Automatic equipment for pretreatment of chemical medicine sample

Abstract

The invention relates to the technical field of chemical medicine treatment, and discloses chemical medicine sample pretreatment automation equipment which comprises a placement table, a weighing mechanism is arranged at one end of the top of the placement table and used for transferring and automatically weighing solid sample powder, and a dilution mechanism is arranged on one side of the outer wall of the weighing mechanism and used for changing the concentration of a processed chemical medicine. An ultrasonic mechanism is arranged at one end of the top of the placing table and used for carrying out ultrasonic treatment on a solution, a constant-volume mechanism for carrying out constant-volume operation on the solution is further arranged on one side of the outer wall of the ultrasonic mechanism, and a filtering mechanism is arranged at the other end of the top of the placing table. Various automatic functions of storage and use of the test preparation rack, opening and closing of a container cover, liquid suction, volume metering, overturning and shaking up, filtering, filling and the like are integrated. The multiple functions are integrated on one device, the trouble that multiple independent devices are used for different operations is avoided, and meanwhile overall management and maintenance of the device are facilitated.

Description

Technical Field

[0001] The invention relates to the technical field of chemical drug processing, in particular to automated equipment for pre-processing chemical drug samples. Background Art

[0002] In the field of chemical drug testing, especially before ultra-high performance liquid chromatography analysis, pretreatment of samples in injection vials is a crucial step. The traditional process of chemical drug sample pretreatment often relies on manual operation, which has many disadvantages.

[0003] In the sample weighing process, it is difficult to achieve high-precision requirements when weighing manually using ordinary balances. For example, when it is necessary to be accurate to a smaller mass unit, factors such as visual errors in manual operation and instability of operating techniques will lead to inaccurate weighing results. Similarly, in the volume determination operation, the volume of the solution is determined by manually observing the scale line of the volumetric flask. Due to the limited resolution of the human eye and the difference in observation angles, it is easy to cause inaccurate volume determination, which in turn affects the accuracy of subsequent chemical analysis results, and different operators may have different operating procedures when performing sample pretreatment. For example, during the liquid addition and dilution process, when manually adding liquid using a pipette, it is difficult to ensure that the volume of liquid added each time is completely consistent, and the operating details such as the speed of adding liquid and the mixing method also vary from person to person. This inconsistency in the operating process will lead to deviations in the sample processing results, making the data between different batches or even different samples in the same batch lack comparability. Summary of the invention

[0004] In view of the deficiencies in the prior art, the present invention provides an automated device for pre-processing chemical drug samples, which solves the problem that inconsistency in operating procedures may lead to deviations in sample processing results.

[0005] To achieve the above objectives, the present invention is implemented through the following technical solutions: an automated device for pretreatment of chemical drug samples, comprising a placement table, a weighing mechanism is provided at one end of the top of the placement table, which is used for transferring and automatically weighing solid sample powder, a dilution mechanism is provided on one side of the outer wall of the weighing mechanism, which is used to change the concentration of processed chemicals, an ultrasonic mechanism is provided at one end of the top of the placement table, which is used for ultrasonic treatment of the solution, a volume setting mechanism is also provided on one side of the outer wall of the ultrasonic mechanism for setting the volume of the solution, a filtering mechanism is provided at the other end of the top of the placement table, which is used for filtering and packaging the liquid after the volume setting is completed, and a slide rail is fixedly connected to one side of the outer wall of the placement table.

[0006] Preferably, the weighing mechanism includes a spiral powder feeder, the bottom of which is fixedly connected to the surface of the placement table, the input end of the spiral powder feeder is connected to the outside world, the output end of the spiral powder feeder is located above the weighing end of a one-hundred-thousandth balance, and the one-hundred-thousandth balance is placed on the surface of the placement table. A carrying gripper is slidably connected to one end of the inner part of the slide rail, and a stack is fixedly connected to one side of the outer wall of the placement table, and sample bottles are placed inside the stack.

[0007] Preferably, the dilution mechanism includes a dilution table, which is fixedly connected to the surface of the placement table, a peristaltic pump is installed on one side of the outer wall of the dilution table, the input end of the peristaltic pump is connected to the interior of the dilution table, the output end of the peristaltic pump is connected to a pipette tip 1, and the pipette tip 1 is fixedly connected to the middle of the dilution table, a shaker is provided on one side of the outer wall of the dilution table, and a transport gripper 2 is slidably connected to the interior of the slide rail.

[0008] Preferably, the ultrasonic mechanism comprises an ultrasonic cleaning machine, the ultrasonic cleaning machine is fixedly connected to one side of the outer wall of the placement table, a cradle is placed inside the ultrasonic cleaning machine, and a transport gripper three is slidably connected to one end of the inner side of the slide rail.

[0009] Preferably, the constant volume mechanism includes a constant volume table, the constant volume table is fixedly connected to the surface of the placing table, an injection pump is fixedly connected to one side of the outer wall of the constant volume table, the input end of the injection pump is connected to the liquid storage tank located on the top of the constant volume table, the output end of the injection pump is connected to the outside, a camera is placed on one side of the outer wall of the constant volume table, a shaking frame is fixedly connected to one side of the outer wall of the constant volume mechanism, a motor is fixedly connected to one side of the outer wall of the shaking frame, the output end of the motor passes through the shaking frame and is fixedly connected to a fixing plate, one side of the outer wall of the fixing plate is fixedly connected to one end of a telescopic rod, the output end of the telescopic rod is fixedly connected to an auxiliary frame, and the inner side of the slide rail is slidably connected to a transport gripper four.

[0010] Preferably, the filtering mechanism comprises a primary filter frame and a secondary filter frame, the primary filter frame and the secondary filter frame are sequentially mounted on the surface of the placement table, a needle filter is fixedly connected to one side of the outer wall of the primary filter frame, a pipette needle is fixedly connected to one side of the outer wall of the secondary filter frame, the filtering mechanism also comprises a switch cover assembly, the switch cover assembly comprises a narrow frame, one end of a short rod is fixedly connected to the interior of the narrow frame, and the other end of the short rod is fixedly connected to a clamping arm.

[0011] Preferably, the dilution mechanism further comprises a locking assembly, the locking assembly comprises a locking frame, the locking frame is slidably connected to one side of the outer wall of the shaking table, and a long rod is fixedly connected to the inside of the locking frame.

[0012] Preferably, the ultrasonic mechanism also includes a water absorption component, which includes a water absorption ring, which is fixedly connected to one side of the outer wall of the placement table, one end of a spring is fixedly connected to the inside of the water absorption ring, and the other end of the spring is fixedly connected to water absorbent cotton.

[0013] Preferably, the constant volume mechanism further comprises a backlight source panel, and the backlight source panel is fixedly connected to one side of the outer wall of the placement table.

[0014] In addition, the present invention also provides an automated processing method for chemical drug sample pretreatment, comprising the following steps:

[0015] S1. Sample weighing. At the weighing station, the stack provides a solid sample source. The screw-rotating powder adding mechanism transfers the solid sample powder to the top of the weighing end of the one-hundred-thousandth balance for weighing. The weighed solid sample powder is loaded into a volumetric bottle by a handling gripper, and then transported to the next station.

[0016] S2, add liquid to dilute and shake well. The second handling gripper takes away the cap of the volumetric flask, and twenty peristaltic pumps extract the corresponding volume of liquid into the volumetric flask. After the liquid is added, it is placed on a horizontal shaker and shaken to mix the sample and the diluent evenly.

[0017] S3, ultrasonic treatment, the diluted and shaken solution is ultrasonically treated by an ultrasonic cleaning machine, and the volumetric flask cradle with an internal shaking design promotes solution mixing;

[0018] S4, volume setting and shaking. The handling gripper 3 transfers the volumetric flask to the water draining and absorption device and then to the volume setting, flipping and shaking station. The volume setting operation is performed through the volume setting mechanism. After completion, the bottle cap is installed and the flask is transferred to the flipping and shaking mechanism for mixing again;

[0019] S5, filtration, transfer the volumetric flask to the filtration station, open the bottle cap, filter the solution through the filtration device to obtain the filtrate, and use the aspiration needle to absorb the filtrate and fill it into the injection vial;

[0020] S6, vial packaging, the sampling vial is transferred to the switch cover mechanism, the vial cap is rotated to the sampling vial, and the pre-treatment process of the chemical drug inspection sampling vial is completed.

[0021] Working principle: At the weighing station, the sample storage stack provides a solid sample source. A set of threaded rotary powder adding mechanisms transfers the solid sample powder to the top of the weighing end of a one-hundred-thousandth balance for precise weighing. After that, a set of handling grippers are used to load the weighed solid sample powder into a volumetric flask, and then the handling grippers transfer the volumetric flask to the next liquid addition, dilution, and shaking station. In the liquid addition, dilution, and shaking station, when the volumetric flask is transferred from the weighing station by the handling grippers, the external robot takes away the cap of the volumetric flask and places it in the cap storage position. Twenty peristaltic pumps extract the corresponding volume of liquid according to the program settings, and inject it into the volumetric flask through twenty sets of stainless steel pipette tips to achieve the liquid addition and dilution operation. After the liquid addition is completed, the volumetric flask is placed on a horizontal shaker and shaken according to the predetermined program to fully mix the sample and the diluent. After the shaking is completed, the handling grippers transfer the volumetric flask to the ultrasonic station, where two sets of ultrasonic cleaning machines perform ultrasonic treatment on the solution. Each ultrasonic instrument has 6-8 volumetric flasks in a cradle with a shaking design. During the ultrasonic process, the internal shaking further promotes the mixing of the solution. After the ultrasonic process is completed, the handling gripper transfers the volumetric flask to the drainage and water absorption device, which absorbs the liquid on the outer wall of the bottle to prevent the residual liquid from affecting the subsequent operation. Then the handling gripper transfers the volumetric flask to the volume setting, flipping and shaking station. After the volume setting, flipping and shaking station receives the volumetric flask, the mechanical gripper first opens the volumetric flask cap and places it in the volumetric flask cap storage position, and then transfers the volumetric flask to the visual volume setting area. A set of 20 groups of syringe pumps in a volume setting mechanism absorb the solution with a set program and inject it into the volumetric flask through 20 groups of pipette tips. The camera in the volume setting mechanism captures the liquid level image in the volumetric flask, and the backlight panel provides uniform background light to determine the liquid level. When the preset liquid level is reached, the syringe pump stops adding liquid and the volume setting operation is completed. Next, the handling gripper installs the volumetric flask cap back to the volumetric flask, and then transfers the volumetric flask to the flip-shaking mechanism. The flip-shaking mechanism holds the cap to flip the volumetric flask so that the sample and the solution are fully mixed again. After that, the handling gripper transfers the volumetric flask to the filtration station. In the filtration station, the handling gripper first transfers the volumetric liquid to the switch cover mechanism and opens the volumetric flask cap, transfers the cap to the temporary storage position of the volumetric flask cap, and then transfers the volumetric flask to the filtration device. The filtration device absorbs the solution in the volumetric flask, and the solution is filtered through a disposable syringe and a needle filter to obtain the filtrate, which is stored in the transfer container. Two sets of aspiration needles with electric pipettes absorb the filtrate in the transfer container and fill it into the injection vial. After the filling is completed, the injection vial is transferred to the switch cover mechanism, and the vial cap is rotated to the injection vial, thus completing the entire chemical drug inspection injection vial pretreatment process.

[0022] The present invention provides an automated device for pre-processing chemical drug samples. It has the following beneficial effects:

[0023] 1. The present invention integrates multiple automated functions such as storage and use of test racks, opening and closing of container lids, liquid aspiration, liquid addition and dilution, ultrasound, horizontal shaking, constant volume, flip shaking, filtration, filling, label printing, etc. This multi-function integration in one device avoids the trouble of using multiple separate devices for different operations, reduces the equipment footprint, and also facilitates the overall management and maintenance of the equipment.

[0024] 2. The present invention sets multiple stations, and different stations can perform different operations at the same time. For example, when the weighing station is weighing the sample, the adding, diluting, and shaking stations can prepare to receive the volumetric flask of the previous station for adding liquid, and the ultrasonic station can also perform ultrasonic treatment on the previous solution at the same time. This parallel operation mode makes full use of time and further improves the overall work efficiency.

[0025] 3. The present invention covers the entire process from solid samples to the final formation of sample-injectable vials from all aspects of sample pretreatment, realizing full-process integrated operation. This integrated design eliminates the need for frequent transfer of samples between different devices during the processing process, reduces the risk of sample loss and contamination, and ensures the integrity and accuracy of sample processing. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a three-dimensional diagram of the automation equipment in the present invention;

[0027] Figure 2 It is a schematic diagram of the automation equipment in the present invention;

[0028] Figure 3 It is a display diagram of the weighing mechanism in the present invention;

[0029] Figure 4 is a schematic diagram of the dilution mechanism in the present invention;

[0030] Figure 5 This is a diagram showing the ultrasonic mechanism of the present invention;

[0031] Figure 6 for Figure 5 A in the enlarged view;

[0032] Figure 7 Schematic diagram of the volume setting mechanism in the present invention;

[0033] Figure 8 It is a display diagram of the filtering mechanism in the present invention.

[0034] Among them, 1. Placement table; 2. Slide rail; 3. Spiral powder adding machine; 4. One-hundred-thousandth balance; 5. Transport gripper one; 6. Stack; 7. Dilution table; 8. Peristaltic pump; 9. Pipette tip one; 10. Shaking table; 11. Transport gripper two; 12. Ultrasonic cleaning machine; 13. Cradle; 14. Transport gripper three; 15. Constant volume table; 16. Syringe pump; 17. Liquid storage tank; 18. Camera; 19. Shaking rack; 20. Motor; 21. Fixed plate; 22. Telescopic rod; 23. Auxiliary rack; 24. Transport gripper four; 25. Primary filter rack; 26. Secondary filter rack; 27. Needle filter; 28. Liquid aspiration needle; 29. ​​Card rack; 30. Long rod; 31. Water absorption ring; 32. Spring; 33. Water absorption cotton; 34. Backlight board; 35. Narrow rack; 36. Short rod; 37. Clamping arm. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] Please see attached Figure 1 -Attached Figure 8 An embodiment of the present invention provides an automated device for pre-processing chemical drug samples, including a placement table 1. A weighing mechanism is provided at one end of the top of the placement table 1, which is used for transferring and automatically weighing solid sample powder. A dilution mechanism is provided on one side of the outer wall of the weighing mechanism, which is used for changing the concentration of processed chemicals. An ultrasonic mechanism is provided at one end of the top of the placement table 1, which is used for ultrasonically treating a solution. A volumetric mechanism for volumetrically fixing the solution is also provided on one side of the outer wall of the ultrasonic mechanism. A filtering mechanism is provided at the other end of the top of the placement table 1, which is used for filtering and packaging the liquid after volume fixing. A slide rail 2 is fixedly connected to one side of the outer wall of the placement table 1.

[0037] The weighing mechanism includes a spiral powder feeder 3, the bottom of which is fixedly connected to the surface of the placement table 1, the input end of the spiral powder feeder 3 is connected to the outside, the output end of the spiral powder feeder 3 is located above the weighing end of a one-hundred-thousandth balance 4, the one-hundred-thousandth balance 4 is placed on the surface of the placement table 1, one end of the inner side of the slide rail 2 is slidably connected to a carrying gripper 5, one side of the outer wall of the placement table 1 is fixedly connected to a stack 6, and a sample bottle is placed inside the stack 6;

[0038] Specifically, in actual operation, the screw-rotating powder adding mechanism gradually transfers the solid sample powder to the top of the weighing end of the balance, and the one-hundred-thousandth balance 4 weighs it accurately. After the weighing is completed, the transport gripper 5 transfers the volumetric flask containing the weighed solid sample powder to the next station. This process ensures the accurate weighing of the solid sample and smoothly enters the next processing link.

[0039] The dilution mechanism includes a dilution table 7, which is fixedly connected to the surface of the placement table 1. A peristaltic pump 8 is installed on one side of the outer wall of the dilution table 7. The input end of the peristaltic pump 8 is connected to the inside of the dilution table 7. The output end of the peristaltic pump 8 is connected to a pipette tip 9, which is fixedly connected to the middle of the dilution table 7. A shaking table 10 is arranged on one side of the outer wall of the dilution table 7. A transport gripper 11 is slidably connected to the inside of the slide rail 2.

[0040] The dilution mechanism also includes a clamping assembly, which includes a clamping frame 29, which is slidably connected to one side of the outer wall of the shaking table 10, and a long rod 30 is fixedly connected to the inside of the clamping frame 29;

[0041] Specifically, this station supports the movement of the volumetric flask of the weighing station here. First, the external robot removes the cap of the volumetric flask and places it in the cap storage position. Then, the peristaltic pump 8 extracts the liquid according to the volume set in the program, and accurately injects the liquid into the volumetric flask through the stainless steel pipette tip to achieve the liquid adding operation. After the liquid addition is completed, the volumetric flask is placed on a horizontal shaker 10 and shaken according to a predetermined program to fully mix the added liquid and the solid sample to achieve the purpose of dilution. After the shaking operation is completed, the carrying gripper transfers the volumetric flask to the next station.

[0042] The ultrasonic mechanism includes an ultrasonic cleaning machine 12, which is fixedly connected to one side of the outer wall of the placement table 1, a cradle 13 is placed inside the ultrasonic cleaning machine 12, and a carrying gripper 14 is slidably connected to one end of the inner side of the slide rail 2;

[0043] The ultrasonic mechanism also includes a water absorption component, which includes a water absorption ring 31, which is fixedly connected to one side of the outer wall of the placement table 1, and one end of a spring 32 is fixedly connected to the inside of the water absorption ring 31, and the other end of the spring 32 is fixedly connected to a water absorption cotton 33;

[0044] Specifically, according to the preset procedure, the transport gripper 3 14 transfers the volumetric flask containing the solution of the previous step to the preset station inside the ultrasonic cleaning machine 12. The ultrasonic cleaning machine 12 starts to work and ultrasonically treats the solution, which helps to further mix and react the components in the solution. After the ultrasonic treatment is completed, the transport gripper transfers the volumetric flask to the drainage and water absorption device, which absorbs the liquid on the outer wall of the bottle through the water absorption material, and then transfers the volumetric flask to the next station.

[0045] The constant volume mechanism includes a constant volume table 15, which is fixedly connected to the surface of the placement table 1, and a syringe pump 16 is fixedly connected to one side of the outer wall of the constant volume table 15. The input end of the syringe pump 16 is connected to a liquid storage tank 17 located on the top of the constant volume table 15, and the output end of the syringe pump 16 is connected to the outside world. A camera 18 is placed on one side of the outer wall of the constant volume table 15, and a shaking frame 19 is fixedly connected to one side of the outer wall of the constant volume mechanism. A motor 20 is fixedly connected to one side of the outer wall of the shaking frame 19, and the output end of the motor 20 passes through the shaking frame 19 and is fixedly connected to a fixed plate 21. One end of a telescopic rod 22 is fixedly connected to one side of the outer wall of the fixed plate 21, and the output end of the telescopic rod 22 is fixedly connected to an auxiliary frame 23, and a transport gripper 24 is slidably connected to one side of the inner side of the slide rail 2;

[0046] The volume fixing mechanism further includes a backlight source plate 34, which is fixedly connected to one side of the outer wall of the placement table 1;

[0047] Specifically, the transport gripper three 14 transfers the volumetric flask that has been ultrasonically completed to this station. The mechanical gripper opens the cap of the volumetric flask and places it in the cap storage position. Then, the volumetric flask is transferred to the visual volume setting area, and the injection pump 16 absorbs the solution that has been set in the program and injects it into the volumetric flask through the pipette tip. In this process, the camera 18 captures the liquid level image in the volumetric flask, the backlight panel 34 provides uniform background light, and the liquid level height is determined by a specific image processing algorithm. When the preset liquid level is reached, the injection pump 16 stops adding liquid and completes the volume setting operation. Next, the transport gripper four 24 installs the volumetric flask cap to the volumetric flask, and then transfers the volumetric flask to the flipping and shaking mechanism. The flipping and shaking mechanism holds the cap and flips the volumetric flask to fully shake the sample and the solution to ensure the uniformity of the solution and prepare for subsequent filtration operations.

[0048] The filtering mechanism includes a primary filtering frame 25 and a secondary filtering frame 26, which are sequentially mounted on the surface of the placing table 1, a needle filter 27 is fixedly connected to one side of the outer wall of the primary filtering frame 25, and a liquid aspiration needle 28 is fixedly connected to one side of the outer wall of the secondary filtering frame 26;

[0049] The filter mechanism further includes a switch cover assembly, which includes a narrow frame 35, one end of a short rod 36 is fixedly connected to the inside of the narrow frame 35, and the other end of the short rod 36 is fixedly connected to a clamping arm 37;

[0050] Specifically, after the transport gripper 4 24 transfers the volumetric liquid to the switch cover mechanism, it opens the volumetric flask cover and transfers it to the temporary storage position of the volumetric flask cover. Then, the volumetric flask is transferred to the filtering device, which absorbs the solution in the volumetric flask. After the solution is filtered through a disposable syringe and a needle filter 27, a filtrate is obtained and placed in a transfer container. After that, the aspiration needle 28 absorbs the filtrate in the transfer container and fills it into the injection vial. After the filling is completed, the injection vial is transferred to the switch cover mechanism, and the vial cap is rotated to the injection vial, completing the last step of the entire chemical sample pretreatment process, so that the treated sample can be smoothly used for subsequent ultra-high performance liquid phase injection analysis and other operations.

[0051] In addition, the present invention also provides an automated processing method for chemical drug sample pretreatment, comprising the following steps:

[0052] S1. Sample weighing. At the weighing station, the stack provides a solid sample source. The screw-rotating powder adding mechanism transfers the solid sample powder to the top of the weighing end of the one-hundred-thousandth balance for weighing. The weighed solid sample powder is loaded into a volumetric bottle by a handling gripper, and then transported to the next station.

[0053] S2, add liquid to dilute and shake well, the handling gripper 2 11 takes away the cap of the volumetric flask, and 20 peristaltic pumps 8 extract the corresponding volume of liquid into the volumetric flask. After the addition of liquid, it is placed on a horizontal shaker 10 and shaken to mix the sample and the diluent evenly;

[0054] S3, ultrasonic treatment, the diluted and shaken solution is ultrasonically treated by an ultrasonic cleaning machine 12, and a volumetric flask cradle 13 with an internal shaking design promotes solution mixing;

[0055] S4, volume setting and shaking, the handling gripper 3 14 transfers the volumetric flask to the water draining and absorption device and then transfers it to the volume setting, flipping and shaking station, and performs the volume setting operation through the volume setting mechanism. After completion, the bottle cap is installed and transferred to the flipping and shaking mechanism for mixing again;

[0056] S5, filtration, transfer the volumetric flask to the filtration station, open the bottle cap, filter the solution through the filtration device to obtain the filtrate, and the aspiration needle 28 absorbs the filtrate and fills it into the injection vial;

[0057] S6, vial packaging, the sampling vial is transferred to the switch cover mechanism, the vial cap is rotated to the sampling vial, and the pre-treatment process of the chemical drug inspection sampling vial is completed.

[0058] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An automated device for pre-processing a chemical drug sample, comprising a placement table (1), characterized in that: A weighing mechanism is arranged at one end of the top of the placement table (1), which is used for transferring and automatically weighing solid sample powder; a dilution mechanism is arranged on one side of the outer wall of the weighing mechanism, which is used for changing the concentration of the processing chemical; an ultrasonic mechanism is arranged at one end of the top of the placement table (1), which is used for ultrasonically treating the solution; a volume setting mechanism is also arranged on one side of the outer wall of the ultrasonic mechanism for setting the volume of the solution; a filtering mechanism is arranged at the other end of the top of the placement table (1), which is used for filtering and packaging the liquid after the volume setting is completed; and a slide rail (2) is fixedly connected to one side of the outer wall of the placement table (1).

2. The automated equipment for pre-treatment of chemical drug samples according to claim 1, characterized in that: The weighing mechanism comprises a spiral powder feeder (3), the bottom of which is fixedly connected to the surface of a placing table (1), the input end of which is connected to the outside, the output end of which is located above the weighing end of a one-hundred-thousandth balance (4), the one-hundred-thousandth balance (4) being placed on the surface of the placing table (1), one end of the interior of the slide rail (2) being slidably connected to a transport gripper (5), one side of the outer wall of the placing table (1) being fixedly connected to a stack (6), and a sample bottle being placed inside the stack (6).

3. The automated equipment for pre-treatment of chemical drug samples according to claim 1, characterized in that: The dilution mechanism comprises a dilution table (7), the dilution table (7) is fixedly connected to the surface of the placement table (1), a peristaltic pump (8) is installed on one side of the outer wall of the dilution table (7), the input end of the peristaltic pump (8) is connected to the inside of the dilution table (7), the output end of the peristaltic pump (8) is connected to a pipette tip (9), the pipette tip (9) is fixedly connected to the middle of the dilution table (7), a shaking table (10) is arranged on one side of the outer wall of the dilution table (7), and a transport gripper (11) is slidably connected to the inside of the slide rail (2).

4. The automated equipment for pre-treatment of chemical drug samples according to claim 1, characterized in that: The ultrasonic mechanism comprises an ultrasonic cleaning machine (12), the ultrasonic cleaning machine (12) is fixedly connected to one side of the outer wall of the placement table (1), a cradle (13) is placed inside the ultrasonic cleaning machine (12), and a transport gripper (14) is slidably connected to one end of the interior of the slide rail (2).

5. The automated equipment for pre-treatment of chemical drug samples according to claim 1, characterized in that: The volume setting mechanism comprises a volume setting platform (15), the volume setting platform (15) is fixedly connected to the surface of the placement platform (1), an injection pump (16) is fixedly connected to one side of the outer wall of the volume setting platform (15), the input end of the injection pump (16) is connected to a liquid storage tank (17) located on the top of the volume setting platform (15), and the output end of the injection pump (16) is connected to the outside, a camera (18) is placed on one side of the outer wall of the volume setting platform (15), a shaking frame (19) is fixedly connected to one side of the outer wall of the volume setting mechanism, a motor (20) is fixedly connected to one side of the outer wall of the shaking frame (19), the output end of the motor (20) passes through the shaking frame (19) and is fixedly connected to a fixed plate (21), one end of a telescopic rod (22) is fixedly connected to one side of the outer wall of the fixed plate (21), and the output end of the telescopic rod (22) is fixedly connected to an auxiliary frame (23), and a transport gripper (24) is slidably connected to one side of the inner side of the slide rail (2).

6. The automated equipment for pre-treatment of chemical drug samples according to claim 1, characterized in that: The filtering mechanism comprises a primary filtering frame (25) and a secondary filtering frame (26), the primary filtering frame (25) and the secondary filtering frame (26) being sequentially mounted on the surface of a placing table (1), a needle filter (27) being fixedly connected to one side of an outer wall of the primary filtering frame (25), a liquid aspiration needle (28) being fixedly connected to one side of an outer wall of the secondary filtering frame (26), the filtering mechanism further comprises a switch cover assembly, the switch cover assembly comprising a narrow frame (35), one end of a short rod (36) being fixedly connected to the interior of the narrow frame (35), and a clamping arm (37) being fixedly connected to the other end of the short rod (36).

7. The automated equipment for pre-treatment of chemical drug samples according to claim 3, characterized in that: The dilution mechanism also includes a latching assembly, wherein the latching assembly includes a latching frame (29), the latching frame (29) is slidably connected to one side of the outer wall of the shaking table (10), and a long rod (30) is fixedly connected to the inside of the latching frame (29).

8. The automated equipment for pre-treatment of chemical drug samples according to claim 4, characterized in that: The ultrasonic mechanism also includes a water absorption component, which includes a water absorption ring (31). The water absorption ring (31) is fixedly connected to one side of the outer wall of the placement table (1), and one end of a spring (32) is fixedly connected to the inside of the water absorption ring (31), and the other end of the spring (32) is fixedly connected to a water absorption cotton (33).

9. The automated equipment for pre-treatment of chemical drug samples according to claim 5, characterized in that: The volume-fixing mechanism further comprises a backlight source plate (34), and the backlight source plate (34) is fixedly connected to one side of the outer wall of the placement platform (1).

10. An automated method for pre-treatment of chemical drug samples, characterized in that: An automated device for pre-processing a chemical drug sample according to any one of claims 1 to 9, comprising the following steps: S1. Sample weighing. At the weighing station, the stack provides a solid sample source. The screw-rotating powder adding mechanism transfers the solid sample powder to the top of the weighing end of the one-hundred-thousandth balance for weighing. The weighed solid sample powder is loaded into a volumetric bottle by a handling gripper, and then transported to the next station. S2, add liquid to dilute and shake well, the second handling gripper (11) removes the cap of the volumetric flask, and twenty peristaltic pumps (8) extract the corresponding volume of liquid and inject it into the volumetric flask. After the liquid is added, it is placed on a horizontal shaker (10) and shaken to mix the sample and the diluent evenly; S3, ultrasonic treatment, using an ultrasonic cleaning machine (12) to ultrasonically treat the diluted and shaken solution, and a volumetric flask cradle (13) with an internal shaking design promotes solution mixing; S4, volume setting and shaking. The handling gripper 3 (14) transfers the volumetric flask to the water draining and absorption device and then to the volume setting, flipping and shaking station. The volume setting mechanism is used to perform the volume setting operation. After completion, the bottle cap is installed and the flask is transferred to the flipping and shaking mechanism for further mixing. S5, filtering, transferring the volumetric flask to the filtering station, opening the bottle cap, filtering the solution through the filtering device to obtain the filtrate, and the aspiration needle (28) sucks the filtrate and fills it into the injection vial; S6, vial packaging, the sampling vial is transferred to the switch cover mechanism, the vial cap is rotated to the sampling vial, and the pre-treatment process of the chemical drug inspection sampling vial is completed.

Images