Ultrasonic and magnetic field combined type magnetic solid-phase extraction device

Abstract

The utility model provides a combined type magnetic solid-phase extraction device based on ultrasound and a magnetic field. The combined type magnetic solid-phase extraction device comprises an ultrasonic tank, a beaker array is arranged in the ultrasonic tank, an XY-axis module is arranged above the ultrasonic tank, an extraction head is arranged on the XY-axis module, the extraction head comprises a protective shell, and an electromagnet is fixed in the protective shell. The electromagnet is separated from a solution through the protective shell, so that the solution is prevented from being polluted, and the electromagnet is protected; through cooperation of the X-axis module and the Y-axis module and the beaker array, the steps of extraction, phase separation, cleaning, desorption, regeneration and the like are completed by moving the extraction head, the process is smooth, and time is saved.

Description

Technical Field

[0001] The utility model relates to the technical field of extraction devices, in particular to a magnetic solid phase extraction device based on a composite type of ultrasound and magnetic field. Background Art

[0002] Magnetic solid phase extraction is to add magnetic extraction materials to the sample solution containing the target analyte, and use auxiliary stirring to evenly disperse the magnetic extraction materials in the sample solution, and adsorb the target analyte on the surface of the magnetic extraction material. Then, an external magnetic field is used to separate the magnetic extraction material and the sample solution. Finally, the target analyte adsorbed on the magnetic extraction material is eluted for subsequent detection.

[0003] Patent document CN207423632U discloses an automated magnetic solid phase extraction device, including parallel extraction tanks and waste liquid tanks, and a rotating sample rack, wherein an electromagnet is fixed to the bottom of the sample rack, and the sample rack is provided with an inlet and outlet for sample solution, cleaning solution, and eluent. This structure has the following problems during extraction: 1. The electromagnet is in direct contact with the aqueous solution in the extraction tank. As the use time increases, the electromagnet is easily corroded, which affects the effect of its magnetic attraction; 2. The sample rack needs to be rotated to dispense the waste liquid in the test tube. For example, after extraction and phase separation, the sample rack needs to be rotated first to discharge the waste liquid in the test tube, and then the cleaning solution can be introduced for cleaning, and then the liquid can be rotated to discharge, and the eluent can be introduced for desorption. The process is cumbersome and time-consuming, and all extraction, phase separation, cleaning, desorption and other processes are carried out in the same test tube, which is prone to residual waste liquid, affecting the effect of subsequent treatment. Utility Model Content

[0004] The utility model proposes a magnetic solid phase extraction device based on a composite of ultrasound and magnetic field, in which an electromagnet and a solution are separated by a protective shell to avoid contamination of the solution and also to protect the electromagnet; through the cooperation of an XY axis module and a beaker array, extraction, phase separation, cleaning, desorption and regeneration steps are completed by moving an extraction head, and the process is smooth and time-saving.

[0005] The technical solution of the utility model is implemented as follows: a magnetic solid phase extraction device based on a composite of ultrasound and magnetic field, comprising an ultrasonic tank, a beaker array is arranged in the ultrasonic tank, an XY axis module is arranged above the ultrasonic tank, an extraction head is arranged on the XY axis module, the extraction head comprises a protective shell, and an electromagnet is fixed in the protective shell.

[0006] Furthermore, the beaker array includes an extraction beaker, a cleaning beaker, a desorption beaker and a regeneration beaker which are arranged in sequence.

[0007] Furthermore, an ultrasonic generator is arranged at the bottom of the ultrasonic tank.

[0008] Furthermore, a limit plate is provided on the protective shell.

[0009] Beneficial effects of the utility model:

[0010] The extraction head of the utility model separates the electromagnet and the solution through a protective shell, thereby protecting the electromagnet and preventing the electromagnet from being corroded and affecting the magnetic attraction effect. At the same time, it also prevents the electromagnet from contaminating the sample solution or the desorption solution and affecting the subsequent detection effect.

[0011] The utility model drives the lateral and vertical movement of the extraction head through the XY axis module, and completes the steps of extraction, phase separation, cleaning, desorption and regeneration in sequence by moving the extraction head. There is no need to rotate to pour out the waste liquid, which simplifies the process, makes the process smooth and saves time.

[0012] The utility model can be divided into extraction, cleaning, desorption and regeneration areas according to the extraction process through the arrangement of the beaker array, and the required solutions are added into the beakers in the corresponding areas, so that the extraction, phase separation, cleaning, desorption and regeneration steps are carried out in different beakers. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0014] Figure 1 It is a schematic diagram of the structure of the utility model;

[0015] Figure 2 is a schematic diagram of the structure of the beaker array;

[0016] Figure 3 Schematic diagram of the structure of the extraction head.

[0017] Ultrasonic tank 1, beaker array 2, extraction beaker 21, cleaning beaker 22, desorption beaker 23, regeneration beaker 24, XY axis module 3, X axis linear module 31, Y axis linear module 32, connecting plate 4, extraction head 5, electromagnet 6, ultrasonic generator 7, limit plate 8, protective shell 9. DETAILED DESCRIPTION

[0018] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0019] like Figure 1 and 2 As shown, a magnetic solid phase extraction device based on a composite of ultrasound and magnetic field includes an ultrasonic tank 1, and an ultrasonic generator 7 is fixed at the bottom of the ultrasonic tank 1. A beaker array 2 is fixed in the ultrasonic tank 1, and the beaker array 2 includes an extraction beaker 21, a cleaning beaker 22, a desorption beaker 23 and a regeneration beaker 24 fixed in sequence. The extraction beaker 21, the cleaning beaker 22, the desorption beaker 23 and the regeneration beaker 24 all include multiple beakers, such as 5 rows and 2 columns, etc., which can be specifically set as needed. The extraction beaker 21 is used to hold the sample solution to be extracted, the cleaning beaker 22 is used to hold the cleaning solution, the desorption beaker 23 is used to hold the desorption solution, and the regeneration beaker 24 is used to hold the regeneration solution.

[0020] An XY axis module 3 is arranged above the ultrasonic tank 1. The structure of the XY axis module 3 is conventional technology. The XY axis module 3 includes an X axis linear module 31. A Y axis linear module 32 is arranged on the X axis linear module 31. A connecting plate 4 is fixed on the slide seat of the Y axis linear module 32. A plurality of extraction heads 5 are fixed at the lower end of the connecting plate 4, such as 5 rows and 2 columns, which can be arranged specifically as required. The extraction head 5 is driven to move up and down by the Y axis linear module 32, and is driven to move horizontally by the X axis linear module 31.

[0021] like Figure 3 As shown, the extraction head 5 includes a protective shell 9, in which an electromagnet 6 is fixed. The electromagnet 6 is separated from the sample solution and the like by the provision of the protective shell 9, thereby protecting the electromagnet 6 and preventing the electromagnet 6 from being corroded and also preventing the electromagnet 6 from contaminating the sample solution and the like. A limiting plate 8 is fixed on the protective shell 9, and the limiting plate 8 is used to limit the length of the extraction head 5 entering the corresponding beaker.

[0022] The method for using the magnetic solid phase extraction device comprises the following steps:

[0023] (1) The sample solution and the magnetic extraction material are placed in an extraction beaker 21, the cleaning solution is placed in a cleaning beaker 22, the desorption solution is placed in a desorption beaker 23, and the regeneration solution is placed in a regeneration beaker 24;

[0024] (2) Turn on the ultrasonic generator 7, and the target analyte in the sample solution is adsorbed on the magnetic extraction material. After the extraction is completed, the XY-axis module 3 drives the extraction head 5 to be located above the extraction beaker 21, and the Y-axis linear module 32 drives the extraction head 5 to move down into the extraction beaker 21. The electromagnet 6 is turned on, and the magnetic extraction material is adsorbed on the outside of the protective shell 9 to separate from the sample solution. After the phase separation is completed, the Y-axis linear module 32 drives the extraction head 5 to move up and reset;

[0025] (2) The X-axis linear module 31 drives the Y-axis linear module 32 and the extraction head 5 to move to the upper side of the cleaning beaker 22, and the Y-axis linear module 32 drives the extraction head 5 to move downward into the cleaning beaker 22 to clean the residual sample solution. After the cleaning is completed, the Y-axis linear module 32 drives the extraction head 5 to move upward and reset;

[0026] (3) The X-axis linear module 31 drives the Y-axis linear module 32 and the extraction head 5 to move to the upper side of the desorption beaker 23, and the Y-axis linear module 32 drives the extraction head 5 to move downward into the desorption beaker 23. The electromagnet 6 is turned off, and the magnetic extraction material is dispersed in the desorption solution. The target analyte is desorbed from the magnetic extraction material and dispersed into the desorption solution. After the desorption is completed, the electromagnet 6 is turned on, and the magnetic extraction material is adsorbed on the outer side of the protective shell 9. The Y-axis linear module 32 drives the extraction head 5 to move upward and reset.

[0027] (4) The X-axis linear module 31 drives the Y-axis linear module 32 and the extraction head 5 to move to the upper side of the regeneration beaker 24, and the Y-axis linear module 32 drives the extraction head 5 to move downward into the regeneration beaker 24. The electromagnet 6 is turned off, and the magnetic extraction material is dispersed in the regeneration solution. The magnetic extraction material and the extraction head 5 are regenerated and cleaned to remove the waste liquid remaining on the surface. Finally, the electromagnet 6 is turned on to recycle the magnetic extraction material. After the recycling is completed, the Y-axis linear module 32 drives the extraction head 5 to move upward and reset, and the ultrasonic generator 7 is turned off.

[0028] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A magnetic solid phase extraction device based on a composite of ultrasound and magnetic field, comprising an ultrasonic tank, characterized in that: A beaker array is arranged in the ultrasonic tank, an XY axis module is arranged above the ultrasonic tank, an extraction head is arranged on the XY axis module, the extraction head comprises a protective shell, and an electromagnet is fixed in the protective shell.

2. The magnetic solid phase extraction device based on ultrasound and magnetic field composite according to claim 1, characterized in that: The beaker array comprises an extraction beaker, a cleaning beaker, a desorption beaker and a regeneration beaker which are arranged in sequence.

3. The magnetic solid phase extraction device based on a composite of ultrasound and magnetic field according to claim 1 or 2, characterized in that: An ultrasonic generator is arranged at the bottom of the ultrasonic tank.

4. The magnetic solid phase extraction device based on a composite of ultrasound and magnetic field according to claim 1 or 2, characterized in that: A limit plate is arranged on the protective shell.

Images