Blood filtering membrane preparation device and method

Abstract

The invention discloses a blood filtering membrane preparation device and method, and belongs to the technical field of blood filtering membrane preparation. The method comprises the steps that materials are prepared, a membrane material is polyethersulfone, a solvent is a mixed solvent and specifically comprises N-methyl pyrrolidone (NMP) and gamma-butyrolactone, additives comprise a pore-forming agent, an anticoagulant and bioactive molecules, and the bioactive molecules are heparin. A spinning solution is uniformly dispersed through the ultrasonic dispersion instrument and the magnetic stirrer, the agglomeration state of a membrane material and an additive in a solvent is effectively broken through through the strong vibration and cavitation effect of the ultrasonic dispersion instrument, and full contact and mixing of all components are promoted; therefore, the uniformity of a mixed solution before spinning is remarkably improved, a blood filtering film forming structure is more compact, pore distribution is more uniform, the spinning solution is stirred in cooperation with a magnetic stirrer, agglomeration of particles in the spinning solution is reduced, and the uniformity and stability of the spinning solution can be more effectively improved.

Description

Technical Field

[0001] The invention relates to the technical field of blood filter membrane preparation, in particular to a blood filter membrane preparation device and a method thereof. Background Art

[0002] In the field of biomedical engineering, blood filter membranes are key components for blood purification, detection and separation, and their performance directly affects treatment outcomes and patient safety. In traditional blood filter membrane preparation processes, the mixing of membrane materials, solvents and additives is often done using simple mechanical stirring. Although this method can achieve basic mixing, it often has problems such as uneven mixing and particle agglomeration, which results in unstable permeability and poor retention during subsequent use of the blood filter membrane.

[0003] In the prior art, the preparation process of blood filter membrane mainly relies on the dry-wet spinning method. This method has obvious deficiencies in the mixing treatment of membrane materials, solvents and additives before spinning. Although mechanical stirring can preliminarily mix the components, due to the limitation of stirring intensity and the singleness of stirring method, it is difficult to ensure the uniform dispersion of membrane materials and additives in the solvent. This uneven mixing state will directly affect the formation of fibers and the uniformity of membrane structure during the spinning process, which will lead to the difficulty in controlling the pore structure and pore size of the blood filter membrane during use, resulting in large fluctuations in permeability when filtering blood, affecting the filtration efficiency and effect. Summary of the invention

[0004] The object of the present invention is to provide a blood filter membrane preparation device and method thereof, which can evenly disperse the spinning solution by setting an ultrasonic disperser and a magnetic stirrer, thereby solving the problem of uneven distribution of membrane materials in a single stirring method.

[0005] The present invention is achieved through the following technical solutions:

[0006] The present invention is a method for preparing a blood filter membrane, comprising the following steps:

[0007] S1. Material preparation:

[0008] The membrane material is polyethersulfone, and the solvent is a mixed solvent, specifically N-methylpyrrolidone NMP and γ-butyrolactone, the ratio of N-methylpyrrolidone NMP to γ-butyrolactone is 9:1, N-methylpyrrolidone NMP and γ-butyrolactone can optimize the solubility, viscosity and surface tension of the spinning solution, thereby improving the stability of the spinning process and the final performance of the membrane, and the additives are pore formers, anticoagulants and bioactive molecules, the mass of the pore formers and anticoagulants is 1%-10% of the mass of the membrane material, wherein the bioactive molecule is heparin, and heparin can improve the biocompatibility of the blood filtration membrane, improve the interaction between the membrane and the blood, and reduce the coagulation reaction.

[0009] S2, mixing and stirring:

[0010] The membrane material, the solvent and the additive are mixed and treated, and the membrane material is dissolved in the solvent under heating and stirring conditions to form a spinning solution;

[0011] S3, ultrasonic dispersion:

[0012] An ultrasonic disperser is used to utilize the strong vibration and cavitation effect of ultrasonic waves to disperse the membrane material and additives more evenly in the solvent. When the ultrasonic disperser is used, the power, frequency and processing time of the ultrasonic disperser are set according to the composition of the spinning solution and the desired effect, and the configured spinning solution is poured into the container of the above ultrasonic disperser to ensure that the liquid level does not exceed the safety line of the container. The ultrasonic disperser is started and the ultrasonic probe is allowed to penetrate into the spinning solution for dispersion treatment. When the spinning solution achieves the expected dispersion effect, the ultrasonic disperser is turned off and the spinning solution is taken out for subsequent treatment or spinning operation. When the ultrasonic probe is penetrated into the spinning solution, the spinning solution is stirred magnetically at the same time. During magnetic stirring, the magnetic field is used to drive the magnetic stirrer placed in the spinning solution to rotate so that the spinning solution is stirred evenly.

[0013] S4, dry and wet spinning method preparation:

[0014] The dry-wet spinning method is adopted to extrude the spinning solution through the spinneret to form filaments. At the same time, a dry layer is set on the outer layer, so that the solvent is partially volatilized in the dry layer to form a preliminary structure. The filaments are immersed in a coagulation bath to exchange the solvent with the substances in the coagulation bath to further solidify the membrane structure. After the membrane is solidified, the membrane filaments or membrane sheets are washed with deionized water or purified water to remove residual solvents, additives and other impurities. The washed membrane is placed in an oven or a drying chamber, and the membrane is dried at a suitable temperature to remove moisture and solidify the membrane structure.

[0015] A blood filter membrane preparation device comprises a mixing tank, which is provided with a feed port and a discharge port, a feed pipe is installed in the feed port, a discharge pipe is installed in the discharge port, a motor is installed on the mixing tank, a vertical rod is installed at the output end of the motor, and a plurality of rows of stirring blades are installed on the vertical rod. After the membrane material, solvent and additive are placed in the mixing tank through the feed pipe, the vertical rod is driven to rotate by starting the motor, thereby driving the plurality of rows of stirring blades to stir and mix the materials, and the materials are discharged through the discharge pipe after mixing.

[0016] The present invention has the following beneficial effects:

[0017] The present invention evenly disperses the spinning solution by means of an ultrasonic disperser and a magnetic stirrer. The strong vibration and cavitation effect of the ultrasonic disperser effectively break the agglomeration state of the membrane material and the additive in the solvent, promote the full contact and mixing between the components, thereby significantly improving the uniformity of the mixed solution before spinning, making the structure of the blood filter membrane more compact and the pore distribution more uniform. The spinning solution is stirred with a magnetic stirrer to reduce the agglomeration between the particles in the spinning solution, and can more effectively improve the uniformity and stability of the spinning solution.

[0018] The present invention selects a mixed solvent, N-methylpyrrolidone (NMP) and gamma-butyrolactone, to improve the solubility, viscosity and surface tension of the spinning solution, thereby improving the stability of the spinning process and the final performance of the membrane. At the same time, bioactive molecules are added to the additives, and heparin can improve the biocompatibility of the blood filter membrane, improve the interaction between the membrane and blood, and reduce the coagulation reaction.

[0019] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 Schematic diagram of the preparation of blood filter membrane;

[0021] Figure 2 is a schematic diagram of the structure of the mixing device;

[0022] In the figure: 1. mixing tank; 101. feed pipe; 102. discharge pipe; 2. motor; 3. vertical rod; 4. stirring blade. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0024] See also Figure 1-2 The present invention provides a technical solution: a method for preparing a blood filter membrane, comprising the following steps:

[0025] S1. Material preparation:

[0026] The membrane material is polyethersulfone, and the solvent is a mixed solvent, specifically N-methylpyrrolidone NMP and γ-butyrolactone, the ratio of N-methylpyrrolidone NMP to γ-butyrolactone is 9:1, N-methylpyrrolidone NMP and γ-butyrolactone can optimize the solubility, viscosity and surface tension of the spinning solution, thereby improving the stability of the spinning process and the final performance of the membrane, and the additives are pore formers, anticoagulants and bioactive molecules, the mass of the pore formers and anticoagulants is 1%-10% of the mass of the membrane material, wherein the bioactive molecule is heparin, and heparin can improve the biocompatibility of the blood filtration membrane, improve the interaction between the membrane and the blood, and reduce the coagulation reaction;

[0027] S2, mixing and stirring:

[0028] The membrane material, the solvent and the additive are mixed and treated, and the membrane material is dissolved in the solvent under heating and stirring conditions to form a spinning solution;

[0029] S3, ultrasonic dispersion:

[0030] The ultrasonic disperser is used to utilize the strong vibration and cavitation effect of ultrasound to disperse the membrane material and additives more evenly in the solvent. When the ultrasonic disperser is used, the power, frequency and processing time of the ultrasonic disperser are set according to the composition of the spinning solution and the required effect, and the configured spinning solution is poured into the container of the above-mentioned ultrasonic disperser to ensure that the liquid level does not exceed the safety line of the container. The ultrasonic disperser is started, and the ultrasonic probe is allowed to penetrate into the spinning solution for dispersion treatment. When the spinning solution achieves the expected dispersion effect, the ultrasonic disperser is turned off, and the spinning solution is taken out for subsequent treatment or spinning operation. When the ultrasonic probe is penetrated into the spinning solution, the spinning solution is stirred magnetically at the same time. During magnetic stirring, the magnetic field is used to drive the magnetic stirrer placed in the spinning solution to rotate so that the spinning solution is stirred evenly. The strong vibration and cavitation effect of the ultrasonic disperser effectively break the agglomeration state of the membrane material and additives in the solvent, promote the full contact and mixing between the components, thereby significantly improving the uniformity of the mixed solution before spinning. This highly uniform mixing state lays a solid foundation for the subsequent dry-wet spinning process, and helps to form a blood filter membrane with a denser structure and more uniform pore distribution. Secondly, due to the improved uniformity of the mixed solution, the blood filter membrane can form a more stable and consistent fiber structure during the spinning process, thereby improving the permeability and interception effect of the blood filter membrane. The stability of permeability helps to maintain the balance of flow and pressure during the blood filtration process, while the enhanced interception effect can more effectively remove impurities and harmful substances in the blood, improving the efficiency and quality of blood purification. In addition, the magnetic stirrer in the spinning solution also helps to improve the mechanical strength of the blood filter membrane. The uniform mixing state reduces the internal defects caused by uneven material distribution during the spinning process, making the blood filter membrane more stable and reliable when subjected to blood flow pressure and external mechanical forces, extending its service life and improving safety.

[0031] S4, dry and wet spinning method preparation:

[0032] The dry-wet spinning method is adopted, and the spinning liquid is extruded through the spinneret to form filaments. At the same time, a dry layer is set on the outer layer, so that the solvent is partially volatilized in the dry layer to form a preliminary structure, and the filaments are immersed in a coagulation bath to exchange the solvent with the substances in the coagulation bath to further solidify the membrane structure. Specifically, the prepared spinning liquid and core liquid are respectively supplied to the corresponding positions of the spinning equipment, and the spinning liquid is squeezed into a thin stream through the spinneret, while the core liquid flows out through the central channel of the spinneret at the same time, and then the spinning liquid thin stream is ejected from the spinneret and first passes through an air gap (3mm-20mm). During this process, the spinning The liquid stream is affected by air resistance and its own gravity, and undergoes a certain degree of stretching and deformation to form a preliminary fiber structure. Subsequently, the spinning liquid stream enters a coagulation bath. The coagulation bath is generally composed of a non-solvent of the solvent, which can quickly precipitate the solvent in the spinning liquid to form a solid fiber membrane. In the coagulation bath, the fiber membrane is further solidified and shaped, and the core liquid is discharged to form a hollow structure. In or after the coagulation bath, the fiber membrane is stretched by a stretching device to improve its strength and orientation. The stretched fiber membrane undergoes a series of post-processing steps (such as washing, drying, etc.) to finally obtain a formed blood filter membrane.

[0033] After the membrane is solidified, the membrane filaments or membrane sheets are washed with deionized water or purified water to remove residual solvents, additives and other impurities. The washed membrane is placed in an oven or drying chamber and the membrane is dried at a suitable temperature to remove moisture and solidify the membrane structure. The prepared blood filter membrane is then subjected to various performance tests, including permeability, retention effect, mechanical strength, biocompatibility and other indicators, to ensure that it meets the requirements for use.

[0034] A blood filter membrane preparation device comprises a mixing tank 1, wherein the mixing tank 1 is provided with a feed port and a discharge port, wherein a feed pipe 101 is installed in the feed port, wherein a discharge pipe 102 is installed in the discharge port, wherein a motor 2 is installed in the mixing tank 1, wherein a vertical rod 3 is installed at the output end of the motor 2, wherein a plurality of rows of stirring blades 4 are installed on the vertical rod 3, wherein after the membrane material, the solvent and the additive are placed in the mixing tank 1 through the feed pipe 101, the vertical rod 3 is driven to rotate by starting the motor 2, thereby driving the plurality of rows of stirring blades 4 to stir and mix the materials, and the materials are discharged through the discharge pipe 102 after the mixing is completed.

[0035] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A method for preparing a blood filter membrane, characterized in that: The steps include: S1. Material preparation: The membrane material is polyethersulfone, the solvent is a mixed solvent, specifically N-methylpyrrolidone (NMP) and γ-butyrolactone, and the additives are a pore former, an anticoagulant and a bioactive molecule, wherein the bioactive molecule is heparin; S2, mixing and stirring: Mixing membrane materials, solvents and additives; Under heating and stirring conditions, the membrane material is dissolved in the solvent to form a spinning solution; S3, ultrasonic dispersion: An ultrasonic disperser is used to utilize ultrasound to disperse the membrane material and additives more evenly in the solvent; S4, dry and wet spinning method preparation: The wet-dry spinning method is adopted to extrude the spinning solution through the spinneret to form filaments, and at the same time, a dry layer is set on the outer layer so that the solvent partially evaporates in the dry layer to form a preliminary structure; The filaments are immersed in a coagulation bath to allow the solvent to exchange with the substances in the coagulation bath, further solidifying the membrane structure.

2. The method for preparing a blood filter membrane according to claim 1, characterized in that: When the ultrasonic disperser is used, the ultrasonic disperser is started and the ultrasonic probe is allowed to penetrate into the spinning solution for dispersion treatment. When the spinning solution achieves the expected dispersion effect, the ultrasonic disperser is turned off and the spinning solution is taken out for subsequent treatment or spinning operation.

3. The method for preparing a blood filter membrane according to claim 2, characterized in that: When the ultrasonic probe is inserted deep into the spinning solution, the spinning solution is stirred magnetically at the same time.

4. A method for preparing a blood filter membrane according to claim 3, characterized in that: During magnetic stirring, the magnetic field is used to drive the magnetic stirring bar placed in the spinning solution to rotate, so that the spinning solution is stirred evenly.

5. The method for preparing a blood filter membrane according to claim 1, characterized in that: The ratio of N-methylpyrrolidone (NMP) to γ-butyrolactone is 9:

1.

6. The method for preparing a blood filter membrane according to claim 1, characterized in that: The mass of the pore former and the anticoagulant is 1%-10% of the mass of the membrane material.

7. The method for preparing a blood filter membrane according to claim 1, characterized in that: After the membrane is cured, the membrane filaments or sheets are washed with deionized or purified water.

8. The method for preparing a blood filter membrane according to claim 7, characterized in that: Place the washed membrane in an oven or drying chamber and select a suitable temperature to dry the membrane.

9. A blood filter membrane preparation device, suitable for the blood filter membrane preparation method according to any one of claims 1 to 8, characterized in that: The mixing tank (1) comprises a mixing tank (1), wherein a feed port and a discharge port are provided on the mixing tank (1), a feed pipe (101) is installed in the feed port, and a discharge pipe (102) is installed in the discharge port.

10. A blood filter membrane preparation device according to claim 9, characterized in that: The mixing tank (1) is equipped with a motor (2), the output end of the motor (2) is equipped with a vertical rod (3), and the vertical rod (3) is equipped with multiple rows of stirring blades (4).

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