Medicinal and edible traditional Chinese medicine composition for dispelling effects of alcohol as well as preparation method and application of medicinal and edible traditional Chinese medicine composition

Abstract

The invention provides a medicinal and edible anti-alcohol traditional Chinese medicine composition as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following components: radix puerariae, cardamom, poria cocos, phaseolus calcaratus, fructus amomi, white hyacinth bean flower, ginseng, platycodon grandiflorum, malt, ginger and liquorice. The preparation method comprises the following steps: (1) distilling and extracting cardamom and fructus amomi to obtain volatile oil, dregs and a distilled water solution; (2) adding water into medicine residues and other components, decocting to obtain decoction, and filtering to obtain filtrate; (3) combining and concentrating the filtrate and the aqueous solution to obtain a concentrated solution; (4) adding ethanol into the concentrated solution, standing, and separating to obtain supernate; (5) filtering the supernate, and concentrating to obtain clear paste; granulating the clear paste, and uniformly mixing with the volatile oil to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition obtained by adopting the components and the preparation method disclosed by the invention has the advantages of easily available raw materials, low price, no additive, low cost, no toxic or side effect and obvious effects of preventing drunkenness and dispelling the effects of alcohol.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for relieving alcoholism as both a medicine and a food, and a preparation method and application thereof. Background Art

[0002] Traditional names for wine include brewing, ang, alcohol, cho, li, dai, sake, rice wine, etc. Wine has a mellow and unique aroma and is highly irritating. It also has the effects of promoting the efficacy of medicine, activating blood circulation, unblocking meridians, dispelling wind and cold, and correcting odor. However, frequent drinking not only destroys structures such as microtubules and mitochondria in liver cells, produces cytotoxic products, and thus easily causes liver damage, alcoholic fatty liver, cirrhosis, and affects liver metabolism, but also easily stimulates brain nerves, causing memory loss, irritability, mental excitement or dizziness, dementia, etc. Excessive drinking can cause acute and chronic alcohol poisoning, causing damage to multiple tissues and organs such as the digestive, cardiovascular and nervous systems, endangering physical health, and even leading to death. Therefore, it is urgent to find drugs or foods that have both alcohol sobering effects and no toxic side effects.

[0003] Traditional Chinese medicine has the advantages of less toxic side effects, less liver and kidney damage, and can sober up, detoxify, regulate the liver and treat alcoholic liver damage to a certain extent, so it has become the first choice for many people to sober up. For example, patent CN106729188 A discloses a composition with the function of clearing heat and sobering up and a preparation method thereof. The composition contains 31 ingredients, and finally the composition is made into a brewing-resistant tea or beverage. Not only is the product good in color, aroma and taste, but it also enhances the body's heat-clearing and detoxifying, diuretic and detoxifying functions, while comprehensively adjusting the body's internal organs balance, and can effectively avoid the adverse reactions of general heat-clearing and detoxifying drugs to the gastrointestinal tract, and has good effects on relieving oral inflammation and other internal heat symptoms, increasing the amount of alcohol consumed by social drinkers, relieving drunkenness symptoms and promoting drunken people to recover their physical condition as soon as possible. However, its preparation method needs to undergo multiple purifications, and the steps are relatively cumbersome.

[0004] For example, patent CN103356977 A discloses a hangover-relieving product, specifically disclosing a Chinese medicine composition containing 15 ingredients, including ginseng, gastrodia, cardamom, amomum, tangerine peel, costusroot, tuckahoe, oriental rhizome, atractylodes, ginger, hawthorn, kudzu flower, kudzu root, licorice and sucrose, and provides two methods for preparing the composition, namely, direct crushing and mixing and volatile oil extraction tank plus sandwich pot concentration preparation, and can be made into various dosage forms of medicines, health products or foods, such as Chinese medicine decoctions, pills, pills, lotions, pastes and oral liquids, health products, foods such as oral liquids, beverages, candies and teas. This product treats both the symptoms and the root causes, relieves hangover quickly, and has a very outstanding health care effect; for another example, patent CN 101028500 A discloses a kind of food and medicine with the effects of appetizing, refreshing and sobering up, and a preparation method thereof. Specifically disclosed is a Chinese medicine composition containing yam, white dung bean, lily, white dung bean flower, chicken gizzard lining, Poria, red bean, coix seed, jujube seed, bergamot, citron, bitter orange, gardenia, black plum, papaya, platycodon, malt, perilla, polygonatum, kudzu root, licorice, fresh reed root, light black beans, ginger, oyster, hawthorn, lotus leaf, light bamboo leaf, chrysanthemum, angelica, mint, amomum, patchouli, mulberry leaf, tangerine peel and radish seed, and auxiliary materials are xylitol and sugar color, a total of 38 ingredients. The preparation method is grinding and decocting with water to concentrate. The food and medicine has the effects of appetizing, refreshing and sobering up, and can be combined in a variety of dosage forms and food shapes, which is convenient for patients to take, and the health care effect of the food is good. Although the preparation methods disclosed in these two patents are simple, the Chinese medicine compositions contain many ingredients and all contain sucrose, which is a difficult hangover remedy for the increasing number of people who pay more attention to healthy eating.

[0005] For example, patent CN 114586879 A discloses a hangover-relieving composition, a hangover-relieving preparation containing the same, and its preparation method and application. Specifically, it discloses a Chinese medicine composition containing 10 kinds of medicinal and edible materials, including Poria cocos, Pueraria root, Phyllanthus emblica, Lycium barbarum, Cassia seed, Prunus mume, Hovenia dulcis, Citrus aurantium, Adzuki bean and Hibiscus sabdariffa, which has the effects of relieving alcohol and protecting the liver, protecting the brain, and improving the stomach. After taking, it can be quickly absorbed by the human body, tastes sweet, relieves symptoms after drinking, has no toxic side effects, is easy to eat, and is easy for the public to accept and promote. Although the invention contains a small number of ingredients, a simple preparation method, and a Chinese medicine composition with a hangover-relieving effect of 86%, alcohol increases the risk of serious health problems, and its hangover-relieving effect needs to be further enhanced, and more research is needed.

[0006] Therefore, there is an urgent need to develop a Chinese medicine composition with a simple preparation method, few ingredients and good hangover relief effect and a preparation method thereof. Summary of the invention

[0007] Based on the deficiencies of the prior art, the present invention aims to provide a Chinese medicine composition with a simple preparation method, few ingredients and good hangover-relieving effect, as well as a preparation method and application thereof. The ingredients contained in the method are kudzu root, cardamom, poria, red bean, amomum, white hyacinth flower, ginseng, platycodon, malt, ginger and licorice. The selected raw materials are all substances that can be used as both medicine and food. After reasonable preparation and scientific formulation, the Chinese medicine composition is finally proved to have a good hangover-relieving effect and the effect of preventing drunkenness through experiments.

[0008] In order to achieve the above object, the present invention adopts the following technical solutions:

[0009] On the one hand, the present invention provides a Chinese medicine composition for sobering up as both a medicine and a food. The Chinese medicine composition comprises the following components by weight: 10-20 parts of Pueraria root, 6-12 parts of cardamom, 6-12 parts of Poria cocos, 6-12 parts of red bean, 6-12 parts of Amomum villosum, 6-10 parts of white hyacinth bean flower, 6-10 parts of ginseng, 6-10 parts of Platycodon grandiflorum, 6-10 parts of malt, 3-8 parts of ginger and 3-8 parts of licorice.

[0010] Preferably, the Chinese medicine composition comprises the following components by weight: 12-18 parts of Pueraria root, 8-10 parts of cardamom, 8-10 parts of Poria cocos, 8-10 parts of red bean, 8-10 parts of Amomum villosum, 7-9 parts of white hyacinth bean flower, 7-9 parts of ginseng, 7-9 parts of Platycodon grandiflorum, 7-9 parts of malt, 3-7 parts of ginger and 3-7 parts of licorice.

[0011] More preferably, the Chinese medicine composition comprises the following components by weight: 14-16 parts of Pueraria root, 9-10 parts of cardamom, 9-10 parts of Poria cocos, 9-10 parts of adzuki bean, 9-10 parts of Amomum villosum, 8-9 parts of white hyacinth bean flower, 8-9 parts of ginseng, 8-9 parts of Platycodon grandiflorum, 8-9 parts of malt, 3-5 parts of ginger and 3-5 parts of licorice.

[0012] As a most preferred embodiment, the Chinese medicine composition includes the following components by weight: 15 parts of Pueraria root, 10 parts of cardamom, 10 parts of Poria cocos, 10 parts of red bean, 10 parts of Amomum villosum, 9 parts of white hyacinth bean flower, 9 parts of ginseng, 9 parts of Platycodon grandiflorum, 9 parts of malt, 6 parts of ginger and 3 parts of licorice.

[0013] Each component of the present invention is selected from the catalog of medicinal materials with the same origin as medicine and food, and can be both medicinal materials and food, and its drug mechanism is:

[0014] Pueraria root and cardamom are the main drugs. Pueraria root: sweet and spicy in taste, cool in nature, sobers up and invigorates the spleen. "Materia Medica": "It can treat parasites, nausea and vomiting, stimulate appetite, detoxify alcohol, and stop thirst."

[0015] Cardamom: spicy and warm in nature, it can dispel dampness and promote qi, relieve alcohol and stop vomiting. "Compendium of Materia Medica" says: "It can treat choking, cold and heat, and relieve alcohol poisoning." The two herbs are used together to invigorate the spleen and relieve alcohol poisoning.

[0016] Poria, red bean, Amomum villosum, and white lentil flower are the assistant drugs. Poria, with a light taste and a neutral nature, can promote diuresis and eliminate dampness, and strengthen the spleen. "Compendium of Materia Medica" says: "Poria can promote the orifices and remove dampness, which can open the heart and improve intelligence, and can guide turbidity and produce body fluid."; Red bean, with a sweet taste and a neutral nature, can promote diuresis and detoxify. "Shennong's Materia Medica" says: "It can treat thirst caused by cold and heat, stop diarrhea and dysentery, promote urination, lower abdominal distension, vomiting and sudden diarrhea.". The combination of Poria and red bean can promote the dampness of alcohol and expel it through urination. Amomum villosum, with a spicy taste and a warm nature, can eliminate dampness and stimulate the appetite, and regulate qi. "Pharmaceutical Meaning" says: "If the spleen is weak and full, the old food cannot be digested, and the alcohol poisoning hurts the stomach, this can be used to disperse stagnation and transform qi."; White lentil flower, with a sweet taste and a warm nature, can strengthen the spleen and eliminate dampness, and harmonize the middle. "Compendium of Materia Medica" says: "It tastes sweet, has a fragrant smell, is warm and neutral in nature, and is non-toxic. It can clear the three burners, raise the clear and lower the turbid." The combination of Sha and Bian can remove dampness with aromatic properties, strengthen the spleen and harmonize the stomach. The combination of the four herbs can eliminate alcohol dampness.

[0017] Ginseng, Platycodon grandiflorum, malt and ginger are adjuvants. Ginseng tastes sweet and slightly bitter, and is slightly warm in nature. It replenishes qi and strengthens the spleen, and supports the positive energy. "Yao Xing Lun" says: "It is mainly used to treat insufficient qi in the five internal organs, five kinds of fatigue and seven kinds of injuries, weakness and impotence, vomiting and inability to eat, stop cholera, depression and vomiting, replenish the five internal organs and six bowels, and protect the middle and guard the spirit." Platycodon grandiflorum tastes bitter and pungent, and is neutral in nature. It can eliminate bloating and digestion. "Ben Cao Jing Ji Zhu" says: "It is mainly used to treat abdominal distension, rumbling in the intestines, fear and palpitations. It benefits the five internal organs and intestines, replenishes blood and qi, eliminates cold, heat, wind and numbness, and warms the middle and digests food." Malt can relax the middle and lower qi, digest food and stop vomiting. "Yunnan Materia Medica" says: "It relaxes the middle, lowers qi, stops vomiting, eliminates old food, stops acid reflux and vomiting, stops diarrhea, and relieves stomach and diaphragm." Ginger is pungent and warm in nature, and can stimulate appetite and stop vomiting. "Ming Yi Bie Lu" says: "It is mainly used to treat cough, reverse breathing, and stop vomiting." Tangerine, ginger and malt are used together to stimulate appetite and stop vomiting.

[0018] Licorice is a guiding drug. Licorice is sweet and mild in nature. It not only helps ginseng to nourish the spleen and replenish qi, but also harmonizes various drugs. "Rihuazi Materia Medica" says: "It calms the soul and spirit. It replenishes the five kinds of labor and seven kinds of injuries, and treats all kinds of weakness, palpitations, depression, and forgetfulness. It opens the nine orifices, benefits all meridians, nourishes essence and qi, strengthens muscles and bones, and relieves cold and heat."

[0019] On the other hand, the present invention also provides a method for preparing the above-mentioned Chinese medicine composition for alcohol sobering up as both a medicine and food, comprising the following steps:

[0020] (1) Mix cardamom and amomum villosum, and then extract by steam distillation to obtain volatile oil, medicinal residues and aqueous solution after distillation, and set aside;

[0021] (2) Take the residue from (1), kudzu root, poria, adzuki bean, white lentil flower, ginseng, platycodon, malt, ginger, and liquorice, add water, decoct to obtain a decoction, filter to obtain a filtrate, and set aside;

[0022] (3) combining the filtrate obtained in step (2) with the aqueous solution obtained in step (1), concentrating, cooling, and obtaining a concentrated solution for standby use;

[0023] (4) taking the concentrated solution obtained in step (3), adding an equal amount of ethanol, allowing to stand, separating and obtaining a supernatant for later use;

[0024] (5) filtering the supernatant obtained in step (4), recovering ethanol from the filtrate, and concentrating to obtain a clear paste;

[0025] (6) taking the clear paste obtained in step (5), adding dextrin and ethanol, making granules, drying and setting aside;

[0026] (7) Add the granules obtained in step (6) to the volatile oil obtained in step (1), and mix well to obtain a Chinese medicine composition.

[0027] Preferably, the temperature of steam distillation extraction in the above step (1) is 100° C. and the time is 2 hours.

[0028] Preferably, the solid-liquid ratio of water added in the above step (2) is 1:5-10; preferably 1:6-9; more preferably 1:7-8; further preferably 1:7.

[0029] Preferably, the ethanol concentration in the above step (4) is 85-95%, preferably 95%.

[0030] Preferably, the standing time in the above step (4) is 18-30 hours; preferably 24 hours.

[0031] Preferably, in the above step (5), the mass ratio of the amount of dextrin added to the clear paste is 1.5-2.5:1, and the mass ratio of the amount of ethanol added to the volume of the clear paste is 2-6mL:100g. Further preferably, the mass ratio of the amount of dextrin added to the clear paste is 2:1, and the mass ratio of the amount of ethanol added to the volume of the clear paste is 4mL:100g.

[0032] Preferably, the drying temperature in the above step (6) is 50-70°C; more preferably 60°C.

[0033] In another aspect, the present invention also provides the use of the above-mentioned Chinese medicine composition for preventing drunkenness and sobering up.

[0034] The dosage form of the product is granules, tablets, capsules or oral liquid.

[0035] Compared with the prior art, the present invention has the following beneficial effects:

[0036] (1) It is made from Chinese medicine that is both a medicine and food and has readily available and low-priced raw materials. It contains no additives, is low-cost, and has no toxic or side effects.

[0037] (2) The operation is simple and feasible, and the product quality is controllable.

[0038] (3) The test shows that the Chinese medicine composition has a significant alcohol sobering effect of up to 93%. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 Latent time for drunkenness;

[0040] Figure 2 Maintain time for drunkenness. DETAILED DESCRIPTION

[0041] The present invention is further described in detail below with reference to specific embodiments.

[0042] Example 1 A Chinese medicine composition for alcohol sobering up and its preparation method

[0043] The Chinese medicine composition comprises the following components by weight:

[0044] 15 parts of kudzu root, 10 parts of cardamom, 10 parts of poria, 10 parts of red bean, 10 parts of amomum, 9 parts of white hyacinth flower, 9 parts of ginseng, 9 parts of platycodon, 9 parts of malt, 6 parts of ginger and 3 parts of liquorice.

[0045] The preparation method comprises the following steps:

[0046] (1) Mix cardamom and amomum villosum, and then use steam distillation to extract for 2 hours to obtain volatile oil, medicinal residues and aqueous solution after distillation, which are set aside;

[0047] (2) Take the residue from (1), kudzu root, poria, adzuki bean, white lentil flower, ginseng, platycodon, malt, ginger, and liquorice, add 7 times the amount of water, decoct twice, each time for 1 hour, combine the decoction, filter, and take the filtrate for later use;

[0048] (3) combining the filtrate from (2) with the aqueous solution after distillation from (1), concentrating, cooling, and obtaining a concentrated solution for later use;

[0049] (4) Take the concentrated solution in (3), add an equal amount of 95% ethanol, let stand at 26°C for 24 h, separate the supernatant and set aside;

[0050] (5) filtering the supernatant of step (4), recovering ethanol from the filtrate, and concentrating the filtrate to a clear paste having a relative density of 1.12-1.16 (50-55° C.);

[0051] (6) Take the clear paste in (5), add dextrin, the mass ratio of dextrin to the clear paste is 2:1, and the volume mass ratio of ethanol to the clear paste is 4 mL:100 g, make granules, dry at 60° C., granulate, and set aside;

[0052] (7) Take the granules in (6) and add the volatile oil prepared in (1) and mix well.

[0053] Example 2 A Chinese medicine composition for alcohol sobering up and its preparation method

[0054] The Chinese medicine composition comprises the following components by weight:

[0055] 20 parts of kudzu root, 12 parts of cardamom, 12 parts of tuckahoe, 12 parts of red bean, 12 parts of amomum, 10 parts of white hyacinth flower, 10 parts of ginseng, 10 parts of platycodon, 10 parts of malt, 8 parts of ginger and 8 parts of liquorice.

[0056] The preparation method is different from that of Example 1 only in that: the steam distillation extraction in step (1) is performed for 1 hour; the decoction in step (2) is performed once, each time for 0.5 hours; and the standing time in step (4) is 18 hours. The other preparation steps are the same as those of Example 1.

[0057] Example 3 A Chinese medicine composition for alcohol sobering up and its preparation method

[0058] The Chinese medicine composition comprises the following components by weight:

[0059] 10 parts of kudzu root, 6 parts of cardamom, 6 parts of poria, 6 parts of red bean, 6 parts of amomum, 6 parts of white hyacinth flower, 6 parts of ginseng, 6 parts of platycodon, 6 parts of malt, 3 parts of ginger and 3 parts of liquorice.

[0060] The preparation method is different from that of Example 1 only in that: in step (1), the steam distillation is performed for 3 hours; in step (2), the decoction is performed for 3 times, each time for 3 hours; and in step (4), the standing time is 30 hours. The other preparation steps are the same as those of Example 1.

[0061] Example 4 A Chinese medicine composition for alcohol sobering up and its preparation method

[0062] The Chinese medicine composition comprises the following components by weight:

[0063] 18 parts of kudzu root, 10 parts of cardamom, 8 parts of tuckahoe, 8 parts of red bean, 10 parts of amomum, 7 parts of white hyacinth flower, 9 parts of ginseng, 7 parts of platycodon, 9 parts of malt, 4 parts of ginger and 7 parts of liquorice.

[0064] The preparation method is consistent with that in Example 1.

[0065] Example 5 A Chinese medicine composition for alcohol sobering up and its preparation method

[0066] The Chinese medicine composition comprises the following components by weight:

[0067] 14 parts of kudzu root, 8 parts of cardamom, 10 parts of tuckahoe, 10 parts of red bean, 8 parts of amomum, 9 parts of white hyacinth flower, 7 parts of ginseng, 9 parts of platycodon, 7 parts of malt, 8 parts of ginger and 3 parts of liquorice.

[0068] The preparation method is consistent with that in Example 1.

[0069] Comparative Example 1

[0070] The only difference from Example 1 is that the preparation method is different, and step 7 is omitted, which is specifically:

[0071] (1) Mix cardamom and amomum, extract by steam distillation for 2 h, and obtain the residue and the aqueous solution after distillation for later use;

[0072] (2) Take the cardamom and Amomum villosum residues in (1), kudzu root, Poria cocos, red bean, white lentil flower, ginseng, platycodon, malt, ginger, and liquorice, add 7 times the water, decoct twice, each time for 1 hour, combine the decoctions, filter, and take the filtrate for later use;

[0073] (3) combining the filtrate from (2) with the aqueous solution after distillation from (1), concentrating, cooling, and obtaining a concentrated solution for later use;

[0074] (4) Take the concentrated solution in (3), add an equal amount of 95% ethanol, let stand at 26°C for 24 h, separate the supernatant and set aside;

[0075] (5) filtering the supernatant of (4), recovering ethanol from the filtrate, and concentrating the filtrate to a clear paste with a relative density of 1.12-1.16 (50-55° C.);

[0076] (6) Take the clear paste in (5), add dextrin, the mass ratio of dextrin to the clear paste is 2:1, and the volume mass ratio of ethanol to the clear paste is 4mL:100g, make granules, dry at 60°C, granulate and set aside. Make granules, dry at 60°C.

[0077] Comparative Example 2

[0078] The difference from Example 1 is that cardamom is omitted, the content of kudzu root is increased to 25 parts, and the rest is the same as Example 1.

[0079] The difference between the preparation method and Example 1 is only that:

[0080] (1) Take Amomum villosum, extract it by steam distillation for 2 h, and obtain the residue and the aqueous solution after distillation for later use;

[0081] (2) Take the residue of Amomum villosum in (1), Pueraria root, Poria cocos, Adzuki bean, White lentil flower, Ginseng, Platycodon grandiflorum, Malt, Ginger, Licorice, add 7 times of water, decoct twice, each time for 1 hour, combine the decoction, filter, take the filtrate, and set aside;

[0082] The other steps are consistent with Example 1.

[0083] Comparative Example 3

[0084] The difference from Example 1 is that: Poria cocos and red bean are omitted, the content of Amomum villosum is increased to 20 parts, and the content of White Laba Bean Flower is increased to 19 parts, and the rest is the same as Example 1.

[0085] The difference between the preparation method and Example 1 is only that:

[0086] (1) Mix cardamom and amomum, extract by steam distillation for 2 h, and obtain the residue and the aqueous solution after distillation for later use;

[0087] (2) Take the cardamom and amomum residues in (1), kudzu root, white lentil flower, ginseng, platycodon, malt, ginger, and liquorice, add 7 times the water, decoct twice, each time for 1 hour, combine the decoctions, filter, and take the filtrate for later use;

[0088] The other steps are consistent with Example 1.

[0089] Comparative Example 4

[0090] The difference from Example 1 is that cardamom, Poria cocos and red bean are omitted, the content of Pueraria root is increased to 25 parts, the content of Amomum villosum is increased to 20 parts, the content of white hyacinth bean flower is increased to 19 parts, and the rest is the same as Example 1.

[0091] The difference between the preparation method and Example 1 is only that:

[0092] (1) Take Amomum villosum, extract it by steam distillation for 2 h, and obtain the residue and the aqueous solution after distillation for later use;

[0093] (2) Take the residue of Amomum villosum in (1), Pueraria root, white hyacinth flower, ginseng, Platycodon grandiflorum, malt, ginger, and liquorice, add 7 times of water, decoct twice, each time for 1 hour, combine the decoction, filter, and take the filtrate for later use;

[0094] The other steps are consistent with Example 1.

[0095] Effect test:

[0096] Test Example 1: Behavior after drinking and hangover sobering effect test:

[0097] Experimental methods:

[0098] 120 SPF Kunming mice were selected and adaptively fed for 3 days, and then randomly divided into a model group, an embodiment-low dose group, an embodiment-medium dose group, an embodiment-high dose group, and a comparative example group according to their body weight.

[0099] Model group, high-dose group in Example 1, medium-dose group in Example 1, low-dose group in Example 1, medium-dose group in Example 2, medium-dose group in Example 3, medium-dose group in Example 4, medium-dose group in Example 5, medium-dose group in Comparative Example 1, medium-dose group in Comparative Example 2, medium-dose group in Comparative Example 3, and medium-dose group in Comparative Example 4, a total of 12 experimental groups, 10 mice in each group, half of them were male and half were female, and the weight of each mouse was weighed.

[0100] The high, medium and low dose groups were set to 15, 10 and 5 g / kg, respectively, and diluted with distilled water to equal volumes (20 mL) of the composition solution. After fasting for 12 hours but not water, the 12 groups of mice were gavaged with the composition solution at 20 mL / kg on the same day, and the model group was gavaged with an equal volume of normal saline. After 30 minutes, 12 groups of mice were gavaged with 56° Red Star Erguotou at 17 mL / kg, and the timing was started immediately to observe the behavioral state of the mice. The mice were recorded for symptoms such as death, abdominal distension, vomiting, and urination. The results are shown in Table 1 below; the disappearance and recovery time of the righting reflex of the drunk mice were recorded, and the drunkenness rate, latent period of drunkenness and maintenance time of the mice were calculated. The results are shown in Table 2 below.

[0101] The drunkenness of mice was determined by the disappearance of righting reflex, that is, mice were in a supine position and could not right themselves for 30 seconds or more, which was considered drunkenness; mice were considered sober if they recovered their righting reflex. Drunkness rate = number of drunk mice / total number of mice in the group. The incubation period of drunkenness was the time from the intragastric administration of liquor to the disappearance of righting reflex. The duration of drunkenness was the time from the disappearance of righting reflex to the recovery of righting reflex. Mice that were still not sober after 8 hours were calculated as 480 minutes.

[0102] Table 1 Behavioral signs of mice

[0103]

[0104] Experimental results analysis:

[0105] The results showed that the low, medium and high experimental groups all had good urination effects, and the high-dose group was better than the model group in eliminating abdominal distension, vomiting and unsteady walking.

[0106] Comparative Example 1 is similar to the medium-dose Example 1 group in terms of urination effect, but it is weaker than the low-dose Example 1 group in terms of relieving abdominal distension, vomiting and unsteady walking, indicating that the addition of cardamom and amomum villosum volatile oils helps to relieve drunken behavioral symptoms such as abdominal distension, vomiting and unsteady walking.

[0107] The comparative example 2 group was equivalent to the low-dose example 1 group in terms of urination effect, but was weaker than the low-dose example 1 group in terms of relieving abdominal distension and vomiting, indicating that the combination of cardamom and kudzu root can enhance the elimination of drunken behavioral symptoms such as abdominal distension and vomiting.

[0108] The comparative example 3 group was comparable to the medium-dose example 1 group in eliminating abdominal distension symptoms, but the urination effect was reduced, indicating that the addition of Poria cocos and adzuki beans can greatly enhance the urination effect.

[0109] The comparative example 4 group was comparable to the low-dose example 1 group in eliminating abdominal distension and vomiting, but was weaker than the low-dose example 1 group in relieving urination and unsteady walking, indicating that the addition of cardamom, poria and red bean can not only significantly play a role in urination, but also improve the symptoms of unsteady walking.

[0110] Table 2 Evaluation of alcohol sobering in mice

[0111]

[0112]

[0113] Note: Compared with the model group, *, p<0.05; **, p<0.01

[0114] Experimental results analysis:

[0115] Table 2 shows that compared with the model group, the preventive administration of low, medium and high doses of Example 1 and Comparative Example 1, Comparative Example 2, Comparative Example 3 and Comparative Example 4 all have a certain preventive effect on sobering up, and Example 1 has the best sobering up effect, among which the high dose group has the best effect.

[0116] SPSS software was used to conduct statistical analysis on the intoxication latency time and intoxication maintenance time in Table 2. The results are as follows Figure 1-2 The results showed that compared with the model group, the middle and high dose groups of Example 1 had significant differences in the intoxication latency time and intoxication maintenance time.

[0117] Compared with the model group, the low, medium and high dose groups and comparative example 1 group (lack of cardamom and Amomum villosum volatile oil), comparative example 2 group (lack of cardamom), comparative example 3 group (lack of Poria cocos, red bean), comparative example 4 group (lack of cardamom, Poria cocos, red bean) can prolong the incubation period of drunkenness, among which the high dose group can effectively prolong the incubation period of drunkenness and shorten the maintenance time of drunkenness, and has a good effect of preventing drunkenness and sobering up. The data of comparative example 1 group (lack of cardamom and Amomum villosum volatile oil), comparative example 2 group (lack of cardamom), comparative example 3 group (lack of Poria cocos, red bean), comparative example 4 group (lack of cardamom, Poria cocos, red bean) show that compared with the embodiment 1 group, the synergy between cardamom and Amomum villosum volatile oil, the monarch drug, and the compatibility between the monarch and minister drugs in the present invention can synergistically increase the effect of sobering up and preventing drunkenness. When the addition of volatile oil is lacking, or the monarch drug cardamom is lacking, or some monarch and minister drugs cardamom, Poria cocos, and red bean are lacking, the effect of preventing drunkenness and sobering up is low.

[0118] The alcohol-relieving Chinese medicinal composition of the present invention is suitable for people of any age group to take before or after drinking. The following analysis data are provided to further illustrate the alcohol-relieving effect and the effect of preventing drunkenness of the compound alcohol-relieving Chinese medicinal composition of the present invention.

[0119] Test Example 2: Drunkenness Prevention Test

[0120] Experimental methods:

[0121] 60 healthy drinking subjects, including 38 men and 22 women, were selected for the drunkenness prevention test. All 60 subjects met the following exclusion criteria: no alcohol allergy; no liver dysfunction, severe cardiovascular disease; no coagulation dysfunction; no congenital heart disease; no malignant tumor. The 60 subjects were aged 23-47 years old, with an average age of (32.67±5.24) years old. The prepared compound hangover granules were given 30 minutes before drinking, 10 servings per person, and dissolved in 100 mL of water; the average alcohol consumption of the subjects was 250-500 mL, and the subjects' reactions were recorded 2 hours after the end of drinking.

[0122] Preventing drunkenness effect:

[0123] Among them, 93.33% of drinkers had no feeling of vomiting, headache or other obvious discomfort; 95.00% of drinkers spoke clearly and had normal logic; and 86.67% of drinkers basically recovered to be like normal people.

[0124] The above shows that the present invention has a good effect of preventing drunkenness, can significantly reduce the discomfort of drinkers after drinking, and reduce the occurrence of drunkenness.

[0125] Test Example 3: Alcohol Sobering Effect Test

[0126] Test method:

[0127] 63 drinking subjects, including 28 men and 35 women, were collected to conduct a hangover effect test. All 63 drinking subjects met the following exclusion criteria: no alcohol allergy; no liver dysfunction, cardiovascular and other serious diseases; no coagulation dysfunction; no congenital heart disease; no malignant tumors. The 63 drinking subjects were aged 21-48 years old, with an average age of (36.31±4.67) years old. The average alcohol consumption of the subjects was 250-500mL. The subjects were provided with the same volume of the compound hangover oral liquid of the present invention 30 minutes after drinking, and the subjects' reactions were recorded 1 hour after taking the oral liquid.

[0128] Alcohol sobering effect:

[0129] Among them, 93.65% of the drinkers had their complexion return to normal, the feeling of vomiting disappeared, the headache was significantly alleviated, and other discomforts were significantly alleviated; 96.83% of the drinkers spoke clearly, had normal logic, and had clear memory; and 88.89% of the drinkers basically returned to normal.

[0130] The above shows that the compound hangover oral liquid of the present invention has a good hangover sobering effect, can significantly reduce the discomfort of drinkers after drinking, and can achieve complete hangover sobering in a short time.

[0131] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicine composition for alcohol sobering up that can be used as both medicine and food, characterized in that: The Chinese medicine composition comprises the following components by weight: 10-20 parts of kudzu root, 6-12 parts of cardamom, 6-12 parts of poria, 6-12 parts of red bean, 6-12 parts of amomum, 6-10 parts of white hyacinth bean flower, 6-10 parts of ginseng, 6-10 parts of platycodon, 6-10 parts of malt, 3-8 parts of ginger and 3-8 parts of licorice.

2. The Chinese medicine composition according to claim 1, characterized in that: The composition includes the following components by weight: 12-18 parts of kudzu root, 8-10 parts of cardamom, 8-10 parts of poria, 8-10 parts of adzuki bean, 8-10 parts of amomum villosum, 7-9 parts of white hyacinth bean flower, 7-9 parts of ginseng, 7-9 parts of platycodon, 7-9 parts of malt, 3-7 parts of ginger and 3-7 parts of liquorice.

3. The Chinese medicine composition according to claim 1, characterized in that The composition includes the following components by weight: 14-16 parts of kudzu root, 9-10 parts of cardamom, 9-10 parts of poria, 9-10 parts of adzuki bean, 9-10 parts of amomum villosum, 8-9 parts of white hyacinth bean flower, 8-9 parts of ginseng, 8-9 parts of platycodon, 8-9 parts of malt, 3-5 parts of ginger and 3-5 parts of licorice.

4. The method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The steps include: (1) Mix cardamom and amomum villosum, and extract by distillation to obtain volatile oil, medicinal residues and aqueous solution after distillation, and set aside; (2) mixing the residue obtained in step (1) with kudzu root, poria, adzuki bean, white lentil flower, ginseng, platycodon, malt, ginger and liquorice, adding water, boiling and filtering to obtain a filtrate for later use; (3) combining the filtrate obtained in step (2) with the aqueous solution obtained in step (1), concentrating, cooling, and obtaining a concentrated solution for standby use; (4) taking the concentrated solution obtained in step (3), adding ethanol, allowing to stand, separating and obtaining a supernatant for later use; (5) filtering and concentrating the supernatant obtained in step (4) to obtain a clear paste; (6) taking the clear paste obtained in step (5), adding dextrin and ethanol, making granules, drying and setting aside; (7) The particles obtained in step (6) are mixed with the volatile oil obtained in step (1) to obtain a Chinese medicine composition.

5. The preparation method according to claim 4, characterized in that: The distillation described in step (1) is steam distillation.

6. The preparation method according to claim 4, characterized in that: The distillation time in step (1) is 1-3h.

7. The preparation method according to claim 4, characterized in that: The decoction in step (2) is performed 1 to 3 times, each time for 0.5 to 3 hours.

8. The preparation method according to claim 4, characterized in that: The standing time described in step (4) is 18-30 hours.

9. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of alcohol sobering and hangover sobering products.

10. A product for sobering up from alcohol, characterized in that: The Chinese medicine composition comprises any one of claims 1 to 3, wherein the dosage form of the product is granules, tablets, capsules or oral liquid.

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