Delivery of nrf2 as therapy for protection against reactive oxygen species

Abstract

The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or inflammation, including ocular inflammation. In some embodiments, the methods comprise administering an expression vector that delivers a secretable and cell penetrating Nrf2 to a subject in need thereof.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of the filing date of U.S. Provisional Application No. 61 / 941,885 filed Feb. 19, 2014, the entire contents of which are incorporated by reference herein.GOVERNMENT FUNDING[0002]The invention was made with government support under R01 EY020825 awarded by the National Institutes of Health. The federal government has certain rights in this invention.BACKGROUND[0003]Sustained oxidative stress is known to be involved in the pathophysiology of diseases like Diabetic Retinopathy (DR), Amyotrophic Lateral Sclerosis (ALS), and Age-related Macular Degeneration (AMD). The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) leads to the oxidation or nitration of proteins, lipids and DNA. These changes are deleterious to the cell since they lead to the degradation of modified proteins, accumulation of oxidized lipids and mutations in the DNA sequence. Furthermore, some of these modifi...

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Benefits of technology

[0004]Aspects of the disclosure relate to polypeptides comprising one or more peptide or protein domains for delivery of an Nrf2 peptide to a cell. In some em

Problems solved by technology

These changes are deleterious to the cell since they lead to the degradation of modified proteins, accumulation of oxidized lipids and

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