Fluorescent flexible fiber membrane dosimeter as well as preparation method and application thereof

Abstract

The invention relates to a fluorescent flexible fiber membrane dosimeter and a preparation method and application thereof.The method comprises the following steps that 0.01-0.02 part of quinoline fluorescent dye is added into 100 parts of mixed solvent of tetrahydrofuran and N, N-dimethylformamide to be stirred for 30 minutes at the room temperature, then 10-15 parts of polyvinyl chloride powder is added to be stirred for 2 hours at the temperature of 50 DEG C, and after the quinoline fluorescent dye is completely dissolved, a fluorescent flexible fiber membrane is obtained; standing at room temperature to remove bubbles, and finally obtaining a uniform spinning solution; preparing the spinning solution into a fluorescent flexible fiber membrane dosimeter through an electrostatic spinning technology, wherein the electrostatic spinning parameters are as follows: the voltage is 10-18kV, the spinning distance is 13-15cm, the flow of the spinning solution is 3.5-5.5 ml / h, and the temperature is 20-40 DEG C; the fiber diameter of the fluorescent flexible fiber membrane dosimeter can reach 100 nm-900 nm, the linear response range can reach 0-350 Gy, and the fluorescent flexible fiber membrane dosimeter can be applied to ionizing radiation.

Description

Technical Field

[0001] The invention belongs to the technical field of polymer radiation chemistry, and in particular relates to a fluorescent flexible fiber membrane dosimeter and a preparation method and application thereof. Background Art

[0002] Since its discovery, X-rays have been widely used in the fields of medical treatment, industrial inspection, sterilization, security inspection and scientific research. At the same time, radiation protection for relevant personnel has become a global problem that urgently needs to be solved. In order to accurately calibrate the dose, many dosimeters have also been invented. For example, although the ionization chamber dosimeter has good accuracy and can read the dose directly, it requires connecting cables and providing high voltage. Thermoluminescent dosimeters can be used as point dose measurements, but the pretreatment and operation procedures are too complicated and require more readout and calibration time. However, for medical personnel, maintenance personnel and astronauts working in space who are exposed to ionizing radiation environments for a long time, their limbs and chests are the most exposed parts. The commercially available personal dosimeters carried are not only inconvenient to observe or uncomfortable to wear, but they can only monitor the environmental dose and cannot accurately measure these important parts of the body. If they can change according to the fluorescent color of the clothes or gloves they wear, they can avoid danger in time. Therefore, there is an urgent need for a flexible and wearable fluorescent X-ray dosimeter.

[0003] A polymer fluorescent film dosimeter is a solid film whose fluorescent color can change after being exposed to a certain dose of ionizing radiation. The film has the advantages of high sensitivity, wide dose response range and easy manufacturing, so it has broad application prospects. In the prior art, fluorescent quinoline dyes have the characteristics of changing from blue to red fluorescence when exposed to acid. After being compounded with PVC into a film, it has radiation response performance, but the sensitivity and linear range are not high, and the general film-forming method has great limitations, making it difficult to achieve lightweight and flexibility. With the increasing demand for flexible dosimeters, some polymer films prepared by solution method are too hard, and polymer fibers are gradually being used to manufacture film dosimeters. Ordinary spinning technology cannot produce ultrafine fibers. Dry spinning and wet spinning processes can usually obtain fibers with diameters between 5μm and 50μm, while electrospinning is a technology that can produce uniform nanofibers. Fibers produced by electrospinning technology have the advantages of good flexibility, uniform diameter, high specific surface area and high porosity. Producing flexible fluorescent nanofiber membranes by mixing polymers and fluorescent dyes and using electrospinning technology is an effective way to prepare ionizing radiation dosimeters. The new dosimeter obtained by combining electrospinning technology with fluorescent quinoline dye can achieve multiple advantages such as better flexibility, response sensitivity, and linear response range, and has significant advantages over existing technologies. Summary of the invention

[0004] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a fluorescent flexible fiber membrane dosimeter and a preparation method and application thereof, wherein the fluorescent fiber membrane dosimeter has a linear response in the range of 0-350Gy. In addition, the dosimeter also has the advantages of high sensitivity, stable performance, good flexibility and skin adhesion, and can be used in radiation medicine, scientific research and radiation industry.

[0005] In order to achieve the purpose of the present invention, the present invention will be implemented by adopting the technical solution described below.

[0006] A fluorescent flexible fiber membrane dosimeter is prepared by weight portions of 10-15 parts of polyvinyl chloride, 0.01-0.02 parts of fluorescent quinoline dye, and 100 parts of an organic solvent; wherein:

[0007] The structural formula of the fluorescent quinoline dye is:

[0008]

[0009] The fiber diameter of the fluorescent flexible fiber membrane dosimeter is 100nm to 900nm;

[0010] The linear dose response range of the fluorescent flexible fiber membrane dosimeter is 0 to 350 Gy;

[0011] The organic solvent is a mixture of tetrahydrofuran and N,N-dimethylformamide, and the mixing ratio is 5-7:3-5.

[0012] A method for preparing a fluorescent flexible fiber membrane dosimeter comprises the following steps:

[0013] S21, adding 0.01-0.02 parts of fluorescent quinoline dye to 100 parts of organic solvent, stirring and dissolving at room temperature, and after complete dissolution, adding 10-15 parts of polyvinyl chloride powder, stirring at 50° C. for 2 hours, and after complete dissolution, standing at room temperature to remove bubbles, and obtaining a uniform spinning solution; wherein the organic solvent is a mixture of tetrahydrofuran and N,N-dimethylformamide, and the mixing ratio is 5-7:3-5;

[0014] S22, using electrospinning technology to prepare the spinning solution obtained in step S21 into an electrospinning flexible fiber membrane, and completely volatilizing the solvent at room temperature; wherein the electrospinning parameters are voltage 10-18 kV, spinning distance 13-15 cm, spinning solution flow rate 3.5-5.5 ml / h, temperature 20-40° C.;

[0015] S23. Peeling the dried electrospun flexible fiber membrane off the aluminum foil to obtain a fluorescent flexible fiber membrane dosimeter, wherein the fiber diameter of the fluorescent flexible fiber membrane dosimeter is 100 nm to 900 nm and the dose linear response range is 0 to 350 Gy.

[0016] A fluorescent flexible fiber membrane dosimeter is used in measuring ionizing radiation. The fluorescent flexible fiber membrane dosimeter is prepared from 10-15 parts of polyvinyl chloride, 0.01-0.02 parts of fluorescent quinoline dye, and 100 parts of organic solvent in parts by weight; wherein:

[0017] The structural formula of the fluorescent quinoline dye is:

[0018]

[0019] The fiber diameter of the fluorescent flexible fiber membrane dosimeter is 100nm to 900nm;

[0020] The linear dose response range of the fluorescent flexible fiber membrane dosimeter is 0 to 350 Gy;

[0021] The organic solvent is a mixture of tetrahydrofuran and N,N-dimethylformamide, and the mixing ratio is 5-7:3-5.

[0022] As a preferred embodiment of the present invention, the fluorescent flexible fiber membrane dosimeter shows red fluorescence color after irradiation, and there is a gradient color difference as the irradiation dose changes, and the color change is obvious, which is easy to observe.

[0023] As a preferred embodiment of the present invention, the radiation source of the ionizing radiation is an X-ray tube.

[0024] As a preferred embodiment of the present invention, the dose rate of the ionizing radiation is 0.4 Gy / min-4.98 Gy / min.

[0025] As a preferred embodiment of the present invention, the fluorescent flexible fiber membrane dosimeter is used in radiation therapy.

[0026] As a preferred embodiment of the present invention, the fluorescent flexible fiber membrane dosimeter is used in scientific experiments.

[0027] As a preferred embodiment of the present invention, the fluorescent flexible fiber membrane dosimeter is used in the radiation industry.

[0028] As a preferred embodiment of the present invention, the fluorescent flexible fiber membrane dosimeter can be sewn on gloves and wearable devices, and is used for personal dose monitoring in radiation interventional therapy and high-risk radiochemical operation dangerous environments.

[0029] Beneficial Effects

[0030] 1. The fluorescent fiber membrane dosimeter made by the present invention adopts electrostatic spinning technology. The fiber membrane has good flexibility and can fit the skin. It has broad application prospects in radiation medicine and wearable dosimeters. It has the advantages of low weight, high sensitivity, easy preparation, stable performance, and easy measurement.

[0031] 2. The fluorescent fiber membrane dosimeter made by the present invention has a double emission peak in the blue region and the red region in its steady-state emission spectrum after irradiation. The linear relationship is established by using the fluorescence intensity ratio of the double peaks and the radiation dose. The dose response linear range is 0-350Gy. Compared with the volatilization film-forming method, the fluorescent fiber dosimeter prepared by spinning has a wider linear response range; on the other hand, since the fiber membrane has a larger surface area, its contact area with the air increases, and compared with the non-fiber membrane, the air can better penetrate into the material. Since oxygen can participate in and accelerate the radiation cracking of the polymer under radiation, the fiber membrane can produce more acid under the same radiation dose, making the acid-responsive fluorescent molecules respond more strongly; accordingly, the thinner the fiber membrane, the more acid it produces. The introduction of electrospinning achieves multiple effects of increasing response sensitivity and linear range while achieving flexibility, which is the benefit of the present invention relative to other fluorescent radiation dosimeters.

[0032] 3. Due to the improvement of response performance, compared with other reported fiber membrane fluorescence dosimeters with fluorescence brightness changes after irradiation, the fluorescent fiber membrane produced by the present invention exhibits strong blue fluorescence under 365nm excitation light when not irradiated, and the fluorescence color is red after irradiation, and there is a gradient color difference with the irradiation dose. The color changes are obvious, which is easy to observe, and can even be taken by mobile phones and other portable devices to achieve fast reading; BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 The response relationship between the double peak (red region emission peak and blue region emission peak) fluorescence intensity ratio of the thin film fluorescent flexible fiber membrane with different fiber thicknesses in the present invention and the radiation dose is compared with the solvent volatilization film-forming material;

[0034] Figure 2 These are photos of the fluorescent flexible fiber membrane of the present invention after being irradiated with different doses;

[0035] Figure 3 The present invention Figure 2 The color value (RGB value) of the photos of the medium fluorescent flexible fiber membrane after irradiation with different doses, the response relationship between the B / R value and the radiation dose;

[0036] Figure 4 It is a photo of a fluorescent flexible fiber membrane of a certain formula in the present invention after being irradiated with a lead plate covered with holes of different shapes to distinguish the irradiated area from the non-irradiated area, wherein the blue area is the non-irradiated area and the red area is the irradiated area;

[0037] Figure 5 Schematic diagram of visual sensing of protons generated by X-ray irradiated PVC by fluorescent quinoline groups. DETAILED DESCRIPTION

[0038] The embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. The following embodiments are implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operation processes are given, but the protection scope of the present invention is not limited to the following embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0039] As an embodiment of the present invention, a fluorescent flexible fiber membrane dosimeter is prepared by weight of 15 parts of polyvinyl chloride, 0.015 parts of fluorescent quinoline dye, 50 parts of tetrahydrofuran and 50 parts of N,N-dimethylformamide; wherein:

[0040] The structural formula of the fluorescent quinoline dye is:

[0041]

[0042] The fiber diameter of the fluorescent flexible fiber membrane dosimeter is 864nm;

[0043] The dose linear response range of the fluorescent flexible fiber membrane dosimeter is 0 to 350 Gy.

[0044] As an embodiment of the present invention, Figures 1 to 3 As shown, a method for preparing a fluorescent flexible fiber membrane dosimeter comprises the following steps:

[0045] First, 0.015 parts of quinoline fluorescent dye was added to a mixed solvent of 50 parts of tetrahydrofuran and 50 parts of N,N-dimethylformamide and stirred at room temperature for 30 minutes, and then 15 parts of polyvinyl chloride powder was added and stirred at 50°C for 2 hours. After complete dissolution, it was allowed to stand at room temperature to remove bubbles, and finally a uniform spinning solution was obtained.

[0046] The spinning solution was loaded into a 10 ml syringe and fixed on a syringe pump, with a voltage of 10 kV, a spinning distance of 15 cm, a spinning solution flow rate of 5.5 ml / h, and a temperature of 25 ° C. The needle was made to reciprocate at a uniform speed using a reciprocating pump to obtain a nanofiber dosimeter with uniform thickness. After winding, the fiber membrane was evaporated overnight at room temperature to ensure that the solvent was completely evaporated. The dried fiber membrane was peeled off from the aluminum foil to obtain a fluorescent flexible fiber membrane dosimeter.

[0047] After the fiber membrane dosimeter was placed in X-ray radiation, the fluorescence spectrum change was obtained by the microplate reader, and the double peak (red region emission peak and blue region emission peak) fluorescence intensity ratio was linearly fitted with the radiation dose. The linear response relationship between the fluorescence ratio intensity and the X-ray dose is shown in the following figure: Figure 1 The color of the film changes with the radiation dose under 365nm ultraviolet light excitation as shown in Figure 2 As shown in the figure, the response relationship between the B / R value and the radiation dose is as follows Figure 3 Lead plates with holes of different shapes are covered on the surface of the fiber membrane dosimeter and placed in the X-ray radiation field. The resulting photos are as shown in Figure 4 As shown, the blue area is the unirradiated area, and the red area is the irradiated area.

[0048] As an embodiment of the present invention, a fluorescent flexible fiber membrane dosimeter contains 10 parts of polyvinyl chloride powder, 0.01 parts of fluorescent quinoline dye, 60 parts of tetrahydrofuran and 40 parts of N,N-dimethylformamide by weight.

[0049] The structural formula of the fluorescent quinoline dye is:

[0050]

[0051] The fiber diameter of the fluorescent flexible fiber membrane dosimeter is 123nm;

[0052] The dose linear response range of the fluorescent flexible fiber membrane dosimeter is 0 to 350 Gy.

[0053] As an embodiment of the present invention, Figures 1 to 3 As shown, a method for preparing a fluorescent flexible fiber membrane dosimeter comprises the following steps:

[0054] First, 0.01 parts of quinoline fluorescent dye was added to a mixed solvent of 60 parts of tetrahydrofuran and 40 parts of N,N-dimethylformamide and stirred at room temperature for 30 minutes, and then 10 parts of polyvinyl chloride powder was added and stirred at 50°C for 2 hours. After complete dissolution, it was allowed to stand at room temperature to remove bubbles, and finally a uniform spinning solution was obtained.

[0055] The spinning solution was loaded into a 10 ml syringe and fixed on a syringe pump, with a voltage of 15 kV, a spinning distance of 13.5 cm, a spinning solution flow rate of 4 ml / h, and a temperature of 25°C. A reciprocating pump was used to make the needle move back and forth at a uniform speed to obtain a nanofiber dosimeter with uniform thickness. After winding, the fiber membrane was evaporated overnight at room temperature to ensure that the solvent was completely evaporated. The dried fiber membrane was peeled off from the aluminum foil to obtain a fluorescent flexible fiber membrane dosimeter.

[0056] After the fiber membrane dosimeter was placed in X-ray radiation, the fluorescence spectrum change was obtained by the microplate reader, and the double peak (red region emission peak and blue region emission peak) fluorescence intensity ratio was linearly fitted with the radiation dose. The linear response relationship between the fluorescence ratio intensity and the X-ray dose is shown in the following figure: Figure 1 shown.

[0057] As an embodiment of the present invention, a fluorescent flexible fiber membrane dosimeter contains 15 parts of polyvinyl chloride powder, 0.015 parts of fluorescent quinoline dye, 70 parts of tetrahydrofuran and 30 parts of N,N-dimethylformamide by weight.

[0058] The structural formula of the fluorescent quinoline dye is:

[0059]

[0060] The fiber diameter of the fluorescent flexible fiber membrane dosimeter is 540nm;

[0061] The dose linear response range of the fluorescent flexible fiber membrane dosimeter is 0 to 350 Gy.

[0062] As an embodiment of the present invention, a method for preparing a fluorescent flexible fiber membrane dosimeter comprises the following steps:

[0063] First, 0.015 parts of quinoline fluorescent dye was added to a mixed solvent of 70 parts of tetrahydrofuran and 30 parts of N,N-dimethylformamide and stirred at room temperature for 30 minutes, and then 15 parts of polyvinyl chloride powder was added and stirred at 50°C for 2 hours. After complete dissolution, it was allowed to stand at room temperature to remove bubbles, and finally a uniform spinning solution was obtained.

[0064] The spinning solution was loaded into a 10 ml syringe and fixed on a syringe pump, with a voltage of 15 kV, a spinning distance of 14 cm, a spinning solution flow rate of 5.5 ml / h, and a temperature of 25 ° C. The needle was made to reciprocate at a uniform speed using a reciprocating pump to obtain a nanofiber dosimeter with uniform thickness. After winding, the fiber membrane was evaporated overnight at room temperature to ensure that the solvent was completely evaporated. The dried fiber membrane was peeled off from the aluminum foil to obtain a fluorescent flexible fiber membrane dosimeter.

[0065] After the fiber membrane dosimeter was placed in X-ray radiation, the fluorescence spectrum change was obtained by the microplate reader, and the double peak (red region emission peak and blue region emission peak) fluorescence intensity ratio was linearly fitted with the radiation dose. The linear response relationship between the fluorescence ratio intensity and the X-ray dose is shown in the following figure: Figure 1 shown.

[0066] As an embodiment of the present invention, a fluorescent flexible fiber membrane dosimeter contains 12 parts of polyvinyl chloride powder, 0.024 parts of fluorescent quinoline dye, 50 parts of tetrahydrofuran and 50 parts of N,N-dimethylformamide by weight.

[0067] The structural formula of the fluorescent quinoline dye is:

[0068]

[0069] The fiber diameter of the fluorescent flexible fiber membrane dosimeter is 400nm;

[0070] The dose linear response range of the fluorescent flexible fiber membrane dosimeter is 0 to 350 Gy.

[0071] As an embodiment of the present invention, Figures 1 to 3 As shown, a method for preparing a fluorescent flexible fiber membrane dosimeter comprises the following steps:

[0072] First, 0.024 parts of quinoline fluorescent dye was added to a mixed solvent of 50 parts of tetrahydrofuran and 50 parts of N,N-dimethylformamide and stirred at room temperature for 30 minutes, and then 12 parts of polyvinyl chloride powder was added and stirred at 50°C for 2 hours. After complete dissolution, it was allowed to stand at room temperature to remove bubbles, and finally a uniform spinning solution was obtained.

[0073] The spinning solution was loaded into a 10 ml syringe and fixed on a syringe pump, with a voltage of 18 kV, a spinning distance of 14 cm, a spinning solution flow rate of 5.5 ml / h, and a temperature of 25 ° C. The needle was made to reciprocate at a uniform speed using a reciprocating pump to obtain a nanofiber dosimeter with uniform thickness. After winding, the fiber membrane was evaporated overnight at room temperature to ensure that the solvent was completely evaporated. The dried fiber membrane was peeled off from the aluminum foil to obtain a fluorescent flexible fiber membrane dosimeter.

[0074] As an embodiment of the present invention, a fluorescent flexible fiber membrane dosimeter is used in measuring ionizing radiation, wherein the components of the fluorescent flexible fiber membrane dosimeter are composed of 10-15 parts of polyvinyl chloride, 0.01-0.02 parts of fluorescent quinoline dye, and 100 parts of organic solvent in terms of weight; wherein:

[0075] The structural formula of the fluorescent quinoline dye is:

[0076]

[0077] The linear dose response range of the fluorescent flexible fiber membrane dosimeter is 0 to 350 Gy. Figure 2 shown.

[0078] As an embodiment of the present invention, Figure 2 and Figure 3As shown, after the fluorescent flexible fiber membrane dosimeter is irradiated with ionizing radiation, the fluorescent color and emission wavelength of the fluorescent flexible fiber membrane dosimeter change.

[0079] As an embodiment of the present invention, the radiation source of the ionizing radiation is an X-ray tube.

[0080] As an embodiment of the present invention, the dose rate of the ionizing radiation is 0.4 Gy / min-4.98 Gy / min.

[0081] As an embodiment of the present invention, Figure 4 As shown, the fluorescent flexible fiber membrane dosimeter can be used in radiation medicine, scientific research and radiation industry.

[0082] As an embodiment of the present invention, the fluorescent flexible fiber membrane dosimeter can be sewn on wearable devices such as gloves, and used for personal dose monitoring in dangerous environments such as radiation interventional treatment and high-risk radiochemical operations.

[0083] Figure 5 It is a schematic diagram of visual sensing of protons generated by X-ray irradiated PVC by fluorescent quinoline groups, indicating that in the prior art, the fluorescent quinoline dye used has the characteristic of being able to transform from blue to red fluorescence when exposed to acid.

[0084] The preferred embodiments of the present invention are described above with reference to the accompanying drawings, but the scope of the rights of the present invention is not limited thereto. Any modification, equivalent substitution and improvement made by a person skilled in the art without departing from the scope and essence of the present invention should be within the scope of the rights of the present invention.

Claims

1. A fluorescent flexible fiber membrane dosimeter, characterized in that: The fluorescent flexible fiber membrane dosimeter is prepared from 10-15 parts of polyvinyl chloride, 0.01-0.02 parts of fluorescent quinoline dye, and 100 parts of organic solvent in parts by weight; wherein: The structural formula of the fluorescent quinoline dye is: The fiber diameter of the fluorescent flexible fiber membrane dosimeter is 100nm to 900nm; The linear dose response range of the fluorescent flexible fiber membrane dosimeter is 0 to 350 Gy; The organic solvent is a mixture of tetrahydrofuran and N,N-dimethylformamide, and the mixing ratio is 5-7:3-5.

2. A method for preparing a fluorescent flexible fiber membrane dosimeter, characterized in that: The following steps are involved: S21, adding 0.01-0.02 parts of fluorescent quinoline dye to 100 parts of organic solvent, stirring and dissolving at room temperature, and after complete dissolution, adding 10-15 parts of polyvinyl chloride powder, stirring at 50° C. for 2 hours, and after complete dissolution, standing at room temperature to remove bubbles, and obtaining a uniform spinning solution; wherein the organic solvent is a mixture of tetrahydrofuran and N,N-dimethylformamide, and the mixing ratio is 5-7:3-5; S22, using electrospinning technology to prepare the spinning solution obtained in step S21 into an electrospinning flexible fiber membrane, and completely volatilizing the solvent at room temperature; wherein the electrospinning parameters are voltage 10-18 kV, spinning distance 13-15 cm, spinning solution flow rate 3.5-5.5 ml / h, temperature 20-40° C.; S23. Peeling the dried electrospun flexible fiber membrane off the aluminum foil to obtain a fluorescent flexible fiber membrane dosimeter, wherein the fiber diameter of the fluorescent flexible fiber membrane dosimeter is 100 nm to 900 nm and the dose linear response range is 0 to 350 Gy.

3. Application of a fluorescent flexible fiber membrane dosimeter in measuring ionizing radiation, characterized in that: The fluorescent flexible fiber membrane dosimeter is prepared from 10-15 parts of polyvinyl chloride, 0.01-0.02 parts of fluorescent quinoline dye, and 100 parts of organic solvent in parts by weight; wherein: The structural formula of the fluorescent quinoline dye is: The fiber diameter of the fluorescent flexible fiber membrane dosimeter is 100nm to 900nm; The linear dose response range of the fluorescent flexible fiber membrane dosimeter is 0 to 350 Gy; The organic solvent is a mixture of tetrahydrofuran and N,N-dimethylformamide, and the mixing ratio is 5-7:3-5.

4. The use of a fluorescent flexible fiber membrane dosimeter in measuring ionizing radiation according to claim 3, characterized in that: The fluorescent flexible fiber membrane dosimeter shows red fluorescence color after irradiation, and has gradient color difference along with the irradiation dose, and the color changes obviously, which is convenient for observation.

5. The use of a fluorescent flexible fiber membrane dosimeter in measuring ionizing radiation according to claim 3, characterized in that: The radiation source of the ionizing radiation is an X-ray tube.

6. The use of a fluorescent flexible fiber membrane dosimeter in measuring ionizing radiation according to claim 3, characterized in that: The dose rate of the ionizing radiation is 0.4 Gy / min-4.98 Gy / min.

7. Use of a fluorescent flexible fiber membrane dosimeter according to claim 3, 4, 5 or 6 in measuring ionizing radiation, characterized in that: The fluorescent flexible fiber membrane dosimeter is used in radiation medicine.

8. Use of a fluorescent flexible fiber membrane dosimeter according to claim 3, 4, 5 or 6 in measuring ionizing radiation, characterized in that: The application of the fluorescent flexible fiber membrane dosimeter in scientific experiments.

9. Use of a fluorescent flexible fiber membrane dosimeter according to claim 3, 4, 5 or 6 in measuring ionizing radiation, characterized in that: The fluorescent flexible fiber membrane dosimeter is used in radiation industry.

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