Nutritional composition for promoting children to grow tall and application thereof

Abstract

The invention provides a nutritional composition for promoting children to grow tall and application of the nutritional composition. The invention firstly provides a composition which comprises zinc, lactoferrin, bovine colostrum and yeast beta-glucan, and the mass ratio of the zinc to the lactoferrin to the bovine colostrum to the yeast beta-glucan is (1.5-12): (16-800): (95-480): (14-75) according to the dry matter amount. The invention also provides a food containing the composition, and an application of the composition or the food in preparation of a product for promoting children to grow tall.

Description

Technical Field

[0001] The invention belongs to the technical field of nutritional compositions, and in particular relates to a nutritional composition, food and application thereof that promote children's height growth. Background Art

[0002] The early stage of life is the fastest period of growth and development of the body. The childhood stage is the golden period of growth and development throughout the entire life stage. It is very important to ensure the stable growth and development of children. Balanced nutrition has the most important impact on growth and development. The younger the age, the greater the impact of nutrition. Nutrition and health status at this stage have an important impact on weight, height growth, bone development, immune system development and brain maturation, intestinal flora, etc. Malnutrition in children can lead to varying degrees of growth retardation, affecting the growth of weight and height and the development of various organs, especially the brain and skeletal system, causing future physical development, motor skills and intellectual development to lag behind normal children.

[0003] As for bone growth, childhood and adolescence are periods of rapid bone growth and development, with bone construction as the main focus, accelerated bone turnover, and bone formation as the dominant factor, so bone mass grows steadily. The weight of human bones at birth is 70-95g. By the end of adolescence, the average total weight of bones reaches 2400g for females and 3300g for males. Bone growth includes linear growth and bone mass accumulation. Linear growth is the main growth in childhood, with an average growth rate of about 5-6cm per year. Bone mass accumulation is the main growth during adolescence, especially puberty. About 40%-60% of adult bone mass is achieved during adolescence, and 90% of peak bone mass has been accumulated by the age of 18. Therefore, if we can make full use of the rapid bone mass accumulation period in childhood and adolescence to promote the body to reach a higher peak bone mass, it will have positive significance for the bone health of children and adolescents and the prevention of osteoporosis in middle-aged and elderly people.

[0004] There are many internal and external factors that affect the growth and development of bones in children and adolescents, such as genetics, endocrine, nutrition, exercise, disease and drugs. Nutrition plays an important role in bone growth and development and height growth, and a lot of research has been done on nutrients such as protein, fat, calcium and vitamin D.

[0005] Zinc is the second most abundant trace element in the human body. It is essential for protein metabolism and contraction, nucleic acid metabolism, and cell membrane stability. Zinc participates in the activity of enzymes as a cofactor of more than 300 coenzymes and is necessary for a variety of cellular metabolic functions. Zinc deficiency is a systemic disease caused by zinc deficiency in the human body, manifested as short stature, genital dysplasia, iron deficiency anemia, hepatosplenomegaly, and lack of energy. The zinc deficiency rate in children is relatively high, and there is a problem of low bioavailability.

[0006] Although there is little research on the combined effects of various components in the prior art regarding the effects of lactoferrin, bovine colostrum, etc. on bone health and height, how to optimize the proportion and method of adding these ingredients to achieve the best nutritional effect is a technical problem that needs to be urgently solved in this field. Summary of the invention

[0007] An object of the present invention is to provide a composition for promoting children's height growth.

[0008] Another object of the present invention is to provide a product, such as a food, comprising the composition.

[0009] Another object of the present invention is to provide related applications of the composition or food in promoting children's growth, especially for preventing and / or alleviating weight loss and increasing femur length and weight.

[0010] On the one hand, the present invention provides a composition, wherein the composition comprises a zinc source, lactoferrin, bovine colostrum and yeast β-glucan, and the mass ratio of zinc, lactoferrin, bovine colostrum and yeast β-glucan is 1.5-12:16-800:95-480:14-75, based on the dry mass of zinc in the zinc source and lactoferrin, bovine colostrum and yeast β-glucan.

[0011] There are many internal and external factors that affect the growth and development of bones in children and adolescents, such as heredity, endocrine, nutrition, exercise, disease and drugs. Nutrition plays an important role in bone growth and development and height growth. Nutrients such as protein, fat, calcium and vitamin D have been studied a lot. Zinc is the second most abundant trace element in the human body. It is essential for protein metabolism and contraction, nucleic acid metabolism and cell membrane stability. Zinc participates in the activity of enzymes as a cofactor of more than 300 coenzymes and is necessary for a variety of cell metabolic functions. Therefore, zinc has important physiological functions in growth and development, immune system development and function. The zinc deficiency rate in children is high, and there is a problem of low bioavailability. Zinc deficiency is a systemic disease caused by zinc deficiency in the human body, which manifests as short stature, genital dysplasia, iron deficiency anemia, hepatosplenomegaly, and lack of energy. Animal experimental studies have shown that the femur length, femur diameter and femur weight of zinc-deficient animal models during the growth period are lower than those of the normal feed group. Zinc deficiency can cause changes in bone morphology and pathology and affect bone growth and development.

[0012] Lactoferrin is a glycoprotein belonging to the transferrin family. It has multiple functions such as promoting iron absorption in the body, antivitamin activity, antiviral, immune regulation, promoting neurodevelopment and cognition, and osteogenic activity. In vitro cell experiments have shown that lactoferrin can be used as an effective synthetic factor to promote bone growth, promote the proliferation and differentiation of bone-forming cells and osteoblasts, and effectively inhibit the formation of bone-absorbing cells and osteoclasts, thereby regulating bone mass balance. In in vivo experiments, research on lactoferrin is mostly focused on the treatment of bone diseases such as osteoporosis and osteoarthritis, as well as the immunity of newborns, but there is limited research on the effects of lactoferrin intake on bone formation, bone mass, and height growth in adolescents. Research on yeast β-glucan focuses on blood sugar and immunity, but there is no report on its effects on bone health, especially height. At present, the intervention dose of bovine colostrum on bone health is very high, resulting in problems such as high effective dose, high cost, and poor compliance.

[0013] Although the existing technology focuses on the effects of lactoferrin, bovine colostrum, etc. on bone health and height, and relatively little on the combined effects of the components, there is still a lack of in-depth research on how to optimize the proportion and method of adding these ingredients to achieve the best nutritional effect.

[0014] The present invention has found that combining bovine colostrum, lactoferrin and yeast β-glucan in a specific ratio has a synergistic effect on promoting children's height growth, jointly promoting bone growth and development, improving and / or preventing growth retardation, and thus contributing to children's bone health and height development.

[0015] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of zinc, lactoferrin, bovine colostrum and yeast β-glucan is 1.6-11.9:20-800:98.1-476:14.7-70; According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of zinc, lactoferrin, bovine colostrum and yeast β-glucan is 1.6-11.9:30-800:100-476:15-70; According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of zinc, lactoferrin, bovine colostrum and yeast β-glucan is 1.6-11.9:50-800:110-476:15-50.

[0016] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of lactoferrin, bovine colostrum and yeast β-glucan is 5-20:40-80:6-12. The amount of zinc can be determined with reference to the above-mentioned ratio range of zinc to lactoferrin.

[0017] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of lactoferrin, bovine colostrum and yeast β-glucan is 40-60:40-80:6-12. The amount of zinc can be determined with reference to the above-mentioned ratio range of zinc to lactoferrin.

[0018] According to some specific embodiments of the present invention, in the composition of the present invention, the mass ratio of lactoferrin, bovine colostrum and yeast β-glucan is 80-120:40-80:6-12. The amount of zinc can be determined with reference to the above-mentioned ratio range of zinc to lactoferrin.

[0019] According to a specific embodiment of the present invention, in the composition of the present invention, the raw materials of each component can be commercially available.

[0020] According to a specific embodiment of the present invention, in the composition of the present invention, the raw material providing zinc includes one or a combination of two or more of zinc sulfate, zinc gluconate, zinc glycinate, zinc oxide, zinc lactate, zinc citrate, zinc chloride, zinc acetate, zinc carbonate and zinc citrate trihydrate (i.e., zinc citrate (trihydrate)).

[0021] According to a specific embodiment of the present invention, in the composition of the present invention, the bovine colostrum can be liquid bovine colostrum, bovine colostrum powder, or colostrum alkaline protein prepared by processing bovine colostrum as raw material. Unless otherwise specified, the mass ratio or weight portion of bovine colostrum to lactoferrin described in the present invention is based on the amount of dry matter. In some specific embodiments of the present invention, the bovine colostrum is a powdered or finely crystalline product made from bovine colostrum as raw material, through processes such as sterilization, centrifugal defatting, and low-temperature drying; or it is colostrum alkaline protein made from bovine colostrum as raw material, through processes such as sterilization, defatting, centrifugal separation, removal of casein, α-lactalbumin, β-lactoglobulin, microfiltration, ultrafiltration, and freeze drying.

[0022] According to a specific embodiment of the present invention, in the composition of the present invention, the lactoferrin may be a lactoferrin raw material from cow's milk, goat's milk and their products. For example, the raw material for providing lactoferrin may be pure lactoferrin powder, or may include but not limited to whole milk powder, skim milk powder, casein and whey protein powder. In some specific embodiments, whey protein powder is preferably used as the raw material for providing lactoferrin. Unless otherwise specified, the ratio of lactoferrin to other functional components in the composition of the present invention is based on the content of lactoferrin in the raw material.

[0023] According to a specific embodiment of the present invention, in the composition of the present invention, the yeast β-glucan is produced by extraction, acid-base treatment, spray drying and other steps using brewer's yeast as raw material, and meets the requirements of the announcement on approving five items such as Camellia chrysantha and Inula japonica (small black medicine) as new resource foods (No. 9 of 2010), and the β-glucan content used is ≥ 70%. Unless otherwise specified, the ratio of the yeast β-glucan to other functional components in the composition of the present invention is based on the β-glucan content in the raw materials.

[0024] According to some specific embodiments of the present invention, the composition of the present invention is a nutritional composition.

[0025] According to some specific embodiments of the present invention, the composition of the present invention is a food composition.

[0026] In another aspect, the present invention further provides a food, comprising the composition of the present invention.

[0027] On the other hand, the present invention also provides the use of the composition or the food in preparing food that can promote children's height growth.

[0028] According to a specific embodiment of the present invention, the method of promoting children's height growth comprises:

[0029] Prevent and / or alleviate weight loss caused by zinc deficiency or insufficient zinc intake;

[0030] Increase femur length; and / or

[0031] Add weight to the femur.

[0032] According to a specific embodiment of the present invention, when the composition or the food is used, the amount of yeast β-glucan used is 10 to 50 mg / day, preferably less than 50 mg / day, based on the yeast β-glucan in the composition;

[0033] According to a specific embodiment of the present invention, when the composition or the food is used, the amount of yeast β-glucan in the composition is 11.5-49 mg / day;

[0034] According to a specific embodiment of the present invention, when the composition or the food is used, the amount of yeast β-glucan in the composition is 12.5-49 mg / day.

[0035] According to some preferred specific embodiments of the present invention, in the present invention, the product is a food, for example, it can be a common food or a functional food. More specifically, the food can be a common food, a nutritional supplement, a dietary supplement, a snack food, a health food or a special medical formula food. The present invention does not make special requirements on the specific form of the food, for example, the snack food can be a milk tablet, candy, etc., and the nutritional supplement, dietary supplement health food or special medical formula food can be in the form of oral liquid, powder, capsule, etc.

[0036] According to a specific embodiment of the present invention, in the present invention, the food is a milk-containing product, such as a prepared milk or milk beverage, a fermented milk or milk beverage, a frozen drink, milk powder, milk slices or cheese. The milk-containing product can be a food for children, adults or middle-aged and elderly people, such as milk powder for middle-aged and elderly people.

[0037] According to a specific embodiment of the present invention, the food of the present invention contains 1.8-20 mg zinc / 100 g food dry matter.

[0038] According to some preferred specific embodiments of the present invention, the food contains 2.0-19.8 mg / 100g of zinc, 20-1323 mg / 100g of food dry matter, 109-800 mg / 100g of food dry matter, and 16.3-119 mg / 100g of food dry matter.

[0039] According to some preferred specific embodiments of the present invention, the food contains 2.0-19.8 mg / 100g of zinc, 30-1300 mg / 100g of food dry matter, 110-800 mg / 100g of food dry matter, and 20-80 mg / 100g of food dry matter, respectively.

[0040] According to some preferred specific embodiments of the present invention, the food contains 2.0-19.8 mg / 100 g of zinc, 50-1300 mg / 100 g of food dry matter, 160-800 mg / 100 g of food dry matter, and 16.3-50 mg / 100 g of food dry matter, respectively.

[0041] The present invention has the following beneficial technical effects:

[0042] The present invention mixes lactoferrin, bovine colostrum, zinc and yeast beta-glucan in a certain proportion, which helps to promote children's growth, prevent and / or alleviate weight loss, prevent and / or increase femur length, prevent and / or increase femur weight, and the composition achieves unexpected health effects within the preferred proportion range. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 1 is the effect of different groups of experimental examples on femur length in a specific embodiment of the present invention.

[0044] Figure 2 1 is the effect of different groups of experimental examples on femoral weight in a specific embodiment of the present invention. DETAILED DESCRIPTION

[0045] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for describing the specific embodiments rather than for limiting the scope of protection of the present invention.

[0046] When the embodiments give numerical ranges, it should be understood that, unless otherwise specified in the present invention, both endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meaning as those generally understood by those skilled in the art. In addition to the specific methods, equipment, and materials used in the embodiments, according to the grasp of the prior art by those skilled in the art and the record of the present invention, any methods, equipment, and materials of the prior art similar or equivalent to the methods, equipment, and materials described in the embodiments of the present invention can also be used to realize the present invention.

[0047] Unless otherwise stated, the experimental methods, detection methods, and preparation methods disclosed in the present invention all adopt conventional techniques in the technical field.

[0048] In the animal experiment, lactoferrin was commercially available lactoferrin powder, in which the lactoferrin content was 95%. Bovine colostrum was commercially available bovine colostrum powder, in which the protein content was 63.2% and the immunoglobulin (IgG) content was ≥10%. The source of yeast β-glucan was commercially available yeast β-glucan powder, in which the β-glucan content was ≥70%.

[0049] Experimental study on the efficacy of nutritional composition in regulating body weight and bone development in rats

[0050] 1. Experimental animals and groups

[0051] Newly weaned (21 days) SPF SD male rats were housed in an animal room with an ambient temperature of 20-23°C, a relative humidity of 40% - 70%, a 12-h artificial lighting / dark cycle, and a ventilation rate of ≥15 times / h.

[0052] The rat diet was prepared with reference to the current common experimental animal pure diet formula AIN-93G. Among them, casein was soaked in 1% disodium EDTA aqueous solution for many times to remove zinc, then rinsed with deionized ultrapure water and dried to prepare a zinc-deficient diet. A certain amount of zinc sulfate was added to the zinc-deficient diet to prepare diets with different zinc contents (5mg / kg, 10mg / kg, 30mg / kg), and the feed zinc concentration was detected by the standard method of atomic absorption spectrophotometer.

[0053] After 4 days of adaptive feeding, 56 SD rats were randomly divided into 7 groups according to body weight, with 8 rats in each group. Lactoferrin, bovine colostrum and yeast β-glucan were administered by gavage. The experimental groups are shown in the table below. The animals were weighed regularly and the intervention lasted for 5 weeks. After the experiment, the rats were killed by cervical dislocation and quickly dissected. The femur and other tissues were removed and properly preserved for subsequent experiments. The experimental groups are shown in Table 1.

[0054] Table 1

[0055]

[0056] Note: (1) Experimental Example 1 is the normal zinc control group; Experimental Example 2 is the zinc deficiency group, which is 1 / 6 of the normal zinc control group;

[0057] (2) The dosage per kilogram of body weight of rats is calculated based on their weight, food intake and zinc content in the feed. A zinc content of 10 mg / kg in the feed translates to a dosage of 1-1.5 mg / kg per kilogram of body weight of rats.

[0058] (3) Based on the average weight range of 10.3-50 kg for children aged 3-12 years, the daily supplement of zinc is 1.5-12 mg, the daily supplement of lactoferrin is 16-800 mg, the daily supplement of bovine colostrum is 95-480 mg, and the daily supplement of yeast β-glucan is 10-75 mg.

[0059] 2. Experimental methods

[0060] 1. Weight

[0061] Monitor the weight changes and diet of each rat, and calculate the animal weight during the experiment based on the animal weight and food intake.

[0062] 2. Femoral weight and femoral length

[0063] The femur length was measured and recorded using a ruler, and the femur weight was weighed on an analytical balance.

[0064] (III) Experimental results

[0065] 1. Effects of different experimental cases on the weight gain of growing rats

[0066] Weight gain is one of the important signs that describes whether rats grow and develop normally and whether their bodies are healthy. The results of weight changes in different groups showed that compared with Experimental Example 1, the weight gain of Experimental Examples 2-8 slowed down significantly after three weeks of intervention, and this trend continued until the fifth week, suggesting that reducing the zinc content in the feed, that is, zinc deficiency or insufficient zinc intake can lead to slow weight gain in growing rats and cause growth retardation.

[0067] Compared with Experimental Example 2, there was no significant difference in the weight of Experimental Example 4 after 3 weeks of intervention and 4 weeks of intervention, but the weight of Experimental Example 2 after 5 weeks of intervention was significantly higher than that of Experimental Example 2. Compared with Experimental Example 2, the weight of Experimental Examples 5-8 was significantly higher than that of Experimental Example 3 from the beginning of the 3rd week of intervention, and this trend of change continued until the 5th week; from the data of the 5th week of intervention, it can be seen that the slow weight gain caused by zinc deficiency or insufficient zinc intake in Experimental Examples 6-8 is better than that in Experimental Example 4, and the difference is significant; although there is no significant difference between Experimental Examples 6, 7 and 8, the weight of Experimental Examples 6-8 has an increasing trend with the increase of the enhanced dose, and Experimental Example 8 is closer to the normal feed control group of Experimental Example 1. Compared with Experimental Example 3, at the 5th week of intervention, Experimental Examples 6-8 were significantly higher than Experimental Example 3; compared with Experimental Example 5, at the 5th week of intervention, the weight of Experimental Examples 6 and 7 was significantly higher than that of Experimental Example 5.

[0068] The above results suggest that simply increasing the zinc content in the feed or lactoferrin + bovine colostrum + yeast β-glucan can alleviate the slow weight gain caused by zinc deficiency or insufficient zinc intake to a certain extent; but on the basis of increasing the zinc content, giving lactoferrin or lactoferrin + bovine colostrum + yeast β-glucan at the same time can further alleviate the slow weight gain caused by zinc deficiency or insufficient zinc intake, but the group technical effect of zinc + lactoferrin + bovine colostrum + yeast β-glucan nutritional composition is the best, and there is a certain synergistic effect. The effects of different experimental examples on the weight gain of growing rats are shown in Table 2.

[0069] Table 2

[0070]

[0071] 2. Effects of different experimental cases on bone development

[0072] In order to evaluate the effects of different experimental examples on the skeletal development of growth retardation animal models, the effects of 5-week intervention of each experimental example on the femur length and femur weight of rats were measured.

[0073] (1) Femoral length

[0074] The effects of different groups of embodiments on femur length in the specific embodiments of the present invention are as follows: Figure 1 As shown, compared with Experimental Example 1, the femur length of Experimental Example 2 decreased significantly, indicating that zinc deficiency or insufficient zinc intake can affect the development of femur length in growing rats, inhibit bone development, and lead to retardation of femur length. Compared with Experimental Example 2, although the femur length of Experimental Examples 3, 4, and 5 increased (by 2.7%, 2.2%, and 3.6%, respectively), there was no significant difference, indicating that simply increasing the zinc content in the feed, increasing lactoferrin + bovine colostrum + yeast β-glucan, and increasing zinc and lactoferrin at the same time have a tendency to alleviate the retardation of femur length growth, but there is no significant increase. Compared with Experimental Example 2, the femur length of Experimental Examples 6, 7, and 8 increased significantly, by 5.2%, 6.3%, and 6.9%, respectively, and gradually approached Experimental Example 1, and there was no significant difference between Experimental Example 1.

[0075] The above experimental results indicate that the zinc + lactoferrin + bovine colostrum + yeast β-glucan nutritional composition has a promoting effect on the femur development of growing rats and can significantly increase the femur length. There is a synergistic reaction between the components, which can synergistically increase the femur length and promote bone growth and development. With the increase of the dose, the femur length of the animals shows a trend of gradual recovery, showing a dose-dependent relationship. The effects of different experimental examples on the femur length of growing rats are shown in Figure 3.

[0076] Table 3

[0077]

[0078] (2) Femoral weight

[0079] The effects of different groups of embodiments on femoral weight in the specific embodiments of the present invention are as follows: Figure 2As shown, compared with Experimental Example 1, the femur weight of Experimental Example 2 decreased significantly, indicating that zinc deficiency or insufficient zinc intake can affect the development of the femur of growing rats, inhibit bone development, and lead to a decrease in femur weight and slow femoral growth. Compared with Experimental Example 2, the femur weight of Experimental Example 4 increased (increased by 22% compared with the control group), but there was no significant difference; compared with Experimental Example 2, the femur weight of Experimental Example 3 and Experimental Examples 5-8 increased significantly, increasing by 19.5%, 30.5%, 57.3%, 80.9%, and 93.9%, respectively; but compared with Experimental Examples 3 and 4, the femur weight of Experimental Examples 6-8 gradually increased, and the effects of Experimental Examples 6 and 7 gradually approached Experimental Example 1, and there was no significant difference between Experimental Example 1.

[0080] The above indicates that simply increasing the zinc content in the feed has a tendency to alleviate the growth retardation of femur length, but there is no significant increase; however, on the basis of increasing the zinc content, giving lactoferrin or lactoferrin + bovine colostrum + yeast β-glucan at the same time can further alleviate the decrease in femur weight caused by zinc deficiency or insufficient zinc intake, but the group technical effect of zinc + lactoferrin + bovine colostrum + yeast β-glucan nutritional composition is the best, and the effect is better than that of lactoferrin + bovine colostrum + yeast β-glucan group. There is a synergistic reaction between the components, which can synergistically increase the weight of the femur and promote bone growth and development. With the increase of the dose, the femur weight of the animal shows a trend of gradual recovery, and there is a certain synergistic effect and dose-effect relationship. The effects of different experimental examples on the femur weight of growing rats are shown in Table 4.

[0081] Table 4

[0082]

[0083] In summary, zinc deficiency or insufficient zinc intake can cause slow growth in body weight and femur length, decreased femur weight, affect bone development, and lead to growth retardation in growing rats. The zinc + lactoferrin + bovine colostrum + yeast β-glucan nutritional composition has significant effects on body weight gain, femur length and femur weight increase through a specific proportion and range, and the effect is better than that of the zinc alone fortified group, the lactoferrin alone fortified group, and the lactoferrin + bovine colostrum + yeast β-glucan group. There is a certain synergistic enhancement and dose-effect relationship between the components, which promotes the body weight and femur development of growing rats, promotes bone growth and development, improves or prevents growth retardation, and thus contributes to children's bone health and height development.

[0084] The above description of the embodiments is to facilitate the understanding and use of the invention by those skilled in the art. It is obvious that those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative work. Therefore, the present invention is not limited to the above embodiments, and improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the scope of protection of the present invention.

Claims

1. A composition, characterized in that The composition comprises a zinc source, lactoferrin, bovine colostrum and yeast beta-glucan. Calculated by the dry weight of zinc in the zinc source and lactoferrin, bovine colostrum and yeast beta-glucan, the mass ratio of zinc, lactoferrin, bovine colostrum and yeast beta-glucan is 1.5-12:16-800:95-480:14-75.

2. The composition according to claim 1, characterized in that The mass ratio of zinc, lactoferrin, bovine colostrum and yeast β-glucan is 1.6-11.9:20-800:98.1-476:14.7-70.

3. The composition according to claim 2, characterized in that The mass ratio of zinc, lactoferrin, bovine colostrum and yeast β-glucan is 1.6-11.9:30-800:100-476:15-70.

4. The composition according to claim 3, characterized in that The mass ratio of zinc, lactoferrin, bovine colostrum and yeast β-glucan is 1.6-11.9:50-800:110-476:15-50.

5. The composition according to claim 1, characterized in that The raw material providing zinc in the composition includes one or a combination of two or more of zinc sulfate, zinc gluconate, zinc glycinate, zinc oxide, zinc lactate, zinc citrate, zinc chloride, zinc acetate, zinc carbonate and zinc citrate trihydrate.

6. The composition according to claim 1, characterized in that The bovine colostrum is liquid bovine colostrum, bovine colostrum powder, or colostrum alkaline protein prepared by taking bovine colostrum as raw material.

7. The composition according to any one of claims 1 to 6, characterized in that The composition is a nutritional composition or a food composition.

8. A food, characterized in that The food comprises the composition according to any one of claims 1 to 7.

9. The food according to claim 8, characterized in that The food is ordinary food, nutritional supplement, dietary supplement, snack food, health food or special medical purpose formula food.

10. The food according to claim 9, characterized in that The food is a dairy product.

11. The food according to claim 10, characterized in that The milk-containing products include reconstituted milk or milk beverages, fermented milk or milk beverages, frozen drinks, milk powder, milk flakes or cheese.

12. The food according to any one of claims 8 to 11, characterized in that The food contains 1.8-20 mg zinc per 100 g of food dry matter.

13. The food according to claim 12, characterized in that The food contains 2.0-19.8 mg / 100g of food dry matter, 20-1323 mg / 100g of food dry matter, 109-800 mg / 100g of food dry matter, and 16.3-119 mg / 100g of food dry matter of zinc, lactoferrin, bovine colostrum and yeast beta-glucan.

14. The food according to claim 12, characterized in that The food contains 2.0-19.8 mg / 100g of dry matter, 30-1300 mg / 100g of dry matter, 110-800 mg / 100g of dry matter, and 20-80 mg / 100g of dry matter of zinc, lactoferrin, bovine colostrum, and yeast β-glucan, respectively; or, the food contains 2.0-19.8 mg / 100g of dry matter, 50-1300 mg / 100g of dry matter, 160-800 mg / 100g of dry matter, and 16.3-50 mg / 100g of dry matter of zinc, lactoferrin, bovine colostrum, and yeast β-glucan, respectively.

15. Use of the composition according to any one of claims 1 to 7 or the food according to claims 8 to 14 in preparing food capable of promoting children's height growth.

16. The use according to claim 15, characterized in that The said promotion of children's growth includes: Prevent and / or alleviate weight loss caused by zinc deficiency or insufficient zinc intake; Increase femur length; and / or Add weight to the femur.

17. The use according to claim 15 or 16, characterized in that: Calculated on the basis of the yeast β-glucan in the composition, the application amount of the yeast β-glucan is 10-50 mg / day.

18. The use according to claim 17, characterized in that The application amount of yeast beta-glucan in the composition is 11.5-49 mg / day.

19. The use according to claim 17, characterized in that: The application amount of yeast beta-glucan in the composition is 12.5-49 mg / day.

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