Traditional Chinese medicine concentrated pill melting process and equipment for treating chronic heart failure

Abstract

The invention belongs to the technical field of preparation of traditional Chinese medicine preparations, and particularly relates to a process and equipment for melting traditional Chinese medicine concentrated pills for treating chronic heart failure. The melting process comprises the following steps: pretreatment, extraction, melting, granulation and drying; a porous structure is formed by introducing gas in the melting step, so that the surface area of the traditional Chinese medicine concentrated pill can be increased, and the absorption rate of the medicine can be improved, because the larger surface area means that more medicine molecules can be in contact with liquid in the digestive tract, the dissolution and absorption of the medicine are accelerated; the porous structure can also help to control the release rate of the medicine, which is particularly important for the treatment of chronic diseases because the porous structure can provide a more continuous and controllable medicine release mechanism; meanwhile, due to the existence of the porous structure, water in the medicine particles can be diffused outwards through a plurality of paths, and more uniform drying can be achieved.

Description

Technical Field

[0001] The invention belongs to the technical field of preparation of traditional Chinese medicine preparations, and in particular relates to a melting process and equipment for traditional Chinese medicine concentrated pills for treating chronic heart failure. Background Art

[0002] Chronic heart failure is a serious heart disease that occurs when the heart cannot effectively pump enough blood to meet the body's needs. This condition causes fluid to accumulate in the lungs and other tissues, leading to symptoms such as difficulty breathing, fatigue and limb swelling. Traditionally, the treatment of chronic heart failure has mainly relied on Western medicine, but compared with it, Chinese medicine has received increasing attention due to its potential lower side effects, especially for patients with chronic diseases who need to take medication for a long time.

[0003] Although Chinese medicine has many advantages in the treatment of chronic heart failure, the traditional form of Chinese medicine (such as decoction) has some obvious disadvantages. For example, when the dosage needs to be finely adjusted, the decoction form is difficult to achieve precise control; at the same time, decoctions usually require decocting, which is time-consuming and complicated, and may affect patients' willingness to continue using it. In view of these limitations, Chinese medicine concentrated pills came into being, with the aim of improving the convenience of taking and the accuracy of dosage.

[0004] The preparation methods of concentrated Chinese medicine pills mainly include panning and molding. Panning is to boil and extract some Chinese medicine and concentrate it into paste, which is used as a binder and evenly mixed with other Chinese medicine powders. Then water or ethanol of different concentrations is used as a wetting agent and the pills are made by hand or machine. The molding method is to mix the concentrated paste with the fine powder of other medicinal materials, and then add appropriate water, ethanol and other binders to make pills of appropriate hardness and softness. The pills are squeezed and made into pills by machine, and then the wet pills are dried and coated.

[0005] Although both methods have their own advantages and disadvantages, they both have some common problems. First, current pill-making equipment usually operates independently, which means that the medicinal materials need to be transferred multiple times between different machines (such as trough mixers, medicine refining machines, pill-making machines, etc.) before they become the final concentrated pills. This multi-step operation process is not only inefficient, but also easily introduces impurities during transportation, increasing the risk of cross-contamination.

[0006] Secondly, most existing melting processes use direct heating. However, many Chinese herbal medicines contain heat-sensitive active ingredients that are easily decomposed and ineffective at high temperatures. If the temperature is not properly controlled or the heating is uneven during the melting process, it may lead to the loss of active ingredients, thus affecting the quality and consistency of the final product.

[0007] Finally, during the drying stage, uneven distribution of temperature and humidity in the granules is also a thorny issue. If the drying conditions are not properly controlled, some areas may crack due to over-drying, while other areas may have too much residual moisture due to under-drying. This uneven drying condition will directly affect the quality stability of the TCM concentrated pills, including important characteristics such as its shelf life and bioavailability. Summary of the invention

[0008] In view of this, the purpose of the present invention is to provide a melting process and equipment for Chinese medicine concentrated pills for treating chronic heart failure, which forms a porous structure by injecting gas during the melting and mixing process. Specifically, the medicinal material extract and the molten auxiliary material are mixed evenly through the stirring of the stirring paddle and the injection of gas, and a porous structure is formed. The formation of this porous structure not only improves the absorption rate of the drug, but also improves the dispersibility of the drug, thereby optimizing the dissolution and release effect of the drug in the body.

[0009] In order to solve the above technical problems, the technical solution 1 of the present invention is a melting process of a Chinese medicine concentrated pill for treating chronic heart failure. The Chinese medicine prescription for treating chronic heart failure is composed of the following raw materials in percentage by mass: 2.1%-4.3% datura flower, 0.8%-2.5% ginseng, 1%-4% pilose antler, 6%-10.2% cinnamon, 52%-60% aconite, 16%-28% notoginseng, 0.08%-0.15% borneol, 0.1%-0.25% musk, and 0.1%-0.18% toad venom. The melting process comprises the following steps:

[0010] S1. Pretreatment: According to the Chinese medicine prescription for treating chronic heart failure, weigh each medicinal material separately and set aside;

[0011] S2, extraction: extracting datura flower, ginseng and half of Panax notoginseng with ethanol, concentrating and drying to obtain datura flower paste, ginseng paste and Panax notoginseng paste; extracting aconite with water and ethanol precipitation, concentrating and drying to obtain aconite paste; extracting cinnamon volatile oil from cinnamon, extracting with water, concentrating and drying to obtain cinnamon paste;

[0012] The antler, borneol, musk and the remaining Panax notoginseng are crushed and the toad venom is ground to obtain antler fine powder, borneol fine powder, musk fine powder, Panax notoginseng fine powder and toad venom fine powder, which are set aside;

[0013] S3, melting: mixing datura flower dry paste, ginseng dry paste, notoginseng dry paste, aconite dry paste, cinnamon dry paste, pilose antler powder, borneol powder, musk powder, notoginseng powder, toad venom powder and cinnamon volatile oil with melting auxiliary materials, and heating to a molten state to form a uniform melt; introducing gas during the mixing process to form a porous structure of the melt;

[0014] S4, granulation: the melt is extruded and cut into pellets;

[0015] S5. Drying: Drying the prepared pills to obtain dried concentrated Chinese medicine pills.

[0016] Preferably, the extraction of cinnamon in the extraction adopts steam distillation or supercritical carbon dioxide extraction to obtain cinnamon volatile oil.

[0017] Preferably, the container used to mix the medicinal material extract and the molten auxiliary material is in a sealed state during the melting.

[0018] In order to solve the above technical problems, the second technical solution of the present invention is a Chinese medicine concentrated pill, which is prepared by the melting process described in the first technical solution, and has a porous structure.

[0019] In order to solve the above technical problems, the third technical solution of the present invention is a melting device for Chinese medicine concentrated pills for treating chronic heart failure, the melting device is used to realize the melting step and granulation step in the melting process described in the first technical solution, the melting device includes a container, the container is used to hold materials; a cover plate, a connecting disk is provided on the cover plate, and the connecting disk and the cover plate are concentrically rotatably connected; a stirring paddle, the stirring paddle is used for mixing and stirring the medicinal material extract with the molten auxiliary material during the melting step; the stirring paddle is arranged at the bottom end of the connecting disk and driven by the connecting disk, the stirring paddle is composed of a rotating shaft and a stirring member, a gas channel is provided in the rotating shaft and is connected to the connecting disk, and an outlet connected to the gas channel is provided on the stirring member; gas is introduced through the gas channel when the materials are melted, mixed and stirred, so that the molten material forms a porous structure; through the injection and dispersion of gas, the molten material is mixed evenly and the melting temperature of the material is uniform.

[0020] Preferably, the melting equipment also includes a gas collecting tank, the cover plate and the container are sealed, and the gas channel on the rotating shaft is connected to the gas collecting tank; an exhaust valve is provided on the cover plate, and the exhaust valve is connected to the gas collecting tank; when the materials are melted, mixed and stirred, gas is introduced, and the gas is injected into the melt through the gas channel from the gas collecting tank, and the gas emitted from the melt returns to the gas collecting tank through the exhaust valve.

[0021] Preferably, the melting equipment also includes an installation box, on which a first bevel gear and a second bevel gear are provided; a transmission shaft is provided on the connecting plate, on which a third bevel gear is provided; the first bevel gear is provided with an independent driving motor, and the second bevel gear is a transmission gear between the first bevel gear and the third bevel gear; the connecting plate drives the rotation of the stirring paddle by the first bevel gear, the second bevel gear and the third bevel gear; the installation box is sealed and provided with an air inlet, and the transmission shaft has an air inlet circuit connected to the gas channel, and the gas passes through the air inlet and the air inlet circuit in turn to reach the gas channel; the installation box allows the stirring paddle to be introduced with gas while it is rotating, so that the gas is introduced into the material when it is melted, mixed and stirred.

[0022] Furthermore, the melting equipment also includes a cutter; an extrusion port is opened on the cover plate, and the extrusion port is used for extruding material in the granulation step; the cutter is arranged at the top of the cover plate and driven by the connecting disk, and the cutter is used for the cutting action in the granulation step; the molten material is squeezed out of the extrusion port by pressing down the cover plate, and is cut by the cutter to form pills.

[0023] Furthermore, the melting device also includes a stirring baffle and an extrusion baffle; the melting device can switch between a stirring state and an extrusion state; when the melting device is used to process the melting step in the melting process, the melting device is in a stirring state; when the melting device is used to process the granulation step in the melting process, the melting device is in an extrusion state; when the melting device is in a stirring state, the connecting plate is connected to the stirring paddle, and the extrusion port is blocked by the stirring baffle; when the melting device is in an extrusion state, the connecting plate is connected to the cutter, and the intake circuit is blocked by the extrusion baffle.

[0024] Furthermore, the melting equipment also includes a frame, which is composed of a lifting column, a mounting plate and a telescopic cylinder; the mounting plate is used to connect and fix the drive motor and the mounting box, and the mounting plate is controlled to rise and fall by the lifting column; the telescopic cylinder is installed on the mounting plate and connected to the cover plate, and the lifting column and the telescopic cylinder control the cover plate to extrude and discharge the molten material.

[0025] The technical effects of the present invention are mainly reflected in the following aspects: the melting process and melting equipment of the present invention form a porous structure by introducing gas when the melt is stirred, which can not only increase the surface area of ​​the Chinese medicine concentrated pills, but also help to improve the absorption rate of the drug, because a larger surface area means that more drug molecules can contact the liquid in the digestive tract, thereby accelerating the dissolution and absorption of the drug. At the same time, through the injection and emission of gas, a phenomenon similar to boiling can be produced; the bubbles formed by the gas stir the melt during the rising process, promote the full mixing of the medicinal material extract and the molten excipients, and ensure the uniformity of the mixing; the introduction of gas can promote heat exchange inside the melt, so that the heat is more evenly distributed throughout the melt.

[0026] The melting equipment realizes the rapid conversion between different processes through the connection of the connecting plate with the stirring paddle or the cutter, and the blocking effect of the stirring baffle and the extrusion baffle. This design makes the production process smoother and reduces the waiting time and manual intervention between processes. The connecting plate can drive both the stirring paddle and the cutter; the stirring baffle and the extrusion baffle block the extrusion port and the air intake circuit respectively, ensuring the independence and effectiveness of different processes, and realizing continuous and integrated production from melt mixing to granulation. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a structural diagram of the present invention;

[0028] Figure 2 is a cross-sectional view of the present invention;

[0029] Figure 3 for Figure 1 Structural diagram of the middle cover plate and the installation box;

[0030] Figure 4 for Figure 2 Schematic diagram of the structure of the middle cover plate and the stirring paddle;

[0031] Figure 5 for Figure 1 Structural sectional view of the middle installation box;

[0032] Figure 6 for Figure 1 Schematic diagram of the structure of the middle cover plate and the cutter;

[0033] Figure 7 for Figure 1 Schematic diagram of the structure of the middle rack;

[0034] Figure 8 It is a schematic diagram of the coordination of the container and the gas collecting tank in the present invention;

[0035] In the figure: 1. container; 2. cover plate, 21. connecting plate, 22. extrusion port; 3. stirring paddle, 31. rotating shaft, 32. stirring member, 33. gas channel, 34. gas outlet; 4. mounting box, 41. first bevel gear, 42. second bevel gear, 43. transmission shaft, 44. third bevel gear, 45. air inlet, 46. air inlet circuit; 5. cutter, 51. collecting hopper; 6. frame, 61. lifting column, 62. mounting plate, 63. telescopic cylinder; 7. exhaust valve; 8. gas collecting tank. DETAILED DESCRIPTION

[0036] The specific implementation modes of the present invention are further described below in conjunction with the accompanying drawings to make the technical solutions of the present invention easier to understand and grasp.

[0037] In this embodiment, it should be understood that the terms "middle", "upper", "lower", "top", "right", "left end", "above", "back", "middle", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0038] In addition, in this specific embodiment, if the connection or fixing method between components is not specifically described, the connection or fixing method can be through bolt fixing or pin fixing, or pin shaft connection and the like commonly used in the prior art, and therefore, it will not be described in detail in this embodiment.

[0039] Embodiment 1

[0040] A melting process for a concentrated Chinese medicine pill for treating chronic heart failure. The Chinese medicine prescription for treating chronic heart failure is composed of the following raw materials in percentage by mass: 2.1%-4.3% datura flower, 0.8%-2.5% ginseng, 1%-4% pilose antler, 6%-10.2% cinnamon bark, 52%-60% aconite root, 16%-28% notoginseng, 0.08%-0.15% borneol, 0.1%-0.25% musk, and 0.1%-0.18% toad venom. The melting process comprises the following steps:

[0041] S1. Pretreatment: According to the Chinese medicine prescription for treating chronic heart failure, weigh each medicinal material separately and set it aside; the pretreatment is mainly to remove impurities in the medicinal materials to ensure the quality of the medicinal materials, and it may also change the properties of the medicinal materials to make them more suitable for subsequent extraction processes. Specifically, when washing the medicinal materials, the water temperature can be controlled between 20-30℃; for medicinal materials that need to be coarsely crushed for extraction (such as Panax notoginseng and Aconitum), special equipment should be used, and check whether the coarse crushing is complete.

[0042] S2, extraction: datura flower, ginseng and half of panax notoginseng are extracted with ethanol, and datura flower paste, ginseng paste and panax notoginseng paste are obtained by concentration and drying; aconite is extracted by water extraction and alcohol precipitation method, and aconite paste is obtained by concentration and drying; cinnamon volatile oil is extracted from cinnamon, and cinnamon volatile oil is obtained by steam distillation or supercritical carbon dioxide extraction, and then water extraction is performed, concentrated and dried to obtain cinnamon dry paste; antler, borneol, musk, remaining panax notoginseng and toad venom are crushed and ground to obtain antler powder, borneol powder, musk powder, panax notoginseng powder and toad venom powder for standby use; the selectivity of multiple extraction methods can be used to select the most appropriate method according to the characteristics of specific medicinal materials to maximize the retention of the effective ingredients of the medicinal materials. Specifically, during ethanol extraction, the ethanol concentration is 50%-70%, the extraction temperature is 50-60°C, and the extraction time is 2-4 hours. When water extraction and alcohol precipitation are used, boiling water is used for extraction for 1-2 hours, and then ethanol is added until the solution concentration reaches 60%-70%, and the solution is allowed to stand overnight, and centrifuged the next day. When steam distillation is used, the temperature is controlled at around 100°C, and the distillation time is 1-3 hours. When supercritical CO2 extraction is used, the pressure range is 20-40MPa, the temperature is 30-50°C, and the flow rate can be adjusted according to the equipment.

[0043] S3, melting: Mix the datura flower paste, ginseng paste, notoginseng paste, aconite paste, cinnamon paste, antler powder, borneol powder, musk powder, notoginseng powder and toad venom powder with the melting auxiliary materials, and heat them to a molten state to form a uniform melt; introduce gas during the mixing process to form a porous structure in the melt; during the melting, the vessel used to mix the medicinal material extract and the melting auxiliary materials is in a sealed state. By introducing gas to form a porous structure, the surface area of ​​the concentrated Chinese medicine pills can be increased, which is conducive to improving the absorption rate of the drug because a larger surface area means that more drug molecules can contact the liquid in the digestive tract, thereby accelerating the dissolution and absorption of the drug. The porous structure can also help control the release rate of the drug, which is particularly important for the treatment of chronic diseases because it can provide a more continuous and controllable drug release mechanism. In addition, mixing in a sealed state helps prevent the entry of external impurities and reduce the possibility of contamination. The gas used can be selected from nitrogen, carbon dioxide, compressed air or steam according to actual production needs. Each gas has its specific application characteristics and advantages. Choosing the right gas can improve the production efficiency, product quality and safety of Chinese medicine concentrated pills.

[0044] S4, granulation: the melt is extruded and cut into pellets;

[0045] S5. Drying: The prepared pills are dried to obtain dried concentrated Chinese medicine pills. During the melting step, the melt is formed into a porous structure by introducing gas. During the drying process, if the moisture inside the drug particles cannot be discharged in time, it may cause internal and external pressure difference, which may cause the particles to crack or deform. The porous structure provides multiple channels for moisture to escape, which can effectively alleviate this problem and ensure that the shape of the pills is intact after drying. At the same time, the porous structure helps to accelerate the evaporation rate of water, thereby shortening the drying time. This not only improves production efficiency, but also helps to reduce energy consumption. Due to the presence of the porous structure, the moisture inside the drug particles can diffuse outward through multiple paths, which helps to achieve more uniform drying. Uniform drying can ensure that the moisture content of the pills is consistent after drying, avoid excessive drying or moisture in some areas, and thus ensure the quality stability of the product. Specifically, the drying temperature is generally controlled at 50-60°C to prevent the active ingredients from being destroyed; the drying time is generally 6-12 hours depending on the size of the pills and the initial water content.

[0046] Embodiment 2

[0047] A concentrated Chinese medicine pill, characterized in that the concentrated Chinese medicine pill is made by the melting process described in Example 1, and the concentrated Chinese medicine pill has a porous structure.

[0048] (I) Decomposition rate comparison experiment

[0049] The purpose of this experiment is to verify the effect of gas injection to form a porous structure during stirring on the absorption rate and dispersibility of drugs; by comparing the decomposition rates of the concentrated Chinese medicine pills prepared by traditional process and the concentrated Chinese medicine pills with a porous structure formed by gas injection in this embodiment in artificial gastric fluid (Simulated Gastric Fluid, SGF) and artificial small intestinal fluid (Simulated Intestinal Fluid, SIF), the effect of gas injection on the absorption rate and dispersibility of drugs was evaluated.

[0050] First, the same number of concentrated Chinese medicine pills prepared by traditional process and the concentrated Chinese medicine pills in this embodiment are prepared. The concentrated Chinese medicine pills prepared by traditional process are not gas-passed during pill making, while the concentrated Chinese medicine pills in this embodiment are gas-passed during melting.

[0051] Artificial gastric juice test: artificial gastric juice (pH 1.2) was added to the dissolution apparatus, the temperature was set to 37°C, and the traditional Chinese medicine concentrated pills prepared by the traditional process and the traditional Chinese medicine concentrated pills in this embodiment were placed in the dissolution apparatus respectively. The drug decomposition at different time points was recorded.

[0052] Artificial intestinal fluid test: artificial intestinal fluid (pH 6.8) was added to the dissolution apparatus, the temperature was set to 37°C, and the traditional Chinese medicine concentrated pills prepared by the conventional process and the traditional Chinese medicine concentrated pills in this embodiment were placed in the dissolution apparatus respectively. The drug decomposition at different time points was recorded.

[0053] The test results are as follows:

[0054] (I) Artificial gastric juice and traditional Chinese medicine concentrated pills:

[0055] 5 minutes: Traditional Chinese medicine concentrated pills show almost no obvious signs of decomposition in artificial gastric juice;

[0056] 10 minutes: A small amount of medicine begins to dissolve on the surface of the pill;

[0057] 20 minutes: The surface of the pill gradually dissolves, but there is almost no obvious sign of decomposition of the drug inside;

[0058] 30 minutes: The surface of the pill is completely dissolved, and a small amount of the internal medicine begins to dissolve;

[0059] 60 minutes: Most of the drug has dissolved, but some stubborn areas remain.

[0060] (ii) Artificial gastric juice and the Chinese medicine concentrated pills of this embodiment:

[0061] 5 minutes: The surface of the pills began to erode, with a small amount of decomposition signs;

[0062] 10 minutes: The surface of the pill gradually dissolves, but there is almost no obvious sign of decomposition of the drug inside;

[0063] 20 minutes: The surface of the pill is completely dissolved, and a small amount of the drug inside begins to dissolve;

[0064] 30 minutes: Most of the drug has dissolved, but some stubborn areas remain.

[0065] 60 minutes: The pill is almost completely dissolved.

[0066] (III) Artificial small intestinal fluid and traditional Chinese medicine concentrated pills:

[0067] 5 minutes: The surface of the pills began to erode, with a small amount of decomposition signs;

[0068] 10 minutes: The surface of the pill gradually dissolves, but there is almost no obvious sign of decomposition of the drug inside;

[0069] 20 minutes: The surface of the pill is completely dissolved, and a small amount of the drug inside begins to dissolve;

[0070] 30 minutes: Most of the drug has dissolved, but some stubborn areas remain.

[0071] 60 minutes: The pill is almost completely dissolved.

[0072] (IV) Artificial small intestinal fluid and the Chinese medicine concentrated pills of this embodiment:

[0073] 5 minutes: The surface of the pill is largely dissolved, but there is almost no obvious sign of decomposition of the drug inside;

[0074] 10 minutes: The surface of the pill is completely dissolved, and a small amount of the internal medicine begins to dissolve;

[0075] 20 minutes: Most of the drug has dissolved, but some stubborn areas remain.

[0076] 30 minutes: The pills are almost completely dissolved;

[0077] 60 minutes: The pill is almost completely dissolved.

[0078] The above experimental results show that the decomposition rate of the concentrated Chinese medicine pills in this embodiment in artificial gastric juice and artificial small intestinal juice is higher than that of the concentrated Chinese medicine pills prepared by traditional processes, which indicates that the porous structure formed by gas injection does improve the absorption rate and dispersibility of the drug.

[0079] Embodiment 3

[0080] See also Figure 1 , Figure 2, a Chinese medicine concentrated pill melting device for treating chronic heart failure, the melting device is used to implement the melting step and granulation step in the melting process of the embodiment 1, the melting device comprises: a container 1, the container 1 is used to hold materials; a cover plate 2, the cover plate 2 is provided with a connecting plate 21, the connecting plate 21 and the cover plate 2 are connected in a concentric rotation; a stirring paddle 3, the stirring paddle 3 is used in the melting step, the medicinal material extract is mixed and stirred with the melting auxiliary material; the stirring paddle 3 is arranged at the bottom end of the connecting plate 21 and driven by the connecting plate 21, the stirring paddle 3 is composed of a rotating shaft 31 and a stirring member 32, the rotating shaft 31 is provided with a gas channel 33 and connected to the connecting plate 21, and the stirring member 32 is provided with an outlet 34 connected to the gas channel 33; the design of the stirring paddle 3 not only realizes the mixing of materials, but also can inject gas during the mixing process through the built-in gas channel 33 and the outlet 34. The injection of gas causes the melt to form a porous structure, which increases the surface area of ​​the pill. By injecting gas to form a porous structure during the stirring process, not only can the absorption rate of the drug be increased, but also the dispersibility of the drug in the digestive tract can be improved. This design solves the problem of absorption rate of traditional Chinese medicine concentrated pills. Gas is introduced through the gas channel 33 during the melting, mixing and stirring of the materials, so that the melt forms a porous structure; through the injection and dispersion of the gas, the melt is mixed evenly and the melting temperature of the material is uniform.

[0081] Specifically, the injection of gas not only helps to form a porous structure, but also helps to mix the materials more evenly and ensure the consistency of the melting temperature; through the uniform distribution of gas, local overheating can be avoided, thereby protecting heat-sensitive components from being destroyed; this is especially important for traditional Chinese medicine containing heat-sensitive components. The gas outlet 34 is set on the stirring member 32, which not only improves the stirring efficiency, but also makes the formation of the porous structure more controllable, ensuring the uniformity of mixing and the consistency of the porous structure. At the same time, the gas is introduced into the stirring paddle 3 through the gas channel 33, and the gas forms bubbles in the melt and rises, which is similar to the boiling phenomenon; the bubbles formed by the gas stir the melt during the rising process, which promotes the full mixing of the medicinal material extract and the molten excipients, and ensures the uniformity of mixing. The introduction of gas can promote heat exchange inside the melt, so that the heat is more evenly distributed throughout the melt.

[0082] See also Figure 8 The melting equipment also includes a gas collecting tank, the cover plate 2 and the container 1 are sealed, the gas channel 33 on the rotating shaft 31 is connected to the gas collecting tank; the cover plate 2 is provided with an exhaust valve connected to the gas collecting tank; when the materials are melted, mixed and stirred, gas is introduced, and the gas is injected into the melt from the gas collecting tank through the gas channel 33, and the gas emitted from the melt returns to the gas collecting tank through the exhaust valve.

[0083] Specifically, the sealed connection between the cover plate 2 and the container 1, and the connection between the exhaust valve and the gas collecting tank, constitute a closed gas circulation system. This ensures the recycling of gas, avoids gas waste, and reduces environmental pollution; at the same time, the closed system helps prevent the entry of external impurities and improves the cleanliness of drug production. Through the coordination of the gas collecting tank and the exhaust valve, the injection and discharge amounts of gas can be accurately controlled, thereby better controlling the formation of bubbles in the melt and ensuring the consistency and controllability of the porous structure.

[0084] See also Figure 3 , Figure 5 The melting equipment also includes an installation box 4, on which a first bevel gear 41 and a second bevel gear 42 are provided; a transmission shaft 43 is provided on the connecting plate 21, and a third bevel gear 44 is provided on the transmission shaft 43; the first bevel gear 41 is provided with an independent driving motor, and the second bevel gear 42 is a transmission gear between the first bevel gear 41 and the third bevel gear 44; the first bevel gear 41, the second bevel gear 42 and the third bevel gear 44 realize the connection plate 21 driving the stirring paddle 3 to rotate; the installation box 4 is sealed and provided with an air inlet 45, and the closed air intake system can prevent external impurities from entering and ensure the purity of the gas. The transmission shaft 43 has an air intake circuit 46 connected to the gas channel 33, and the gas passes through the air inlet 45 and the air intake circuit 46 in turn to reach the gas channel 33; the stirring paddle 3 can be fed with gas while rotating through the installation box 4, so that the material can be fed with gas when it is melted, mixed and stirred.

[0085] See also Figure 6 The melting device also includes a cutter 5; the cover plate 2 is provided with an extrusion port 22, which is used for extrusion discharge in the granulation step; the cutter 5 is arranged at the top of the cover plate 2 and driven by the connecting disk 21, and the cutter 5 is used for cutting in the granulation step; the design of the extrusion port 22 and the cutter 5 enables the melt to be continuously extruded and cut into pills. The melt is extruded from the extrusion port 22 by pressing down the cover plate 2, and is cut by the cutter 5 to form pills. The melting device also includes a collecting hopper 51 and a suction pipe; the collecting hopper 51 is arranged at the non-cutting surface of the cutter 5, and the collecting hopper 51 is used to collect the granulated pills, and the suction pipe is arranged on the side wall of the container 1, and the suction pipe is used to remove the granulated pills from the collecting hopper 51.

[0086] Specifically, by arranging the extrusion port 22 and the cutter 5 on the cover plate 2, an integrated operation from melt mixing to granulation is realized. And it is combined with the stirring paddle 3 and the gas circulation system to realize continuous and integrated production from melt mixing to granulation. Not only the production efficiency and product quality of the concentrated Chinese medicine pills are improved, but also the safety and environmental protection of the operation are improved through the closed system design. The melt is made into pills by the cutter 5, and under the action of the centrifugal force of the rotation of the cutter 5, the pills can be moved to the side of the collecting hopper 51 close to the side wall of the container 1, and then the pills in the collecting hopper 51 are removed by the suction pipe.

[0087] See also Figure 1 , Figure 2 , Figure 7 , the melting device also includes a stirring baffle and an extrusion baffle; the melting device can switch between a stirring state and an extrusion state; when the melting device is used to process the melting step in the melting process, the melting device is in a stirring state; when the melting device is used to process the granulation step in the melting process, the melting device is in an extrusion state; when the melting device is in a stirring state, the connecting plate 21 is only connected to the stirring paddle 3, and the extrusion port 22 is blocked by the stirring baffle; when the melting device is in an extrusion state, the connecting plate 21 is only connected to the cutter 5, and the intake circuit 46 is blocked by the extrusion baffle.

[0088] Specifically, when the melting device is in a stirring state, the connecting plate 21 is only connected to the stirring paddle 3. If new materials need to be added during the stirring process, the cover plate 2 can be removed by connecting the inner and outer sides of the container 1 through the exhaust valve. After the stirring operation is completed, the stirring paddle 3 is removed from the connecting plate 21, and the connecting plate 21 is connected only to the cutter 5. At this time, the exhaust valve is in a closed state; the material is extruded through the action of the lifting column 61 and the telescopic cylinder 63, and the cutter 5 is used for cutting. After the granulation operation is completed, the cover plate 2 can be removed by opening the exhaust valve to connect the inner and outer sides of the container 1 so as to clean the inside of the container 1. The connection between the connecting plate 21 and the stirring paddle 3 or the cutter 5, as well as the blocking effect of the stirring baffle and the extrusion baffle, realizes the rapid conversion of the equipment between different processes. This design makes the production process smoother and reduces the waiting time and manual intervention between processes. The connecting plate 21 can drive both the stirring paddle 3 and the cutting knife 5; the stirring baffle and the extrusion baffle respectively block the extrusion port 22 and the air intake circuit 46, ensuring the independence and effectiveness of different processes and realizing continuous and integrated production from melt mixing to granulation.

[0089] See also Figure 7The melting device also includes a frame 6, which is composed of a lifting column 61, a mounting plate 62 and a telescopic cylinder 63; the mounting plate 62 is used to connect and fix the drive motor and the mounting box 4, and the mounting plate 62 is controlled to rise and fall by the lifting column 61; the telescopic cylinder 63 is installed on the mounting plate 62 and connected to the cover plate 2, and the lifting column 61 and the telescopic cylinder 63 control the cover plate 2 to extrude the molten material.

[0090] Specifically, through the cooperation of the lifting column 61 and the telescopic cylinder 63, the position of the cover plate 2 can be accurately controlled to ensure that the molten material can be accurately extruded from the extrusion port 22; this not only improves the accuracy of the operation, but also enhances the degree of automation of the equipment. At the same time, it also realizes the automatic switching between the stirring state and the extrusion state. This automatic switching mechanism greatly improves the production efficiency, reduces the need for manual intervention, and makes the production process smoother and more efficient.

[0091] In addition, as common knowledge in the industry, the lifting column 61, telescopic cylinder 63, gas collecting tank 8, exhaust valve 7 and driving motor mentioned above are common knowledge, so their principles and structures will not be described in detail.

[0092] Of course, the above are only typical examples of the present invention. In addition, the present invention may also have many other specific implementations. All technical solutions formed by equivalent replacement or equivalent transformation fall within the scope of protection required by the present invention.

Claims

1. A melting process for a concentrated Chinese medicine pill for treating chronic heart failure, wherein the Chinese medicine prescription for treating chronic heart failure is composed of the following raw materials in percentage by mass: 2.1%-4.3% datura flower, 0.8%-2.5% ginseng, 1%-4% pilose antler, 6%-10.2% cinnamon bark, 52%-60% aconite root, 16%-28% notoginseng, 0.08%-0.15% borneol, 0.1%-0.25% musk, and 0.1%-0.18% toad venom, characterized in that: The melting process comprises the following steps: S1. Pretreatment: According to the Chinese medicine prescription for treating chronic heart failure, weigh each medicinal material separately and set aside; S2, extraction: extracting datura flower, ginseng and half of Panax notoginseng with ethanol, concentrating and drying to obtain datura flower paste, ginseng paste and Panax notoginseng paste; extracting aconite with water and ethanol precipitation, concentrating and drying to obtain aconite paste; extracting cinnamon volatile oil from cinnamon, extracting with water, concentrating and drying to obtain cinnamon paste; The antler, borneol, musk and the remaining Panax notoginseng are crushed and the toad venom is ground to obtain antler fine powder, borneol fine powder, musk fine powder, Panax notoginseng fine powder and toad venom fine powder, which are set aside; S3, melting: mixing datura flower dry paste, ginseng dry paste, notoginseng dry paste, aconite dry paste, cinnamon dry paste, pilose antler powder, borneol powder, musk powder, notoginseng powder, toad venom powder and cinnamon volatile oil with melting auxiliary materials, and heating to a molten state to form a uniform melt; introducing gas during the mixing process to form a porous structure of the melt; S4, granulation: the melt is extruded and cut into pellets; S5. Drying: Drying the prepared pills to obtain dried concentrated Chinese medicine pills.

2. The process for melting concentrated Chinese medicine pills according to claim 1, characterized in that: The extraction of cinnamon in the extraction adopts steam distillation method or supercritical carbon dioxide extraction method to obtain cinnamon volatile oil.

3. The process for melting concentrated Chinese medicine pills according to claim 1, characterized in that: During the melting process, the container used to mix the medicinal material extract and the melting auxiliary material is in a sealed state.

4. A Chinese medicine concentrated pill, characterized in that: The concentrated Chinese medicine pills are prepared by the melting process described in any one of claims 1 to 3, and the concentrated Chinese medicine pills have a porous structure.

5. A melting device for concentrated Chinese medicine pills for treating chronic heart failure, the melting device is used to implement the melting step and granulation step in the melting process as described in claims 1 to 3, characterized in that: The melting equipment comprises: A container, the container is used to hold materials, and the container has heating and heat preservation functions; A cover plate, wherein a connecting disk is provided on the cover plate, and the connecting disk and the cover plate are concentrically rotatably connected; A stirring paddle, which is used for mixing and stirring the medicinal material extract and the molten auxiliary material during the melting step; the stirring paddle is arranged at the bottom end of the connecting disk and driven by the connecting disk, and the stirring paddle is composed of a rotating shaft and a stirring member, the rotating shaft is provided with a gas channel and connected to the connecting disk, and the stirring member is provided with a gas outlet connected to the gas channel; Gas is introduced through the gas channel when the materials are melted, mixed and stirred, so that the melt forms a porous structure; through the injection and dispersion of gas, the melt is mixed evenly and the melting temperature of the material is made uniform.

6. The Chinese medicine concentrated pill melting equipment as claimed in claim 5, characterized in that: The melting equipment also includes a gas collecting tank, The cover plate and the container are sealed and connected, and the gas channel on the rotating shaft is connected to the gas collecting tank; an exhaust valve is provided on the cover plate, and the exhaust valve is connected to the gas collecting tank; when the materials are melted, mixed and stirred, gas is introduced, and the gas is injected into the melt from the gas collecting tank through the gas channel, and the gas emitted from the melt returns to the gas collecting tank through the exhaust valve.

7. The Chinese medicine concentrated pill melting equipment as claimed in claim 5 or 6, characterized in that: The melting device further comprises a mounting box, on which a first bevel gear and a second bevel gear are provided; The connecting plate is provided with a transmission shaft, and the transmission shaft is provided with a third bevel gear; the first bevel gear is provided with an independent driving motor, and the second bevel gear is a transmission gear between the first bevel gear and the third bevel gear; the connecting plate drives the rotation of the stirring paddle by the first bevel gear, the second bevel gear and the third bevel gear; The installation box is sealed and provided with an air inlet. The transmission shaft has an air inlet circuit connected to the gas channel. The gas passes through the air inlet and the air inlet circuit in sequence to reach the gas channel. The installation box allows the gas to be introduced into the stirring paddle while it is rotating, so that the gas can be introduced into the material when it is melted, mixed and stirred.

8. The Chinese medicine concentrated pill melting equipment as claimed in claim 7, characterized in that: The melting device also includes a cutter; The cover plate is provided with an extrusion port, which is used for extruding materials in the granulation step; the cutter is arranged on the top of the cover plate and driven by the connecting disk, and the cutter is used for cutting in the granulation step; the molten material is squeezed out of the extrusion port by pressing down the cover plate, and is cut by the cutter to form pills.

9. The Chinese medicine concentrated pill melting equipment as claimed in claim 8, characterized in that: The melting equipment also includes a stirring baffle and an extrusion baffle; The melting device can be switched between a stirring state and an extrusion state; when the melting device is used to process the melting step in the melting process, the melting device is in a stirring state; When the melting device is used to process the granulation step in the melting process, the melting device is in an extrusion state; When the melting device is in a stirring state, the connecting plate is connected to the stirring paddle, and the extrusion port is blocked by the stirring baffle; When the melting device is in an extrusion state, the connecting plate is connected to the cutter, and the air intake circuit is blocked by the extrusion partition.

10. The Chinese medicine concentrated pill melting equipment as claimed in claim 8, characterized in that: The melting device also includes a frame, which is composed of a lifting column, a mounting plate and a telescopic cylinder; The mounting plate is used to connect and fix the drive motor and the mounting box, and the mounting plate is lifted and lowered by the lifting column; the telescopic cylinder is mounted on the mounting plate and connected to the cover plate, and the lifting column and the telescopic cylinder control the cover plate to extrude the molten material.

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