrel 401 always in an inclined state.

[0069] The reduction motor 202 is energized, and the output shaft of the reduction motor 202 drives the driving gear 201 to rotate, and then drives the outer ring gear 203 to rotate in the annular groove 111, and the outer ring gear 203 drives the connecting rod 204 to rotate, so that the connecting rod 204 continuously rotates around the filter barrel 401. Because the roller 205 rotates in a plane and the height remains unchanged, under the action of the roller 205, one end of the filter barrel 401 is always located at a low point and the other end is located at a high point, so that the suspension can continuously move on the surface of the filter paper 403. When the filter paper 403 is conical, the suspension can flow on the conical surface of the filter paper 403, and then the filtration area is adjusted to make the suspension more evenly distributed, improve the filtration effect, and make the suspension drip naturally under the action of gravity.

[0070] Reference Figure 2 - Figure 5A testing mechanism 400 for filtering and testing particles in the suspension is provided inside the storage mechanism 100 and located at the lower side of the driving mechanism 200. The testing mechanism 400 includes a movable rotating seat 402 rotatably arranged in the middle of the limiting ring 112. The middle part of the inner cavity of the movable rotating seat 402 is fixed to the outer wall of the filter barrel 401, and the upper end of the filter barrel 401 protrudes from the upper end of the movable rotating seat 402 to store the suspension. The upper end surface of the filter barrel 401 is a smooth surface, and an active gap is left between the outer periphery of the movable rotating seat 402 and the inner wall of the middle barrel 102. The active gap can ensure that the filter barrel 401 drives the movable rotating seat 402 to tilt under the action of the limiting ring 112 under pressure. 403 is rotated in a fixed manner; under normal conditions, the movable rotating seat 402 is inclined under the pressure of the roller 205, and a circular mounting groove 404 is formed between the lower end surface of the filter barrel 401 and the lower end surface of the movable rotating seat 402. A filter paper 403 for filtering the suspension is laid in the mounting groove 404. The diameter of the filter paper 403 is the same as the diameter of the mounting groove 404 to achieve perfect installation and avoid wrinkles. A snap ring plate 405 is inserted and fixed in the mounting groove 404. The filter paper 403 is located between the top of the mounting groove 404 and the upper end of the snap ring plate 405. The snap ring plate 405 fixes the filter paper 403 when inserted into the mounting groove 404. The filter surface diameter of the filter paper 403 is the same as the inner wall diameter of the middle barrel 102.

[0071] The filter paper 403 is set as a plane in the figure, including but not limited to a plane, and the filter part of the filter paper 403 may also be conical.

[0072] When installing the filter paper 403 , the tester installs the filter paper 403 in the installation groove 404 , and then inserts the snap ring plate 405 into the installation groove 404 to abut and fix the filter paper 403 .

[0073] The connecting rod 204 drives the roller 205 to roll on the filter barrel 401 and drives the filter barrel 401 to tilt and rotate, and at the same time drives the movable swivel seat 402 to rotate on the limiting ring 112. The movable swivel seat 402 is set to an alloy metal material, and the action of gravity is used to prevent the movable swivel seat 402 from separating from the limiting ring 112. This setting can make the suspension flow on the surface of the filter paper 403 in real time in a state similar to a vortex motion, which can lay the suspension well and effectively avoid the large particles inside the suspension from being roughly accumulated in one piece, resulting in a decrease in the filtering performance at this position, which greatly affects the filtration time of the suspension. This structural setting can reduce the error during the suspension test.

[0074] At the same time, the high and low rotation of the filter paper 403 can make the filtered suspension evenly distributed in the glass barrel 103, and at the same time, it is also convenient for the tester to observe the viscosity of the suspension.

[0075] Reference Figure 1The bottom surface of the outer wall of the glass barrel 103 is provided with a scale line 600, and the unit of the scale line 600 is millimeter.

[0076] After the suspension in the glass barrel 103 settles, the height of the precipitated particles can be read through the scale line 600, and then calculated through a calculation formula. At the same time, it can also be measured through other distance detection devices. It can be selected according to actual needs.

[0077] Among them, the laser transmitter 106, the laser receiver 105, the magnetic stirrer 107, the visual inspection camera 110, the magnetic stirrer 113 and the reduction motor 202 are all set to the existing technology, and the structural principle will not be described in detail, and the device is provided with switches, microprocessors, connecting wires and power supplies on the outside, which are not the main technology and will not be described in detail. The device is also provided with a timer on the outside for timing during testing.

[0078] A method for using a sample testing device for inhaled suspension comprises the following steps:

[0079] S01. Insert the middle barrel 102 into the upper end of the glass barrel 103 so that the upper end of the glass barrel 103 is abutted and fixed against the limiting ring 112 , and the lower end of the movable rotating seat 402 is completely located inside the glass barrel 103 .

[0080] S02. Subsequently, the tester turns on the switch of the reduction motor 202, and the external power supply starts the reduction motor 202. The output shaft of the reduction motor 202 drives the outer gear ring 203 to rotate slowly through the driving gear 201. The outer gear ring 203 drives the connecting rod 204 and the bent rod 301 to rotate, and then drives the storage cone barrel 302 to rotate. Subsequently, the suspension to be tested in an amount equal to that of the test tube and the standard suspension is poured into the storage cone barrel 302 and gathered inside the storage cone barrel 302. The suspension to be tested will slowly flow to the surface of the guide plate 303, and the suspension to be tested will be guided to different positions within the radius of the filter paper 403 through the setting of multiple flow equalizing plates 304.

[0081] S03. When the test personnel observes that the suspension flows down the filter paper 403, the timer starts timing, and the timing is stopped when the suspension on the upper end of the filter paper 403 flows into the glass barrel 103 and stops flowing. The Class A test data of this time is retained and compared with the time taken for the standard suspension test, so as to obtain the difference, and then determine whether the size of the particles in the suspension to be tested is consistent, so as to determine the quality of the suspension to be tested. The quality of the suspension to be tested can also be determined by comparing the time taken to collect an equal amount of test suspension. For example, the time taken to collect 20ML of the suspension to be tested and the standard suspension can be used for judgment.

[0082] S04. When the suspension to be tested flows down after being filtered through the filter paper 403, the tester can observe whether the flow of the suspension is in the form of drops or lines to preliminarily judge the viscosity of the suspension. During the filtering process of the filter paper 403, the roller 205 rolls on the upper end of the filter barrel 401 under the action of the connecting rod 204, thereby driving the movable rotating seat 402 to rotate in a circle on the limiting ring 112, so that the flow distribution of the suspension to be tested on the filter paper 403 is more uniform, the fluidity is increased, the suspension is uniformly entered into the glass barrel 103 and gathered, and the particles inside the filtered suspension are more evenly distributed in the glass barrel 103.

[0083] S05. Then, a sedimentation test can be performed on the suspension. The suspension in the glass barrel 103 is allowed to stand and the sedimentation time is recorded by a timer. The thickness of the particle sediment in the suspension is recorded by the scale line 600 and calculated by a formula to obtain the mass of the suspension.

[0084] S06. At the same time, when the suspension enters the glass barrel 103 and stabilizes for a period of time, the tester moves the positions of the laser transmitter 106, the laser receiver 105 and the visual inspection camera 110 to detect the distribution or particle size of the particles inside the suspension. The laser transmitter 106 emits a laser to irradiate the suspension and the laser receiver 105 receives the laser and then calculates the result through an external computing device. At the same time, the visual inspection camera 110 can collect the particle distribution state of the suspension under normal conditions and after being irradiated by the laser, as well as the movement of the particles when they are precipitated.

[0085] S07. After obtaining the data A of the first suspension precipitation, compare it with the standard data. The data can be accurately tested through multiple precipitation tests. Then, the middle barrel 102 is removed and the magnetic stirrer 113 is placed in the glass barrel 103. Then, the magnetic stirrer 113 is rotated rapidly under the action of the magnetic stirrer 107 to break up the precipitated particles and restore the suspension to a mixed state. Then, the step of S05 is repeated to record the precipitation type B data, increase the test data and improve the accuracy of the test.

[0086] At the same time, the suspension also needs to be tested for temperature. At this time, a heating device or a cooling device can be installed on the ear plate 104 to test the circulating liquid's temperature change or state at different temperatures, and then test the storage. Therefore, the glass barrel 103 also needs a cover to be sealed to simulate the storage environment.

[0087] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A sample testing device for inhaled suspension, characterized in that: It comprises a storage mechanism (100) for storing and protecting a suspension, the storage mechanism (100) comprising a laser transmitter (106) rotatably arranged outside a glass barrel (103) and used for detecting the particle distribution of the suspension, a laser receiver (105) and a visual detection camera (110), a magnetic stirrer (107) for mixing and stirring the suspension is fixedly arranged at the lower end of the glass barrel (103), and a magnetic stirrer (113) adapted to the magnetic stirrer (107) is arranged inside the glass barrel (103); The storage mechanism (100) is provided with a discharge mechanism (300) for storing the suspension and causing the suspension to flow slowly and evenly, and the storage mechanism (100) is provided with a driving mechanism (200) for driving the discharge mechanism (300) to rotate and discharge; A testing mechanism (400) for filtering and testing particles in the suspension is arranged inside the storage mechanism (100) and located below the driving mechanism (200). The storage mechanism (100) further comprises a middle barrel (102) which is detachably plugged into the upper end of the glass barrel (103). The middle barrel (102) and the upper barrel (101) are fixedly connected via a connecting frame (500). The connecting frame (500) comprises a plurality of connecting frames and is arranged around the upper barrel (101). The lower end of the upper barrel (101) is connected to the middle barrel ( 102) are provided with an annular groove (111) in the middle of the side wall at the upper end, a limiting ring (112) is fixedly provided on the inner wall of the middle barrel (102) near the lower end, a silicone ring (109) is fixedly sleeved on the outer surface of the glass barrel (103), a ring plate (108) is fixedly provided on the outer side of the silicone ring (109), and an ear plate (104) for fixing the laser transmitter (106), the laser receiver (105) and the visual detection camera (110) is fixedly provided on the outer surface of the ring plate (108); The driving mechanism (200) comprises an outer gear ring (203) rotatably arranged inside an annular groove (111) at the lower end of the upper barrel (101) and the annular groove (111) at the upper end of the middle barrel (102); a reduction motor (202) is fixed to the upper end of the outer wall of the middle barrel (102); an output shaft of the reduction motor (202) is fixedly provided with a driving gear (201) meshing with the outer gear ring (203); a connecting rod (204) is fixedly provided on one side of the outer gear ring (203) located inside the middle barrel (102); and a roller (205) is rotatably arranged on the lower side of the connecting rod (204) at one end away from the outer gear ring (203); The testing mechanism (400) comprises a movable rotating seat (402) rotatably arranged in the middle of the limiting ring (112), a filter barrel (401) is fixedly arranged in the middle of the inner cavity of the movable rotating seat (402), the upper side wall of the filter barrel (401) is in contact with the roller (205), and a movable gap is left between the outer periphery of the movable rotating seat (402) and the inner wall of the middle barrel (102); In a normal state, the movable rotating seat (402) is in an inclined state, and a mounting groove (404) is formed between the lower end surface of the filter barrel (401) and the lower end surface of the movable rotating seat (402), and a filter paper (403) for filtering the suspension is laid in the mounting groove (404), and a clamping ring plate (405) for fixing the filter paper (403) is inserted and fixed in the mounting groove (404), and the filter surface diameter of the filter paper (403) is the same as the inner wall diameter of the middle barrel (102); The unloading mechanism (300) comprises a bent rod (301) fixedly mounted on the upper side of one end of the connecting rod (204) away from the outer gear ring (203); a storage cone barrel (302) for storing a suspension to be tested is fixedly mounted on one end of the bent rod (301); the longitudinal axis of the storage cone barrel (302) coincides with the longitudinal axis of the upper barrel (101); a guide plate (303) for guiding the suspension is fixedly mounted obliquely at the outlet end of the lower end of the storage cone barrel (302); and a plurality of flow equalizing plates (304) of different lengths are arranged in an array on the upper surface of the guide plate (303); The bottom surface of the outer wall of the glass barrel (103) is provided with scale lines (600).

2. A sample testing device for inhaled suspension according to claim 1, characterized in that: The laser transmitter (106) corresponds to the laser receiver (105), and the visual inspection camera (110) is arranged vertically to the laser transmitter (106).

3. A method for using a sample testing device for an inhaled suspension, applied to the sample testing device for an inhaled suspension according to claim 2, characterized in that: The steps include: S01, inserting the middle barrel (102) into the upper end of the glass barrel (103) so that the upper end of the glass barrel (103) is abutted and fixed against the limiting ring (112), and the lower end of the movable rotating seat (402) is completely located inside the glass barrel (103); S02. Subsequently, the tester starts the reduction motor (202) and drives the outer gear ring (203) to rotate slowly. The outer gear ring (203) drives the storage cone barrel (302) to rotate through the connecting rod (204) and the bent rod (301). Then, an equal amount of the suspension to be tested in the test tube is poured into the storage cone barrel (302). The suspension to be tested will flow to the surface of the guide plate (303). The suspension to be tested is guided to different positions within the radius of the filter paper (403) by the arrangement of multiple flow equalizing plates (304); S03. When the tester observes that the suspension flows down the filter paper (403), the timer starts timing, and the timing is stopped when the suspension on the upper end of the filter paper (403) flows into the glass barrel (103) and stops flowing. The Class A test data of this time is retained and compared with the flow time of the standard suspension to obtain the difference, thereby determining whether the size of the particles in the suspension to be tested is consistent. The time for collecting an equal amount of test suspension can also be used to compare and determine the quality of the suspension to be tested; S04. When the suspension to be tested flows down from the filter paper (403) after being filtered, the tester can observe whether the flow of the suspension is in the form of drops or lines to preliminarily judge the viscosity of the suspension. During the filtering process of the filter paper (403), the roller (205) rolls on the upper end of the filter barrel (401) under the action of the connecting rod (204), thereby driving the movable rotating seat (402) to rotate in a circle on the limiting ring (112), so that the suspension evenly enters the glass barrel (103) and gathers, so that the particles inside the filtered suspension are more evenly distributed in the glass barrel (103); S05. Then, the suspension can be subjected to a sedimentation test, and the time required for sedimentation can be recorded by a timer. The thickness of the sediment of particles inside the suspension can be recorded by the scale line (600) and calculated by a formula to obtain the mass of the suspension. S06. At the same time, when the suspension enters the glass barrel (103) and stabilizes for a period of time, the tester moves the positions of the laser transmitter (106), the laser receiver (105), and the visual inspection camera (110) to detect the distribution or particle size of the particles inside the suspension. The laser transmitter (106) emits a laser to irradiate the suspension, and the laser receiver (105) receives the laser and then performs calculations through an external computing device. At the same time, the visual inspection camera (110) can collect the particle distribution state of the suspension under normal conditions and after being irradiated by the laser. S07. After obtaining the data A of the first suspension precipitation, the middle barrel (102) is removed and the magnetic stirrer (113) is placed in the glass barrel (103). Then, the magnetic stirrer (113) is rotated rapidly by the action of the magnetic stirrer (107) to break up the precipitated particles and restore the suspension to a mixed state. Then, the step of S05 is repeated to record the precipitation type B data and increase the test data.

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