Efficient acne-removing composition and preparation method thereof

Abstract

The invention relates to the technical field of skin care products, and particularly discloses an efficient acne removal composition and a preparation method thereof. The high-efficiency acne-removing composition comprises the following components in parts by mass: 0.01-0.2 part of lactoferrin; 0.01 to 0.2 part of antibacterial peptide; 0.01 to 0.1 part of lysozyme; 0.01 to 0.2 part of metallothionein; and 2.1-9 parts of a composite plant extract. The acne removing cream has the advantage of being capable of efficiently and durably removing acnes.

Description

Technical Field

[0001] The invention relates to the field of skin care products, and in particular to a high-efficiency acne-removing composition and a preparation method thereof. Background Art

[0002] Acne is a chronic inflammatory skin disease that occurs frequently in areas with high density of hair follicles and sebaceous glands. Its onset is related to a variety of factors, among which the massive reproduction of Propionibacterium acnes is closely related to the occurrence of acne. Systemic or topical application of antibacterial drugs to inhibit Propionibacterium acnes is an important means of treating acne, but it cannot completely cure or reduce the recurrence of acne. Many acne-removing products work well at the beginning, but after a while, they seem to have no effect, especially antibacterial acne-removing products. If used for a period of time, the effect of the medication will be greatly reduced. This is a manifestation of drug resistance. Antibacterial acne-removing products are divided into two categories: antibiotics and non-antibiotics. The most commonly used antibiotics are tetracyclines, sulfonamides, macrolides, clindamycin, etc. Non-antibiotics mainly include benzoyl peroxide, zinc preparations, azelaic acid, etc. In recent years, due to the widespread use of systemic or topical broad-spectrum antibiotics and non-antibiotics in the treatment of acne, the drug resistance of Propionibacterium acnes has increased significantly, and there is cross-resistance, which reduces the treatment effect. As a result, existing acne removal products have poor effects after a period of use, and acne is prone to recurrence. Therefore, there is still room for improvement. Summary of the invention

[0003] In order to effectively and durably remove acne, the present application provides a highly effective acne-removing composition and a preparation method thereof.

[0004] In the first aspect, the present application provides an efficient acne-removing composition, which adopts the following technical solution: An efficient acne-removing composition comprises the following components in parts by weight: Lactoferrin 0.01-0.2 parts; Antimicrobial peptide 0.01-0.2 parts; Lysozyme 0.01-0.1 parts; Metallothionein 0.01-0.2 parts; 2.1-9 parts of compound plant extract.

[0005] By adopting the above technical scheme, through the compounding of lactoferrin, antimicrobial peptides, lysozyme and metallothionein, it can play a significant antibacterial and antimicrobial effect, and has a significant inhibitory effect on Propionibacterium acnes, so that acne can be treated quickly and well, and the acne removal effect is very significant. Lactoferrin, antimicrobial peptides, lysozyme and metallothionein are antimicrobial and antimicrobial ingredients contained in the human body. When lactoferrin, antimicrobial peptides, lysozyme and metallothionein are compounded, Propionibacterium acnes will not develop drug resistance and have no side effects on the skin, so that continuous use of the high-efficiency acne removal composition can always achieve a good acne removal effect, consumers do not need to frequently change products, the variation of Propionibacterium acnes is reduced, and Propionibacterium acnes is easier to inhibit. Long-term use can make the acne removal effect more and more efficient, which can well meet the needs of consumers.

[0006] Preferably, the mass ratio of lactoferrin, antimicrobial peptide, lysozyme and metallothionein is 0.08-0.12: 0.08-0.12: 0.04-0.06: 0.08-0.12.

[0007] By adopting the above technical scheme and specifically selecting the mass ratio of lactoferrin, antimicrobial peptides, lysozyme and metallothionein, the lactoferrin, antimicrobial peptides, lysozyme and metallothionein can cooperate with each other better, play a more significant antibacterial and antibacterial effect, and make the acne removal effect more efficient.

[0008] Preferably, the composite plant extract is a combination of andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract and raspberry extract.

[0009] By adopting the above technical scheme, and by specifically selecting andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia extract, and raspberry extract, the high-efficiency acne-removing composition can not only inhibit Propionibacterium acnes, but also has the effects of rapid anti-inflammatory and regulating water-oil balance, so that the skin can quickly recover to health, and in particular can lastingly regulate the water-oil balance of the skin, so that the moisture content in the skin is high and the oil content is significantly reduced, thereby reducing the accumulation of sebum in the hair follicles, and thus fundamentally reducing the occurrence of acne. After stopping the use of the high-efficiency acne-removing composition, acne is not easy to recur, and a more thorough acne-removing effect is achieved, reducing dependence on the product.

[0010] Preferably, the mass ratio of the Andrographis paniculata extract, the Thyme extract, the Clove extract, the Eucalyptus globulus extract, the Forsythia suspensa extract, and the Raspberry extract is 0.5-2:0.2-1:0.2-1:0.2-1:0.5-2:0.5-2.

[0011] By adopting the above technical scheme and specifically selecting the mass ratio of andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract and raspberry extract, the andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract and raspberry extract cooperate with each other better, and the effect of regulating the water-oil balance of the skin is better.

[0012] Preferably, the mass ratio of the Andrographis paniculata extract, the Thyme extract, the Clove extract, the Eucalyptus globulus extract, the Forsythia suspensa extract, and the Raspberry extract is 1-1.5: 0.5-0.7: 0.5-0.7: 0.5-0.7: 1-1.5: 1-1.5.

[0013] By adopting the above technical scheme, by specifically selecting the mass ratios of Andrographis paniculata extract, Thyme extract, Clove extract, Eucalyptus globulus extract, Forsythia suspensa extract, and Raspberry extract, the effect of regulating the water-oil balance of the skin can be better exerted, so that the skin moisture content is higher and the skin's water-locking ability is better. Especially after discontinuing the use of the high-efficiency acne-removing composition, the skin can maintain a better water-locking ability for a longer period of time, making the skin healthier and less likely to induce acne, making the acne-removing effect very thorough.

[0014] Preferably, the Andrographis paniculata extract, Thyme extract, Clove extract, Eucalyptus globulus extract, Forsythia suspensa extract, and Raspberry extract are all water-soluble extracts.

[0015] By adopting the above technical solution and specifically selecting water-soluble extracts, the composite plant extracts can be easily absorbed by the skin, and each active ingredient can effectively play a role in the skin, with a significant effect on conditioning the skin.

[0016] Preferably, the extraction ratio of the Andrographis paniculata extract, the Thyme extract, the Clove extract, the Eucalyptus globulus extract, the Forsythia suspensa extract, and the Raspberry extract is 10:1.

[0017] By adopting the above technical solution and specifically selecting the extraction ratio, the composite plant extract can have a better skin conditioning effect.

[0018] In a second aspect, the present application provides a method for preparing an efficient acne-removing composition, using the following technical solution: A method for preparing the above-mentioned high-efficiency acne-removing composition comprises the following steps: Step 1), lactoferrin, antimicrobial peptide, lysozyme and metallothionein are uniformly mixed to obtain a premix; Step 2), adding the composite plant extract to the premix and mixing evenly to obtain a highly effective acne-removing composition.

[0019] By adopting the above technical scheme, the prepared high-efficiency acne-removing composition can quickly kill Propionibacterium acnes, and can quickly reduce inflammation, can well regulate the water-oil balance of the skin, has a high efficiency in removing acne, and after removing acne, the skin repair effect is better, and acne is not easy to recur.

[0020] In summary, this application has the following beneficial effects: 1. The present invention can play a significant antibacterial and antimicrobial effect through the compounding of lactoferrin, antimicrobial peptides, lysozyme and metallothionein, and has a significant inhibitory effect on Propionibacterium acnes, so that acne can be treated quickly and well, and the acne removal effect is very significant. Lactoferrin, antimicrobial peptides, lysozyme and metallothionein are antibacterial and antimicrobial ingredients contained in the human body. When lactoferrin, antimicrobial peptides, lysozyme and metallothionein are compounded, Propionibacterium acnes will not develop drug resistance and have no side effects on the skin, so that continuous use of the high-efficiency acne removal composition can always obtain a good acne removal effect, consumers do not need to frequently change products, the variation of Propionibacterium acnes is reduced, and Propionibacterium acnes is easier to inhibit. Long-term use can make the acne removal effect more and more efficient, which can well meet the needs of consumers.

[0021] 2. In the present application, it is preferred to specifically select the mass ratio of lactoferrin, antimicrobial peptides, lysozyme and metallothionein so that the lactoferrin, antimicrobial peptides, lysozyme and metallothionein cooperate with each other better, which can play a more significant antibacterial and antibacterial effect and make the acne removal effect more efficient.

[0022] 3. In the present application, it is preferred to specifically select Andrographis paniculata extract, Thyme extract, Clove extract, Eucalyptus globulus extract, Forsythia suspensa extract, and Raspberry extract, so that the high-efficiency acne-removing composition can not only inhibit Propionibacterium acnes, but also have the effect of quickly reducing inflammation and regulating water-oil balance, so that the skin can quickly restore health, especially can lastingly regulate the water-oil balance of the skin, so that the moisture content in the skin is high and the oil content is significantly reduced, thereby reducing the accumulation of sebum in the hair follicles, and then fundamentally reducing the occurrence of acne. After stopping the use of the high-efficiency acne-removing composition, acne is not easy to recur, which has a more thorough acne-removing effect and reduces dependence on the product. DETAILED DESCRIPTION

[0023] The present application is further described in detail below in conjunction with embodiments.

[0024] Example 1 An efficient acne-removing composition comprises the following components: Lactoferrin, antimicrobial peptides, lysozyme, metallothionein, andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract, raspberry extract.

[0025] Lactoferrin was purchased from Guangzhou Bochi Biotechnology Co., Ltd., batch number: LH7023A001.

[0026] Antimicrobial peptides were purchased from Sichuan Jisheng Biopharmaceutical Co., Ltd., model: JMO43.

[0027] Lysozyme was purchased from Wuhan Heyuan Biotechnology Co., Ltd., batch number: HYC042R01.

[0028] Metallothionein was purchased from Guangzhou Fanhai Fine Chemical Co., Ltd., model: NB656.

[0029] Andrographis paniculata extract was purchased from Anhui Xinsheng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0030] Thyme extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0031] Clove extract was purchased from Xi'an Biotech Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0032] The eucalyptus globulus extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0033] Forsythia suspensa extract was purchased from Shandong Xinxiong Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0034] Raspberry extract was purchased from Shaanxi Saien Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0035] The preparation method of the high-efficiency acne-removing composition is as follows: Step 1), 0.01 kg lactoferrin, 0.01 kg antimicrobial peptide, 0.01 kg lysozyme and 0.01 kg metallothionein are put into a stirred tank, the speed is 120 r / min, stirred for 15 min, and mixed evenly to obtain a premix.

[0036] Step 2), add 0.5kg of Andrographis paniculata extract, 0.2kg of Thyme extract, 0.2kg of Clove extract, 0.2kg of Eucalyptus globulus extract, 0.5kg of Forsythia suspensa extract, and 0.5kg of Raspberry extract to the premix, rotate at 120r / min, stir for 20min, mix evenly, and obtain a highly effective acne-removing composition.

[0037] Example 2 An efficient acne-removing composition comprises the following components: Lactoferrin, antimicrobial peptides, lysozyme, metallothionein, andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract, raspberry extract.

[0038] Lactoferrin was purchased from Guangzhou Bochi Biotechnology Co., Ltd., batch number: LH7023A001.

[0039] Antimicrobial peptides were purchased from Sichuan Jisheng Biopharmaceutical Co., Ltd., model: JMO43.

[0040] Lysozyme was purchased from Wuhan Heyuan Biotechnology Co., Ltd., batch number: HYC042R01.

[0041] Metallothionein was purchased from Guangzhou Fanhai Fine Chemical Co., Ltd., model: NB656.

[0042] Andrographis paniculata extract was purchased from Anhui Xinsheng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0043] Thyme extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0044] Clove extract was purchased from Xi'an Biotech Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0045] The eucalyptus globulus extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0046] Forsythia suspensa extract was purchased from Shandong Xinxiong Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0047] Raspberry extract was purchased from Shaanxi Saien Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0048] The preparation method of the high-efficiency acne-removing composition is as follows: Step 1), 0.08 kg lactoferrin, 0.08 kg antimicrobial peptide, 0.04 kg lysozyme and 0.08 kg metallothionein are put into a stirring tank, the speed is 120 r / min, stirring for 15 min, mixing evenly, to obtain a premix.

[0049] Step 2), add 1kg of Andrographis paniculata extract, 0.5kg of Thyme extract, 0.5kg of Clove extract, 0.5kg of Eucalyptus globulus extract, 1kg of Forsythia suspensa extract, and 1kg of Raspberry extract to the premix, rotate at 120r / min, stir for 20min, mix evenly, and obtain a highly effective acne-removing composition.

[0050] Example 3 An efficient acne-removing composition comprises the following components: Lactoferrin, antimicrobial peptides, lysozyme, metallothionein, andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract, raspberry extract.

[0051] Lactoferrin was purchased from Guangzhou Bochi Biotechnology Co., Ltd., batch number: LH7023A001.

[0052] Antimicrobial peptides were purchased from Sichuan Jisheng Biopharmaceutical Co., Ltd., model: JMO43.

[0053] Lysozyme was purchased from Wuhan Heyuan Biotechnology Co., Ltd., batch number: HYC042R01.

[0054] Metallothionein was purchased from Guangzhou Fanhai Fine Chemical Co., Ltd., model: NB656.

[0055] Andrographis paniculata extract was purchased from Anhui Xinsheng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0056] Thyme extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0057] Clove extract was purchased from Xi'an Biotech Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0058] The eucalyptus globulus extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0059] Forsythia suspensa extract was purchased from Shandong Xinxiong Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0060] Raspberry extract was purchased from Shaanxi Saien Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0061] The preparation method of the high-efficiency acne-removing composition is as follows: Step 1), 0.1 kg lactoferrin, 0.1 kg antimicrobial peptide, 0.05 kg lysozyme and 0.1 kg metallothionein are put into a stirring tank, the speed is 120 r / min, stirring for 15 min, mixing evenly, to obtain a premix.

[0062] Step 2), add 1.25kg of Andrographis paniculata extract, 0.6kg of Thyme extract, 0.6kg of Clove extract, 0.6kg of Eucalyptus globulus extract, 1.25kg of Forsythia suspensa extract, and 1.25kg of Raspberry extract to the premix, rotate at 120r / min, stir for 20min, mix evenly, and obtain a highly effective acne-removing composition.

[0063] Example 4 An efficient acne-removing composition comprises the following components: Lactoferrin, antimicrobial peptides, lysozyme, metallothionein, andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract, raspberry extract.

[0064] Lactoferrin was purchased from Guangzhou Bochi Biotechnology Co., Ltd., batch number: LH7023A001.

[0065] Antimicrobial peptides were purchased from Sichuan Jisheng Biopharmaceutical Co., Ltd., model: JMO43.

[0066] Lysozyme was purchased from Wuhan Heyuan Biotechnology Co., Ltd., batch number: HYC042R01.

[0067] Metallothionein was purchased from Guangzhou Fanhai Fine Chemical Co., Ltd., model: NB656.

[0068] Andrographis paniculata extract was purchased from Anhui Xinsheng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0069] Thyme extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0070] Clove extract was purchased from Xi'an Biotech Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0071] The eucalyptus globulus extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0072] Forsythia suspensa extract was purchased from Shandong Xinxiong Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0073] Raspberry extract was purchased from Shaanxi Saien Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0074] The preparation method of the high-efficiency acne-removing composition is as follows: Step 1), 0.12 kg lactoferrin, 0.12 kg antimicrobial peptide, 0.06 kg lysozyme and 0.12 kg metallothionein are put into a stirring tank, the speed is 120 r / min, stirring for 15 min, mixing evenly, and obtaining a premix.

[0075] Step 2), add 1.5kg of Andrographis paniculata extract, 0.7kg of Thyme extract, 0.7kg of Clove extract, 0.7kg of Eucalyptus globulus extract, 1.5kg of Forsythia suspensa extract, and 1.5kg of Raspberry extract to the premix, rotate at 120r / min, stir for 20min, mix evenly, and obtain a highly effective acne-removing composition.

[0076] Example 5 An efficient acne-removing composition comprises the following components: Lactoferrin, antimicrobial peptides, lysozyme, metallothionein, andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract, raspberry extract.

[0077] Lactoferrin was purchased from Guangzhou Bochi Biotechnology Co., Ltd., batch number: LH7023A001.

[0078] Antimicrobial peptides were purchased from Sichuan Jisheng Biopharmaceutical Co., Ltd., model: JMO43.

[0079] Lysozyme was purchased from Wuhan Heyuan Biotechnology Co., Ltd., batch number: HYC042R01.

[0080] Metallothionein was purchased from Guangzhou Fanhai Fine Chemical Co., Ltd., model: NB656.

[0081] Andrographis paniculata extract was purchased from Anhui Xinsheng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0082] Thyme extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0083] Clove extract was purchased from Xi'an Biotech Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0084] The eucalyptus globulus extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0085] Forsythia suspensa extract was purchased from Shandong Xinxiong Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0086] Raspberry extract was purchased from Shaanxi Saien Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0087] The preparation method of the high-efficiency acne-removing composition is as follows: Step 1), 0.2 kg lactoferrin, 0.2 kg antimicrobial peptide, 0.1 kg lysozyme and 0.2 kg metallothionein are put into a stirring tank, the speed is 120 r / min, stirring for 15 min, mixing evenly, to obtain a premix.

[0088] Step 2), add 2kg of Andrographis paniculata extract, 1kg of Thyme extract, 1kg of Clove extract, 1kg of Eucalyptus globulus extract, 2kg of Forsythia suspensa extract, and 2kg of Raspberry extract to the premix, rotate at 120 r / min, stir for 20 minutes, mix evenly, and obtain a highly effective acne-removing composition.

[0089] Comparative Example 1 An efficient acne-removing composition, compared with Example 3, differs only in that: Erythromycin ethylsuccinate was used to replace lactoferrin in equal amounts.

[0090] Comparative Example 2 An efficient acne-removing composition, compared with Example 3, differs only in that: The antimicrobial peptide was replaced with an equal amount of clarithromycin.

[0091] Comparative Example 3 An efficient acne-removing composition, compared with Example 3, differs only in that: Azithromycin was used in an equal amount to replace lysozyme.

[0092] Comparative Example 4 An efficient acne-removing composition, compared with Example 3, differs only in that: An equal amount of telithromycin was used to replace metallothionein.

[0093] Comparative Example 5 An efficient acne-removing composition, compared with Example 3, differs only in that: Erythromycin ethylsuccinate was used to replace lactoferrin in equal amounts; clarithromycin was used to replace antimicrobial peptides in equal amounts; azithromycin was used to replace lysozyme in equal amounts; and telithromycin was used to replace metallothionein in equal amounts.

[0094] Comparative Example 6 An efficient acne-removing composition, compared with Example 3, differs only in that: An equal amount of chamomile extract was used to replace the andrographis extract.

[0095] Chamomile extract was purchased from Shaanxi New Horizon Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0096] Comparative Example 7 An efficient acne-removing composition, compared with Example 3, differs only in that: An equal amount of purslane extract was used to replace the thyme extract.

[0097] Purslane extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0098] Comparative Example 8 An efficient acne-removing composition, compared with Example 3, differs only in that: An equal amount of licorice extract was used to replace the clove extract.

[0099] Licorice extract was purchased from Jiangsu Jiujia Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0100] Comparative Example 9 An efficient acne-removing composition, compared with Example 3, differs only in that: An equal amount of olive extract was used to replace the eucalyptus globulus extract.

[0101] Olive extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0102] Comparative Example 10 An efficient acne-removing composition, compared with Example 3, differs only in that: An equal amount of Centella asiatica extract was used to replace the Forsythia suspensa extract.

[0103] Centella asiatica extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0104] Comparative Example 11 An efficient acne-removing composition, compared with Example 3, differs only in that: Replace raspberry extract with white willow bark extract in equal amounts.

[0105] White willow bark extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0106] Comparative Example 12 An efficient acne-removing composition, compared with Example 3, differs only in that: An equal amount of chamomile extract was used to replace the andrographis paniculata extract; an equal amount of purslane extract was used to replace the thyme extract; an equal amount of licorice extract was used to replace the clove extract; an equal amount of olive extract was used to replace the eucalyptus globulus extract; an equal amount of Centella asiatica extract was used to replace the forsythia extract; an equal amount of white willow bark extract was used to replace the raspberry extract.

[0107] Chamomile extract was purchased from Shaanxi New Horizon Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0108] Purslane extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0109] Licorice extract was purchased from Jiangsu Jiujia Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0110] Olive extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0111] Centella asiatica extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0112] White willow bark extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0113] Experiment 1 The high-efficiency anti-acne composition of each embodiment and comparative example was used to prepare the test sample.

[0114] Recruit a number of volunteers with 20-30 patches of acne on their faces. All of them have used anti-acne products continuously and their acne has continued to recur. The history of using anti-acne products is 3-5 years.

[0115] The volunteers were randomly divided into groups, with ten people in each group.

[0116] Each group of volunteers conducted experiments using the test samples of each embodiment and comparative example.

[0117] During the experiment, volunteers washed their faces with a disposable face towel and clean water every morning and evening, wiped off the water after washing, took 3 ml of the test sample and applied it evenly on the face, once in the morning and once in the evening. No other skin care products and cosmetics were used during the experiment.

[0118] Before using the test sample, record the number of facial acne, and record the number of facial acne again after using the test sample for 15 days and 30 days.

[0119] Stop using it after 30 days, and conduct a follow-up visit after 60 days of discontinuation to record the number of facial acne to determine whether there is recurrence.

[0120] The experimental data of each group were averaged.

[0121] Preparation of the sample to be tested: Take 10g of the high-efficiency anti-acne composition, 50g of water, and 40g of butylene glycol, and stir evenly to obtain the sample to be tested.

[0122] The specific test data of Experiment 1 are shown in Table 1.

[0123] Table 1 According to the data comparison of each embodiment and comparative example in Table 1, after 15 days of use, the acne repair effect of each embodiment is significantly better than that of comparative examples 1-6. It can be seen that each embodiment can effectively treat acne and eliminate acne quickly because it has no drug resistance. Although the antibiotics used in comparative examples 1-6 have a strong antibacterial effect, since the volunteers have used various acne removal products for a long time, the Propionibacterium acnes on the face has mutated and has strong drug resistance, resulting in poor acne removal effect.

[0124] There was no recurrence in each embodiment after 14 days of discontinuation of use, while there was a certain recurrence in comparative examples 7-13. It can be seen that the composite plant extract formed by adding andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract, and raspberry extract can well regulate the water and oil balance of the skin, and the skin repair effect can be very long-lasting, making the skin less likely to relapse of acne, and the effect of treating acne is more thorough. Although moisturizing plant extracts are added to comparative examples 7-13, the composite system of andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract, and raspberry extract is destroyed, so that the effect of regulating the water and oil balance of the skin is reduced. The skin has not been completely repaired after 30 days of use, resulting in the phenomenon of acne recurrence after discontinuation.

[0125] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. An efficient acne-removing composition, characterized in that: The composition includes the following components in parts by weight: Lactoferrin 0.01-0.2 parts; Antimicrobial peptide 0.01-0.2 parts; Lysozyme 0.01-0.1 parts; Metallothionein 0.01-0.2 parts; 2.1-9 parts of compound plant extract.

2. The highly effective anti-acne composition according to claim 1, characterized in that: The mass ratio of the lactoferrin, antimicrobial peptide, lysozyme and metallothionein is 0.08-0.12: 0.08-0.12: 0.04-0.06: 0.08-0.

12.

3. The highly effective anti-acne composition according to claim 2, characterized in that: The composite plant extract is a compound of andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract and raspberry extract.

4. The highly effective anti-acne composition according to claim 3, characterized in that: The mass ratio of the andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract and raspberry extract is 0.5-2:0.2-1:0.2-1:0.2-1:0.5-2:0.5-2.

5. The highly effective anti-acne composition according to claim 4, characterized in that: The mass ratio of the andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract and raspberry extract is 1-1.5: 0.5-0.7: 0.5-0.7: 0.5-0.7: 1-1.5: 1-1.

5.

6. The highly effective anti-acne composition according to claim 1, characterized in that: The andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract and raspberry extract are all water-soluble extracts.

7. The highly effective anti-acne composition according to claim 6, characterized in that: The extraction ratio of the andrographis paniculata extract, thyme extract, clove extract, eucalyptus globulus extract, forsythia suspensa extract and raspberry extract is 10:

1.

8. A method for preparing the highly effective anti-acne composition according to any one of claims 1 to 7, characterized in that: The following steps are involved: Step 1), lactoferrin, antimicrobial peptide, lysozyme and metallothionein are uniformly mixed to obtain a premix; Step 2), adding the composite plant extract to the premix and mixing evenly to obtain a highly effective acne-removing composition.

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