Purification device for drug-loaded nanocapsules

Abstract

The invention belongs to the technical field of chemical equipment, and particularly relates to a purification device for drug-carrying nanocapsules; the device comprises a cylindrical shell, in which a first purification part and a second purification part are arranged in sequence from top to bottom; a feed port is arranged on the top of the shell; the first purification part comprises a first tank body and a flushing pipeline; a truncated cone-shaped cylinder with upper and lower ends opened is arranged below the first purification part; the second purification part is located below the truncated cone-shaped cylinder and comprises a second tank body; the tank body of the first purification part can be used to remove impurities smaller than 1 μm, unqualified nanoparticles and excess solvent; the flushing pipeline can be used to flush the drug-carrying nanocapsules on the inner wall of the tank body during the rotation of the tank body and enter the second purification part through a feed port to achieve primary purification; the filter membrane and rotating blades of the second purification part can be used to remove impurities larger than 500 μm and agglomerated nanoparticles to achieve secondary purification.

Description

Technical Field

[0001] The invention belongs to the technical field of chemical equipment, and in particular relates to a purification device for drug-carrying nanocapsules. Background Art

[0002] Nanotechnology is the commanding height of strategic technology in the 21st century. It is a comprehensive technical system that conducts preparation research and industrialization of materials at the nanoscale, and uses nanoscale materials for cross-research and industrialization. The research on nanoparticles in the field of pharmacy predates the emergence of the concept of "nanotechnology". In the 1970s, various nanocarriers such as nanoliposomes, polymer nanocapsules and nanospheres were studied. Nanoparticles and related technologies in drug delivery systems are mainly used to promote drug dissolution, improve absorption, enhance targeting and thus improve effectiveness. In recent years, more attention has been paid to studying the role of nanosystems in the delivery of biomacromolecule drugs. Nanocapsules are mainly prepared from biodegradable polymer materials such as polylactic acid, polylactide-glycolide, chitosan, gelatin, etc., and can be used to encapsulate hydrophilic drugs as well as hydrophobic drugs. According to the performance of the material, it is suitable for different routes of administration, such as the targeting effect of intravenous injection, the sustained-controlled release effect of intramuscular or subcutaneous injection, and nanocapsules for oral administration can also be made of non-degradable materials such as cellulose acetate.

[0003] The drug-loaded nanocapsules synthesized in water need to be purified. In the prior art, multiple centrifugation methods are often used to purify nanocapsules, which is cumbersome, time-consuming and labor-intensive. Summary of the invention

[0004] The present invention solves the above technical problems existing in the prior art and provides a purification device for drug-loaded nanocapsules.

[0005] To solve the above problems, the technical solution of the present invention is as follows:

[0006] The purification device of drug-loaded nanocapsules comprises a cylindrical shell, wherein a first purification section and a second purification section are arranged in sequence from top to bottom in the shell; and a feed port is arranged at the top of the shell;

[0007] The first purification part includes a first tank body and a flushing pipeline, the first tank body includes a cylindrical barrel located at the top and a conical bottom located at the bottom; the first tank body is connected to the first rotating shaft through a fixing rod, and the first rotating shaft is connected to the first rotating motor; the central axis of the first tank body coincides with the first rotating shaft; a filtrate outlet pipe is arranged on the outer side wall of the first tank body, and an electromagnetic valve is arranged on the filtrate outlet pipe; a first filter membrane is arranged on the inner side wall of the cylindrical first tank body, and the pore size of the first filter membrane is less than 1 μm; the flushing pipeline extends from the top of the shell body, and the outlet points to the upper edge of the inner wall of the first tank body; a feed port is arranged at the bottom of the first tank body; and the feed port is located directly above the first tank body;

[0008] A truncated cone-shaped cylinder with upper and lower ends opened is arranged below the first purification part, and the lower edge of the truncated cone-shaped cylinder is seamlessly connected to the shell; a waste liquid outlet is arranged above the lower edge of the truncated cone-shaped cylinder;

[0009] The second purification section is located below the truncated cone-shaped cylinder and includes a second trough body. The second trough body is cylindrical and has a second filter membrane at the bottom. The pore size of the second filter membrane is greater than 500 μm. Rotating blades are arranged in the second trough body. The center position of the outer bottom wall of the second trough body is connected to the second rotating motor through a second rotating shaft.

[0010] As an improvement of the present invention, a discharge port is provided at the bottom of the shell body to facilitate discharge.

[0011] As an improvement of the present invention, a pressure pump is provided on the flushing pipeline to improve flushing efficiency.

[0012] As an improvement of the present invention, the angle between the flushing pipe and the vertical direction is 5-15°, which further improves the flushing effect and avoids damage to the filter membrane.

[0013] As an improvement of the present invention, the diameter of the upper edge of the truncated cone-shaped cylinder is larger than the maximum diameter of the first tank body, so as to prevent the filtrate from entering the second purification part and reducing the purification effect.

[0014] Compared with the prior art, the advantages of the present invention are as follows:

[0015] The drug-loaded nanocapsule purification device of the present invention can remove impurities smaller than 1 μm, unqualified nanoparticles and excess solvent by arranging a trough body in a first purification part, can wash down the drug-loaded nanocapsules on the inner wall of the trough body through a flushing pipe during the rotation of the trough body and enter the second purification part through a feed opening to achieve primary purification, and can collect and remove filtrate by arranging a truncated cone-shaped cylinder and utilizing the space formed between the cylinder and the shell to prevent the filtrate from entering the subsequent process; can remove impurities larger than 500 μm and agglomerated nanoparticles by arranging a filter membrane and rotating blades in the second purification part to achieve secondary purification; the device of the present invention can efficiently purify drug-loaded nanocapsules, is easy to operate, and has a good purification effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 The schematic diagram of the purification device for drug-loaded nanocapsules;

[0017] In the figure: 1 is the shell, 2 is the feed inlet, 3 is the first tank body, 4 is the flushing pipe, 5 is the cylindrical barrel, 6 is the conical bottom, 7 is the fixing rod, 8 is the first rotating shaft, 9 is the first rotating motor, 10 is the filtrate outlet pipe, 11 is the electromagnetic valve, 12 is the first filter membrane, 13 is the feed outlet, 14 is the truncated cone-shaped cylinder, 15 is the waste liquid outlet, 16 is the second tank body, 17 is the second filter membrane, 18 is the rotating blade, 19 is the second rotating shaft, 20 is the second rotating motor, 21 is the discharge port, and 22 is the pressure pump. DETAILED DESCRIPTION

[0018] Embodiment 1:

[0019] See also Figure 1 , a purification device for drug-loaded nanocapsules, comprising a cylindrical shell 1, wherein a first purification section and a second purification section are sequentially arranged from top to bottom in the shell 1; a feed port 2 is arranged at the top of the shell 1;

[0020] The first purification part includes a first tank body 3 and a flushing pipeline 4, the first tank body 3 includes a cylindrical barrel 5 located at the top and a conical bottom 6 located at the bottom; the first tank body 3 is connected to the first rotating shaft 8 through a fixing rod 7, and the first rotating shaft 8 is connected to the first rotating motor 9; the central axis of the first tank body 3 coincides with the first rotating shaft 8; a filtrate outlet pipe 10 is arranged on the outer wall of the first tank body 3, and an electromagnetic valve 11 is arranged on the filtrate outlet pipe 10; a first filter membrane 12 is arranged on the inner wall of the cylindrical first tank body 3, and the pore size of the first filter membrane 12 is less than 1 μm; the flushing pipeline 4 extends from the top of the shell 1, and the outlet points to the upper edge of the inner wall of the first tank body 3; a feed port 13 is arranged at the bottom of the first tank body 3; the feed port 2 is located directly above the first tank body 3;

[0021] A truncated cone-shaped cylinder 14 with upper and lower ends opened is disposed below the first purification unit, and the lower edge of the truncated cone-shaped cylinder 14 is seamlessly connected to the housing 1; a waste liquid outlet 15 is disposed above the lower edge of the truncated cone-shaped cylinder 14;

[0022] The second purification section is located below the truncated cone-shaped cylinder 14 and includes a second trough body 16. The second trough body 16 is cylindrical and has a second filter membrane 17 at the bottom. The pore size of the second filter membrane 17 is greater than 500 μm. Rotating blades 18 are arranged in the second trough body 16. The center position of the outer bottom wall of the second trough body 16 is connected to the second rotating motor 20 through a second rotating shaft 19.

[0023] Embodiment 2:

[0024] See also Figure 1 As an improvement of the present invention, a discharge port 21 is provided at the bottom of the housing 1 to facilitate discharge.

[0025] Embodiment 3:

[0026] See also Figure 1 As an improvement of the present invention, a pressure pump 22 is provided on the flushing pipeline 4 to improve the flushing efficiency.

[0027] Embodiment 4:

[0028] See also Figure 1 As an improvement of the present invention, the angle between the flushing pipe 4 and the vertical direction is 5-15°, which further improves the flushing effect and avoids damage to the filter membrane.

[0029] Embodiment 5:

[0030] See also Figure 1 As an improvement of the present invention, the diameter of the upper edge of the truncated cone-shaped cylinder 14 is larger than the maximum diameter of the first tank 3. This prevents the filtrate from entering the second purification part and reducing the purification effect.

[0031] The present invention can also combine at least one of the technical features described in Examples 2, 3, 4, and 5 with Example 1 to form a new implementation manner.

[0032] It should be noted that the above embodiments are merely preferred embodiments of the present invention and are not intended to limit the protection scope of the present invention. Equivalent replacements or substitutions made on the basis of the above embodiments all fall within the protection scope of the present invention.

Claims

1. A purification device for drug-loaded nanocapsules, characterized in that: It comprises a cylindrical shell, in which a first purification part and a second purification part are arranged in sequence from top to bottom; a feed port is arranged at the top of the shell; The first purification part includes a first tank body and a flushing pipeline, the first tank body includes a cylindrical barrel located at the top and a conical bottom located at the bottom; the first tank body is connected to the first rotating shaft through a fixing rod, and the first rotating shaft is connected to the first rotating motor; the central axis of the first tank body coincides with the first rotating shaft; a filtrate outlet pipe is arranged on the outer side wall of the first tank body, and an electromagnetic valve is arranged on the filtrate outlet pipe; a first filter membrane is arranged on the inner side wall of the first tank body, and the pore size of the first filter membrane is less than 1 μm; the flushing pipeline extends from the top of the shell body, and the outlet points to the upper edge of the inner wall of the first tank body; a feed port is arranged at the bottom of the first tank body; and the feed port is located directly above the first tank body; A truncated cone-shaped cylinder with upper and lower ends opened is arranged below the first purification part, and the lower edge of the truncated cone-shaped cylinder is seamlessly connected to the shell; a waste liquid outlet is arranged above the lower edge of the truncated cone-shaped cylinder; The second purification part is located below the truncated cone-shaped cylinder and includes a second tank body, which is cylindrical and has a second filter membrane at the bottom, and the pore size of the second filter membrane is greater than 500 μm; a rotating blade is arranged inside the second tank body; and the center position of the bottom wall of the second tank body is connected to the second rotating motor through a second rotating shaft; A discharge port is arranged at the bottom of the shell; A pressure pump is arranged on the flushing pipeline.

2. The device for purifying drug-loaded nanocapsules according to claim 1, characterized in that: The angle between the flushing pipe and the vertical direction is 5-15°.

3. The purification device for drug-loaded nanocapsules according to claim 1, characterized in that: The diameter of the upper edge of the truncated cone-shaped cylinder is greater than the maximum diameter of the first trough body.

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