Single traditional Chinese medicine powder spray for radically treating allergic rhinitis as well as preparation and application of single traditional Chinese medicine powder spray

Abstract

The invention discloses a single traditional Chinese medicine powder spray for radically treating allergic rhinitis and preparation and application thereof.The single traditional Chinese medicine powder spray only contains gleditsia sinensis powder, is simple in composition and can temporarily stimulate epithelial cells to secrete normal nasal discharge to block and flush allergens, and nasal cavity flushing is achieved; the traditional Chinese medicine composition can change the local microenvironment of nasal mucosa and cut off the biological process of occurrence and development of allergic rhinitis, and enters the nasal mucosa to serve as a descaling agent, so that an IgE receptor Fc epsilon R1 on a sensitized mast cell membrane is separated from IgE and cannot be combined with allergens, and the mast cell cannot activate and release an allergic medium, so that the allergic rhinitis is radically treated; the preparation process of the single traditional Chinese medicine powder spray is simple and easy to operate, batch production can be realized, and after the saponin powder is processed by the alum, the astringency effect is remarkable, so that the clear water snot symptom of the allergic rhinitis can be improved; the nasal spray is used for treating allergic rhinitis, stimulates secretion of nasal discharge after being sprayed, and is beneficial to cleaning nasal cavities and improving nasal ventilation; the traditional Chinese medicine composition also has a sterilization function and can effectively inhibit bacterial and fungal infection induced by allergic rhinitis.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a single-flavor traditional Chinese medicine powder spray for radically curing allergic rhinitis, and a preparation method and application thereof. Background Art

[0002] Allergic rhinitis is an allergic reaction disease of the nasal mucosa after people with allergic constitution come into contact with (inhale) allergens. It is a non-infectious chronic inflammatory reaction disease with a prevalence rate of 10% to 40%. Allergic rhinitis often recurs, and in severe cases, it even increases the risk of asthma, sinusitis, conjunctivitis, etc.

[0003] There are two main strategies for the treatment of allergic rhinitis in Western medicine. One is the combination of glucocorticoids, antihistamines, leukotriene receptor antagonists and other drugs. Treatment for 2 to 4 weeks can control the symptoms of most patients. Its biggest disadvantage is that it cannot cure the disease. The second is desensitization therapy: by repeatedly exposing patients to low-dose allergen extracts to improve tolerance to allergens, the purpose of no longer getting sick or reducing symptoms after being exposed to allergens again is achieved. It has a radical cure for common allergens or allergens that patients have been exposed to for a long time, but the disadvantages are: ① The sources and types of medical allergen extracts are limited, and only a part of allergic rhinitis can be cured; ② The course of treatment is long and the cost is high; ③ The commonly used allergen extracts may induce anaphylactic shock or systemic hypersensitivity reaction when injected subcutaneously, and it may cause adverse reactions such as itching and swelling of the lips and sublingual area when taken sublingually.

[0004] Traditional Chinese medicine is the quintessence of our country. It is not only necessary but also feasible to develop drugs for curing allergic rhinitis from traditional Chinese medicine resources based on modern medical theories and methods. At present, there are no Chinese patent medicine preparations specifically for treating allergic rhinitis on the market, but there are many Chinese patent medicines for treating rhinitis, which can be used to treat allergic rhinitis, at least to relieve symptoms. Some Chinese patent medicines clearly include allergic rhinitis in their indications. The existing anti-rhinitis Chinese patent medicines for allergic rhinitis have the following shortcomings: ① Limited effect, often need to be used in combination with Western medicines such as antihistamines and glucocorticoids; ② Unstable efficacy, the same medicine has uncertain effects on different people, or even on allergic rhinitis in the same person at different times, and in actual application, it is often forced to change the medicine midway; ③ Most of them cannot cure the disease, including oral preparations and topical preparations.

[0005] A Chinese patent discloses a drug for treating rhinitis, called Bitong ointment (CN103251709B), which is a Chinese medicine ointment preparation for smearing on the nasal mucosa. The main drugs include 8 Chinese medicines such as asarum, saponin, borneol, and menthol. Its indications include allergic rhinitis, and a specific example report cures one case of allergic rhinitis. However, the invention has not been transformed in the market so far, and the treatment course is long, the cost is high, and there is still a lack of sufficient data support for its radical effect on allergic rhinitis. Summary of the invention

[0006] In view of the problems that existing drugs for treating allergic rhinitis generally have long treatment courses, high costs, uncertain efficacy, and cannot be cured, especially the technical status quo that traditional Chinese medicine preparations for treating allergic rhinitis have large complex prescriptions, outdated theories, unclear mechanisms, and uncertain curative efficacy, the present invention aims to provide a single traditional Chinese medicine powder spray for curing allergic rhinitis, as well as a preparation method and application thereof.

[0007] The present invention is achieved through the following technical solutions:

[0008] A single-flavor Chinese medicine powder spray for radically curing allergic rhinitis, the powder spray is composed of sapodilla powder, and the particle size of the sapodilla powder is less than 75 μm.

[0009] The soapnut powder is derived from soapnuts that have been naturally dried for more than one year.

[0010] The powder spray is an aerosol.

[0011] The preparation method of the single-flavor Chinese medicine powder spray for curing allergic rhinitis comprises: cutting soap beans to remove seeds, cutting into sections, preparing with alum solution, drying, crushing and screening to obtain the powder spray for curing allergic rhinitis.

[0012] The length of the soapberry segments is 0.5 to 1 cm.

[0013] The alum solution is prepared, and the concentration of the alum solution is 200g / L to 300g / L.

[0014] In the alum preparation, the mass ratio of saponin to alum solution is 100-120:60-70.

[0015] The drying temperature is 40° C. to 60° C., and the drying time is 10 h to 16 h.

[0016] The mesh number of the medicine sieve used for the sieving is 200 meshes.

[0017] The use of the above-mentioned single-flavor Chinese medicine powder spray for radically curing allergic rhinitis in the preparation of a drug for radically curing allergic rhinitis.

[0018] At the same time, the application of the single Chinese medicine powder spray for radically curing allergic rhinitis provided by the present invention in radically curing allergic rhinitis is to spray twice on the first day of the treatment of allergic rhinitis attack, once each on the 2nd, 3rd and 8th day, and once each in the 3rd week and the 5th week; if allergic rhinitis has not attacked: intermittent nasal spray treatment 3 times, with an interval period of 1 to 2 weeks.

[0019] Compared with existing prevention and treatment methods and related drugs, the present invention has the following beneficial prevention and treatment effects:

[0020] The single-flavor Chinese medicine powder spray for radically curing allergic rhinitis provided by the present invention contains only saponin powder and has a simple composition. It can temporarily stimulate epithelial cells to secrete normal nasal mucus to block and wash allergens, thereby flushing the nasal cavity; it can change the local microenvironment of the nasal mucosa, cut off the biological process of the occurrence and development of allergic rhinitis, enter the nasal mucosa as a descaling agent to separate the IgE receptor FcεR1 on the membrane of sensitized mast cells from IgE, and cannot bind to allergens, resulting in the inability of mast cells to activate and release allergic mediators, thereby radically curing allergic rhinitis; it also has a bactericidal function, and can effectively inhibit bacterial and fungal infections induced by allergic rhinitis.

[0021] The preparation process of the single-flavor Chinese medicine powder spray for radically curing allergic rhinitis is simple and easy to operate, and batch production can be realized. After the soap locust powder is processed with alum, the astringent effect is remarkable, and the clear water-like nasal discharge symptom of allergic rhinitis is helped to improve the clear water-like nasal discharge symptom of allergic rhinitis. The spray is used for the treatment of allergic rhinitis, and a small amount of local external application can control the symptoms of allergic rhinitis with a single application, and can radically cure allergic rhinitis with intermittent use for 6 to 7 times (once every 1 to 2 weeks). After a 2-week course of treatment, the total effective rate is as high as 100%, and the 3-year recurrence index is only 0.07, without adverse reactions, thereby improving the safety of treatment and the comfort of patients. After spraying, the short-term stimulation in the early stage is close to the physiological nasal discharge, which helps to clean the nasal cavity and improve nasal ventilation. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 The diagram is a diagram of the mechanism of action of the single-flavor Chinese medicine powder spray for radically curing allergic rhinitis of the present invention, wherein 1 is an allergen, 2 is a nasal mucosal epithelial cell, 3 is a blood vessel in the mucosa, 4 is a macrophage, 5 is a T lymphocyte, 6 is a B lymphocyte, 7 is a specific antibody IgE, 8 is a sensitized basophil, 9 is a sensitized mast cell, 10 is a re-entering allergen that binds to the IgE on the sensitized mast cell to activate the cell and release allergic mediators, 11 is saponin, and 12 is a "desensitized" mast cell;

[0023] Figure 2 This is a comparison chart of the forearm skin prick test in patients with house dust mite allergic rhinitis;

[0024] Figure 3 This is a comparison chart of mast cell fluorescence staining test using water injection puncture method to obtain cells;

[0025] Figure 4 This is a sample picture of a single Chinese medicine powder spray for radically curing allergic rhinitis according to the present invention. DETAILED DESCRIPTION

[0026] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiment of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiment of the present invention. Obviously, the described embodiment is only an embodiment of a part of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work should fall within the scope of protection of the present invention.

[0027] The present invention is further described in detail below in conjunction with the accompanying drawings:

[0028] If no specific experimental steps or conditions are specified in the examples, the experiments can be carried out according to the conventional experimental steps or conditions described in the literature in the art. If no manufacturer is specified for the reagents or instruments used, they are all conventional reagent products that can be obtained commercially.

[0029] Example 1: Preparation of a single Chinese medicine powder spray for radically curing allergic rhinitis

[0030] The preparation method of the single-flavor Chinese medicine powder spray for radically curing allergic rhinitis of the present invention comprises the following steps:

[0031] 1) Cut the soap beans that have been naturally dried for more than one year, remove the seeds and cut them into small pieces about 0.5 cm long, and prepare them with alum: add 12.5 kg of alum to 50 liters of distilled water and heat it to boiling to fully dissolve the alum, add 100 kg of dried soap bean small pieces, stir and heat on low heat for about 20 minutes, so that the alum evenly penetrates the soap bean small pieces, some of the water evaporates, and the surface of the soap bean small pieces is slightly charred, and then place them in a constant temperature forced air drying oven overnight (temperature 50°C) to fully dry them.

[0032] 2) The processed soapberry segments obtained in step 1) are crushed into fine powder, sieved, and the fine powder passing through the sieve holes (the inner diameter of the sieve holes is 75 μm, i.e., 200 meshes / inch) is collected for later use.

[0033] 3) Weigh 2 grams of the fine sapodilla powder obtained in step 2) and put it into a plastic powder spray bottle (10 grams) to prepare a sapodilla powder nasal spray preparation.

[0034] 4) Take the powder spray bottle prepared in step 3), aim the nozzle at one nostril, and squeeze the bottle body with the thumb and index finger to spray out the soapnut powder. The squeezing force should be about 5 to 10 mg each time.

[0035] Example 2: Mechanism test of single Chinese medicine powder spray for radical cure of allergic rhinitis

[0036] Allergic rhinitis is a type I allergic reaction, which goes through two stages: sensitization and onset. The mechanism of action of the single-flavor Chinese medicine powder spray for radically curing allergic rhinitis provided by the present invention is specifically described in the attached Figure 1 shown.

[0037] By the attached Figure 1 It can be seen that when the allergen (1) enters the nasal cavity for the first time, it enters the blood vessels in the mucosa (3) through the nasal mucosal epithelial cells (2), is recognized, processed and presented by macrophages (4), and under the action of IL-4, IL-13 and the like released by helper T lymphocytes (5), B lymphocytes (6) produce and release specific antibodies IgE (7) against the allergen. IgE binds to FcεR1 (IgE receptor) on the surface of basophils to form sensitized basophils (8). The sensitized basophils leave the blood and reside in the connective tissue of the nasal mucosa, changing their name to sensitized mast cells (9). When the allergen (1) enters the nasal mucosa again and binds to the IgE on the sensitized mast cells (10), the cells release allergic mediators such as histamine, kininogenase, leukotrienes (LTs), platelet activating factor (PAF), prostaglandin D2 (PGD2), etc., causing symptoms of allergic rhinitis. The saponins (11) in the soapnut powder suspension enter the nasal mucosa and can separate the IgE on the sensitized mast cells from the FcεR1, turning them into "desensitized" mast cells (12) that are difficult to be activated by allergens; certain components in the soapnut stimulate the epithelial cells of the nasal mucosa to secrete nasal mucus that is similar to normal, blocking the entry of allergens through the sneezing reflex. In short, applying soapnut powder topically to the nasal mucosa several times can completely change the local microenvironment of the nasal mucosa through multiple effects, cutting off the conditions for the onset of allergic rhinitis.

[0038] Skin prick test is one of the methods to diagnose allergic rhinitis. We used the improved skin prick test to preliminarily verify that the topical application of soapberry powder can separate FcεR1 from IgE on sensitized mast cells, making it difficult to be activated by allergens. The method is to give physiological saline or soapberry powder suspension (5mg / ml) to different points on the left forearm of a patient with house dust mite allergic rhinitis diagnosed by skin prick test for 20 minutes. After wiping and cleaning the skin, the house dust mite allergen was pricked in situ. The results are shown in Figure 2 As shown, cells were obtained by water injection puncture for mast cell fluorescence staining. The results are shown in the attached Figure 3 shown.

[0039] By the attached Figure 2 It can be seen that the skin papules at the site of saline pretreatment were strongly positive (about 6 mm in diameter), while the papules at the site of saponin powder suspension pretreatment were negative. Figure 3 The results of mast cell fluorescence staining by water injection puncture method showed that the mast cells in the normal saline control area were positive for house dust mite IgE, while the mast cells in the area pretreated with saponin powder suspension were negative for house dust mite IgE.

[0040] Gleditsia sinensis is pungent, warm, slightly toxic, enters the lung and large intestine meridians, and can be taken internally to remove phlegm and open the orifices, and can be used externally to disperse knots and reduce swelling. It is recorded in "Danxi Xinfa Fu Yu" that "blow a little Tongguan Powder into the nose to induce sneezing." Gleditsia sinensis is contained in its Tongguan Powder. Lv Shulan of Qingdao Traditional Chinese Medicine Hospital once blew gleditsia powder into the nasal cavity, and at the same time applied the ointment prepared with gleditsia powder and vinegar to the Yingxiang points beside the nose on both sides to treat allergic rhinitis, achieving good results (Journal of Traditional Chinese Medicine, 1995, 36 (6): 327), but no further observation was made whether it could be cured; the invention patent (CN103251709B) disclosed a nose-passing ointment containing 8 Chinese medicines, of which the mass of gleditsia sinensis accounted for 23.2% to 28%. The understanding and functional positioning of gleditsia sinensis is to reduce swelling and remove toxins, warm the meridians and dredge the collaterals, and promote blood circulation and remove blood stasis.

[0041] Based on the pathogenesis of allergic rhinitis and the pharmacological ligand-receptor theory, we first proposed to use detergents to elute IgE bound to sensitized mast cell FcεR1 to cure allergic rhinitis. The chemical composition of soap nuts, saponin, is in line with expectations. This is also our new understanding and functional positioning of the pharmacological mechanism of soap nuts in treating allergic rhinitis. Soap nuts can be taken orally to treat diseases, indicating that various ingredients including saponin are not harmful to humans within a certain dose range. However, large doses of soap nuts are toxic when taken orally, including hemolysis. Hemolysis can be understood as high concentrations of saponin damaging the red blood cell membrane. Local use of soap nut powder on the nasal mucosa may cause the deconstruction of FcεR1-IgE on the surface of local mast cells in the nasal mucosa, avoiding potential toxicity after oral administration. There is a small amount of secretion (nasal mucus) in the nasal cavity under physiological conditions. The exudate increases during allergic rhinitis. The soap nut powder sprayed into the nasal cavity is very easy to adhere to the nasal mucosa, and the dissolved chemical components are very easy to penetrate into the mucosa.

[0042] Example 3: Clinical trial of a single Chinese medicine powder spray for radical cure of allergic rhinitis

[0043] 1 Cases and methods

[0044] 1.1 Research subjects A total of 58 patients with allergic rhinitis were admitted to Xi'an Jiaotong University Hospital from April 2018 to April 2020. Their symptoms and medical history met the diagnostic criteria for allergic rhinitis in the "Guidelines for the Diagnosis and Treatment of Allergic Rhinitis in China" (2017 revised edition) formulated by the Rhinology Group of the Otorhinolaryngology Head and Neck Surgery Branch of the Chinese Medical Association. The patients had a history of allergic rhinitis for at least 2 years at the same time as the scheduled study time in the year, had not used antihistamines or glucocorticoids in the past 2 weeks, or had not achieved the expected effect by taking anti-rhinitis Chinese patent medicines. Pregnant women, patients with mental illness, severe heart disease, chronic sinusitis, and patients with a history of asthma were excluded. A control group of 30 patients (19 males and 11 females, with an average age of 27.8±10.7 years and an average course of disease of 3.2±1.3 years) was assigned; an experimental group of 28 patients (21 males and 7 females, with an average age of 28.9±8.0 years and an average course of disease of 3.0±0.9 years) was assigned. All patients were informed and agreed to provide timely feedback on treatment outcomes; patients in the experimental group agreed to proactively provide feedback on recurrence within three years and were willing to come to the hospital for confirmation.

[0045] 1.2 Evaluation Criteria

[0046] The clinical symptom scoring standard is: 1 point for ≤5 consecutive sneezes, 2 points for 6-10, and 3 points for ≥11; 1 point for ≤4 times per day of nose blowing / runny nose, 2 points for 5-9 times, and 3 points for ≥10 times; 1 point for intermittent nasal itching, 2 points for tolerable formication nasal itching, and 3 points for unbearable formication nasal itching; 1 point for nasal congestion during conscious inhalation, 2 points for intermittent nasal congestion, and 3 points for nasal congestion almost all day long.

[0047] The clinical sign scoring standard is as follows: 1 point if the inferior turbinate is slightly swollen, and the middle turbinate and nasal septum are visible; 2 points if the inferior turbinate is close to the nasal floor (or nasal septum) but there is a small gap; 3 points if the inferior turbinate is close to the nasal floor (or nasal septum) and the middle turbinate cannot be seen or the middle turbinate has undergone mucosal polyp-like changes or even formed polyps.

[0048] 1.3 Treatment The control group was treated with budesonide + desloratadine citrate for 2 weeks. Budesonide nasal spray (Shanghai Johnson Pharmaceutical Co., Ltd.) was sprayed into the left and right nostrils twice a day, 2 sprays / time, and desloratadine citrate tablets (Guangzhou Hairui Pharmaceutical Co., Ltd.) were taken orally at 10 mg / time / day. The experimental group was treated with saponin powder nasal spray, spraying about 5-10 mg into the nostrils each time, twice on the first day of treatment, once on the 2nd, 3rd, and 8th day, and once in the 3rd and 5th week.

[0049] 1.4 Efficacy evaluation Total efficacy score = (total score before treatment - total score after treatment) / total score before treatment × 100%, which is divided into markedly effective (total efficacy score ≥ 66%), effective (total efficacy score 26% to 65%) and ineffective (total efficacy score ≤ 25%); total effective rate = (markedly effective + effective) / number of cases (30 or 28) × 100%. Record the time of relief of nasal itching, nasal congestion, runny nose and sneezing symptoms after the start of treatment. Within three years, doctors will regularly call back the experimental group patients to check the recurrence of allergic rhinitis. If the patients have rhinitis-related diseases, they will take the initiative to come to the hospital in time to identify whether they have allergic rhinitis. The recurrence index of each group within three years was calculated. Recurrence index = number of recurrences / number of cases

[0050] 1.5 Statistical analysis The data were processed using GraphPad Prism 9.0.0.121 software. P < 0.05 was considered statistically significant.

[0051] Table 1: Effectiveness of allergic rhinitis treatment within 2 weeks and recurrence index within 3 years after treatment

[0052]

[0053] *P<0.001

[0054] Table 1 shows the statistics of the effective rate after 2 weeks of treatment and the recurrence index within 3 years. From the data in Table 1, it can be seen that the total effective rate of allergic rhinitis in the control group after 2 weeks of treatment was 96.7%, and the total effective rate in the experimental group was 100%, and there was no statistically significant difference between the groups (P>0.05); the recurrence index of allergic rhinitis within 3 years after treatment was 4.77 in the control group and 0.07 in the experimental group, and the difference between the groups was statistically significant (P<0.001).

[0055] Table 2 shows the statistics of the relief time of allergic rhinitis symptoms. It can be seen from the data in Table 2 that after the start of treatment, compared with the control group, the sneezing and runny nose symptoms of the experimental group were relieved earlier (P < 0.05 or 0.01), the nasal itching was relieved later (P < 0.01), and there was no significant difference in the relief time of nasal congestion (P > 0.05).

[0056] Table 2: Time to onset of allergic rhinitis symptom relief (d)

[0057] Grouping n sneeze Clear runny nose Itchy nose Nasal congestion Comparison 30 3.9±0.9 4.5±1.4 3.3±0.9 3.9±0.9 experiment 28 2.3±0.8** 3.5±0.7* 4.9±0.8** 3.7±0.6

[0058] *P<0.05, **P<0.01

[0059] Based on Examples 1-2, this example tests the use of the single-flavor Chinese medicine powder spray for radically curing allergic rhinitis of the present invention, and the results show that:

[0060] (1) Allergic rhinitis attacks: Spray twice on the first day of treatment, once on the 2nd, 3rd and 8th day, and once in the 3rd and 5th week.

[0061] (2) Allergic rhinitis not yet in progress: intermittent nasal spray treatment 3 times, with an interval of 1 to 2 weeks.

[0062] From the above data, it can be seen that continuous treatment of budesonide nasal spray combined with oral desloratadine citrate for 2 weeks can control most of the symptoms of allergic rhinitis, but cannot cure it completely; spraying a small amount of saponin powder in the nasal cavity for several times can effectively control the symptoms of allergic rhinitis, and spraying it intermittently for several times can prevent the recurrence of allergic rhinitis for a long time. The product provided by the present invention, saponin, not only has the functions of reducing swelling and detoxification, warming the meridians and dredge the collaterals, and promoting blood circulation and removing blood stasis, but also can improve the local microenvironment of the nasal mucosa and cut off the biological process of the occurrence and development of allergic rhinitis; saponin can separate the IgE receptor FcεR1 on the sensitized mast cells from IgE, lose the ability to bind to allergens, briefly stimulate normal nasal secretion to cause sneezing reflex, help clear the nasal cavity, and improve nasal ventilation; after the saponin powder is processed with alum, the astringent effect is significant, which helps to improve the clear nasal discharge symptoms of allergic rhinitis.

[0063] The above contents are only for explaining the technical idea of ​​the present invention and cannot be used to limit the protection scope of the present invention. Any changes made on the basis of the technical solution in accordance with the technical idea proposed by the present invention shall fall within the protection scope of the claims of the present invention.

Claims

1. A single Chinese medicine powder spray for radically curing allergic rhinitis, characterized in that: The powder spray is composed of sapodilla powder, and the particle size of the sapodilla powder is less than 75 μm.

2. A single Chinese medicine powder spray for radically curing allergic rhinitis according to claim 1, characterized in that: The soapnut powder is derived from soapnuts that have been naturally dried for more than one year.

3. A single Chinese medicine powder spray for radically curing allergic rhinitis according to claim 1, characterized in that: The powder spray is an aerosol.

4. A method for preparing a single-flavor Chinese medicine powder spray for radically curing allergic rhinitis according to any one of claims 1 to 3, characterized in that: include: Cut the soap beans open to remove the seeds, cut into sections, prepare with alum solution, dry, crush and sieve to obtain a powder spray that can cure allergic rhinitis.

5. The method for preparing a single Chinese medicine powder spray for radically curing allergic rhinitis according to claim 4, characterized in that: The length of the soapberry segments is 0.5 to 1 cm.

6. The method for preparing a single Chinese medicine powder spray for radically curing allergic rhinitis according to claim 4, characterized in that: The alum solution is prepared, and the concentration of the alum solution is 200-300 g / L.

7. The method for preparing a single Chinese medicine powder spray for radically curing allergic rhinitis according to claim 4, characterized in that: In the alum preparation, the mass ratio of saponin to alum solution is 100-120:60-70.

8. The method for preparing a single Chinese medicine powder spray for radically curing allergic rhinitis according to claim 4, characterized in that: The drying temperature is 40° C. to 60° C., and the drying time is 10 h to 16 h.

9. The method for preparing a single Chinese medicine powder spray for radically curing allergic rhinitis according to claim 4, characterized in that: The mesh number of the medicine sieve used for the sieving is 200 meshes.

10. Use of the single Chinese medicine powder spray for radically curing allergic rhinitis according to claim 1 in preparing a drug for radically curing allergic rhinitis.

Images