A non-ablative fractional laser therapy device with real-time OCT monitoring function

Abstract

The invention discloses a non-ablative fractional laser therapeutic apparatus with real-time OCT monitoring function, which has a treatment mode, a drug delivery mode and an OCT monitoring mode, and comprises a treatment laser module, a dispersion frequency sweeping module, an interference module, an optical signal acquisition and processing module, a laser head module and a control module; by setting the OCT monitoring function, the laser treatment process can be monitored in real time; a drug delivery component is added to realize drug delivery operation on a target area; in the drug delivery mode, interval switching with the OCT monitoring mode is adopted to effectively ensure the drug delivery effect and realize accurate drug delivery; a pulsed laser is adopted as a light source, and a photonic crystal fiber, a fiber Bragg grating and a multimode fiber are added to the system to ensure effective monitoring; the laser therapeutic apparatus is not only suitable for biological tissues, but also suitable for drilling detection of optomechanical systems or other structures in industry.

Description

Technical Field

[0001] The invention relates to a laser therapeutic apparatus, and in particular to a non-ablative fractional laser therapeutic apparatus with a real-time OCT monitoring function. Background Art

[0002] Keloid is a benign skin tumor caused by skin injury and characterized by abnormal proliferation of fibroblasts. Its main manifestations are that it exceeds the boundaries of the original wound, invades the surrounding normal skin tissue, cannot disappear spontaneously, and has a high recurrence rate after simple surgical excision. Keloids in the active stage often invade the surrounding skin and are often accompanied by symptoms such as itching and pain, and even restrict activities, seriously affecting the patient's quality of life. In addition, keloids seriously affect the appearance, leading to cosmetic problems, and bring negative impacts to patients, especially young people, in many aspects such as social interaction, marriage and love, causing psychological pressure on patients and even mental illness. Therefore, most patients with keloids have a strong desire for treatment.

[0003] At present, the method used in clinical treatment of acne scars is mainly the fractional laser technology that appeared in 2004. This technology is based on the "focal photothermolysis principle" (Fractional photothermolysis, FP). This theory is an extension and expansion of the "selective photothermolysis principle" and has established a new laser treatment mode - the fractional mode. This laser is the third type of laser after ablative laser and non-ablative laser, and its efficacy and safety are between the two. The target color base of the fractional laser is tissue water. After the scar area absorbs laser energy and causes damage, it stimulates the activation of keratinocytes in the surrounding normal tissues and quickly migrates to the damaged area to repair the epidermis. The type I collagen in the dermis also shrinks immediately under thermal stimulation. When the temperature and time reach a certain value, the collagen fibers begin to denature, inducing the surrounding normal tissues to start the wound repair process, so that collagen is rearranged and regenerated. The purpose of laser treatment is achieved through the regeneration of the stratum corneum, the regeneration of fibers and collagen. Further studies have found that the effect of fractional laser combined with drug treatment is more significant than that of fractional laser alone. It can effectively reduce the 2-year recurrence rate, improve the effect of a single treatment and thus shorten the treatment time.

[0004] Although the fractional laser system can accomplish the task of scar removal, the specific form, distribution, and depth of the columnar thermal denaturation zone formed by the laser under the skin can only be guessed by the doctor's experience, or rely on the observation of the patient's trauma (such as observing the patient's bleeding volume, etc.). Not only is the operation inconvenient and the treatment inaccurate, but it also causes pain to the patient and prolongs the course of treatment. If the fractional laser is combined with drug treatment, the injection amount of the drug is theoretically required to infiltrate the entire scar tissue and its subcutaneous part. However, in reality, the injection amount is completely dependent on the doctor's feeling. The only available monitoring indicator is the color of the scar, and the injection amount cannot be accurately determined.

[0005] Therefore, the prior art still needs to be improved and developed. Summary of the invention

[0006] The purpose of the present invention is to provide a non-ablative fractional laser therapy device with real-time OCT monitoring function, aiming to solve the problem that the existing fractional laser system cannot monitor the fractional laser operation and drug injection.

[0007] The technical solution of the present invention is as follows: a non-ablative fractional laser therapeutic device with real-time OCT monitoring function, wherein it has a treatment mode, a drug delivery mode and an OCT monitoring mode, including:

[0008] Therapeutic laser module, which generates instantaneous high-energy therapeutic laser pulses;

[0009] Dispersion sweep module, which changes the wavelength of laser light over time through the dispersion effect, and can be used for OCT detection;

[0010] Interference module, distributes OCT laser and amplifies the detection signal;

[0011] The optical signal acquisition and processing module converts the optical signal into a digital signal that can be recognized by the computer;

[0012] The laser head module, in treatment mode, emits laser to create a thermal denaturation zone matrix on the target area; in drug delivery mode, delivers drug delivery to the target area to be treated; in OCT monitoring mode, emits laser on the target area to form an image of the target area;

[0013] The control module controls the entire laser therapy device and converts the signals collected by the optical signal acquisition and processing module into images.

[0014] The non-ablative fractional laser therapy device with real-time OCT monitoring function, wherein the therapeutic laser module includes a laser that emits laser and an electrically controlled optical switch, the electrically controlled optical switch is electrically connected to the control module, the laser is connected to the electrically controlled optical switch, the control module controls the output power of the laser, and the electrically controlled optical switch controls the laser direction of the laser.

[0015] The non-ablative fractional laser therapeutic apparatus with real-time OCT monitoring function, wherein the dispersion sweeping module comprises a photonic crystal fiber, a first collimator, a filter, a transmission grating, a converging lens, a multimode fiber, a first circulator and a fiber linear chirped Bragg grating, the first circulator is connected to the interference module, and the electrically controlled optical switch is connected to the photonic crystal fiber; in the OCT monitoring mode, the control module controls the electrically controlled optical switch and the laser, so that the laser's lower power output laser enters the photonic crystal fiber, in the photonic crystal fiber, through the strong nonlinear effect, the original narrow pulse width laser is violently dispersed and broadened to become a wide spectrum light; then, it is projected onto the filter through the first collimator to filter out part of the light with inappropriate wavelength; then, it is dispersed and expanded through the transmission grating, and then coupled to the multimode fiber by the converging lens for dispersion broadening, and then enters the fiber linear chirped Bragg grating through the first circulator for dispersion broadening, and then the laser becomes a swept frequency light.

[0016] The non-ablative fractional laser therapy device with real-time OCT monitoring function, wherein the interference module includes a first coupler with a certain splitting ratio, a second circulator, a third circulator, a second collimator, a reflector and a second coupler with a certain splitting ratio, the second coupler is connected to the optical signal acquisition and processing module, and the second circulator is connected to the laser head module; after the swept-frequency light enters the first coupler, a part of the swept-frequency light enters the reference arm of the Mach Zehnder interferometer, and a part of the swept-frequency light enters the sample arm of the Mach Zehnder interferometer; the swept-frequency light entering the reference arm of the Mach Zehnder interferometer The light is projected onto the reflector through the third circulator and the second collimator, and then reflected along the original path through the second collimator to enter the third circulator and then enter the second coupler; at the same time, the swept light entering the sample arm of the Mach Zehnder interferometer passes through the second circulator and then enters the laser head module, and the control module controls the laser head module to project the laser onto the target area and scan continuously as needed; the laser reflected by the target area enters the second circulator along the original path, and enters the second coupler together with part of the swept light entering the reference arm of the Mach Zehnder interferometer, and the signal is collected by the optical signal collection and processing module and fed back to the control module.

[0017] The non-ablative fractional laser therapy device with real-time OCT monitoring function, wherein the optical signal acquisition and processing module includes an acquisition card and a balanced detector, the acquisition card is connected to the balanced detector, the balanced detector is connected to the interference module, and the acquisition card is connected to the control module.

[0018] The non-ablative fractional laser therapy device with real-time OCT monitoring function, wherein the laser head module includes a moving component, a drug delivery component and a treatment monitoring component arranged in the laser head housing, wherein the drug delivery component and the treatment monitoring component are both arranged on the moving component and are driven to move by the moving component, and the moving component, the drug delivery component and the treatment monitoring component are all connected to the control module; in the treatment mode, the treatment monitoring component is driven by the moving component to move to a suitable position to perform laser treatment on the target area; in the drug delivery mode, the drug delivery component is driven by the moving component to move to a suitable position to perform drug delivery treatment on the target area; in the OCT monitoring mode, the treatment monitoring component is driven by the moving component to move to a suitable position to obtain an image of the target area.

[0019] The non-ablative fractional laser therapy device with real-time OCT monitoring function, wherein the moving component includes an X-axis driving mechanism for driving the drug delivery component and the treatment monitoring component to move along the X-axis direction, a Y-axis driving mechanism for driving the drug delivery component and the treatment monitoring component to move along the Y-axis direction, and a Z-axis driving mechanism for driving the drug delivery component and the treatment monitoring component to move along the Z-axis direction, and the X-axis driving mechanism, the Y-axis driving mechanism, and the Z-axis driving mechanism are all connected to the control module.

[0020] The non-ablative fractional laser therapeutic device with real-time OCT monitoring function, wherein the drug delivery component includes an electric injector, and the electric injector is connected to a control module, and the control module controls the electric injector to inject a given amount of medicine into the target area.

[0021] The non-ablative fractional laser therapy device with real-time OCT monitoring function, wherein the treatment monitoring component includes a third collimator, a galvanometer and a scanning mirror, the galvanometer is connected to the control module, the laser is projected from the third collimator onto the galvanometer, the galvanometer is controlled by the control module, and the laser is projected onto the target area via the scanning mirror.

[0022] The non-ablative fractional laser therapy device with real-time OCT monitoring function, wherein the laser head module also includes a camera, the camera is connected to the control module, the camera moves with the moving component, and the camera realizes full-process monitoring in the treatment mode, drug administration mode and OCT monitoring mode.

[0023] The beneficial effects of the present invention are as follows: the present invention provides a non-ablative fractional laser therapy device with real-time OCT monitoring function, which has a treatment mode, a drug delivery mode and an OCT monitoring mode, and includes a treatment laser module, a dispersion frequency scanning module, an interference module, an optical signal acquisition and processing module, a laser head module and a control module; by setting the OCT monitoring function, the laser therapy process can be monitored in real time; a drug delivery component is added to achieve drug delivery operations on the target area; in the drug delivery mode, interval switching with the OCT monitoring mode is adopted to effectively ensure the drug delivery effect and achieve precise drug delivery; a pulsed laser is used as a light source, and photonic crystal fiber, fiber Bragg grating and multimode optical fiber are added to the system to ensure effective monitoring; the laser therapy device is not only suitable for biological tissues, but also suitable for drilling detection of optomechanical systems or other structures in industry. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a module connection diagram of the non-ablative fractional laser therapeutic device with real-time OCT monitoring function in the present invention.

[0025] Figure 2 It is an internal cross-sectional view of the laser head module in the present invention.

[0026] Figure 3 and Figure 4 It is a diagram of the internal parts of the laser head module in the present invention. DETAILED DESCRIPTION

[0027] The embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0028] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "multiple" is two or more, unless otherwise clearly and specifically defined.

[0029] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or mutual communication; it can be a direct connection, or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0030] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0031] The disclosure below provides many different embodiments or examples to realize different structures of the present invention. In order to simplify the disclosure of the present invention, the parts and settings of specific examples are described below. Of course, they are only examples, and the purpose is not to limit the present invention. In addition, the present invention can repeat reference numbers and / or reference letters in different examples, and this repetition is for the purpose of simplicity and clarity, which itself does not indicate the relationship between the various embodiments and / or settings discussed. In addition, the present invention provides various specific examples of processes and materials, but those of ordinary skill in the art can be aware of the application of other processes and / or the use of other materials.

[0032] like Figure 1 As shown, a non-ablative fractional laser therapy device with real-time OCT monitoring function switches between treatment mode, drug delivery mode and OCT monitoring mode, including:

[0033] Therapeutic laser module A1, generates instantaneous high-energy therapeutic laser pulses;

[0034] Dispersion sweep module A2, which changes the wavelength of laser light over time through the dispersion effect, and can be used as OCT detection laser;

[0035] Interference module A3 distributes OCT laser and amplifies the detection signal;

[0036] The optical signal acquisition and processing module A4 converts the optical signal into a digital signal that can be recognized by a computer;

[0037] Laser head module A5, in treatment mode, emits laser to create a thermal denaturation zone matrix on the target area; in drug delivery mode, delivers drug delivery to the target area to be treated; in OCT monitoring mode, emits laser on the target area to form an image of the target area;

[0038] The control module controls the entire laser therapy device and converts the signals collected by the optical signal acquisition and processing module A4 into images.

[0039] In some specific embodiments, the control module is implemented as a computer 24 .

[0040] In some specific embodiments, the therapeutic laser module A1 includes a laser 1 that emits laser and an electrically controlled optical switch 2, wherein the electrically controlled optical switch 2 is electrically connected to a computer 24, and the laser 1 is connected to the electrically controlled optical switch 2, wherein the computer 24 controls the output power of the laser 1, and the electrically controlled optical switch 2 controls the laser direction of the laser 1.

[0041] As a preferred embodiment, the wavelength of the laser 1 is 1550, or other wavelengths.

[0042] In some specific embodiments, the dispersion scanning module A2 includes a photonic crystal fiber 3, a first collimator 4, a filter 5, a transmission grating 6, a converging lens 7, a multimode fiber 8, a first circulator 9 and a fiber linear chirped Bragg grating 10, the first circulator 9 is connected to the interference module A3, and the electrically controlled optical switch 2 is connected to the photonic crystal fiber 3; in the OCT monitoring mode, the computer 24 controls the electrically controlled optical switch 2 and the laser 1, so that the lower power output laser of the laser 1 enters the photonic crystal fiber 3, and in the photonic crystal fiber 3, via Due to the strong nonlinear effect, the originally narrow pulse width laser is violently dispersed and broadened to become wide spectrum light; then, it is projected onto the filter 5 through the first collimator 4 to filter out some light with too long and too short wavelengths; the light beam is then dispersed and expanded through the transmission grating 6, and then coupled to the multimode optical fiber 8 by the converging lens 7 for dispersion broadening, and then enters the optical fiber linear chirped Bragg grating 10 through the first circulator 9 for dispersion broadening. At this time, the laser has become a swept light composed of continuous light pulses with a wide wavelength and narrow line width similar to the output of a swept laser.

[0043] As a preferred embodiment, the length of the photonic crystal fiber 3 can be set according to actual needs, generally 1 meter, or other lengths.

[0044] As a preferred embodiment, the length of the multimode optical fiber 8 can be set according to actual needs, generally 25 meters, or other lengths.

[0045] In some specific embodiments, the interference module A3 includes a first coupler 11 with a certain splitting ratio, a second circulator 12, a third circulator 13, a second collimator 14, a reflector 15 and a second coupler 16 with a certain splitting ratio, the second coupler 16 is connected to the optical signal acquisition and processing module A4, and the second circulator 12 is connected to the laser head module A5; after the swept-frequency light enters the first coupler 11, a part of the swept-frequency light enters the reference arm of the Mach Zehnder interferometer (when the first coupler 11 adopts a coupler 90 / 10, the 10 part of the swept-frequency light enters the reference arm), and a part of the swept-frequency light enters the sample arm of the Mach Zehnder interferometer (when the first coupler 11 adopts a coupler 90 / 10, the 90 part The swept-frequency light enters the sample arm); the swept-frequency light entering the reference arm of the Mach Zehnder interferometer is projected onto the reflector 15 through the third circulator 13 and the second collimator 14, and then reflects along the original path through the second collimator 14 and enters the third circulator 13 and then enters the second coupler 16; at the same time, the swept-frequency light entering the sample arm of the Mach Zehnder interferometer passes through the second circulator 12 and then enters the laser head module A5, which is controlled by the control module to project the laser onto the target area and scan continuously as needed; the laser reflected by the target area enters the second circulator 12 along the original path, and enters the second coupler 16 together with part of the swept-frequency light entering the reference arm of the Mach Zehnder interferometer, and the signal is collected by the optical signal collection and processing module A4 and fed back to the control module.

[0046] As a preferred embodiment, the first coupler 11 adopts a 90 / 10 coupler (where 90 / 10 is the splitting ratio of the coupler); the second coupler 16 adopts a 50 / 50 coupler (where 50 / 50 is the splitting ratio of the coupler).

[0047] As a preferred embodiment, the distance between the reflector 15 and the second collimator 14 can be adjusted so as to match the length of the two arms of the Mach Zehnder interferometer.

[0048] In some specific embodiments, the optical signal acquisition and processing module A4 includes an acquisition card 26 and a balanced detector 25, the acquisition card 26 is connected to the balanced detector 25, the balanced detector 25 is connected to the second coupler 16, and the acquisition card 26 is connected to the computer 24; after the laser is reflected by the target area, it enters the second circulator 12 along the original path, enters the second coupler 16 together with the laser of the Mach Zehnder interferometer, and then enters the balanced detector 25 to be converted into an analog electrical signal, enters the acquisition card 26 to be converted into a digital electrical signal, and finally is converted into an image by the computer 24.

[0049] In certain specific embodiments, such as Figures 2 to 4As shown, the laser head module A5 includes a moving component, a drug delivery component and a treatment monitoring component arranged in the laser head housing 28, and the drug delivery component and the treatment monitoring component are both arranged on the moving component and driven to move by the moving component; in the treatment mode, the treatment monitoring component is driven by the moving component to move to a suitable position to perform laser treatment on the target area; in the drug delivery mode, the drug delivery component is driven by the moving component to move to a suitable position to perform drug delivery treatment on the target area; in the OCT monitoring mode, the treatment monitoring component is driven by the moving component to move to a suitable position to acquire an image of the target area.

[0050] As a preferred embodiment, the moving component includes an X-axis driving mechanism 221 for driving the drug administration component and the treatment monitoring component to move along the X-axis direction, a Y-axis driving mechanism 222 for driving the drug administration component and the treatment monitoring component to move along the Y-axis direction, and a Z-axis driving mechanism 223 for driving the drug administration component and the treatment monitoring component to move along the Z-axis direction.

[0051] Among them, the X-axis drive mechanism 221, the Y-axis drive mechanism 222, and the Z-axis drive mechanism 223 can be implemented by a through-axis screw motor or a linear motor. Other types of screw motors are also within the protection scope of this technical solution.

[0052] As a preferred embodiment, the drug delivery assembly includes an electric injector 20, and the electric injector 20 is connected to a computer 24, and the computer 24 controls the electric injector 20 to inject a given amount of medicine into the target area.

[0053] As a preferred embodiment, the treatment monitoring component includes a third collimator 17, a galvanometer 18 and a scanning mirror 19. The galvanometer 18 is connected to a computer 24. The laser is projected from the third collimator 17 onto the galvanometer 18. The galvanometer 18 is controlled by the computer 24 to project the laser onto the target area via the scanning mirror 19.

[0054] As a preferred embodiment, the scanning mirror 19 is designed so that the laser spot is only 30-50 microns.

[0055] As a preferred embodiment, the laser head module A5 also includes a camera 21, which is connected to a computer 24. The camera 21 moves along with the mobile component. In the treatment mode, medication mode and OCT monitoring mode, the camera 21 can realize full-process monitoring, thereby improving the use effect of the laser therapy device.

[0056] The working process of this non-ablative fractional laser therapy device with real-time OCT monitoring function in different treatment modes is as follows:

[0057] (1) In the OCT monitoring mode, the computer 24 controls the electrically controlled optical switch 2 to allow the relatively low-power output laser of the laser 1 to enter the photonic crystal fiber 3. In the photonic crystal fiber 3, the laser light with a narrow pulse width is strongly dispersed and broadened through a strong nonlinear effect, and becomes a wide-spectrum light. Then, it is projected onto the filter 5 through the first collimator 4 to filter out some light with too long or too short wavelengths. The light beam is then dispersed and expanded through the transmission grating 6, and then coupled to the multimode fiber 8 by the converging lens 7 for dispersion broadening. Then, it is dispersed and broadened through the first circulator 9 and enters the fiber linear chirped Bragg grating 10 for dispersion broadening. At this time, the laser light has become a wide-wavelength, narrow-linewidth swept-frequency light composed of continuous light pulses similar to the output of a swept-frequency laser. After the swept-frequency light enters the first coupler 11, part of the swept-frequency light enters the reference arm of the Mach Zehnder interferometer, and part of the swept-frequency light enters the Mach The sample arm of the Mach Zehnder interferometer; the swept-frequency light entering the reference arm of the Mach Zehnder interferometer is projected onto the reflector 15 through the third circulator 13 and the second collimator 14, and then reflects along the original path through the second collimator 14 and enters the third circulator 13 and then enters the second coupler 16; at the same time, the swept-frequency light entering the sample arm of the Mach Zehnder interferometer passes through the second circulator 12 and then enters the third collimator 17 and is projected onto the galvanometer 18. The galvanometer 18 is controlled by a computer 24 and can project the laser onto the target area through a scanning mirror 19 and scan continuously as needed; after being reflected by the target area, the laser enters the second circulator 12 along the original path, and enters the second coupler 16 together with part of the swept-frequency light entering the reference arm of the Mach Zehnder interferometer, and then enters the balanced detector 25 to be converted into an analog electrical signal, enters the acquisition card 26 to be converted into a digital electrical signal and fed back to the computer 24, and finally converted into an image by the computer 24.

[0058] (2) In the treatment mode, the computer 24 controls the electrically controlled optical switch 2 so that the higher power output laser of the laser 1 does not enter the photonic crystal fiber 3, but directly enters the laser head module A5, is projected to the galvanometer 18 through the third collimator 17, and then is reflected through the scanning mirror 19 and projected onto the target area; in this mode, the galvanometer 18 will control the laser to produce a thermal denaturation zone matrix on the target area. In the matrix, the spot spacing is 30 microns. The matrix is ​​generally a 30*30 matrix, and the spacing between matrices is 1-2mm. These parameters can be adjusted on the computer 24 to achieve the best treatment effect; when generating the thermal denaturation zone, the laser therapy device will automatically switch from the treatment mode to the OCT monitoring mode after each projection to check whether the depth of the thermal denaturation zone meets the preset value, that is, in the treatment mode, the treatment mode and the OCT monitoring mode can be switched at high frequency to achieve real-time monitoring of the effect of the treatment mode.

[0059] (3) In the drug administration mode, first use the OCT monitoring mode to scan the target area, obtain the three-dimensional structure of the target area, determine the amount of drug to be administered and the needle insertion position; then switch to the drug administration mode, the X-axis drive mechanism 221 and the Y-axis drive mechanism 222 drive the electric syringe 20 to reach the upper part of the needle insertion position, and then the Z-axis drive mechanism 223 drives the electric syringe 20 to penetrate the target area, and the electric syringe 20 injects according to the given amount of drug; drive the X-axis drive mechanism 221, the Y-axis drive mechanism 222 and the Z-axis drive mechanism 223 to reset the electric syringe 20; then switch to the OCT monitoring mode, drive the X-axis drive mechanism 221, the Y-axis drive mechanism 222 and the Z-axis drive mechanism 223 to drive the scanning mirror 19 to reach the upper part of the needle insertion position, and perform OCT scanning again to detect the drug administration effect. If the drug administration effect meets the requirements, the drug administration mode is terminated. If the drug administration effect does not meet the requirements, switch to the drug administration mode again... and so on until the drug administration effect meets the set requirements.

[0060] In the treatment mode, drug administration mode and OCT monitoring mode, the camera 21 realizes full-process monitoring to improve the use effect of the laser therapeutic device.

[0061] This technical solution has an OCT monitoring function, which can realize real-time monitoring of the laser treatment process; a drug delivery component is added to realize drug delivery operations in the target area; in the drug delivery mode, the interval switching with the OCT monitoring mode is adopted to effectively ensure the drug delivery effect and realize precise drug delivery; a pulsed laser is used as the light source, and photonic crystal fiber, fiber Bragg grating and multimode fiber are added to the system to ensure effective monitoring; this laser therapy device is not only suitable for biological tissues, but also for drilling detection of optomechanical systems or other structures in industry.

[0062] In the description of this specification, the description with reference to the terms "one embodiment", "certain embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0063] It should be understood that the application of the present invention is not limited to the above examples. For ordinary technicians in this field, improvements or changes can be made based on the above description. All these improvements and changes should fall within the scope of protection of the claims attached to the present invention.

Claims

1. A non-ablative fractional laser therapy device with real-time OCT monitoring function, characterized in that: It has treatment mode, drug delivery mode and OCT monitoring mode, including: Therapeutic laser module, which generates instantaneous high-energy therapeutic laser pulses; Dispersion sweep module, which changes the wavelength of laser light over time through the dispersion effect, thus enabling it to be used for OCT detection; Interference module, distributes OCT laser and amplifies the detection signal; The optical signal acquisition and processing module converts the optical signal into a digital signal that can be recognized by the computer; The laser head module, in treatment mode, emits laser to create a thermal denaturation zone matrix on the target area; in drug delivery mode, delivers drug delivery to the target area to be treated; in OCT monitoring mode, emits laser on the target area to form an image of the target area; The control module controls the entire laser therapy device and converts the signals collected by the optical signal acquisition and processing module into images; The therapeutic laser module includes a laser for emitting laser light and an electrically controlled optical switch, wherein the electrically controlled optical switch is electrically connected to the control module, the laser is connected to the electrically controlled optical switch, the control module controls the output power of the laser, and the electrically controlled optical switch controls the laser direction of the laser; The dispersion frequency sweeping module comprises a photonic crystal fiber, a first collimator, a filter, a transmission grating, a converging lens, a multimode fiber, a first circulator and a fiber linear chirped Bragg grating, wherein the first circulator is connected to the interference module, and the electrically controlled optical switch is connected to the photonic crystal fiber; in the OCT monitoring mode, the control module controls the electrically controlled optical switch and the laser, so that the laser output laser with a lower power enters the photonic crystal fiber, and in the photonic crystal fiber, through a strong nonlinear effect, the laser with a narrow pulse width is violently dispersed and broadened to become a wide-spectrum light; then, it is projected onto the filter through the first collimator to filter out part of the light with an inappropriate wavelength; then, the light beam is dispersed and expanded through the transmission grating, and then coupled to the multimode fiber by the converging lens for dispersion broadening, and then, after entering the fiber linear chirped Bragg grating through the first circulator for dispersion broadening, the laser becomes a frequency sweeping light; The interference module includes a first coupler with a certain splitting ratio, a second circulator, a third circulator, a second collimator, a reflector and a second coupler with a certain splitting ratio, the second coupler is connected to the optical signal acquisition and processing module, and the second circulator is connected to the laser head module; after the swept-frequency light enters the first coupler, a part of the swept-frequency light enters the reference arm of the Mach Zehnder interferometer, and a part of the swept-frequency light enters the sample arm of the Mach Zehnder interferometer; the swept-frequency light entering the reference arm of the Mach Zehnder interferometer is projected onto the reflector through the third circulator and the second collimator, and then reflects along the original path and enters the third circulator through the second collimator before entering the second coupler; at the same time, the swept-frequency light entering the sample arm of the Mach Zehnder interferometer enters the laser head module after passing through the second circulator, and the control module controls the laser head module to project the laser onto the target area and scan continuously as needed; the laser reflected by the target area enters the second circulator along the original path, and enters the second coupler together with the part of the swept-frequency light entering the reference arm of the Mach Zehnder interferometer, and the signal collected by the optical signal acquisition and processing module is fed back to the control module; The optical signal acquisition and processing module comprises an acquisition card and a balanced detector, wherein the acquisition card is connected to the balanced detector, the balanced detector is connected to the interference module, and the acquisition card is connected to the control module.

2. The non-ablative fractional laser therapy device with real-time OCT monitoring function according to claim 1, characterized in that: The laser head module includes a moving component, a drug delivery component and a treatment monitoring component arranged in the laser head housing, wherein the drug delivery component and the treatment monitoring component are both arranged on the moving component and are driven to move by the moving component, and the moving component, the drug delivery component and the treatment monitoring component are all connected to the control module; in the treatment mode, the treatment monitoring component is driven by the moving component to move to a suitable position to perform laser treatment on the target area; in the drug delivery mode, the drug delivery component is driven by the moving component to move to a suitable position to perform drug delivery treatment on the target area; in the OCT monitoring mode, the treatment monitoring component is driven by the moving component to move to a suitable position to obtain an image of the target area.

3. The non-ablative fractional laser therapy device with real-time OCT monitoring function according to claim 2, characterized in that: The moving component includes an X-axis driving mechanism for driving the drug administration component and the treatment monitoring component to move along the X-axis direction, a Y-axis driving mechanism for driving the drug administration component and the treatment monitoring component to move along the Y-axis direction, and a Z-axis driving mechanism for driving the drug administration component and the treatment monitoring component to move along the Z-axis direction. The X-axis driving mechanism, the Y-axis driving mechanism, and the Z-axis driving mechanism are all connected to the control module.

4. The non-ablative fractional laser therapy device with real-time OCT monitoring function according to claim 2, characterized in that: The drug delivery component includes an electric injector, which is connected to a control module. The control module controls the electric injector to inject a given amount of medicine into a target area.

5. The non-ablative fractional laser therapy device with real-time OCT monitoring function according to claim 2, characterized in that: The treatment monitoring component includes a third collimator, a galvanometer and a scanning mirror. The galvanometer is connected to the control module. The laser is projected from the third collimator onto the galvanometer. The galvanometer is controlled by the control module to project the laser onto the target area via the scanning mirror.

6. The non-ablative fractional laser therapy device with real-time OCT monitoring function according to any one of claims 2 to 5, characterized in that: The laser head module also includes a camera, which is connected to the control module. The camera moves along with the moving component. In the treatment mode, the drug administration mode and the OCT monitoring mode, the camera can monitor the entire process.

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