Integrated multifunctional biological sample processor

Abstract

The present invention relates to an integrated multifunctional biological sample processor, comprising a test tube body, the test tube body comprising a sampling processing section and an optical observation section, the sampling processing section and the optical observation section are connected to form a test tube body as a whole, a test tube plug is provided on the test tube body inlet cover at one end of the sampling processing section, the optical observation section comprises an observation section, the biological sample entering the sampling processing section is processed to form a sampling liquid entering the optical observation section, and an external inspection device observes the sample and collects sample parameters through the observation section. The present invention adopts an integrated processor to realize the integration of multiple biological sample processing functions, and has the characteristics of convenient operation and high efficiency.

Description

Technical Field

[0001] The invention relates to an integrated multifunctional biological sample processor, in particular to an intelligent integrated multifunctional biological sample processor, and belongs to the field of biological sample processing. Background Art

[0002] At present, the biological sample processing process in the field of medical inspection or life science experiments usually includes manual operation process and instrument operation process. The manual operation process is: the operator collects the sample with a sampling needle, a sampling tester, a sampling spoon, etc. and puts it into a test tube. If the sample needs to be diluted, the diluent is added and the sample is mixed (stool, leucorrhea, blood, etc.). If the sample needs to be centrifuged, it is centrifuged as required (urine sediment, blood, etc.). Insert the pipette into the nozzle, then use the pipette to absorb the supernatant or pour out the supernatant and absorb the sediment, and then inject the sample in the pipette tip into the slide or counting pool plate, and then put the slide or counting pool under a microscope after adding a cover glass to observe the morphology and count of its components. Another way is to inject the sample in the pipette tip into the test strip reaction plate or other reactor, and then put the reaction plate or reactor into the analytical instrument for detection and analysis, and finally knock off the pipette nozzle. During the processing of the automatic analyzer, the pipette gun is replaced by the automatic analyzer suction needle and silicone tube. The suction needle sucks the sample and injects it into the slide or reactor, or the suction needle sucks it and draws it into the counting pool through the silicone tube. The rest is the same as manual operation. Each sample processing process is: suction, discharge, cleaning, and disinfection.

[0003] Whether it is a manual pipette or an instrument sample suction needle, it is very troublesome to pipette liquid, especially after centrifugation, the process of pouring out the supernatant in the test tube and taking the sediment is particularly complicated. The specific process of pipetting with a pipette is: first add the tip, then transfer the sample from the test tube to the counting pool, and then remove the tip, which is time-consuming and labor-intensive. There are also problems such as pouring out the supernatant and affecting the quality of quantitative accuracy and the contamination of biological samples during sample transfer. Automated instruments can only use sample suction needles and manipulators instead of human hands and pipettes. At the same time, it also involves pipeline blockage, and a large amount of waste liquid and reagent consumption is generated in the cleaning and disinfection pipelines. Especially when sucking the sediment after centrifugation, the sample suction needle is particularly difficult to suck because of the high viscosity of the sediment. It is impossible to transport it to the flow counting pool through a silicone tube, which is also time-consuming and labor-intensive. In addition, some samples need to be layered after centrifugation. For example, some test items of blood samples require the supernatant of centrifugation, and some require the cell sediment after centrifugation. For example, urine sediment requires the cell sediment after centrifugation. During the liquid collection process, the upper and lower layers affect each other, which is not conducive to operation. Summary of the invention

[0004] The integrated multifunctional biological sample processor of the present invention discloses a new solution, which uses an integrated processor to realize the integration of multiple biological sample processing functions, thereby solving the problems of cumbersome operation and low efficiency of the existing solution.

[0005] The integrated multifunctional biological sample processor of the present invention comprises a test tube body, which comprises a sampling processing section and an optical observation section. The sampling processing section and the optical observation section are connected to form a test tube body as a whole. A test tube plug is provided on the upper cover of the test tube body inlet at one end of the sampling processing section. The optical observation section comprises an observation section. The biological sample entering the sampling processing section is processed to form a sampling liquid which enters the optical observation section. An external inspection device observes the sample and collects sample parameters through the observation section.

[0006] Furthermore, part of the side wall of the sampling and processing section of the present scheme is a cylindrical structure, and part of the side wall of the observation part of the optical observation section is a plane structure. The cylindrical structure and the plane structure are connected by an inclined structure to form part of the side wall of the entire test tube body. The external inspection equipment observes the sample and collects the sample parameters through the plane structure.

[0007] Furthermore, the test tube plug of the present embodiment is a columnar structure whose shape matches the inner side of the inlet of the test tube body. A plurality of raised sealing rings extending circumferentially are provided on the outer side of the columnar structure. The test tube plug is pushed to close the sample liquid into the test paper reaction assembly, and the sealing ring prevents the biological sample in the test tube body from leaking out.

[0008] Furthermore, an elastic hollow ball is provided on the outer end of the test tube plug of the present invention, and the elastic hollow ball is squeezed to discharge the sample liquid into the test paper reaction component.

[0009] Furthermore, the test tube plug of the present embodiment includes a test tube plug cavity, which is fixed in the inlet of the test tube body. A discharge piston is provided on the inlet side of the test tube body of the test tube plug cavity, and the discharge piston is pushed to discharge the sample liquid into the test paper reaction assembly.

[0010] Furthermore, a columnar quantitative discharge piston is provided on the outer end of the test tube plug of the present embodiment, and a discharge scale is provided on the outer side of the columnar quantitative discharge piston along the discharge direction. The columnar quantitative discharge piston is pushed according to the discharge scale to discharge the sample liquid into the test paper reaction assembly.

[0011] Furthermore, the test tube plug of the present embodiment is provided with a sampling square spoon on one end inside the test tube body. The sampling square spoon includes a spoon head and a spoon handle. The spoon handle is a cylindrical structure. The sampling square spoon is sleeved on the connecting handle on one end of the test tube plug inside the test tube body through the spoon handle.

[0012] Furthermore, the spoon head of the sampling square spoon of the present solution is provided with a plurality of through-hole structures.

[0013] Furthermore, the test tube plug of the present embodiment is provided with a fiber tester on one end of the test tube body, the fiber tester comprises a fiber tester head and a fiber tester rod, the fiber tester rod is a cylindrical structure, and the fiber tester is sleeved on a connecting handle on one end of the test tube plug provided in the test tube body through the fiber tester rod.

[0014] Furthermore, a sampling baffle A is provided in the rear section of the sampling processing section of the test tube body of the present embodiment, and a flow gap is provided between the sampling baffle A and the inner wall of the sampling processing section. The sampling baffle A includes a sloped guide surface. After centrifugal treatment, the biological sample in the sampling processing section is precipitated to the observation part of the optical observation section through the sloped guide surface.

[0015] Furthermore, a sampling baffle B is provided in the rear section of the sampling processing section of the test tube body of the present embodiment. The sampling baffle B is tightly combined with the inner wall of the sampling processing section along the circumferential direction. A plurality of filtering through holes are provided on the sampling baffle B. The biological sample in the sampling processing section is filtered through the filtering through holes and then enters the observation part of the optical observation section.

[0016] Furthermore, a sampling combination baffle is provided in the rear section of the sampling processing section of the test tube body of the present embodiment, and the sampling combination baffle is in close contact with the inner wall of the sampling processing section along the circumferential direction. The sampling combination baffle includes baffle a, baffle b, and baffle c which are sequentially connected by elastic parts to form the sampling combination baffle as a whole. Baffle b is provided with a connecting rod connected to the test tube plug, and the inner end of the connecting rod is movably sleeved in a fixed guide ring. The distal side of baffle a is connected to the guide ring through the elastic part, and the distal side of baffle c is connected to the guide ring through the elastic part. The test tube plug is pushed to link the connecting rod to push baffle b so that the sampling combination baffle is deformed and folded to form a flow gap between the inner wall of the sampling processing section. The biological sample in the sampling processing section enters the observation part of the optical observation section through the flow gap and exits the test tube plug. The sampling combination baffle is reset under the action of the elastic part.

[0017] Furthermore, a sampling baffle is provided in the sampling processing section of the test tube body of the present embodiment, and one end of the sampling baffle extends into the observation portion of the optical observation section to form a sample carrier. The external inspection equipment observes the sample on the sample carrier and collects sample parameters through the observation portion.

[0018] Furthermore, the observation part of the optical observation section of the present scheme includes a sample slide, a cover glass is provided on the sample slide, a fixed frame is fixed on the cover glass, the fixed frame presses the cover glass on the sample slide, and an external inspection device observes the sample on the sample slide through the cover glass and collects the sample parameters.

[0019] Furthermore, the optical observation section of the present solution is a closed structure, and a sample carrier is provided at a position corresponding to the observation portion. The external inspection equipment observes the sample on the sample carrier and collects sample parameters through the observation portion.

[0020] Furthermore, a drainage tube body is provided on the outer side of the test tube body of the present embodiment, and the drainage tube body is provided with a liquid collection through hole connected to the optical observation section of the test tube body, and a drainage through hole connected to the test paper reaction component arranged on the outer side of the drainage tube body; a drainage guide column is provided in the drainage tube body, and the drainage guide column includes a cut-off section and a flow section, the outer diameter of the flow section is smaller than the outer diameter of the cut-off section, the cut-off section is in seamless sliding contact with the inner side wall of the drainage tube body, the flow section and the inner side wall of the drainage tube body form a drainage loop, connecting the liquid collection through hole, the drainage through hole and the drainage loop, and pushing the test tube plug to discharge the sampled liquid from the liquid collection through hole, the drainage loop and the drainage through hole into the test paper reaction component.

[0021] Furthermore, a reset spring is provided between the drainage guide column and the bottom of the drainage tube body of the present invention, which drives the drainage guide column to connect the liquid intake hole, the drainage hole and the drainage loop to complete the drainage operation, and the drainage guide column is reset under the action of the reset spring.

[0022] Furthermore, the outer side of the test tube body of the present embodiment is provided with a drainage groove, the drainage groove is provided with a liquid collection hole, a drainage slider is provided in the drainage groove, the drainage slider is provided with a drainage hole, the drainage hole is connected with the liquid collection hole, and the test tube plug is pushed to discharge the sampled liquid from the liquid collection hole and the drainage hole into the test paper reaction component fixed on the drainage slider.

[0023] Furthermore, the test paper reaction component of the present solution includes a long strip groove substrate, a test paper strip insert is arranged in the slot of the long strip groove substrate, a test paper strip is arranged in the test paper strip insert, and the sampling liquid discharged from the liquid discharge hole undergoes a detection chemical reaction with the test paper strip.

[0024] Furthermore, the long strip groove substrate of the present invention is a rectangular parallelepiped structure, the long side wide surface A on one side of the long strip groove substrate is open, and the short side narrow surface A on the side adjacent to the long side wide surface A is open, and the test strip insert is inserted into the long strip groove substrate from the short side narrow surface A.

[0025] Internally, a plurality of round-headed stopper structures protruding inwardly from the long side wide surface A are arranged on the opening edge of the long side wide surface A, and the round-headed stopper structures prevent the test strip inserting plate from falling from the long side wide surface A.

[0026] Furthermore, the long side wide surface C on one side of the test strip insert of the present scheme is opened, and the test strip is inserted into the test strip insert from the long side wide surface C. A plurality of round-headed limit block structures protruding toward the inside of the test strip insert are provided on the inner edge of the opening of the long side wide surface C, and the round-headed limit block structures prevent the test strip from falling from the long side wide surface C.

[0027] Furthermore, the test paper reaction component of the present scheme includes a long strip groove substrate, a test paper strip groove is provided in the slot of the long strip groove substrate, a reaction circular through hole A and a reaction long through hole A are provided at the bottom of the test paper strip groove, a test paper strip is provided in the test paper strip groove, a test paper strip pressure plate is provided above the test paper strip groove in the long strip groove substrate, a reaction circular through hole B and a reaction long through hole B are provided on the test paper strip pressure plate, the reaction circular through hole B corresponds to the reaction circular through hole A, the reaction long through hole B corresponds to the reaction long through hole A, the sampling liquid discharged from the discharge through hole enters the reaction circular through hole B and the reaction long through hole B to produce a detection chemical reaction with the test paper strip.

[0028] Furthermore, an L-shaped drainage tube is provided on the outer side of the test tube body of the present embodiment, one end of the L-shaped drainage tube is connected to the optical observation section, and a drainage control cap is provided on the other end of the L-shaped drainage tube. The test tube plug is pushed to discharge the sample liquid from the other end of the L-shaped drainage tube into the test paper reaction assembly.

[0029] Furthermore, the other end of the L-shaped drainage tube of the present embodiment is a tube structure whose outer diameter gradually decreases along the drainage direction. The drainage control cap is pushed along the disengagement direction to form a limiting contact with the cap stopper provided on the outside of the test tube body, and the sampled liquid is discharged along the gap between the other end of the L-shaped drainage tube and the inner side of the drainage control cap.

[0030] Furthermore, the end portion of the other end of the L-shaped drainage tube of the present embodiment is a closed structure, and a drainage hole is provided on the outer side of the other end of the L-shaped drainage tube. The drainage hole is connected with the optical observation section through the internal cavity of the L-shaped drainage tube. The drainage control cap is pushed in the disengagement direction to form a limiting contact with the cap stopper provided on the outer side of the test tube body, and the sample liquid is discharged from the drainage hole.

[0031] Furthermore, a spring is provided on the other end of the L-shaped discharge tube of the present invention, and the spring presses the discharge control cap against the cap stopper on the outside of the test tube body to form a limiting contact. The end portion of the other end of the L-shaped discharge tube is a closed structure, and a discharge hole is provided on the outside of the other end of the L-shaped discharge tube. The discharge control cap is pushed to overcome the stress of the spring to open the discharge hole, and the sampled liquid is discharged from the discharge hole.

[0032] Furthermore, a liquid discharge nozzle is provided at the far end of the optical observation section of the present solution, and a liquid discharge control cap is sleeved on the liquid discharge nozzle, and the test tube plug is pushed to discharge the sample liquid from the liquid discharge nozzle into the test paper reaction component.

[0033] The integrated multifunctional biological sample processor of the present invention adopts an integrated processor to realize the integration of multiple biological sample processing functions, and has the characteristics of convenient operation and high efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 It is a structural diagram of the integrated multifunctional biological sample processor of the present invention.

[0035] Figure 2It is a cross-sectional structural diagram of the test tube along the central axis of the flow direction of the sampling liquid.

[0036] Figure 3 It is the assembly structure diagram of the test tube stopper and the sampling square spoon.

[0037] Figure 4 It is a structural diagram of the sampling baffle A.

[0038] Figure 5 It is a structural diagram of sampling baffle B.

[0039] Figure 6 It is a structural diagram of the sampling combination baffle in the closed flow state.

[0040] Figure 7 It is a structural diagram of the sampling combination baffle in the open flow state.

[0041] Figure 8 It is the assembly structure diagram of the drainage guide column and the return spring.

[0042] Fig. 9 It is a structural diagram of the test tube body and the drainage tube body.

[0043] Fig.10 It is a structural diagram of the first embodiment of the long strip groove substrate.

[0044] Fig.11 It is a structural diagram of the test strip insert.

[0045] Fig.12 It is a structural diagram of the test tube body and the liquid discharge slider.

[0046] Fig.13 It is a structural diagram of the drainage groove on the outside of the test tube body.

[0047] Fig.14 It is a structural diagram of the drain slider.

[0048] Fig.15 It is a structural diagram of the second embodiment of the long strip groove substrate.

[0049] Fig.16 It is a structural diagram of the test strip pressure plate.

[0050] Fig.17 It is a structural diagram of a test tube body and an L-shaped drainage tube.

[0051] Fig.18 It is a structural diagram of the test tube body and the L-shaped liquid discharge tube embodiment 1.

[0052] Fig.19 It is a structural diagram of the test tube body and the L-shaped liquid discharge tube embodiment 2.

[0053] Fig. 20 It is a structural diagram of the test tube body and the L-shaped liquid discharge tube embodiment 3.

[0054] Among them, 100 is a test tube body, 101 is a sample carrier, 110 is a sampling processing section, 120 is an optical observation section, 121 is an observation section, 130 is a test tube plug, 131 is a sealing ring, 132 is a liquid discharge piston, 140 is a sampling square spoon, 150 is a sampling baffle A, 151 is a sloped guide surface, 160 is a sampling baffle B, 170 is a sampling combination baffle, 171 is a baffle a, 172 is a baffle b, 173 is a baffle c, 174 is a connecting rod, 175 is a guide ring, 176 is an elastic part, 200 is a liquid discharge tube body, 210 is a liquid discharge through hole, and 220 is a liquid discharge guide column , 221 is the cut-off section, 222 is the flow section, 230 is the reset spring, 240 is the drainage groove, 250 is the drainage slider, 300 is the test paper reaction component, 301 is the round head limit block structure, 310 is the long strip groove substrate, 320 is the test paper strip plug-in plate, 331 is the test paper strip groove, 332 is the reaction round through hole A, 333 is the reaction long through hole A, 340 is the test paper strip pressure plate, 341 is the reaction round through hole B, 342 is the reaction long through hole B, 410 is the L-shaped drainage tube, 411 is the drainage hole, 420 is the drainage control cap, 430 is the spring, and 440 is the cap stopper. DETAILED DESCRIPTION

[0055] like Figure 1 , 2 As shown, the integrated multifunctional biological sample processor of the present invention includes a test tube body, the test tube body includes a sampling processing section and an optical observation section, the sampling processing section and the optical observation section are connected to form a test tube body as a whole, the test tube body inlet cover at one end of the sampling processing section is provided with a test tube plug, the optical observation section includes an observation section, the biological sample entering the sampling processing section forms a sampling liquid after being processed and enters the optical observation section, and the external inspection equipment observes the sample and collects the sample parameters through the observation section. Further, part of the side wall of the sampling processing section of the present scheme is a cylindrical structure, and part of the side wall of the observation section of the optical observation section is a plane structure, the cylindrical structure and the plane structure are connected by an inclined structure to form part of the side wall of the whole test tube body, and the external inspection equipment observes the sample and collects the sample parameters through the plane structure. The above scheme adopts an integrated processor to realize the integration of sampling processing, sampling observation and other functions, wherein the improvement of the test tube body structure is conducive to adjusting the capacity of the test tube, and at the same time facilitates the external equipment to observe and inspect the sampling, thereby greatly improving the operational efficiency of biological sample inspection.

[0056] In order to realize the liquid drainage function of the test tube stopper, the present solution discloses the following specific embodiments.

[0057] Embodiment 1

[0058] like Figure 3As shown, the test tube plug of the present embodiment is a columnar structure whose shape matches the inner side of the inlet of the test tube body. A plurality of raised sealing rings extending circumferentially are provided on the outer side of the columnar structure. The test tube plug is pushed to cover tightly to discharge the sample liquid into the test paper reaction assembly, and the sealing ring prevents the biological sample in the test tube body from leaking out.

[0059] Embodiment 2

[0060] The test tube plug is fixed and tightly covered with the entrance. An elastic hollow ball is provided on the outer end of the test tube plug. The elastic hollow ball is squeezed to discharge the sample liquid into the observation part. A rubber hollow ball (liquid discharge air bag) connected to the test tube body can be used. The operator squeezes the liquid discharge air bag to increase the air pressure inside the test tube body, and the sample liquid is pushed into the test paper reaction component.

[0061] Embodiment 3

[0062] like Figure 2 As shown, the test tube plug includes a test tube plug cavity, which is fixed in the inlet of the test tube body. The test tube plug cavity is provided with a liquid discharge piston on the inlet side of the test tube body, and the liquid discharge piston is pushed to discharge the sample liquid into the test paper reaction component. The liquid discharge piston forms an air pressure effect through the test tube plug cavity and the test tube body, and the sample liquid is pressed into the test paper reaction component.

[0063] Embodiment 4

[0064] The test tube plug is fixed and tightly covered with the entrance. A columnar quantitative discharge piston is provided on the outer end of the test tube plug. A discharge scale is provided on the outer side of the columnar quantitative discharge piston along the discharge direction. The columnar quantitative discharge piston is pushed according to the discharge scale to discharge the sample liquid into the test paper reaction component.

[0065] In order to realize the biological sample sampling operation function, this solution discloses the following specific embodiments.

[0066] Embodiment 1

[0067] like Figure 3 As shown, the sample square spoon is provided on one end of the test tube plug in the present solution. The sample square spoon includes a spoon head and a spoon handle. The spoon handle is a cylindrical structure. The sample square spoon is sleeved on the connecting handle on one end of the test tube plug in the test tube through the spoon handle. In order to facilitate stirring and mixing the sample, the sample square spoon in the present solution has a plurality of through-hole structures on the spoon head.

[0068] Embodiment 2

[0069] Furthermore, the test tube plug of the present embodiment is provided with a fiber tester on one end of the test tube body, the fiber tester comprises a fiber tester head and a fiber tester rod, the fiber tester rod is a cylindrical structure, and the fiber tester is sleeved on a connecting handle on one end of the test tube plug provided in the test tube body through the fiber tester rod.

[0070] In order to achieve the goal of screening the sampling liquid or material that meets the requirements and discharge it into the observation part for easy observation and detection, the present solution discloses the following specific embodiments.

[0071] Embodiment 1

[0072] like Figure 2 , 4 As shown, a sampling baffle A is provided in the rear section of the sampling processing section of the test tube body of the present solution, and a flow gap is provided between the sampling baffle A and the inner wall of the sampling processing section. The sampling baffle A includes a sloped flow guide surface, and the biological sample in the sampling processing section is precipitated to the observation part of the optical observation section through the sloped flow guide surface after centrifugation. The sloped flow guide surface is conducive to the precipitation of components such as cells from the flow guide surface to the counting pool area at the tail of the test tube when the sample is centrifuged.

[0073] Embodiment 2

[0074] like Figure 2 , 5 As shown, a sampling baffle B is provided in the rear section of the sampling processing section of the test tube body of the present embodiment, and the sampling baffle B is tightly combined with the inner wall of the sampling processing section along the circumferential direction. A plurality of filtering through holes are provided on the sampling baffle B. The biological sample in the sampling processing section is filtered through the filtering through holes and then enters the observation part of the optical observation section. The filtering holes can filter out unnecessary impurities or components according to the set size.

[0075] Embodiment 3

[0076] like Figure 2 , 6 As shown in 7, a sampling combination baffle is provided in the rear section of the sampling processing section of the test tube body of the present scheme. The sampling combination baffle is in close contact with the inner wall of the sampling processing section along the circumferential direction. The sampling combination baffle includes baffle a, baffle b, and baffle c which are sequentially connected by an elastic part to form a whole sampling combination baffle. Baffle b is provided with a connecting rod connected to the test tube plug. The inner end of the connecting rod is movably sleeved in a fixed guide ring. The distal side of baffle a is connected to the guide ring through the elastic part. The distal side of baffle c is connected to the guide ring through the elastic part. The test tube plug is pushed to link the connecting rod to push baffle b so that the sampling combination baffle is deformed and folded to form a flow gap between the inner wall of the sampling processing section. The biological sample in the sampling processing section enters the test paper reaction component through the flow gap and exits the test tube plug. The sampling combination baffle is reset under the action of the elastic part. The above process is to open the sampling combination baffle while the discharge piston is discharging liquid, so as to facilitate the sample liquid to enter the observation part.

[0077] In order to facilitate external equipment such as microscopes to observe the sample and implement sampling operations, the present solution discloses the following specific embodiments.

[0078] Embodiment 1

[0079] like Figure 2 , 4As shown in Figure 5, a sampling baffle is provided in the sampling processing section of the test tube body of the present embodiment, and one end of the sampling baffle extends into the observation section of the optical observation section to form a sample carrier. The external inspection equipment observes the sample on the sample carrier through the observation section and collects the sample parameters.

[0080] Embodiment 2

[0081] like Fig.12 As shown, the observation part of the optical observation section of the present scheme includes a sample slide, a cover glass is provided on the sample slide, a fixed frame is fixed on the cover glass, the fixed frame presses the cover glass on the sample slide, and an external inspection device observes the sample on the sample slide through the cover glass and collects the sample parameters.

[0082] Embodiment 3

[0083] The optical observation section of the present solution is a closed structure, and a sample carrier is provided at a position corresponding to the observation portion. External inspection equipment observes the sample on the sample carrier and collects sample parameters through the observation portion.

[0084] In order to realize the extraction of the sampled liquid from the test tube body, the present solution discloses the following specific embodiments.

[0085] Embodiment 1

[0086] like Fig. 9 As shown, a drainage tube body is provided on the outer side of the test tube body of the present scheme, and the drainage tube body is provided with a liquid collection through hole connected with the optical observation section of the test tube body, and a drainage through hole connected with the test paper reaction component arranged on the outer side of the drainage tube body. A drainage guide column is provided in the drainage tube body, and the drainage guide column includes a cut-off section and a flow section. The outer diameter of the flow section is smaller than the outer diameter of the cut-off section. The cut-off section is in seamless sliding contact with the inner side wall of the drainage tube body. The flow section forms a drainage loop with the inner side wall of the drainage tube body, and the liquid collection through hole, the drainage through hole and the drainage loop are connected. The test tube plug is pushed to discharge the sampled liquid from the liquid collection through hole, the drainage loop and the drainage through hole into the test paper reaction component.

[0087] Embodiment 2

[0088] On the basis of the above scheme, a return spring is arranged between the drainage guide column and the bottom of the drainage tube body in this scheme, such as Figure 8 As shown, the liquid discharge guide column is driven to connect the liquid intake through hole, the liquid discharge through hole and the liquid discharge loop to complete the liquid discharge operation, and the liquid discharge guide column is reset under the action of the reset spring.

[0089] Embodiment 3

[0090] like Fig.12 , 13As shown in 14, the outer side of the test tube body of the present scheme is provided with a drainage groove, the drainage groove is provided with a liquid collection hole, a drainage slider is provided in the drainage groove, the drainage slider is provided with a drainage hole, the drainage hole is connected with the liquid collection hole, and the test tube plug is pushed to discharge the sampled liquid from the liquid collection hole and the drainage hole into the test paper reaction component fixed on the drainage slider.

[0091] Embodiment 4

[0092] Alternatively, a solution of directly opening a liquid discharge port on the observation section may be adopted, that is, a liquid discharge nozzle is provided at the distal end of the optical observation section of this solution, and a liquid discharge control cap is provided on the liquid discharge nozzle, and the test tube plug is pushed to discharge the sample liquid from the liquid discharge nozzle into the external inspection device. The liquid discharge control cap is used to control the discharge of the sample liquid.

[0093] Embodiment 5

[0094] like Fig.17 As shown, an L-shaped drainage tube is provided on the outer side of the test tube body of the present embodiment, one end of the L-shaped drainage tube is connected to the optical observation section, and a drainage control cap is provided on the other end of the L-shaped drainage tube. The test tube plug is pushed to discharge the sample liquid from the other end of the L-shaped drainage tube into the test paper reaction assembly.

[0095] like Fig.18 As shown, in Fig.17 On the basis of the scheme, the other end of the L-shaped discharge tube of this scheme is a tube structure with an outer diameter gradually decreasing along the discharge direction. The discharge control cap is pushed in the disengagement direction to form a limiting contact with the cap stopper provided on the outside of the test tube body, and the sampled liquid is discharged along the gap between the other end of the L-shaped discharge tube and the inner side of the discharge control cap.

[0096] like Fig.19 As shown, in Fig.17 On the basis of the scheme, the end portion of the other end of the L-shaped drainage tube of this scheme is a closed structure, and a drainage hole is provided on the outer side of the other end of the L-shaped drainage tube. The drainage hole is connected with the optical observation section through the internal cavity of the L-shaped drainage tube, and the drainage control cap is pushed in the disengagement direction to form a limiting contact with the cap stopper provided on the outer side of the test tube body, and the sampled liquid is discharged from the drainage hole.

[0097] like Fig. 20 As shown, in Fig.17 On the basis of the scheme, a spring is provided on the other end of the L-shaped discharge tube of this scheme, and the spring presses the discharge control cap against the cap stopper on the outside of the test tube body to form a limiting contact. The end head of the other end of the L-shaped discharge tube is a closed structure, and a discharge hole is provided on the outside of the other end of the L-shaped discharge tube. The discharge control cap is pushed to overcome the stress of the spring to open the discharge hole, and the sampled liquid is discharged from the discharge hole.

[0098] In order to realize the sample liquid introduction into the test paper reaction, the present scheme also discloses the following specific embodiments of the test paper reaction component.

[0099] Embodiment 1

[0100] like Fig.10 , 11 As shown, the test paper reaction component of this scheme includes a long strip groove substrate, a test paper strip insert is arranged in the slot of the long strip groove substrate, a test paper strip is arranged in the test paper strip insert, and the sampling liquid discharged from the liquid discharge through hole undergoes a detection chemical reaction with the test paper strip.

[0101] On the basis of the above scheme, the long strip groove substrate of this scheme is a rectangular parallelepiped structure, with a long side wide surface A on one side of the long strip groove substrate open, and a short side narrow surface A on the side adjacent to the long side wide surface A open, the test strip insert is inserted into the long strip groove substrate from the short side narrow surface A, and a plurality of round-headed stopper structures protruding into the long side wide surface A are provided on the opening edge of the long side wide surface A, and the round-headed stopper structures prevent the test strip insert from falling from the long side wide surface A. Similarly, the long side wide surface C on one side of the test strip insert of this scheme is open, and the test strip is inserted into the test strip insert from the long side wide surface C, and a plurality of round-headed stopper structures protruding into the test strip insert are provided on the inner edge of the opening of the long side wide surface C, and the round-headed stopper structures prevent the test strip from falling from the long side wide surface C.

[0102] Embodiment 2

[0103] like Fig.15 , 16 As shown, the test paper reaction assembly of this scheme includes a long strip groove substrate, a test paper strip groove is provided in the slot of the long strip groove substrate, a reaction round through hole A and a reaction long through hole A are provided at the bottom of the test paper strip groove, a test paper strip is provided in the test paper strip groove, a test paper strip pressing plate is provided above the test paper strip groove in the long strip groove substrate, a reaction round through hole B and a reaction long through hole B are provided on the test paper strip pressing plate, the reaction round through hole B corresponds to the reaction round through hole A, the reaction long through hole B corresponds to the reaction long through hole A, the sampling liquid discharged from the liquid discharge through hole enters the reaction round through hole B and the reaction long through hole B to react with the test paper strip to detect chemical reaction. The reaction of the test paper can be observed through the reaction round through hole A and the reaction long through hole A.

[0104] The present invention discloses a multifunctional biological sample processor which integrates a sampler, a test tube, a filtering and isolating baffle, a counting pool in an optical observation area, a drainage opening and squeezing device, and a test strip chemical reaction plate, and relates to the biological sample processing in the fields of medical inspection and life science. The present invention includes test tubes, a counting pool (optical observation section), a sampling spoon (sampler), a baffle plate in the tube (baffle plate or filter), a piston (tube cover or tube plug), a drainage switch device, a test strip chemical reaction plate and other components, and each component is connected as a whole in an inner cavity container that is interconnected. The counting pool (optical observation section) is connected to the inner cavity of the test tube, and is a sandwich sealing structure. There is a protruding plane (sample carrier) in the middle of the optical observation area, and a groove groove on the side. The middle protruding plane is the optical observation area, and the groove is conducive to the liquid flowing into the middle optical observation area, and is also conducive to processing and manufacturing. The baffle plate in the tube has three forms: a half baffle plate, a mesh baffle plate, and an umbrella baffle plate. The baffle plate is used to separate and filter liquid samples. The half-gear has a plate slope structure, which is conducive to the effective components in the sample entering the counting pool, especially during centrifugation. The mesh baffle has a small hole structure to filter out unnecessary components in the sample. The umbrella-shaped baffle (sampling combination baffle) has an inner tube and an outer tube, and two semicircular baffles are connected to the outer tube through an elastic and foldable connecting piece. The baffle is folded and opened by pushing and pulling the outer tube. When folded, the liquid in the test tube is connected, and when opened, the sample liquid is separated. The discharge switch device (discharge tube body) has a mechanism for opening and closing the discharge hole on the test tube. The piston (tube cover or tube plug) has a mechanism for squeezing the liquid in the test tube out. The test strip chemical reaction plate is clamped on the side of the discharge piston through a card slot, and has a hole that communicates with the discharge piston hole, and a small plug with a chemical test strip is inserted in the middle. By opening the discharge switch (discharge guide column), the piston is pushed to discharge the liquid sample in the test tube into the test strip chemical reaction plate or other container.

[0105] In view of the cumbersome steps in the operation process of the existing scheme, this scheme provides a biological sample processor that does not require a liquid suction gun, a liquid suction needle, a peristaltic pump and a liquid pipeline, which is time-saving, labor-saving, low in manufacturing cost and less in pollution. It can realize microscopic morphological examination without transferring liquid, and realizes liquid transfer to a test strip chemical reaction plate or other container through a liquid discharge switch device, and realizes liquid stratification through a baffle plate. At the same time, there is a container space for sampling tools and sample processing. The inner cavity of the test tube of this scheme is connected to the inner cavity of the counting pool as a whole. The processor is a test tube body with a parallel bottom and a semi-arc-shaped upper part, and the tail is a flat counting pool with a cavity (optical observation section). The two sides or the bottom can be equipped with a liquid discharge switch device (liquid discharge tube body or slot block mechanism), and the side of the liquid discharge switch device can be inserted with a test strip chemical reaction plate (test paper reaction component). A baffle plate can be inserted into the inner cavity of the test tube body. The front half of the tube plug has several layers of raised anti-leakage patterns, and the front half can be inserted with a sampling spoon handle or a spoon integrated on the tube plug.

[0106] like Figure 2 ,4 , 5, and 12 show several counting pool structures. The first structure is that the upper and lower surfaces of the tail of the test tube are flat interlayer cavities, and the thin sheet of the front half of the baffle is inserted into the counting pool. The thickness of the thin sheet is less than the height of the counting pool cavity, and the width is less than the width of the counting pool cavity, so that a sample slide with a protruding plane in the middle and grooves on the sides is formed. The second structure is that the tail of the test tube has a protruding plane (sample slide) in the middle, grooves on the sides, and four small holes at the four corners. A cover glass is covered on the substrate (sample slide), and then the cover glass is buckled on the substrate with a frame-shaped pressure strip, and the four pressure strip column tips of the frame-shaped pressure strip are pressed into the four small holes of the substrate. The third structure is an integrated type, that is, the counting pool and the test tube body are formed at one time, the upper and lower surfaces of the tail of the test tube are flat interlayer cavities, there is a protruding plane (sample slide) at the bottom, and a counting pool with grooves on the sides. The counting cell materials of the above three structures are plastic materials with high transparency close to optical glass, and the cover glass in the second structure can also be glass quartz material.

[0107] like Figure 8 , 9, 12, 13, and 14 show several types of discharge switch structures. In the first structure, the side of the test tube body is a cylindrical cavity (discharge tube body) into which a thick and thin cylindrical discharge port piston (discharge guide column) is inserted, with a spring underneath, and two corresponding holes on both sides of the inner wall of the cylindrical cavity. One hole is on the side of the test tube body, and the hole is connected to the inner cavity of the test tube body, and the other hole is on the side of the cylindrical cavity, and is connected to the outside world. When the spring bounces up, the part of the discharge port piston just blocks the holes on both sides. When the discharge port piston is pressed from the tube mouth, the spring is compressed, and the thin part of the discharge port piston faces the holes on both sides. The thin part of the discharge port piston has a gap connected to the two side holes. In this way, the discharge port of the test tube body realizes the switch action. The second structure is that the side of the test tube body is a strip-shaped cavity into which a thick and thin discharge port piston is inserted. There is no spring below. There are two corresponding holes on both sides of the inner wall of the cylindrical cavity. One hole is on the side of the test tube body and is connected to the inner cavity of the test tube body. The other hole is on the side of the cylindrical cavity and is connected to the outside world. When the discharge port piston is pulled to the outermost, the thick part of the rod body just blocks the holes on both sides. When the discharge port piston is pushed inward from the tube mouth to the bottom, the thin part of the discharge port piston is facing the holes on both sides. There is a gap in the thin part of the discharge port piston and is connected to the two side holes, so that the discharge port of the test tube body can realize the switch action. The third structure is that there is a circular long groove (drainage groove) on the side of the test tube body, and there is a small hole in the middle of the long groove hook that is connected to the inner cavity of the test tube. The oblong clamp protruding on the discharge valve (drainage slider) may be inserted into the groove on the test tube body. There are also a discharge port, a positioning pin, and a hanging groove hole on the discharge valve. When the push-pull drain valve is pushed forward to the left positioning pin to block it, the small hole on the test tube body is blocked by the drain valve and closed. When it is pulled back to the right positioning pin to block it, the small hole on the test tube body and the small hole on the drain valve are connected and opened, so that the drain port of the test tube body can realize the switching action. In the fourth structure, there is a protruding drain nozzle in the optical observation area (section) of the test tube body, and a cap can be put on the drain nozzle. When draining is required, the cap is removed, and the drain piston is pushed. When draining is not required, the cap is covered. In addition to the above four structures, there are many other structural methods such as the plug type, all of which are for realizing the opening and closing actions of the drain port of the inner cavity of the test tube body, and the sealing is good, and manual and mechanical automation operations are convenient. The drain port piston and drain valve components of the above structures are made of soft and elastic plastic materials, which are conducive to the sealing effect.

[0108] like Figures 17-20Several drain nozzle switch structures are shown. First, an L-shaped drain nozzle is provided on the side of the optical observation section. The front section of the L-shaped drain nozzle is thin and the rear section is thick. The center is a tube hole that is connected to the test tube body. A drain control cap is put on the drain nozzle. The side of the cap close to the test tube body is flat, and the side of the test tube close to the cap is also flat. The cap is close to the side of the test tube body. There is a cap baffle on the test tube body. When the cap is pushed to the baffle, a part of the thin section of the L-shaped drain nozzle is exposed. There is a gap channel between the tube hole and the thin section of the drain nozzle, and the test tube plug is pushed to discharge the sample liquid from the drain nozzle into the external inspection equipment. When the drain nozzle is opened, the drain control cap does not need to be taken off the test tube body, but is still put on the drain nozzle column. Secondly, an L-shaped liquid discharge nozzle is provided on the side of the optical observation section. The front section of the L-shaped liquid discharge nozzle is solid, and the rear section is a hollow tube body. A small hole is opened in the hollow part where the solid section and the hollow section meet. A liquid discharge control cap is put on the liquid discharge nozzle. The side of the cap close to the test tube body is flat, and the side of the test tube close to the cap is also flat. The cap is close to the side of the test tube body. There is a cap baffle on the test tube body. When the cap is pushed to the baffle, the small hole of the thin hollow section of the L-shaped liquid discharge nozzle is just exposed, and the test tube plug is pushed to discharge the sample liquid from the liquid discharge nozzle into the external inspection equipment. When the liquid discharge nozzle is opened, the liquid discharge control cap does not need to be removed from the test tube body, but is still put on the liquid discharge nozzle column. Third, an L-shaped liquid discharge nozzle is provided on the side of the optical observation section. The front section of the L-shaped liquid discharge nozzle column is covered with a spring and the rear section is covered with a liquid discharge control cylinder sleeve. The inner wall of the liquid discharge control cylinder sleeve is seamlessly and tightly attached to the L-shaped liquid discharge nozzle column. A small liquid discharge hole is opened near the liquid discharge nozzle hole. A blocking cover is inserted on the liquid discharge nozzle hole. The cylinder sleeve and the blocking cover are flat against the test tube body, and the sides of the test tube against the cylinder sleeve and the blocking cover are also flat. The center of the liquid discharge nozzle is a tube hole connected to the test tube body. The test tube is close to the side of the test tube body against the cylinder sleeve and the blocking cover. Press the liquid discharge control cylinder sleeve to expose the liquid discharge hole, and push the test tube plug to discharge the sample liquid from the liquid discharge nozzle into the external inspection equipment. To realize the liquid discharge opening function, just press the liquid discharge control cylinder sleeve to expose the liquid discharge hole, and release the spring to reset the liquid discharge control cylinder sleeve to block and close the liquid discharge hole.

[0109] This scheme also includes several drainage piston structures: a test tube plug with a sealing ring as a drainage piston; a test tube plug with an air bag as a drainage piston; a tube plug with a cavity of a certain capacity, a vent hole in the cavity communicating with the inner cavity of the test tube, and a drainage piston on the outside of the tube plug; a small drainage piston with a scale on the tube plug (columnar quantitative drainage piston). The drainage piston components of the above four structures are made of soft and elastic plastic material, which is conducive to sealing. When the drainage hole is opened, the drainage piston is pushed inward, the pressure in the test tube increases, and the sample is squeezed out of the test tube through the drainage port, and the sample is dripped into the test paper chemical reaction plate (test paper reaction component) or other containers.

[0110] like Figure 3The spoon structure shown in the figure consists of a pipe plug, a spoon handle and a spoon, and the three parts are spliced ​​together by a mounting hole sleeve. There are small holes on the spoon for convenient stirring and mixing of samples. The spoon structure can also be a non-porous structure, and the shape can also be round, slotted, rod-shaped (the rod surface is spiral, dotted), etc.

[0111] like Figure 2 , 4 , 5, 6, and 7 show several baffle structures. The half baffle is composed of a sloped guide surface, a positioning hole, and a thin layer sheet. The sloped guide surface is conducive to the precipitation of cells and other components from the guide surface to the counting pool area at the tail of the test tube when the sample is centrifuged. The positioning hole cooperates with the positioning column in the inner cavity of the test tube to position the baffle at a fixed position of the test tube, and the thin layer sheet is inserted into the optical observation area of ​​the test tube as a protruding plane (sample carrier). The height of the half baffle is about half of the height of the inner cavity of the test tube. The inner cavities of the test tube are connected. When the optical observation area of ​​the test tube is placed parallel to the microscope for observation, the sediment cells and other components at the tail of the test tube after centrifugation are blocked on the counting pool (observation part). The filter hole full baffle is composed of a filter hole surface, a positioning hole, and a thin layer sheet. The filter hole surface filters out large impurities or unnecessary components, and the mesh size can be designed according to the components to be filtered. The positioning hole cooperates with the positioning column in the inner cavity of the test tube to position the baffle at a fixed position of the test tube, and the thin layer sheet is inserted into the optical observation area of ​​the test tube as a protruding plane (sample carrier). The height of the baffle of the filter hole full baffle is consistent with the height of the inner cavity of the test tube, and the inner cavity of the test tube is connected through the filter hole. The umbrella baffle (sampling combination baffle) is composed of a baffle body, a guide sleeve, a test tube cover, and an operating handle. Like an umbrella-shaped inner and outer tube structure, the operating handle is the inner tube, and the guide sleeve (outer tube) is sleeved outside the operating handle. The baffle body is composed of two semicircular plates (baffle a, baffle c), and the size and shape of the two semicircular plates are the same as the size and shape of the cross-sectional size of the inner cavity of the test tube. The two semicircular baffles of the baffle body have a loose-leaf connection point (elastic part) with the operating handle (inner tube), and the two semicircular baffles of the baffle body each have an elastic soft film (elastic part) connected to the guide sleeve, and the guide sleeve and the test tube cover (plug) are a whole. One hand pinches the operating handle, and the other hand presses the test tube cover inward, and the two semicircular baffles open the umbrella baffle, and the test tube cover is pulled outward, and the two semicircular baffles are closed. By opening and closing the baffle in this way, the inner cavity of the test tube is connected when it is opened, and the inner cavity of the test tube is divided into two closed cavities when it is closed. Since many blood test items require centrifuged serum, the upper serum and the lower blood sediment components can be separated by the umbrella baffle.

[0112] like Figure 1 , 10, 11, 15, and 16 show the structure of the test strip chemical reaction plate (test strip reaction assembly). The test strip chemical reaction plate consists of a main body (long strip groove base plate) and a small test strip plug-in board. There is a protruding cylindrical groove head on the side of the test strip chemical reaction plate. The cylindrical groove head is inserted into the groove on the side of the discharge piston, and the two are spliced ​​together; after splicing, the holes on the test strip chemical reaction plate are aligned with the holes of the discharge piston, and the holes are connected; there is a long groove in the middle of the test strip chemical reaction plate, which can be inserted with a small plug-in board with a test strip; the small test strip plug-in board has a variety of sizes of plug-ins for different test strip sizes on the market, and there is a test strip plug-in board slot on each side of the middle slot of the small plug-in board to fix the test strip, and the test strip is fixed in the middle slot of the small plug-in board.

[0113] The biological sample processor of this solution is mainly used for single microscope morphology examination and combined examination of microscope morphology examination and test strip chemical items. The following is a classification description.

[0114] Single microscope morphological examination: The processor includes the test tube body, optical observation area, test tube plug (cover), spoon, and baffle.

[0115] Embodiment 1

[0116] Urine sediment examination. The baffle is a half baffle, and a spoon is not needed. Add urine to the test tube, plug the mouth of the test tube with a tube stopper, put it into the centrifuge, and centrifuge it. The cell sediment is centrifuged into the optical observation area of ​​the test tube, and then the optical observation area of ​​the test tube (counting pool, observation part) is inserted into the microscope to observe the morphology and count. The half baffle is used to prevent the cell sediment in the optical observation area from flowing back into the supernatant of the test tube when the test tube is placed flat on the microscope stage.

[0117] Embodiment 2

[0118] Stool examination. Use a filter hole baffle, which requires a spoon. The test tube has been pre-added with diluent when it leaves the factory. Use a spoon to take a stool sample and insert it into the test tube, plug the tube tightly. The spoon and the tube plug are integrated. Put it into the oscillator to mix the sample. The mesh shape of the spoon is conducive to mixing the stool sample. Then insert the optical observation area of ​​the test tube into the microscope to observe the morphology and count.

[0119] Embodiment 3

[0120] Gynecological leucorrhea examination: Replace the spoon with a cotton fiber tester (the tester stick is installed and inserted on the pipe plug) and use the cotton fiber tester to take the leucorrhea secretion for examination. The other operating steps are the same as those in the second embodiment.

[0121] Embodiment 4

[0122] Blood test. Use an umbrella-shaped baffle, no spoon is needed, and the test tube has been pre-added with anticoagulant or other treatment fluids when it leaves the factory. Add blood to the test tube, plug the test tube mouth with a tube stopper, fold the umbrella-shaped baffle, put it into the centrifuge, and centrifuge the cell sediment to the optical viewing area of ​​the test tube. After centrifugation, open the umbrella-shaped baffle, and the baffle will separate the upper serum of the test tube from the lower cell sediment. The upper serum can be used for items that require serum samples. The optical observation area is inserted under a microscope for morphological observation and counting inspection.

[0123] Embodiment 5

[0124] Direct biopsy and staining inspection of other cells, bacteria, and microorganisms. According to the needs of different samples and inspection items, different treatment liquids or no treatment liquids are pre-added to the test tubes, different sampling tools are inserted into the tube plugs, centrifugation or no centrifugation, staining liquid or no staining liquid, baffles are optional, and after assembly, the samples in the optical observation area are suitable for the inspection of the project.

[0125] Combined inspection of microscopic morphology and test strip chemical items: The processor includes a test tube body, an optical observation area, a test tube plug (cover), a spoon, a baffle, a discharge switch device, and a test strip chemical reaction plate.

[0126] Embodiment 6

[0127] Urine dry chemical analysis is performed at the same time as urine sediment examination. The sediment examination steps are the same as the separate microscopic morphological examination. Urine dry chemical analysis steps: insert a urine test strip into the test strip chemical reaction plate (test strip reaction component), open the drainage opening mechanism, and then push the drainage plug or drainage air bag. The liquid sample in the test tube is squeezed out of the drainage port and flows into the test strip in the test strip reaction plate for chemical reaction, and then put it into the urine analyzer for scanning and analysis.

[0128] Embodiment 7

[0129] Stool test strips (occult blood, rotavirus, etc.) are checked at the same time as routine stool microscopic cell morphology. The steps for routine stool cell morphology are the same as those for separate microscopic morphology. Stool test strip inspection steps: insert a test strip into the test strip chemical reaction plate, open the drainage opening mechanism, and then push the drainage plug or drainage air bag. The liquid sample in the test tube is squeezed out of the drainage port and flows into the test strip in the test strip reaction plate for chemical reaction. Finally, the human eye interprets or the camera takes a picture and the instrument automatically interprets.

[0130] Embodiment 8

[0131] Gynecological leucorrhea secretion test strips (BV cell bacterial vaginitis test strips, etc.) are examined at the same time as the conventional microscopic morphology of leucorrhea. The steps for conventional microscopic morphology of leucorrhea are the same as those for separate microscopic morphology. Leucorrhea test strip examination steps: insert a test strip into the test strip chemical reaction plate, open the drainage opening mechanism, and then push the drainage plug or drainage air bag. The liquid sample in the test tube is squeezed and flows from the drainage port to the test strip in the test strip reaction plate for chemical reaction. Finally, the human eye interprets or the instrument automatically interprets after the camera takes a picture.

[0132] Embodiment 9

[0133] The serum test strips are tested simultaneously with the blood cell microscopic morphology. The blood cell microscopic morphology test steps are the same as the single microscopic morphology test. The serum test strips are tested as follows: insert a test strip into the test strip chemical reaction plate, open the drainage opening mechanism, and then push the drainage plug or drainage air bag. The liquid sample in the test tube is squeezed and flows from the drainage port to the test strip in the test strip reaction plate for chemical reaction. Finally, the human eye or the instrument automatically reads.

[0134] Embodiment 10

[0135] In the above embodiment, the test strip is replaced by various standard test strips on the market (each manufacturer has installed the test strips in the colloid plate). The operation method is: put the standard test strip chemical reaction plate on the market under the test tube discharge opening mechanism, align the liquid filling hole of the standard test strip reaction plate with the liquid outlet of the discharge opening mechanism, and the test strip chemical reaction plate is not installed on the side of the discharge opening mechanism. Open the discharge opening mechanism, then push the discharge plug or the discharge airbag, and the liquid sample in the test tube is squeezed and dripped from the discharge port to the liquid filling port of the standard test strip reaction plate below, and finally read by human eyes or the instrument automatically.

[0136] The above 10 embodiments can be operated manually or automatically by an instrument. At the same time, more than one test strip chemical reaction plate can be added to the side of the test strip chemical reaction plate, and the test strip chemical reaction plates can be installed on both sides and the parallel bottom of the test tube body. There can also be multiple drainage holes. The cylindrical drainage type can change the cylindrical drainage column into multiple equidistant thick and thin structures to achieve simultaneous opening and closing of multiple drainage holes. The strip-shaped drainage type can change the drainage opening mechanism into multiple equidistant drainage holes. The same number of equidistant drainage holes are also added to the place where the test tube body is inserted for drainage opening.

[0137] The processor of this solution integrates biological sample processing (sampling, loading, dissolving, centrifugation), cell counting pool (optical observation area), drainage, and test strip chemical reaction plate, making the operation steps simpler and more convenient, saving time and cost, and can more effectively improve quality and reduce pollution. In terms of biological samples that require microscopic examination, manual operators do not need to use a pipette gun to draw biological samples from test tubes and then inject them into slides, counting plates, and test strip chemical reaction plates. For automated instruments, there is no need to use aspiration needles, peristaltic pumps, solenoid valves, and complex silicone pipes to transport biological samples to slides, counting plates, and test strip chemical reaction plates. This solution avoids the complicated liquid stratification and transfer of biological samples (such as taking sediment or supernatant after centrifugation). There is no need to pipette after centrifugation, nor is there any need to remove unnecessary liquids first and then take sediment and other cell components. Because the detection and sample processing are in a connected container, the drainage is also controlled by a switch device. Based on the above characteristics, the integrated multifunctional biological sample processor of this solution has outstanding substantive characteristics and significant progress compared with existing similar solutions.

[0138] The integrated multifunctional biological sample processor of the present solution is not limited to the contents disclosed in the specific implementation manner. The technical solutions appearing in the embodiments can be extended based on the understanding of those skilled in the art. Simple replacement solutions made by those skilled in the art based on the present solution combined with common knowledge also fall within the scope of the present solution.

Claims

1. An integrated multifunctional biological sample processor, characterized by , The test tube body comprises a sampling processing section and an optical observation section. The sampling processing section is connected with the optical observation section to form a whole test tube body. A test tube plug is provided on the upper cover of the test tube body inlet at one end of the sampling processing section. The biological sample entering the sampling processing section is processed to form a sampling liquid that enters the optical observation section. The external inspection equipment observes the sample and collects sample parameters through the optical observation section. A drainage tube body is provided on the outer side of the test tube body, and a liquid collection through hole connected to the optical observation section of the test tube body and a liquid discharge through hole connected to the test paper reaction component provided on the outer side of the liquid discharge tube body are provided on the liquid discharge tube body. A liquid discharge guide column is provided in the liquid discharge tube body, and the liquid discharge guide column includes a cut-off section and a flow section. The outer diameter of the flow section is smaller than the outer diameter of the cut-off section. The cut-off section is in sliding contact with the inner side wall of the liquid discharge tube body without a gap. The flow section forms a liquid discharge loop with the inner side wall of the liquid discharge tube body, and the liquid collection through hole and the liquid discharge through hole are connected with the liquid discharge loop. The test tube plug is pushed to discharge the sampled liquid from the liquid collection through hole, the liquid discharge loop and the liquid discharge through hole into the test paper reaction component. A sampling baffle A is provided in the rear section of the sampling processing section of the test tube body, a flow gap is provided between the sampling baffle A and the inner side wall of the sampling processing section, the sampling baffle A comprises a sloped flow guide surface, the biological sample in the sampling processing section is precipitated to the optical observation section through the sloped flow guide surface after centrifugal treatment, and is prevented from backflowing by the sampling baffle A when the test tube body is laid flat, or, A sampling baffle B is provided in the rear section of the sampling processing section of the test tube body. The sampling baffle B is tightly combined with the inner wall of the sampling processing section along the circumferential direction. A plurality of filtering through holes are provided on the sampling baffle B. After being mixed by an oscillator, the biological sample in the sampling processing section is filtered through the filtering through holes and then enters the optical observation section, or, A sampling combination baffle is provided in the rear section of the sampling processing section of the test tube body, and the sampling combination baffle is in close contact with the inner wall of the sampling processing section along the circumferential direction. The sampling combination baffle includes baffle a, baffle b, and baffle c which are sequentially connected by elastic parts to form a sampling combination baffle as a whole. The baffle b is provided with a connecting rod connected to the test tube plug, and the inner end of the connecting rod is movably sleeved in a fixed guide ring. The distal side of the baffle a is connected to the guide ring through an elastic part, and the distal side of the baffle c is connected to the guide ring through an elastic part. The test tube plug is pushed to link the connecting rod to push the baffle b so that the sampling combination baffle is deformed and folded to form a flow gap between the inner wall of the sampling processing section. The biological sample in the sampling processing section enters the optical observation section through the flow gap and exits the test tube plug. The sampling combination baffle is reset under the action of the elastic part.

2. The integrated multifunctional biological sample processor according to claim 1, characterized in that: Part of the side wall of the sampling and processing section is a cylindrical structure, and part of the side wall of the optical observation section is a plane structure. The cylindrical structure and the plane structure are connected by an inclined structure to form a partial side wall of the entire test tube body. External inspection equipment observes samples and collects sample parameters through the plane structure.

3. The integrated multifunctional biological sample processor according to claim 1, characterized in that: The test tube plug is a columnar structure whose shape matches the inner side of the test tube body inlet. A plurality of raised sealing rings extending circumferentially are provided on the outer side of the columnar structure. The test tube plug is pushed to cover tightly to discharge the sample liquid into the test paper reaction assembly. The sealing ring prevents the biological sample in the test tube body from leaking out.

4. The integrated multifunctional biological sample processor according to claim 1, characterized in that: An elastic hollow ball is arranged on the outer end of the test tube plug, and the elastic hollow ball is squeezed to discharge the sample liquid into the test paper reaction component.

5. The integrated multifunctional biological sample processor according to claim 1, characterized in that: The test tube plug comprises a test tube plug cavity, which is fixed in the inlet of the test tube body. The test tube plug cavity is provided with a liquid discharge piston on the inlet side of the test tube body, and the liquid discharge piston is pushed to discharge the sample liquid into the test paper reaction component.

6. The integrated multifunctional biological sample processor according to claim 1, characterized in that: A columnar quantitative liquid discharge piston is provided on the outer end of the test tube plug, and a liquid discharge scale is provided on the outer side of the columnar quantitative liquid discharge piston along the liquid discharge direction. The columnar quantitative liquid discharge piston is pushed according to the liquid discharge scale to discharge the sample liquid into the test paper reaction component.

7. The integrated multifunctional biological sample processor according to claim 1, characterized in that: The test tube plug is provided with a sampling square spoon on one end of the test tube body. The sampling square spoon includes a spoon head and a spoon handle. The spoon handle is a cylindrical structure. The sampling square spoon is sleeved on the connecting handle of the test tube plug on one end of the test tube body through the spoon handle.

8. The integrated multifunctional biological sample processor according to claim 7, characterized in that: The spoon head of the sampling square spoon is provided with a plurality of through-hole structures.

9. The integrated multifunctional biological sample processor according to claim 1, characterized in that: The test tube plug is provided with a fiber tester at one end of the test tube body. The fiber tester includes a fiber tester head and a fiber tester rod. The fiber tester rod is a cylindrical structure. The fiber tester is sleeved on the connecting handle of the test tube plug at one end of the test tube body through the fiber tester rod.

10. The integrated multifunctional biological sample processor according to claim 1, characterized in that: The optical observation section includes a sample slide, a cover glass is provided on the sample slide, a fixing frame is fixed on the cover glass, the fixing frame presses the cover glass on the sample slide, and an external inspection device observes the sample on the sample slide and collects sample parameters through the cover glass.

11. The integrated multifunctional biological sample processor according to claim 1, characterized in that: The optical observation section is a closed structure, and a sample slide is provided at a position corresponding to the optical observation section. External inspection equipment observes the sample on the sample slide and collects sample parameters through the optical observation section.

12. The integrated multifunctional biological sample processor according to claim 1, characterized in that: A reset spring is provided between the drainage guide column and the bottom of the drainage tube body to drive the drainage guide column to connect the liquid intake through hole, the drainage through hole and the drainage annular channel to complete the drainage operation. The drainage guide column is reset under the action of the reset spring.

13. The integrated multifunctional biological sample processor according to claim 1, characterized in that: A drainage groove is provided on the outer side of the test tube body, a liquid collection through hole is provided on the drainage groove, a drainage slider is provided in the drainage groove, a drainage through hole is provided on the drainage slider, the drainage through hole is connected with the liquid collection through hole, and the test tube plug is pushed to discharge the sampled liquid from the liquid collection through hole and the drainage through hole into the test paper reaction component fixed on the drainage slider.

14. The integrated multifunctional biological sample processor according to claim 1 or 13, characterized in that: The test paper reaction component comprises a long strip groove substrate, a test paper strip inserting plate is arranged in the slot of the long strip groove substrate, a test paper strip is arranged in the test paper strip inserting plate, and the sampling liquid discharged from the liquid discharge through hole undergoes a detection chemical reaction with the test paper strip.

15. The integrated multifunctional biological sample processor according to claim 14, characterized in that: The long strip groove substrate is a rectangular structure, with a long side wide surface A on one side of the long strip groove substrate being open, and a short side narrow surface A on the side adjacent to the long side wide surface A being open, and the test strip plug-in plate being inserted into the long strip groove substrate from the short side narrow surface A, and a plurality of round-headed limit block structures protruding into the long side wide surface A are provided on the opening edge of the long side wide surface A, and the round-headed limit block structures prevent the test strip plug-in plate from falling off the long side wide surface A.

16. The integrated multifunctional biological sample processor according to claim 15, characterized in that: The long side wide surface C on one side of the test strip insert is open, and the test strip is inserted into the test strip insert from the long side wide surface C. A plurality of round-headed limit block structures protruding toward the inside of the test strip insert are provided on the inner edge of the opening of the long side wide surface C, and the round-headed limit block structures prevent the test strip from falling from the long side wide surface C.

17. The integrated multifunctional biological sample processor according to claim 11 or 13, characterized in that: The test paper reaction component includes a long strip groove substrate, a test paper strip groove is provided in the slot of the long strip groove substrate, a reaction circular through hole A and a reaction long through hole A are provided at the bottom of the test paper strip groove, a test paper strip is provided in the test paper strip groove, a test paper strip pressing plate is provided above the test paper strip groove in the long strip groove substrate, a reaction circular through hole B and a reaction long through hole B are provided on the test paper strip pressing plate, the reaction circular through hole B corresponds to the reaction circular through hole A, the reaction long through hole B corresponds to the reaction long through hole A, the sampling liquid discharged from the drainage through hole enters the reaction circular through hole B and the reaction long through hole B to produce a detection chemical reaction with the test paper strip.

18. The integrated multifunctional biological sample processor according to claim 1, characterized in that: An L-shaped drainage tube is provided on the outer side of the test tube body, one end of the L-shaped drainage tube is connected to the optical observation section, and a drainage control cap is provided on the other end of the L-shaped drainage tube. The test tube plug is pushed to discharge the sample liquid from the other end of the L-shaped drainage tube into the test paper reaction component.

19. The integrated multifunctional biological sample processor according to claim 18, characterized in that: The other end of the L-shaped discharge tube is a tube structure with an outer diameter that gradually decreases along the discharge direction. The discharge control cap is pushed along the disengagement direction to form a limiting contact with the cap stopper provided on the outside of the test tube body, and the sampled liquid is discharged along the gap between the other end of the L-shaped discharge tube and the inner side of the discharge control cap.

20. The integrated multifunctional biological sample processor according to claim 19, characterized in that: The end portion of the other end of the L-shaped drainage tube is a closed structure, and a drainage hole is provided on the outer side of the other end of the L-shaped drainage tube. The drainage hole is connected with the optical observation section through the internal cavity of the L-shaped drainage tube. The drainage control cap is pushed in the disengagement direction to form a limiting contact with the cap stopper provided on the outer side of the test tube body, and the sample liquid is discharged from the drainage hole.

21. The integrated multifunctional biological sample processor according to claim 19, characterized in that: A spring is sleeved on the other end of the L-shaped discharge tube, and the spring presses the discharge control cap against the cap stopper on the outside of the test tube body to form a limiting contact. The end portion of the other end of the L-shaped discharge tube is a closed structure, and a discharge hole is provided on the outside of the other end of the L-shaped discharge tube. The discharge control cap is pushed to overcome the stress of the spring to open the discharge hole, and the sampled liquid is discharged from the discharge hole.

22. The integrated multifunctional biological sample processor according to claim 1, characterized in that: A liquid discharge nozzle is arranged at the far end of the optical observation section, and a liquid discharge control cap is sleeved on the liquid discharge nozzle. The test tube plug is pushed to discharge the sample liquid from the liquid discharge nozzle into the test paper reaction component.

23. An integrated multifunctional biological sample processor, characterized by , The test tube body comprises a sampling processing section and an optical observation section. The sampling processing section is connected with the optical observation section to form a whole test tube body. A test tube plug is provided on the upper cover of the test tube body inlet at one end of the sampling processing section. The biological sample entering the sampling processing section is processed to form a sampling liquid that enters the optical observation section. The external inspection equipment observes the sample and collects sample parameters through the optical observation section. The test tube plug comprises a test tube plug cavity, which is fixed in the inlet of the test tube body. The test tube plug cavity is provided with a liquid discharge piston on the inlet side of the test tube body, and the liquid discharge piston is pushed to discharge the sample liquid into the test paper reaction component; A drainage tube body is provided on the outer side of the test tube body, and the drainage tube body is provided with a liquid collection through hole connected to the optical observation section of the test tube body, and a drainage through hole connected to the test paper reaction component arranged on the outer side of the drainage tube body. A drainage guide column is provided in the drainage tube body, and the drainage guide column includes a cut-off section and a flow section. The outer diameter of the flow section is smaller than the outer diameter of the cut-off section. The cut-off section is in seamless sliding contact with the inner side wall of the drainage tube body. The flow section forms a drainage loop with the inner side wall of the drainage tube body, and the liquid collection through hole and the drainage through hole are connected with the drainage loop. The test tube plug is pushed to discharge the sampled liquid from the liquid collection through hole, the drainage loop and the drainage through hole into the test paper reaction component.

24. An integrated multifunctional biological sample processor, characterized in that , The test tube body comprises a sampling processing section and an optical observation section. The sampling processing section is connected with the optical observation section to form a whole test tube body. A test tube plug is provided on the upper cover of the test tube body inlet at one end of the sampling processing section. The biological sample entering the sampling processing section is processed to form a sampling liquid that enters the optical observation section. The external inspection equipment observes the sample and collects sample parameters through the optical observation section. The test tube plug comprises a test tube plug cavity, which is fixed in the inlet of the test tube body. The test tube plug cavity is provided with a liquid discharge piston on the inlet side of the test tube body, and the liquid discharge piston is pushed to discharge the sample liquid into the test paper reaction component; A drainage groove is provided on the outer side of the test tube body, a liquid collection through hole is provided on the drainage groove, a drainage slider is provided in the drainage groove, a drainage through hole is provided on the drainage slider, the drainage through hole is connected with the liquid collection through hole, and the test tube plug is pushed to discharge the sampled liquid from the liquid collection through hole and the drainage through hole into the test paper reaction component fixed on the drainage slider.

25. An integrated multifunctional biological sample processor, characterized in that , The test tube body comprises a sampling processing section and an optical observation section. The sampling processing section is connected with the optical observation section to form a whole test tube body. A test tube plug is provided on the upper cover of the test tube body inlet at one end of the sampling processing section. The biological sample entering the sampling processing section is processed to form a sampling liquid that enters the optical observation section. The external inspection equipment observes the sample and collects sample parameters through the optical observation section. The test tube plug comprises a test tube plug cavity, the test tube plug cavity is fixed in the test tube body inlet, the test tube plug cavity is provided with a liquid discharge piston at the part of the test tube body inlet side, and the liquid discharge piston is pushed to discharge the sample liquid into the optical observation section; An L-shaped drainage tube is provided on the outer side of the test tube body, one end of the L-shaped drainage tube is connected to the optical observation section, and a drainage control cap is provided on the other end of the L-shaped drainage tube. The drainage control cap is pushed, and the test tube plug is pushed to discharge the sample liquid from the other end of the L-shaped drainage tube into the test paper reaction component.

26. An integrated multifunctional biological sample processor, characterized in that , The test tube body comprises a sampling processing section and an optical observation section. The sampling processing section is connected with the optical observation section to form a whole test tube body. A test tube plug is provided on the upper cover of the test tube body inlet at one end of the sampling processing section. The biological sample entering the sampling processing section is processed to form a sampling liquid that enters the optical observation section. The external inspection equipment observes the sample and collects sample parameters through the optical observation section. The test tube plug comprises a test tube plug cavity, which is fixed in the inlet of the test tube body. The test tube plug cavity is provided with a liquid discharge piston on the inlet side of the test tube body, and the liquid discharge piston is pushed to discharge the sample liquid into the test paper reaction component; A liquid discharge nozzle is provided at the far end of the optical observation section, and a liquid discharge control cap is sleeved on the liquid discharge nozzle. The liquid discharge control cap is used to control the discharge of the sampled liquid, and the test tube plug is pushed to discharge the sampled liquid from the liquid discharge nozzle into the test paper reaction component.

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