Non-invasive nerve regulation and control device

Abstract

The invention provides a non-invasive nerve regulation and control device. The non-invasive nerve regulation and control device comprises an optical fiber, an optical fiber fixing device arranged at one end of the optical fiber, a laser light source arranged at the other end of the optical fiber and a photoelectric conversion material positioning and injecting assembly. The photoelectric conversion material positioning and injecting assembly is used for injecting a photoelectric conversion material into a specified solution injection point; the photoelectric conversion material is powdery and comprises nanoparticles capable of converting near-infrared light into electric signals, and the photoelectric conversion material is dispersed in normal saline so as to be injected into biological tissues; the laser light source irradiates laser in a near-infrared band to an area where a photoelectric conversion material injection point is located, so that the laser is converted into an electric signal through the photoelectric conversion material, and the electric signal stimulates an area where a solution injection point is located. The non-invasive nerve regulation and control device has the advantages of non-invasiveness, high efficiency, system uniqueness, stability and programmable control, can realize accurate regulation and control of neurons and neural circuits, and has a wide application prospect.

Description

Technical Field

[0001] The present invention belongs to the field of neuromodulation technology, and in particular, relates to a non-invasive neuromodulation device using near-infrared light and photoelectric conversion materials. Specifically, the present invention relates to the fields of neuroscience, materials science, and biomedical engineering, and aims to achieve precise regulation of neuronal activity through advanced photoelectric conversion technology, providing a technical solution with broad application prospects in neurological research and clinical treatment. Background Art

[0002] Existing neuromodulation methods mainly include electrical stimulation and light regulation. Electrical stimulation technology achieves regulation by directly transmitting electrical signals to the nervous system. Its advantage is that it can achieve fast and precise control of neural activity. However, electrical stimulation methods usually require the implantation of electrodes, which not only poses a high challenge to the quality of the electrodes, but also causes damage to brain tissue, resulting in low patient acceptance and increased surgical complexity.

[0003] In contrast, light control technology uses light of a specific wavelength to activate or inhibit neuronal activity. It is non-invasive and has high spatial resolution. It does not damage the organism and can achieve long-term acquisition of neural signals. However, the main disadvantage of light control technology is that short-wavelength light signals have poor penetration, and optical fibers often need to be implanted to reduce the loss of incident light. The implantation of optical fibers will cause brain tissue damage problems similar to electrical stimulation. Near-infrared light has strong penetrating power and is often used in various medical applications.

[0004] In the field of neuromodulation, existing technologies have the following main problems:

[0005] 1. Risk of injury from invasive operations: Traditional electrical stimulation methods require implantation of electrodes to achieve regulation by directly transmitting electrical signals to the nervous system. This method not only places high demands on the quality and durability of the electrodes, but also, due to the invasiveness of surgical implantation, it will inevitably cause damage to brain tissue, increase the risk of infection and other complications, and the electrode stability will also decrease over time, so the long-term stability is poor. Patient acceptance is low, and the surgery is complex and the recovery period is long.

[0006] 2. Penetration limitation of light control methods: Light control technology uses light of a specific wavelength to activate or inhibit neuronal activity, which is non-invasive and has high spatial resolution. However, short-wavelength light has poor penetration and slows down the control response speed.

[0007] Therefore, it is usually necessary to implant optical fibers to increase the penetration depth and reduce the loss of incident light. For example, by implanting optical fibers and introducing exogenous light-sensitive protein genes into living cells through viruses, light-sensitive channel proteins are expressed on the cell membrane structure; then, by irradiating light of a specific wavelength, the activation and shutdown of light-sensitive channel proteins on the cell membrane structure are controlled to control neuronal activation. Because this method requires the introduction of exogenous protein genes through viruses, it has certain potential risks and is similar to implanted electrodes. The long-term presence of optical fibers in brain tissue also damages brain tissue, leading to problems similar to electrical stimulation methods, such as limited movement, making it difficult to be widely used in clinical practice.

[0008] 3. Limitations of existing materials and technologies: Although upconversion materials and photoelectric materials have been used in the field of photoelectric conversion, it is still a challenge to effectively combine these materials to form an efficient and stable photoelectric conversion system for use in neural regulation. In addition, how to ensure the stability and safety of photoelectric conversion materials in the body and how to accurately control the transmission of light and electrical signals are also urgent issues to be solved.

[0009] 4. System integration and operational complexity: Existing photoelectric conversion systems often have deficiencies in the integration of materials and equipment, and cannot form an efficient, stable, and easy-to-operate overall system. This not only affects the effect of neural regulation, but also increases the complexity of operation and the uncertainty of experiments. Summary of the invention

[0010] In view of the above problems, the present invention proposes a non-invasive neuromodulation device, which realizes precise neuromodulation while avoiding the problem of brain tissue damage in traditional methods.

[0011] In order to achieve the purpose, the present invention provides a non-invasive neuromodulatory device, characterized by comprising an optical fiber, an optical fiber fixing device disposed at one end of the optical fiber, a laser light source disposed at the other end of the optical fiber, and a photoelectric conversion material positioning and injection component disposed separately from the optical fiber;

[0012] The photoelectric conversion material positioning and injection assembly is used to inject the photoelectric conversion material into a designated solution injection point; the photoelectric conversion material is in powder form, and contains nanoparticles that can convert near-infrared light into electrical signals, which are dispersed in physiological saline so as to be injected into biological tissues;

[0013] The laser light source is configured to irradiate the area where the solution injection point is located with laser light in the near infrared band, so that the laser light is converted into an electrical signal through the photoelectric conversion material, so that the electrical signal stimulates the area where the solution injection point is located.

[0014] The injection point and injection volume of the photoelectric conversion material solution are pre-planned and determined according to the neural tissue area to be regulated before using the non-invasive neural regulation device.

[0015] The injection volume is between a dozen nanoliters and several dozen microliters, and the solution injection point is within the range of the neural tissue area to be regulated.

[0016] The input light wavelength of the photoelectric conversion material is between 780nm and 2526nm, and the photoelectric conversion material has a photovoltaic effect, and the generated current intensity is in the order of one nanoampere to one hundred milliamperes.

[0017] The photoelectric conversion material positioning and injection assembly includes a syringe, a syringe clamping mechanism for clamping and fixing the main body of the syringe, a motor driving mechanism for driving the push head part of the syringe, and a surgical positioning instrument for moving the syringe clamping mechanism.

[0018] The syringe clamping mechanism includes a back plate and a syringe fixing arm, and the syringe is fixed on the back plate by the syringe fixing arm; the motor drive mechanism includes a controller, a control line and an electric drive block connected in sequence, and the electric drive block can slide on the back plate and is fixedly connected to the push head part of the syringe.

[0019] The positioning accuracy of the injection point of the solution of the photoelectric conversion material is 0.01 mm.

[0020] The optical fiber fixing device includes a threaded locking mechanism that is tightly connected to the optical fiber and a bracket that is fixedly connected to the threaded locking mechanism; the bracket is adhered to the surface of the biological body or the bracket includes a helmet or other wearable device, so that the threaded locking mechanism and the optical fiber are both fixed to the surface of the biological body by the bracket; or, the optical fiber fixing device only includes a stereotaxic instrument whose mobile end is fixedly connected to the optical fiber, so that the optical fiber is driven by the stereotaxic instrument.

[0021] The non-invasive neural regulation device is characterized in that it also includes a non-invasive neural regulation planning system;

[0022] The non-invasive neural regulation planning system comprises: a photoelectric conversion material injection planning module, which is configured to: scan and obtain the positioning information of the organism before using the non-invasive neural regulation device, and pre-plan and determine the injection parameters of the photoelectric conversion material according to the positioning information of the organism and the regulation target; and a photoelectric conversion material injection control module, which is configured to: when the non-invasive neural regulation device is working, drive the photoelectric conversion material positioning and injection component to work according to the injection parameters of the photoelectric conversion material provided by the photoelectric conversion material injection planning module;

[0023] And / or, the non-invasive neuroregulation planning system includes: a laser light source planning module, which is configured to: before using the non-invasive neuroregulation device, pre-plan and determine the laser output parameters of the laser light source according to the regulation target; the laser output parameters of the laser light source include, for example, laser illumination, frequency and irradiation time; and a laser light source control module, which is configured to: when the non-invasive neuroregulation device is working, drive the laser light source to work according to the laser output parameters provided by the laser light source planning module.

[0024] When the non-invasive neural regulation planning system includes a photoelectric conversion material injection planning module and a photoelectric conversion material injection control module, the injection parameters of the photoelectric conversion material include a solution injection point and injection volume of the photoelectric conversion material;

[0025] When the non-invasive neuromodulation planning system includes a laser light source planning module and a laser light source control module, the laser output parameters of the laser light source include at least one of laser illumination, laser power, frequency, irradiation time, and laser pulse width.

[0026] The non-invasive neuromodulator of the present invention has the following characteristics:

[0027] 1. Non-invasive: The present invention achieves non-invasive neural regulation by utilizing near-infrared light and photoelectric conversion materials, thus avoiding the problem of brain tissue damage caused by traditional electrical stimulation and optical fiber implantation.

[0028] 2. High efficiency: The photoelectric effect of photoelectric conversion materials can effectively convert near-infrared light into electrical signals, which can achieve precise stimulation of neurons and has high regulation efficiency.

[0029] 3. System uniqueness: The system device of the present invention organically combines photoelectric conversion materials, material injection equipment, optical fiber fixing devices and lasers to form a unique neural regulation system. The system fully utilizes the characteristics of each component to achieve efficient and stable neural regulation effects.

[0030] 4. Stability: The optical fiber fixing device adopts a threaded locking mechanism and a bracket structure to ensure the stability of the optical fiber and the accuracy of the irradiation position, avoiding the problem of unstable control effect caused by the displacement of the optical fiber position.

[0031] 5. Programmable control: The laser light source device can achieve precise control of laser intensity, frequency and irradiation time through the program control module, and can be adjusted according to different experimental requirements, with high flexibility and applicability.

[0032] In summary, the present invention provides an innovative non-invasive neuromodulatory device that combines photoelectric conversion materials, material injection equipment, optical fiber fixing devices and lasers. It has the advantages of non-invasiveness, high efficiency, system uniqueness, stability and programmable control, can achieve precise regulation of neurons, and has broad application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 It is an overall structural diagram of a non-invasive neuromodulation device according to one embodiment of the present invention, except for the photoelectric conversion material positioning and injection components;

[0034] Figure 2 This is a schematic diagram of the principle of neural regulation in mice.

[0035] Figure 3 It is an overall structural diagram of a non-invasive neuromodulatory device excluding the photoelectric conversion material positioning and injection components according to another embodiment of the present invention.

[0036] Figure 4 It is a structural schematic diagram of a photoelectric conversion material positioning and injection component of a non-invasive nerve regulation device of the present invention.

[0037] Figure 5 It is a structural schematic diagram of a thread locking mechanism of an optical fiber fixing device of a non-invasive neuromodulation device of the present invention;

[0038] Figure 6 and Figure 7 It is a schematic structural diagram of a bracket of an optical fiber fixing device of a non-invasive nerve regulation device of the present invention. DETAILED DESCRIPTION

[0039] The present invention is further described below in conjunction with specific examples. It should be understood that the following examples are only used to illustrate the present invention and are not used to limit the scope of the present invention.

[0040] A non-invasive neuroregulatory device of the present invention is mainly based on the following principle: photoelectric conversion materials (i.e., photoelectric nanoparticles) are accurately injected into the target neural tissue, and then a compiled program module is used to control the laser to emit a controllable frequency laser which is transferred through an optical fiber to directly above the area, irradiating the area through the air, thereby achieving the purpose of outputting electrical signal stimulation from near-infrared light stimulation. It does not require the introduction of exogenous protein genes or the long-term implantation of electrodes or optical fibers, thereby reducing potential brain tissue damage and risks, while retaining the advantages of efficient and accurate stimulation.

[0041] like Figure 1 and Figure 3As shown, the present invention provides a non-invasive neuromodulatory device, including an optical fiber 10, an optical fiber fixing device 20 arranged at one end of the optical fiber 10, a laser light source 30 arranged at the other end of the optical fiber 10, and a photoelectric conversion material positioning and injection component 40 arranged separately from the optical fiber 10, wherein the photoelectric conversion material is in liquid form and contains upconversion material and photoelectric material.

[0042] The photoelectric conversion material positioning and injection component is used to inject the photoelectric conversion material into the designated solution injection point. The solution injection point and injection volume of the photoelectric conversion material are pre-planned and determined according to the neural tissue area to be regulated before using the non-invasive neural regulation device of the present invention. Among them, the injection volume is related to the required concentration of the photoelectric conversion material, and the injection volume can be between a dozen nanoliters and tens of microliters. In the present embodiment, for the neural tissue area to be regulated, only one injection point is required; in some other embodiments, there may be multiple solution injection points within the range of the neural tissue area to be regulated, and adjacent solution injection points need to meet a fixed spacing condition. In addition, if neural regulation is required for multiple neural tissue areas, the solution injection points need to be respectively located in multiple neural tissue areas to be regulated.

[0043] The laser light source 30 is configured to irradiate the near-infrared laser through the emission port of the optical fiber to the area where the solution injection point is located. Figure 2 As shown, the laser is converted into an electrical signal by the photoelectric conversion material injected by the photoelectric conversion material positioning and injection component, so that the electrical signal stimulates the area where the solution injection point is located (ie, the nerve tissue in the area).

[0044] Thus, the photoelectric conversion material is controlled to be uniformly distributed in the neural tissue region to be regulated after being injected and left to stand for a period of time. The neural tissue region may be, for example, a certain specific rat brain neural tissue region, a human brain neural tissue region, etc. When the light source is irradiated in the neural tissue region, the functional neurons in the neural tissue region can be effectively stimulated. If the photoelectric conversion material is separated from the neural tissue region, the functional neurons in the neural tissue region cannot be effectively activated.

[0045] (I) Photoelectric conversion materials: As described above, the photoelectric conversion material is in powder form, which contains nanoparticles that can convert near-infrared light into electrical signals, and is dispersed in physiological saline so that it can be injected into biological tissues, especially neural tissue areas such as the brain.

[0046] In this embodiment, the wavelength of the input light of the photoelectric conversion material is between 780nm and 2526nm, which has high penetration into brain tissue and can provide effective excitation energy to these materials.

[0047] After the photoelectric conversion material absorbs infrared light, electron-hole pairs are generated under the action of the photoelectric effect, thereby realizing photoelectric conversion.

[0048] Photoelectric conversion materials have high photoelectric conversion efficiency and can effectively convert visible light into electrical signals. In this embodiment, the current intensity generated by the photoelectric material needs to be in the range of one nanoampere to one hundred milliamperes to ensure effective induction of neuronal depolarization and generation of action potentials.

[0049] In summary, photoelectric conversion materials can cover any one or more semiconductor materials with photovoltaic effect in the near-infrared band to ensure flexibility and applicability in different application scenarios.

[0050] (II) Photoelectric conversion material positioning and injection assembly 40: like Figure 4 As shown, the photoelectric conversion material positioning and injection assembly 40 includes a syringe 41, a syringe clamping mechanism 42 for clamping and fixing the main body 411 of the syringe 41, a motor driving mechanism 43 for driving the push head part 412 of the syringe 41, and a surgical positioning instrument (not shown) for moving the syringe clamping mechanism 42.

[0051] The syringe clamping mechanism 42 includes a back plate 421 and a syringe fixing arm 422, and the syringe 41 is fixed on the back plate 421 by the syringe fixing arm 422. The syringe clamping mechanism is adjusted according to the size of the syringe 41 to ensure its stability and accuracy.

[0052] The motor drive mechanism 43 includes a controller 431, a control line 432 and an electric drive block 433 connected in sequence, and the electric drive block 433 is slidable on the back plate 421 and fixedly connected to the push head portion 412 of the syringe 41. The syringe 41 is preferably a micro syringe, and the motor drive mechanism 41 controls the injection volume of the photoelectric conversion material at the nanoliter level through the controller 431, thereby ensuring the effective distribution of the photoelectric conversion material.

[0053] Preferably, the surgical positioning instrument is provided with a second electrode driving mechanism, and the two can be designed as an integral whole. The second electrode driving mechanism is used to drive the syringe clamping mechanism 42 to move the position of the syringe.

[0054] The electrical signal action area of ​​the non-invasive nerve regulation device of the present invention is precisely adjusted by controlling the injection point of the photoelectric conversion material solution. Therefore, in the present invention, a surgical positioning instrument with very high positioning accuracy is required. In this embodiment, the positioning accuracy of the injection point of the photoelectric conversion material solution is 0.01 mm.

[0055] Therefore, the present invention quantitatively absorbs the photoelectric conversion material by clamping the syringe 41 on the syringe clamping mechanism 42 and starting the motor drive mechanism 43; then, the syringe 41 is inserted into the designated site (i.e., the nerve tissue area) through the surgical positioning instrument 44, and the motor drive mechanism 43 is started to inject the solution containing the photoelectric conversion material into the designated site to achieve precise injection.

[0056] (III) Optical fiber fixing device 20: The optical fiber fixing device 20 is configured to fix the optical fiber 10 and align the irradiation area of ​​the optical fiber 10 with the neural tissue area that needs to be regulated.

[0057] like Figure 5-Figure 7 As shown, the optical fiber fixing device 20 includes a thread locking mechanism 21 that is fastened to the optical fiber 10, and a bracket 22 that is fastened to the thread locking mechanism 21. Thus, the bracket 22 ensures that the optical fiber 10 can be stably and accurately positioned in the neural tissue area to be regulated during the experiment, and provides a certain mechanical strength for supporting the thread locking mechanism 21 and the optical fiber 10.

[0058] In this embodiment, the number of the optical fiber 10 is 1, and the number of the thread locking mechanism 21 and the bracket 22 is also 1. In other embodiments, if the number of the optical fiber 10 is more than one, each optical fiber 10 requires a separate thread locking mechanism 21 and bracket 22. The irradiation area of ​​the optical fiber 10 is approximately a cylindrical area with a diameter of 5 mm.

[0059] In this embodiment, the bracket 22 is attached to the surface of the organism, so that the thread locking mechanism 21 and the optical fiber 10 are fixed to the surface of the organism by the bracket 22, ensuring the stability of the optical fiber 10 and the accuracy of the irradiation position.

[0060] In this embodiment, the bracket 22 is a hollow cylindrical structure, the outer diameter of the hollow cylindrical structure is consistent, and the cylinder includes a fiber accommodating section with a first inner diameter and a light-passing section with a second inner diameter. The fiber accommodating section is for inserting the threaded locking mechanism 21 and the optical fiber 10, and the light-passing section is used for passing light.

[0061] In this embodiment, the support 22 is adhered to the surface of the organism, such as the brain of the organism. In other embodiments, the support 22 includes a helmet or other wearable device, as long as it is ensured that the irradiation area of ​​the optical fiber 10 can be aligned with the neural tissue area that needs to be regulated.

[0062] The thread locking mechanism 21 includes a thread locking ring with a through hole, the optical fiber 10 is inserted into the through hole of the thread locking ring, and a screw hole is provided on the side of the thread locking ring to lock the optical fiber with two screws. Thus, the thread locking mechanism 21 can realize the rapid fixation and release of the optical fiber through the rotation operation, which is convenient for experimental operation.

[0063] After the optical fiber 10 is locked and fixed with the thread locking mechanism 21, the thread locking mechanism 21 and the optical fiber 10 are inserted into the hollow part of the optical fiber accommodating section of the bracket 22, and then the bracket 22 is adhered and fixed to the surface of the biological body.

[0064] In other embodiments, the threaded locking mechanism 21 and the bracket 22 can be replaced by a stereo positioner (not shown), that is, the optical fiber fixing device 20 only includes a stereo positioner whose moving end is fixedly connected to the optical fiber 10, so that the optical fiber 10 is driven by the stereo positioner. Therefore, if different neurons need to be regulated, the optical fiber 10 can be moved by the stereo positioner to change the irradiation area of ​​the optical fiber 10. Specifically, the position of the optical fiber 10 is adjusted by the knob on the stereo positioner, and the positioning accuracy of the stereo positioner is about 0.01mm.

[0065] (iv) Laser light source 30: The laser light source 30 is configured to output laser light in the near-infrared band, which has strong penetrating power and can effectively penetrate the skin and tissue to activate the photoelectric conversion material.

[0066] (V) Non-invasive neuromodulation planning system50: The present invention also provides a non-invasive neuromodulation planning system 50, which is connected to the laser light source 30 and the photoelectric conversion material positioning and injection component 40, so as to obtain a neuromodulation planning scheme according to the control target before the non-invasive neuromodulation device of the present invention is used. Therefore, when the non-invasive neuromodulation device of the present invention is used, it can directly drive the laser light source 30 and the photoelectric conversion material positioning and injection component 40 to work according to the neuromodulation planning scheme, so as to achieve precise control of the injection parameters of the photoelectric conversion material and the laser output parameters.

[0067] The regulation target includes at least one neural tissue region to be regulated, and the neural regulation planning scheme includes at least one of the following items: (1) injection parameters of the photoelectric conversion material, such as the injection point and injection volume of the photoelectric conversion material solution; (2) laser output parameters of the laser light source 30, such as laser illumination, frequency and irradiation time;

[0068] The non-invasive neural regulation planning system 50 comprises: A photoelectric conversion material injection planning module is configured to: scan and obtain the positioning information of the organism before using the non-invasive neural regulation device, and pre-plan and determine the injection parameters of the photoelectric conversion material according to the positioning information of the organism and the regulation target; the injection parameters of the photoelectric conversion material include, for example, the injection point and injection volume of the photoelectric conversion material solution; and A photoelectric conversion material injection control module, which is configured to: when the non-invasive neuromodulation device is working, drive the photoelectric conversion material positioning and injection component 40 to work according to the injection parameters of the photoelectric conversion material provided by the photoelectric conversion material injection planning module; and / or A laser light source planning module 51 is configured to: before using the non-invasive nerve regulation device, pre-plan and determine the laser output parameters of the laser light source 30 according to the regulation target; the laser output parameters of the laser light source 30 include, for example, at least one of laser illumination, laser power, frequency, irradiation time, and laser pulse width; and The laser light source control module 52 is configured to: when the non-invasive nerve regulation device is working, drive the laser light source 30 to work according to the laser output parameters provided by the laser light source planning module.

[0069] The laser light source planning module 51 is usually installed on a computer, and the laser light source control module 52 is usually installed on a controller connected between the laser light source 30 and the computer.

[0070] It has been found that laser power of about 1W, frequency of 0.5Hz to 20Hz, and pulse width of 10ms to 500ms can effectively activate neurons to emit action potentials and avoid the impact of thermal effects. Therefore, the laser output parameters provided by the laser light source planning module include: laser irradiation power of about 1W, frequency of 0.5Hz to 20Hz, and laser pulse width of 10ms to 500ms. Thus, the laser light source control module controls the laser to emit a laser of a certain frequency and pulse width to irradiate the irradiation area, thereby achieving precise regulation of neurons.

[0071] The non-invasive neuromodulation device of the present invention combines photoelectric conversion materials with material injection equipment, optical fiber fixtures and laser light sources, and achieves the purpose of outputting electrical signal stimulation from near-infrared light stimulation by accurately injecting light-to-electric nanoparticles into the target neural tissue. This method combines the advantages of electrical stimulation and light regulation, and achieves precise neuromodulation through non-invasive light-to-electric stimulation, while avoiding the problem of brain tissue damage in traditional methods.

[0072] The above is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. The above embodiments of the present invention can also be modified in various ways. All simple, equivalent changes and modifications made according to the claims and the description of the present invention fall within the scope of protection of the claims of the present invention. The contents not described in detail in the present invention are all conventional technical contents.

Claims

1. A non-invasive neuromodulatory device, characterized in that: It includes an optical fiber, an optical fiber fixing device arranged at one end of the optical fiber, a laser light source arranged at the other end of the optical fiber, and a photoelectric conversion material positioning and injection component arranged separately from the optical fiber; The photoelectric conversion material positioning and injection assembly is used to inject the photoelectric conversion material into a designated solution injection point; the photoelectric conversion material is in powder form, and contains nanoparticles that can convert near-infrared light into electrical signals, which are dispersed in physiological saline so as to be injected into biological tissues; The laser light source is configured to irradiate the area where the solution injection point is located with laser light in the near infrared band, so that the laser light is converted into an electrical signal through the photoelectric conversion material, so that the electrical signal stimulates the area where the solution injection point is located.

2. The non-invasive neuromodulator according to claim 1, characterized in that: The injection point and injection volume of the photoelectric conversion material solution are pre-planned and determined according to the neural tissue area to be regulated before using the non-invasive neural regulation device.

3. The non-invasive neuromodulator according to claim 2, characterized in that: The injection volume is between a dozen nanoliters and several dozen microliters, and the solution injection point is within the range of the neural tissue area to be regulated.

4. The non-invasive neuromodulatory device according to claim 1, characterized in that: The input light wavelength of the photoelectric conversion material is between 780nm and 2526nm, and the photoelectric conversion material has a photovoltaic effect, and the generated current intensity is in the order of one nanoampere to one hundred milliamperes.

5. The non-invasive neuromodulatory device according to claim 1, characterized in that: The photoelectric conversion material positioning and injection assembly includes a syringe, a syringe clamping mechanism for clamping and fixing the main body of the syringe, a motor driving mechanism for driving the push head part of the syringe, and a surgical positioning instrument for moving the syringe clamping mechanism.

6. The non-invasive neuromodulator according to claim 5, characterized in that: The syringe clamping mechanism comprises a back plate and a syringe fixing arm, and the syringe is fixed on the back plate by the syringe fixing arm; The motor drive mechanism comprises a controller, a control line and an electric drive block which are connected in sequence. The electric drive block can slide on the back plate and is fixedly connected to the push head part of the syringe.

7. The non-invasive neuromodulatory device according to claim 1, characterized in that: The positioning accuracy of the injection point of the solution of the photoelectric conversion material is 0.01 mm.

8. The non-invasive neuromodulatory device according to claim 1, characterized in that: The optical fiber fixing device comprises a thread locking mechanism that is tightly connected to the optical fiber and a bracket that is fixedly connected to the thread locking mechanism; the bracket is adhered to the surface of the organism or the bracket comprises a helmet or other wearable device, so that the thread locking mechanism and the optical fiber are both fixed to the surface of the organism by the bracket; Alternatively, the optical fiber fixing device only includes a stereoscopic positioning instrument whose moving end is fixedly connected to the optical fiber, so that the optical fiber is driven by the stereoscopic positioning instrument.

9. The non-invasive neuromodulatory device according to claim 1, characterized in that: Also included is a non-invasive neuromodulation planning system; The non-invasive neural regulation planning system comprises: A photoelectric conversion material injection planning module, which is configured to: scan and obtain the positioning information of the organism before using the non-invasive neural regulation device, and pre-plan and determine the injection parameters of the photoelectric conversion material according to the positioning information of the organism and the regulation target; and a photoelectric conversion material injection control module, which is configured to: when the non-invasive nerve regulation device is working, drive the photoelectric conversion material positioning and injection component to work according to the injection parameters of the photoelectric conversion material provided by the photoelectric conversion material injection planning module; And / or, the non-invasive neural regulation planning system comprises: A laser light source planning module, which is configured to: before using the non-invasive nerve regulation device, pre-plan and determine the laser output parameters of the laser light source according to the regulation target; and The laser light source control module is configured to: when the non-invasive nerve regulation device is working, drive the laser light source to work according to the laser output parameters provided by the laser light source planning module.

10. The non-invasive neuromodulator according to claim 9, characterized in that: When the non-invasive neural regulation planning system includes a photoelectric conversion material injection planning module and a photoelectric conversion material injection control module, the injection parameters of the photoelectric conversion material include a solution injection point and injection volume of the photoelectric conversion material; When the non-invasive neuromodulation planning system includes a laser light source planning module and a laser light source control module, the laser output parameters of the laser light source include at least one of laser illumination, laser power, frequency, irradiation time, and laser pulse width.

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