A concentration and filtration device for preparing penicillin

Abstract

The present invention provides a concentration and filtration device for preparing penicillin, comprising a centrifugal structure, which comprises a servo motor, the servo motor is arranged at the bottom of the concentration and filtration housing structure, the output end of the servo motor is provided with a transmission shaft, and the outer wall of the transmission shaft is provided with a bracket. The present invention is reasonably designed, and the penicillin solution entering the tail concentration structure is concentrated and filtered by the centrifugal structure, and then centrifuged to check whether emulsification occurs between the separation of the organic phase and the aqueous phase. When the emulsification effect occurs, the penicillin solution in the tail concentration structure is continuously concentrated and filtered. When the emulsification effect does not occur between the separation of the organic phase and the aqueous phase after the centrifugal treatment, the penicillin solution can be discharged for subsequent extraction to avoid more residual protein inside, and the tail concentration structure is used to slow down the reaction time of the emulsification of the organic phase and the aqueous phase during the static process.

Description

Technical Field

[0001] The invention mainly relates to the field of penicillin preparation, and in particular to a concentration and filtration device for preparing penicillin. Background Art

[0002] Penicillin is also known as penicillin G, peillin G, penicillin, and penicillin. Penicillin is a type of antibiotic, which refers to a class of antibiotics that contain penicillin in the molecule, can destroy the cell wall of bacteria and kill bacteria during the reproduction period of bacterial cells. It is an antibiotic extracted from Penicillium. Penicillin belongs to the β-lactam antibiotics (β-lactams), which include penicillin, cephalosporin, carbapenem, monocyclic, cephamycin, etc. Penicillin is a very commonly used antibacterial drug, in which penicillin is prepared through a concentration and filtration device to discharge proteins and other substances inside the penicillin solution.

[0003] When penicillin is prepared by existing concentration and filtration equipment, when the ultrafiltration membrane is unable to discharge impurities inside the penicillin solution, certain hydrophilic and hydrophobic biopolymers such as proteins will remain inside the solution, causing an emulsion layer to appear inside the penicillin solution after concentration and filtration during the extraction process. The emulsion layer is difficult to remove from the solution, resulting in a decrease in the quality of the subsequently prepared penicillin. Summary of the invention

[0004] 1. Technical problems to be solved by the invention:

[0005] The present invention provides a concentration and filtration device for preparing penicillin, which is used to solve the technical problems existing in the above-mentioned background technology.

[0006] 2. Technical solution:

[0007] To achieve the above object, the technical solution provided by the present invention is: a concentration and filtration device for preparing penicillin, comprising a concentration and filtration housing structure, a sealing top cover is arranged on the top of the concentration and filtration housing structure, a primary concentration structure is arranged inside the concentration and filtration housing structure, a centrifugal structure is rotatably connected inside the concentration and filtration housing structure, a tail concentration structure is arranged on the outer wall of the centrifugal structure, the primary concentration structure is connected to the centrifugal structure through a pipeline, and the centrifugal structure is connected to the tail concentration structure through a pipeline;

[0008] A tail concentration structure, comprising a second ultrafiltration membrane, wherein the number of the second ultrafiltration membranes is set to be multiple, and the second ultrafiltration membranes are arranged obliquely;

[0009] A centrifugal structure, comprising a servo motor, the servo motor being arranged at the bottom of the concentration and filtration housing structure, the output end of the servo motor being provided with a transmission shaft, the outer wall of the transmission shaft being provided with a bracket, one end of the bracket being provided with a clamping ring, the inner wall of the clamping ring being in contact with the outer wall of the second ultrafiltration membrane;

[0010] A primary concentration structure, comprising a first ultrafiltration membrane, wherein the first ultrafiltration membrane is disposed on the top of the concentration and filtration housing structure;

[0011] The pore diameter of the second ultrafiltration membrane is smaller than the pore diameter of the first ultrafiltration membrane.

[0012] Furthermore, the concentration and filtration shell structure includes a shell body, a mounting chamber is provided on the top of the shell body, mounting grooves are provided on both sides of the inner wall of the mounting chamber, an inclined plate is provided on the top of the mounting groove, and a fitting tube is provided directly below the inclined plate.

[0013] Furthermore, a guide plate is provided at the bottom of the inner wall of the shell body, a first liquid outlet is opened inside the guide plate, a second liquid outlet is opened inside the guide plate, and the top of the inner wall of the shell body is rotatably connected to a bonding strip, a liquid inlet is opened inside the bonding strip.

[0014] Furthermore, a bottom fitting ring is arranged at the top of the first liquid outlet, a diversion groove is opened inside the bottom fitting ring, and a valve is arranged inside the diversion groove.

[0015] Furthermore, first connecting tubes are provided at both ends of the first ultrafiltration membrane, the first connecting tubes are rotatably connected to the mounting grooves, a transmission gear is provided on the outer wall of the first connecting tube on one side of the first ultrafiltration membrane, and flow ports are opened inside the first connecting tube and the transmission gear.

[0016] Furthermore, a liquid inlet tank is arranged on the top of the transmission shaft, and a water pump body is arranged inside the liquid inlet tank.

[0017] Furthermore, second connecting pipes are provided on both sides of the bottom of the liquid inlet bin, the second connecting pipes are connected to the water pump body, and one end of the second connecting pipe is connected to the liquid inlet.

[0018] Furthermore, auxiliary tubes are provided at the top and bottom of the second ultrafiltration membrane, rotating rings are provided at the top and bottom of the second ultrafiltration membrane, a cannula is provided inside the rotating ring, the cannula is connected to the auxiliary tube, and a scraper is provided on the outer wall of the auxiliary tube at the bottom of the second ultrafiltration membrane.

[0019] Furthermore, the rotating ring at the bottom of the second ultrafiltration membrane is rotatably connected to the inner wall of the bottom fitting ring, and the outer wall of the rotating ring at the top of the second ultrafiltration membrane is provided with a top fitting ring, and the top fitting ring is connected to the fitting strip.

[0020] 3. Beneficial effects:

[0021] Compared with the prior art, the technical solution provided by the present invention has the following beneficial effects:

[0022] The present invention uses a centrifugal structure to concentrate and filter the penicillin solution entering the tail concentration structure, and then conducts centrifugal treatment to check whether emulsification occurs between the separation of the organic phase and the aqueous phase. When the emulsification effect occurs, the penicillin solution in the tail concentration structure is continuously concentrated and filtered. When the emulsification effect does not occur between the separation of the organic phase and the aqueous phase after the centrifugal treatment, the penicillin solution can be discharged for subsequent extraction to avoid more residual protein inside. The tail concentration structure is used to slow down the reaction time of the emulsification of the organic phase and the aqueous phase during the static process.

[0023] The primary concentration structure performs preliminary concentration on the penicillin solution, discharges the water and protein in the solution, and then the solution after the preliminary concentration enters the tail concentration structure for secondary concentration filtration. At the same time, when the valve inside the diversion tank is closed, the penicillin solution inside the second ultrafiltration membrane cannot be discharged, which can increase the pressure of the solution inside the second ultrafiltration membrane.

[0024] When the centrifugal structure drives the tail concentration structure to rotate slowly, the penicillin solution inside the centrifugal structure can be shaken inside the second ultrafiltration membrane, so that the heavier substances in the solution are close to the outer wall at the bottom, and the lighter substances move to the inner side of the top, and the pressure inside the second ultrafiltration membrane increases, so that the protein and other substances in the solution can be slightly separated from the penicillin, allowing the protein and other substances to pass through the second ultrafiltration membrane. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention;

[0026] Figure 2 It is a schematic diagram of a three-dimensional cross-sectional structure of the present invention;

[0027] Figure 3 It is a schematic diagram of the three-dimensional structure of the primary concentration structure of the present invention;

[0028] Figure 4 It is a schematic diagram of the three-dimensional structure of the centrifugal structure of the present invention;

[0029] Figure 5 It is a schematic diagram of a three-dimensional cross-sectional structure of a concentration and filtration housing structure of the present invention;

[0030] Figure 6 It is a schematic diagram of the three-dimensional structure of the tail concentration structure of the present invention.

[0031] Reference numerals:

[0032] 1. Concentration and filtration shell structure; 101. Shell body; 102. Installation chamber; 103. Installation groove; 104. Guide plate; 105. First liquid outlet; 106. Second liquid outlet; 107. Fitting strip; 108. Liquid inlet; 109. Inclined plate; 110. Bottom fitting ring; 111. Diverter groove; 112. Fitting tube; 2. Sealing top cover; 3. Primary concentration structure; 301. First ultrafiltration membrane; 302. A connecting pipe; 303, transmission gear; 304, flow port; 4, centrifugal structure; 401, servo motor; 402, transmission shaft; 403, liquid inlet tank; 404, water pump body; 405, second connecting pipe; 406, bracket; 407, clamping ring; 5, tail concentration structure; 501, second ultrafiltration membrane; 502, auxiliary pipe; 503, rotating ring; 504, intubation; 505, scraper; 506, top fitting ring. DETAILED DESCRIPTION

[0033] To facilitate understanding of the present invention, the present invention will be described more comprehensively below with reference to the relevant drawings. Several embodiments of the present invention are shown in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0034] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "page", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicating orientations or positional relationships are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0035] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0036] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed", "provided with", "provided on" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0037] Example:

[0038] See attached Figure 1-6 , a concentration and filtration device for preparing penicillin, comprising a concentration and filtration housing structure 1, a sealing top cover 2 is arranged on the top of the concentration and filtration housing structure 1, a primary concentration structure 3 is arranged inside the concentration and filtration housing structure 1, a centrifugal structure 4 is rotatably connected inside the concentration and filtration housing structure 1, a tail concentration structure 5 is arranged on the outer wall of the centrifugal structure 4, the primary concentration structure 3 is connected to the centrifugal structure 4 through a pipeline, and the centrifugal structure 4 is connected to the tail concentration structure 5 through a pipeline;

[0039] The tail concentration structure 5 comprises a second ultrafiltration membrane 501, wherein the number of the second ultrafiltration membrane 501 is set to be multiple, and the second ultrafiltration membrane 501 is inclined;

[0040] The centrifugal structure 4 includes a servo motor 401, which is arranged at the bottom of the concentration and filtration housing structure 1. The output end of the servo motor 401 is provided with a transmission shaft 402, and the outer wall of the transmission shaft 402 is provided with a bracket 406. One end of the bracket 406 is provided with a clamping ring 407, and the inner wall of the clamping ring 407 is in contact with the outer wall of the second ultrafiltration membrane 501.

[0041] The primary concentration structure 3 comprises a first ultrafiltration membrane 301, wherein the first ultrafiltration membrane 301 is arranged on the top of the concentration and filtration housing structure 1;

[0042] When the penicillin solution needs to be concentrated and filtered, the penicillin solution is first concentrated and filtered through the primary concentration structure 3, and then the penicillin solution enters the interior of the centrifugal structure 4 and is sent to the interior of the second ultrafiltration membrane 501 through the centrifugal structure 4 for secondary concentration and filtration. The pore diameter of the second ultrafiltration membrane 501 is smaller than the pore diameter of the first ultrafiltration membrane 301 in the primary concentration structure 3. When the liquid in the penicillin solution is discharged, the servo motor 401 is started, and the servo motor 401 drives the second ultrafiltration membrane 501 to rotate, so that the second ultrafiltration membrane 501 produces a centrifugal effect, and the second ultrafiltration membrane 501 is 01, the solution inside is layered, so that the organic phase and the aqueous phase in the solution are separated, and the organic phase and the aqueous phase are separated by the set tail concentration structure 5, and then the organic phase, the aqueous phase separation and the emulsified layer are discharged, and left to stand for a period of time. When no emulsified layer appears between the organic phase and the aqueous phase, the tail concentration structure 5 is concentrated according to the above-mentioned centrifugal structure 4. When an emulsified layer appears between the organic phase and the aqueous phase, the rotation time and speed of the tail concentration structure 5 of the centrifugal structure 4 are increased, and the solution inside the tail concentration structure 5 of the centrifugal structure 4 is centrifuged to accelerate the reaction time of the emulsified layer between the organic phase and the aqueous phase.

[0043] Further, the concentration and filtration shell structure 1 includes a shell body 101, a mounting chamber 102 is provided on the top of the shell body 101, mounting grooves 103 are provided on both sides of the inner wall of the mounting chamber 102, an inclined plate 109 is provided on the top of the mounting groove 103, and a fitting tube 112 is provided directly below the inclined plate 109. The initial concentration structure 3 includes a first ultrafiltration membrane 301, first connecting tubes 302 are provided at both ends of the first ultrafiltration membrane 301, and the first connecting tube 302 is rotatably connected to the mounting groove 103. A transmission gear 303 is provided on the outer wall of the first connecting tube 302 on one side of the first ultrafiltration membrane 301, and a flow port 304 is opened inside the first connecting tube 302 and the transmission gear 303. , the first connecting pipe 302 is rotatably connected with the installation groove 103, the penicillin solution enters the interior of the first ultrafiltration membrane 301 through the flow port 304, and the motor is started. The motor is arranged on the outer wall of the installation bin, and a gear is arranged at the output end of the motor. The gear is meshed with the transmission gear 303, and the motor drives the transmission gear 303 to rotate through the gear, and the transmission gear 303 drives the plurality of first ultrafiltration membranes 301 to rotate, and then the first connecting pipe 302 on one side of the first ultrafiltration membrane 301 is provided with a solenoid valve, and the solenoid valve is closed to increase the pressure of the solution inside the first ultrafiltration membrane 301, so that the solution inside the first ultrafiltration membrane 301 is preliminarily concentrated and filtered, and then the solenoid valve is opened to discharge the preliminarily concentrated solution and enter the liquid inlet bin 403 for storage;

[0044] The fitting tube 112 is inserted into the liquid inlet bin 403 to seal the liquid inlet bin 403 to prevent the liquid in the liquid inlet bin 403 from entering the interior of the shell body 101 during rotation.

[0045] Furthermore, a guide plate 104 is provided at the bottom of the inner wall of the shell body 101, a first liquid outlet 105 is provided inside the guide plate 104, a second liquid outlet 106 is provided inside the guide plate 104, a top of the inner wall of the shell body 101 is rotatably connected to a bonding strip 107, a liquid inlet 108 is provided inside the bonding strip 107, a bottom bonding ring 110 is provided at the top of the first liquid outlet 105, a diversion groove 111 is provided inside the bottom bonding ring 110, and a valve tail concentration structure is provided inside the diversion groove 111 When the concentrated solution inside the tail concentrating structure 5 needs to be discharged, the valve inside the diverter slot 111 is opened, and the tail concentrating structure 5 is aligned with the diverter slot 111, so that the solution inside the diverter slot 111 is discharged, and at the same time, the waste liquid filtered by the tail concentrating structure 5 enters the inside of the second liquid outlet 106 through the first liquid outlet 105 and is discharged. Since the guide plate 104 and the shell body 101 are blocked by the fitting ring 110, the first liquid outlet 105 is opened, so that the liquid inside the first liquid outlet 105 can enter the inside of the shell body 101, avoiding residual liquid in the shell body 101.

[0046] Furthermore, a liquid inlet tank 403 is provided on the top of the transmission shaft 402, and a water pump body 404 is provided inside the liquid inlet tank 403. Second connecting pipes 405 are provided on both sides of the bottom of the liquid inlet tank 403, and the second connecting pipe 405 is connected to the water pump body 404. One end of the second connecting pipe 405 is connected to the liquid inlet 108. The solution filtered by the primary concentration structure 3 enters the liquid inlet tank 403, and the water pump body 404 is started. The water pump body 404 pumps the solution inside the liquid inlet tank 403 into the second connecting pipe 405, and then the solution enters the tail concentration structure 5 for secondary concentration.

[0047] Furthermore, auxiliary tubes 502 are provided at the top and bottom of the second ultrafiltration membrane 501, rotating rings 503 are provided at the top and bottom of the second ultrafiltration membrane 501, a cannula 504 is provided inside the rotating ring 503, and the cannula 504 is connected to the auxiliary tube 502; a scraper 505 is provided on the outer wall of the auxiliary tube 502 at the bottom of the second ultrafiltration membrane 501; the rotating ring 503 at the bottom of the second ultrafiltration membrane 501 is rotatably connected to the inner wall of the bottom bonding ring 110; a top bonding ring 506 is provided on the outer wall of the rotating ring 503 at the top of the second ultrafiltration membrane 501, and the top bonding ring 506 is connected to the bonding strip 107. The above structure mainly enables the solution to enter the interior of the tail concentration structure 5 during the process of the centrifugal structure 4 driving the tail concentration structure 5 to rotate; at the same time, the second ultrafiltration membrane 501 adopts an ultrafiltration membrane of HFPS10 model, and the first ultrafiltration membrane 301 adopts an ultrafiltration membrane of HFPS20 or HFPS50 model. Ultrafiltration membranes of other models with the same inner pore diameter may also be used.

[0048] In this embodiment, when penicillin needs to be prepared by a concentration and filtration device, the penicillin solution enters the interior of the first ultrafiltration membrane 301 through the flow port 304, and the solenoid valve inside the first connecting pipe 302 on one side of the first ultrafiltration membrane 301 is closed, so that the pressure inside the first ultrafiltration membrane 301 in the solution increases, and at the same time, the motor is started, the motor drives the first connecting pipe 302 to rotate, and the first connecting pipe 302 drives the first ultrafiltration membrane 301 to rotate, and then the solenoid valve is opened, so that the initially concentrated and filtered solution enters the interior of the liquid inlet bin 403 through the pipeline for storage;

[0049] The water pump body 404 is started, and the water pump body 404 drives the solution to enter the interior of the second connecting tube 405, and then the solution enters the interior of the top fitting ring 506 through the liquid inlet 108, and then the solution enters the interior of the second ultrafiltration membrane 501 through the cannula 504 and the auxiliary tube 502, and then the servo motor 401 is started, and the servo motor 401 drives the transmission shaft 402 to rotate, and the transmission shaft 402 drives the outer wall clamping ring 407 to rotate, and the clamping ring 407 drives the second ultrafiltration membrane 501 fixed inside to rotate;

[0050] Then, the rotating ring 503 at the bottom of the second ultrafiltration membrane 501 rotates on the inner wall of the bottom fitting ring 110, and the rotating ring 503 at the top of the second ultrafiltration membrane 501 drives the top fitting ring 506 and the liquid inlet 108 to rotate on the inner wall of the shell body 101, so that the solution inside the second ultrafiltration membrane 501 is slightly stratified, and the pressure of the solution inside the second ultrafiltration membrane 501 is increased, so that the biopolymer substances such as proteins with hydrophilic and hydrophobic groups inside the solution of the second ultrafiltration membrane 501 are discharged through the second ultrafiltration membrane 501, and then the speed of the servo motor 401 is increased to make the servo The motor 401 drives the second ultrafiltration membrane 501 to increase its rotation speed through the transmission shaft 402, and observes whether an emulsion layer appears between the organic phase and the aqueous phase. When an emulsion layer appears, it indicates that the hydrophilic and hydrophobic biopolymer substances such as proteins in the solution are not completely discharged, and the concentration and filtration time and pressure of the solution in the second ultrafiltration membrane 501 are increased, and then the above operation is repeated. When the two phases are clear, it means that the protein in the solution has reached a critical value, and then the penicillin solution is subsequently concentrated and filtered according to the above time and pressure, and the solution after concentration and filtration needs to be discharged;

[0051] The valve inside the shunt tank 111 is opened, and the cannula 504 is aligned with the shunt tank 111 , so that the solution inside the second ultrafiltration membrane 501 is discharged through the auxiliary tube 502 , the cannula 504 and the shunt tank 111 .

[0052] The above-described embodiments only express a certain implementation mode of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the patent scope of the present invention. It should be pointed out that, for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be based on the attached claims.

Claims

1. A concentration and filtration device for preparing penicillin, characterized in that: include A concentration and filtration housing structure (1), wherein a sealing top cover (2) is arranged on the top of the concentration and filtration housing structure (1), a primary concentration structure (3) is arranged inside the concentration and filtration housing structure (1), a centrifugal structure (4) is rotatably connected inside the concentration and filtration housing structure (1), a tail concentration structure (5) is arranged on the outer wall of the centrifugal structure (4), the primary concentration structure (3) and the centrifugal structure (4) are connected via a pipeline, and the centrifugal structure (4) and the tail concentration structure (5) are connected via a pipeline; A tail concentration structure (5), comprising a second ultrafiltration membrane (501), wherein the number of the second ultrafiltration membranes (501) is set to be multiple, and the second ultrafiltration membranes (501) are arranged to be inclined; A centrifugal structure (4), comprising a servo motor (401), the servo motor (401) being arranged at the bottom of the concentration and filtration housing structure (1), a transmission shaft (402) being arranged at the output end of the servo motor (401), a bracket (406) being arranged on the outer wall of the transmission shaft (402), a retaining ring (407) being arranged at one end of the bracket (406), and an inner wall of the retaining ring (407) being in contact with the outer wall of the second ultrafiltration membrane (501); A primary concentration structure (3), comprising a first ultrafiltration membrane (301), wherein the first ultrafiltration membrane (301) is arranged on the top of the concentration and filtration housing structure (1); The pore diameter of the second ultrafiltration membrane (501) is smaller than the pore diameter of the first ultrafiltration membrane (301).

2. A concentration and filtration device for preparing penicillin according to claim 1, characterized in that: The concentration and filtration housing structure (1) comprises a housing body (101), a mounting chamber (102) being arranged at the top of the housing body (101), mounting grooves (103) being arranged on both sides of the inner wall of the mounting chamber (102), an inclined plate (109) being arranged at the top of the mounting groove (103), and a fitting tube (112) being arranged directly below the inclined plate (109).

3. A concentration and filtration device for preparing penicillin according to claim 2, characterized in that: A guide plate (104) is provided at the bottom of the inner wall of the shell body (101), a first liquid outlet (105) is provided inside the guide plate (104), a second liquid outlet (106) is provided inside the guide plate (104), and a bonding strip (107) is rotatably connected to the top of the inner wall of the shell body (101), a liquid inlet (108) is provided inside the bonding strip (107).

4. A concentration and filtration device for preparing penicillin according to claim 3, characterized in that: A bottom fitting ring (110) is provided at the top of the first liquid outlet (105), a diversion groove (111) is provided inside the bottom fitting ring (110), and a valve is provided inside the diversion groove (111).

5. A concentration and filtration device for preparing penicillin according to claim 2, characterized in that: First connecting tubes (302) are provided at both ends of the first ultrafiltration membrane (301), the first connecting tube (302) is rotatably connected to the mounting groove (103), a transmission gear (303) is provided on the outer wall of the first connecting tube (302) on one side of the first ultrafiltration membrane (301), and flow ports (304) are provided inside the first connecting tube (302) and the transmission gear (303).

6. A concentration and filtration device for preparing penicillin according to claim 3, characterized in that: A liquid inlet bin (403) is arranged on the top of the transmission shaft (402), and a water pump body (404) is arranged inside the liquid inlet bin (403).

7. A concentration and filtration device for preparing penicillin according to claim 6, characterized in that: Second connecting pipes (405) are provided on both sides of the bottom of the liquid inlet bin (403); the second connecting pipe (405) is connected to the water pump body (404); and one end of the second connecting pipe (405) is connected to the liquid inlet (108).

8. A concentration and filtration device for preparing penicillin according to claim 4, characterized in that: Auxiliary tubes (502) are arranged at the top and bottom of the second ultrafiltration membrane (501), rotating rings (503) are arranged at the top and bottom of the second ultrafiltration membrane (501), a cannula (504) is arranged inside the rotating ring (503), the cannula (504) is connected to the auxiliary tube (502), and a scraper (505) is arranged on the outer wall of the auxiliary tube (502) at the bottom of the second ultrafiltration membrane (501).

9. A concentration and filtration device for preparing penicillin according to claim 8, characterized in that: The rotating ring (503) at the bottom of the second ultrafiltration membrane (501) is rotatably connected to the inner wall of the bottom bonding ring (110), and the outer wall of the rotating ring (503) at the top of the second ultrafiltration membrane (501) is provided with a top bonding ring (506), and the top bonding ring (506) is connected to the bonding strip (107).

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