Sustained-release transdermal patch containing sodium valproate, preparation method and application thereof

A technology of sustained-release transdermal and sodium valproate, applied in the medical field, can solve problems such as difficulty in accurately controlling doses, difficulty in swallowing oral tablets, and affecting sustained-release effects, achieving easy dosage, simple administration methods, and reduced side effects Effect

CN108272773BActive Publication Date: 2019-09-27KUNMING UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2019-09-27

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Abstract

The invention discloses sodium valproate-containing sustained-release transdermal patch as well as a preparation method and application thereof. The sustained-release transdermal patch comprises a back lining layer, a medicine-containing layer and a protective layer, wherein the medicine-containing layer comprises sodium valproate, a complexing agent, an adhesive, a transdermal improver, a bacteriostatic agent and a hot-melt pressure-sensitive adhesive. The preparation method comprises the following steps: heating and melting the hot-melt pressure-sensitive adhesive, adding the sodium valproate, the transdermal improver, the adhesive, the complexing agent and the bacteriostatic agent into the hot-melt pressure-sensitive adhesive to dissolve, mixing uniformly, performing ultrasonic degassing, coating the surface of the protective layer with the mixture to form the medicine-containing layer, and covering the surface of the dried medicine-containing layer with the back lining layer; cutting and packaging. The sodium valproate-containing sustained-release transdermal patch can serve as a medicine for treating pediatric epilepsy. The sodium valproate-containing sustained-release transdermal patch has medicine release uniformity and mild and durable effect, can effectively reduce the administration times, is convenient in dosage adjustment, is convenient to carry, has high patient adaptability, and solves the problem that infantile administration is difficult.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to a sustained-release transdermal patch containing sodium valproate and a preparation method and application thereof. Background technique

[0002] With the development of medical technology, more and more diseases have been overcome, and people enjoy a better life because of this, but there are also some genetic diseases or chronic diseases that are slowly tormenting patients, and epilepsy is a chronic recurrent short-term Brain Dysfunction Syndrome. Seizures are repeated seizures caused by abnormal discharge of brain neurons. Scientific research shows that the incidence of epilepsy is related to age. It is generally believed that the prevalence rate is the highest within 1 year old, and gradually decreases after 1-10 years old. Therefore, this disease is more common in young children. Seizures have a variety of clinical manifestations: generalized tonic-clonic seizures (gran...

Examples

Embodiment 1

[0020] Backing layer: PET film or non-woven fabric; protective layer is PET film.

[0021]

[0022] Preparation method: heat and melt the hot-melt pressure-sensitive adhesive, add sodium valproate, transdermal enhancer, adhesive and antibacterial agent into it to dissolve, mix well, and obtain the drug-containing adhesive after ultrasonic degassing. Apply the drug-containing adhesive on the surface of the protective layer under heat preservation conditions to form a drug-containing layer, dry, cover the surface of the dried drug-containing layer with a backing layer; cut and pack according to the required size, and the product is ready.

Embodiment 2

[0024] Backing layer: PET film or non-woven fabric; protective layer is PET film.

[0025]

[0026] Preparation method: heat and melt the hot-melt pressure-sensitive adhesive, add sodium valproate, transdermal enhancer, adhesive, complexing agent and antibacterial agent into it to dissolve, mix well, and obtain the drug-containing adhesive after ultrasonic degassing glue. Apply the drug-containing adhesive on the surface of the protective layer under heat preservation conditions to form a drug-containing layer, dry, cover the surface of the dried drug-containing layer with a backing layer; cut and pack according to the required size, and the product is ready.

Embodiment 3

[0028] Backing layer: PET film or non-woven fabric; protective layer is PET film.

[0029]

[0030] The preparation method is the same as in Example 2.