Traditional Chinese medicine composition for treating constipation as well as preparation method and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for treating constipation as well as a preparation method and application thereof, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 55-65 parts of figs, 25-35 parts of fresh fig leaves, 45-55 parts of honey, 25-35 parts of kapok, 15-25 parts of tribulus terrestris and 5-15 parts of fructus psoraleae. The preparation method comprises the following steps: grinding the figs and the fructus psoraleae into fine powder, decocting the fig leaves, the kapok and the tribulus terrestris with water, mixing the fine powder with a decoction, mixing with the honey, decocting into paste, and preparing into the suppository. According to the traditional Chinese medicine composition disclosed by the invention, multiple medicines are compatible and have a synergistic effect, the treatment effective rate of constipation patients is up to 92.22%, and the traditional Chinese medicine composition is suitable for popularization and application to provide a new thought for constipation treatment.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating constipation, and a preparation method and application thereof. Background Art

[0002] The statements in this section merely provide background information related to the present disclosure and may not constitute prior art.

[0003] Constipation is a common digestive symptom, characterized by decreased bowel movements, hard and dry stools, and difficulty defecating. It seriously affects the patient's quality of life and may even lead to other health problems. There are various treatments for constipation, including lifestyle adjustments, medication, biofeedback therapy, neuromodulation therapy, and surgical treatment.

[0004] Drug therapy is an important means of treating constipation, including bulk laxatives, osmotic laxatives, stimulant laxatives, lubricants, etc. These drugs increase the volume of intestinal contents, stimulate intestinal peristalsis or lubricate the intestinal wall through different mechanisms, thereby relieving constipation symptoms.

[0005] The prior art with publication number CN100387256C provides a medicine for treating gastric anorectal diseases, which is mainly made of the following raw materials by weight: fresh figs, Codonopsis, Atractylodes macrocephala, honey and licorice. The recipe uses figs to clear the intestines and strengthen the stomach as the main medicine, Codonopsis pilosula, tonifying the middle and replenishing qi, and Atractylodes macrocephala to tonify the stomach and replenish the stomach as the ministerial medicine. Honey is used to tonify the middle and moisten dryness. Licorice is sweet, warm and replenishing qi, and it is used to harmonize various medicines. The prior art CN105148045A also provides a Chinese medicine for treating constipation in pregnant women with hemorrhoids, which is mainly composed of the following components by weight: 25-35 grams of figs, 90-110 grams of polished rice, and 15-25 grams of honey. Polished rice is used in the recipe to strengthen the spleen and stomach, tonify the middle and replenish qi, eliminate restlessness and thirst, and stop diarrhea.

[0006] However, the effect of glutinous rice in relieving restlessness and diarrhea is contrary to constipation itself, so its effectiveness is questionable.

[0007] Codonopsis pilosula and Atractylodes macrocephala are mainly used to invigorate qi, and the medicine is taken orally, so it is slow to reach the lesion and take effect. In order to provide a faster and more accurate new prescription for treating constipation, the inventor of the present application has made new explorations. Summary of the invention

[0008] The purpose of the present invention is to provide a Chinese medicine composition for treating constipation and its preparation method and application in view of the problem that there are few effective Chinese medicine prescriptions for treating constipation and the slow effect. The medicines in the prescription are all medicines and foods of the same origin. The prescriptions and medicines whose main ingredients are both medicines and foods are made into suppositories, which act directly on the affected area, are faster and more fully exert their efficacy than oral preparations.

[0009] The technical solution of the present invention is as follows:

[0010] On one hand, the present invention provides a Chinese medicine composition for treating constipation, which is made from the following raw materials in parts by weight: 55-65 parts of figs, 25-35 parts of fresh fig leaves, 45-55 parts of honey, 25-35 parts of kapok flowers, 15-25 parts of tribulus terrestris and 5-15 parts of psoralea corylifolia.

[0011] According to a preferred embodiment, the Chinese medicine composition for treating constipation comprises the following raw materials in parts by weight: 57-63 parts of figs, 27-33 parts of fresh fig leaves, 47-53 parts of honey, 27-33 parts of kapok flowers, 17-23 parts of Tribulus terrestris and 7-13 parts of Psoralea corylifolia.

[0012] According to a preferred embodiment, the Chinese medicine composition for treating constipation comprises the following raw materials in parts by weight: 60 parts of figs, 30 parts of fresh fig leaves, 50 parts of honey, 30 parts of kapok flowers, 20 parts of Tribulus terrestris and 10 parts of Psoralea corylifolia.

[0013] The Chinese medicinal composition for treating constipation prepared by the present invention has the effect of moistening the intestines and promoting bowel movements, and can be used to treat heat-stagnation constipation, qi stagnation constipation, yang deficiency constipation, intestinal dryness constipation, hemorrhoids, etc., and has good effects. The above-mentioned medicine is both a food and a Chinese medicinal material. Starting from the principle that medicine and food have the same origin, the Chinese medicinal composition for treating constipation prepared by the present invention has a therapeutic efficacy of up to 92.22% for constipation patients through clinical observation.

[0014] Our solution:

[0015] 1) Figs

[0016] Drug source: The fruit of the fig plant (Latin name: Ficus carica Linn.) of the Moraceae family.

[0017] Effects: nourishes the lungs and relieves cough, invigorates the spleen and stimulates appetite, clears the intestines and reduces swelling

[0018] Indications: dry cough, indigestion, hemorrhoids, constipation, dysentery, sore throat, etc. "Compendium of Materia Medica": Treats five types of hemorrhoids and sore throat. "Essentials of Herbal Medicine": Washes hemorrhoids. Seed, cooked with meat, detoxifies. Stamen, promotes lactation. "Suixiju Diet": Clears heat and moisturizes the intestines. "Yunnan Chinese Herbal Medicine": Strengthens the stomach and stops diarrhea, removes phlegm and regulates qi. Treats loss of appetite, indigestion, enteritis, dysentery, sore throat, cough with phlegm, and chest tightness.

[0019] Modern pharmacology: 1. Lubricates the intestines and promotes bowel movements: Figs contain malic acid, citric acid, lipase, protease, hydrolase, etc., which can help the body digest food and promote appetite. Because they contain a variety of lipids, they have a laxative effect. 2. Lowers blood lipids and blood pressure: The lipase and hydrolase contained in figs have the function of lowering blood lipids and decomposing blood lipids, so they can lower blood lipids and reduce the deposition of fat in blood vessels, thereby playing a role in lowering blood pressure and preventing coronary heart disease. 3. Anti-cancer and anti-tumor: The milk of unripe fruits contains active ingredients such as psoralen and bergamot lactone, and the juice of its ripe fruits can extract an aromatic substance "benzaldehyde", both of which have anti-cancer and anti-cancer effects.

[0020] 2) Fig leaves

[0021] Drug source: The leaves of Ficus carica Linn., a plant of the Moraceae family.

[0022] Efficacy: Clears dampness and heat, relieves sore toxins, moistens the intestines and promotes bowel movements, promotes qi and relieves pain.

[0023] Indications: diarrhea due to damp heat, leucorrhea, hemorrhoids, constipation, carbuncle pain, scrofula, heartache and other diseases.

[0024] Modern pharmacological research: 1. Clearing away heat and detoxifying: Fig leaves are rich in flavonoids and oxalic acid, which have the effect of clearing away heat and detoxifying, can effectively relieve the body's internal inflammatory response, and reduce the risk of infectious diseases. 2. Lubricating the intestines and relieving constipation: Fig leaves are rich in plant cellulose, which can stimulate intestinal peristalsis, promote defecation, and relieve constipation. 3. Antioxidant: The flavonoids in fig leaves have antioxidant effects, can remove free radicals in the body, and slow down aging. 4. Lowering blood pressure: Ingredients such as oxalic acid and nitrates in fig leaves can lower blood pressure and help maintain blood vessel health.

[0025] 3) Ripe honey

[0026] It is warm in nature, sweet and peaceful, soft and moist, and has the effects of protecting the spleen and stomach, moistening the intestines and relieving constipation, reducing dryness and detoxification, and regulating yin and yang, and can replenish deficiency and cure the root cause, moisten Taiyin, and can guide the qi of the large intestine downward, unblock the visceral qi, and enhance intestinal peristalsis. Modern pharmacological research has confirmed that the lactulose in honey can be degraded into low-molecular acids in the intestine, which can improve intestinal permeability, increase intestinal fluid exudation, and soften stools; at the same time, honey is converted into low-molecular organic acids by the digestive tract flora in the rectum, which can lower the pH value in the intestine, retain water in the intestine, increase stool volume, stimulate colorectal peristalsis, regulate colorectal physiological rhythms, and promote defecation.

[0027] 4) Tribulus terrestris

[0028] Drug source: The dried mature fruit of Tribulus terrestris L., an annual herb of the genus Tribulus in the family Tribulaceae.

[0029] Effects: Soothe liver and relieve depression, soothe the liver and extinguish wind, clear the liver and improve eyesight

[0030] Indications: dizziness, chest and flank pain, breast pain, breast obstruction, amenorrhea, red eyes, itching due to urticaria, etc.

[0031] Modern pharmacological research: 1. The water extract of Tribulus terrestris has anti-inflammatory effect. 2. It has antihypertensive effect. 3. It has a certain diuretic effect, which may be related to the potassium salt and alkaloids contained. 4. It has anti-acetylcholine effect. 5. It has strengthening and anti-aging effects.

[0032] 5) Psoralea corylifolia

[0033] Drug source: The dried seeds of Cullen corylifolium (Linnaeus) Medikus, an annual herb of the genus Psoralea in the Leguminosae family.

[0034] Effects: warms the kidney and strengthens yang, consolidates semen and reduces urination, promotes qi and relieves asthma, warms the spleen and stops diarrhea

[0035] Indications: impotence, premature ejaculation, infertility due to uterine cold, soreness of waist and knees, kidney deficiency, spermatorrhea, spermatorrhea, enuresis, frequent urination, spleen and kidney yang deficiency, diarrhea at dawn, vitiligo, and alopecia areata.

[0036] Modern pharmacological research: 1. Psoralea corylifolia has estrogen-like effects, which can dilate coronary arteries, excite the heart, accelerate heart rate, contract the uterus, reduce bleeding, etc. 2. Psoralea corylifolia can better promote the body's immune function and strengthen bones. 3. Anti-tumor effect: Through bakuchiol and psoralen, it can inhibit the activity of replicative DNA polymerase. 4. The effect of isopsoralen chalcone in psoralea corylifolia and the effect of psoralen dihydroflavonoid methyl ether can fully exert the anti-Staphylococcus aureus and Staphylococcus epidermidis effects, and the antibacterial effects of both are more obvious.

[0037] 6) Kapok

[0038] Drug source: Dried flowers of Gossampinus malabarica (DC.) Merr, a plant of the Bombacaceae family.

[0039] Efficacy: Clears away heat and dampness, cools blood and detoxifies.

[0040] Indications: diarrhea, dysentery, hemoptysis, metrorrhagia, constipation, hemorrhoids, eczema.

[0041] Modern pharmacological effects: 1. Sterilization effect: Kapok contains rich organic acid components, which has a bactericidal effect, is beneficial to prevent and treat wound infection and promote wound healing. 2. Diuretic and detumescent effect: Kapok contains rich mineral components, which is beneficial to promote the discharge of excess water in the body. 3. Anti-inflammatory effect: Kapok contains rich tannic acid, which has a good astringent effect.

[0042] This prescription makes heavy use of the main medicine fig to clear the intestines and reduce swelling, fresh fig leaves and honey to moisten the intestines and promote bowel movements, used as auxiliary medicines, kapok to cool the blood and detoxify, Tribulus terrestris to soothe the liver and relieve depression, and psoralea corylifolia to warm the kidneys and strengthen yang, also serving as guiding medicines. The above medicines work synergistically when combined.

[0043] Another aspect of the present invention provides a method for preparing the above-mentioned Chinese medicine composition for treating constipation, comprising the following steps:

[0044] Step S1: firstly, 60 parts of figs and 10 parts of psoralea corylifolia are mixed and pulverized into fine powder, which can all pass through a No. 5 sieve and contain no less than 95% of the powder that can pass through a No. 6 sieve;

[0045] Step S2: put 30 parts of fresh fig leaves, 30 parts of kapok flowers, and 20 parts of Tribulus terrestris into 3-5 times the weight of cold water and boil for 5-10 minutes;

[0046] Step S3: The decoction prepared in step S2 and the fine powder prepared in step S1 are evenly mixed to form a medicine, the honey and the medicine are mixed in a mass ratio of 3:1, and then the standard mold is installed on the pharmaceutical machinery, the honey and the medicine are decocted into a paste by the pharmaceutical machinery, and injected into the pharmaceutical machinery mold to produce a 2×3 cm honey plug.

[0047] Compared with the prior art, the present invention has the following beneficial effects:

[0048] 1. Provide a Chinese medicine composition for treating constipation, wherein the main medicine fig is used in the prescription to clear the intestine and reduce swelling, fresh fig leaves and honey are used to moisten the intestine and promote bowel movements, and kapok is used as a ministerial medicine to cool blood and detoxify, Tribulus terrestris is used to soothe the liver and relieve depression, and Psoralea corylifolia is used to warm the kidney and strengthen yang, and is also used as a guiding medicine. The above medicines play a synergistic role after being compatible, and have good effects on heat-induced constipation, qi stagnation constipation, yang deficiency constipation, intestinal dryness constipation, hemorrhoids, etc. The composition can be used to relieve constipation and hemorrhoids in adults of all ages, has good safety, and is suitable for daily use.

[0049] 2. A Chinese medicine composition for treating constipation and a preparation method thereof. The above composition is prepared into a suppository and can be used on the affected area in a targeted manner. It has better efficacy and shorter duration of action than oral administration.

[0050] 3. A Chinese medicine composition for treating constipation, and its preparation method and application, which have better curative effect than the existing formula using honey, figs and fig leaves alone. DETAILED DESCRIPTION

[0051] The specific embodiments listed in the present invention are only examples of the present invention, and the present invention is not limited to the specific embodiments described below. For those skilled in the art, any equivalent modifications and substitutions to the embodiments described below are also within the scope of the present invention. Therefore, the equal transformations and modifications made without departing from the spirit and scope of the present invention should be included in the scope of the present invention. If the specific conditions are not specified in the embodiments, they are carried out according to the conventional conditions or the conditions recommended by the manufacturer. If the manufacturers are not specified for all reagents or instruments, they are all conventional products that can be purchased commercially. In order to better illustrate the present invention, numerous specific details are given in the specific embodiments below. It should be understood by those skilled in the art that the present invention can also be implemented without certain specific details. In other embodiments, the methods, means, equipment and steps well known to those skilled in the art are not described in detail in order to highlight the purport of the present invention.

[0052] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art. Unless otherwise specified, the units used in this specification are all international standard units, and the numerical values ​​and numerical ranges appearing in the present invention should be understood to include the inevitable systematic errors in industrial production.

[0053] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0054] Example 1 Preparation of the Chinese medicine composition for treating constipation

[0055] 1. Preparation of the Chinese medicine composition for treating constipation

[0056] Step S1: first mix 60g figs and 10g psoralea corylifolia and grind into fine powder;

[0057] Step S2: put 30g of fresh fig leaves, 30g of kapok flowers and 20g of Tribulus terrestris into 300g of cold water and boil for 5min;

[0058] Step S3: The decoction prepared in step S2 and the fine powder prepared in step S1 are evenly mixed to form a medicine, 50 g of cooked honey is added, the honey and the medicine are mixed in a mass ratio of 3:1, and then the standard mold is installed on the pharmaceutical machinery, the honey and the medicine are decocted into a paste by the pharmaceutical machinery, and injected into the pharmaceutical machinery mold to produce a 2×3 cm honey plug.

[0059] 2. Preparation of the prescription medicine of honey, fig and fig leaf

[0060] Step S1: first mix 60g of figs and grind into fine powder;

[0061] Step S2: Put 30 g of fresh fig leaves into 300 g of cold water and boil for 5 min;

[0062] Step S3: The decoction prepared in step S2 and the fine powder prepared in step S1 are evenly mixed to form a medicine, 50g of cooked honey is added, and then the standard mold is installed on the pharmaceutical machine, the honey and the medicine are decocted into a paste by the pharmaceutical machine, and injected into the pharmaceutical machine mold to produce a 2×3cm honey plug.

[0063] 3. Preparation of honey, fig, fig leaf and Tribulus terrestris prescription medicine

[0064] Step S1: first mix 60g of figs and grind into fine powder;

[0065] Step S2: Put 30 g of fresh fig leaves and 20 g of Tribulus terrestris into 300 g of cold water and boil for 5 minutes;

[0066] Step S3: The decoction prepared in step S2 and the fine powder prepared in step S1 are evenly mixed to form a medicine, 50g of cooked honey is added, and then the standard mold is installed on the pharmaceutical machine, the honey and the medicine are decocted into a paste by the pharmaceutical machine, and injected into the pharmaceutical machine mold to produce a 2×3cm honey plug.

[0067] Example 2 The therapeutic effect of the Chinese medicine composition of the present application on constipation

[0068] 1. Case data

[0069] All cases were from 180 patients who visited the Acupuncture Department, Spleen and Stomach Department, and Anorectal Department of Kunming Traditional Chinese Medicine Hospital from August 2018 to August 2021. They were diagnosed with constipation after examination. They were divided into three groups, 60 cases in each group, 30 cases in the treatment group and 30 cases in the control group, aged 18 to 65 years old.

[0070] 2. General data comparison

[0071] The general data of the selected cases, such as gender and age, showed no statistically significant differences after statistical processing (see Table 1 for details) (P>0.05), and were comparable.

[0072] Table 1 Comparison of general information (±s)

[0073]

[0074] Note: The two groups were compared by t-test, P>0.05.

[0075] 3. Diagnostic criteria

[0076] The diagnostic criteria are formulated according to the Rome IV diagnostic criteria as follows:

[0077] The patient must meet two or more of the following symptoms; (1) Two or more of the following symptoms must be met: ① Straining during defecation at least 25% of the time; ② Lumpy or hard stools at least 25% of the time; ③ A feeling of incomplete defecation at least 25% of the time; ④ Anorectal obstruction or blockage at least 25% of the time; ⑤ Manual assistance is required for defecation at least 25% of the time; ⑥ Spontaneous bowel movements less than 3 times per week at least 25% of the time. (2) Loose stools are rare when laxatives are not used; (3) The patient does not meet the diagnostic criteria for IBS-C; Symptoms must have occurred for at least 6 months before diagnosis, and the symptoms in the past 3 months meet the above diagnostic criteria.

[0078] 4. Inclusion criteria

[0079] (1) Patients aged 18-65 years;

[0080] (2) Western medical diagnosis was consistent with the Rome IV diagnosis of slow-transmission constipation;

[0081] (4) Patients voluntarily participated in the clinical study and signed the informed consent form;

[0082] (5) The patient did not take any drugs to promote gastrointestinal motility 3 days before joining the study and had good compliance;

[0083] (6) Patients diagnosed by colon transit test.

[0084] 5. Treatment methods

[0085] Treatment group: The Chinese medicine composition of the present application is given to moisten the intestines and promote bowel movements, clear the bowels and eliminate turbidity. The formula is as follows, made into suppositories, 1 suppository per day, inserted 2-3 cm into the anus, and the bowel movements stop as soon as they are relieved.

[0086] Control group: oral lactulose oral solution, 10 mg / time, 3 times / day.

[0087] Lactulose oral solution: [Approval number] National Medicine Standard H20066730, [Manufacturer] Beijing Hanmei Pharmaceutical Co., Ltd.

[0088] 6. Efficacy evaluation criteria

[0089] The efficacy was evaluated after one course of treatment according to the Expert Consensus on Diagnosis and Treatment of Constipation in Traditional Chinese Medicine (2017).

[0090] Cure: major symptoms and signs disappear or almost disappear, with efficacy index ≥ 95%;

[0091] Markedly effective: Major symptoms and signs are significantly improved, 70%≤efficacy index<95%:

[0092] Effective: Major symptoms and signs have improved, 30%≤efficacy index<70%:

[0093] Ineffective: There is no significant improvement in the main symptoms and signs, and the efficacy index is <30%.

[0094] Note: Therapeutic effect index (n) = (score before treatment minus score after treatment) / score before treatment × 100%;

[0095] Total effective rate = cure rate + marked effective rate + effective rate.

[0096] 7. Comparison of efficacy

[0097] 1. Honey + fig + fig leaf

[0098]

[0099] 2. Honey + fig + fig leaf + Tribulus terrestris

[0100]

[0101] 3. Honey + fig + fig leaf + Tribulus terrestris + Kapok + Psoralea corylifolia

[0102]

[0103] The above-mentioned embodiments only express the specific implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the protection scope of the present application. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the technical solution concept of the present application, and these all belong to the protection scope of the present application.

Claims

1. A Chinese medicine composition for treating constipation, characterized in that: The invention comprises the following raw materials in parts by weight: 55-65 parts of figs, 25-35 parts of fresh fig leaves, 45-55 parts of honey, 25-35 parts of kapok flowers, 15-25 parts of tribulus terrestris and 5-15 parts of psoralea corylifolia.

2. A Chinese medicine composition for treating constipation according to claim 1, characterized in that: The invention comprises 57-63 parts of figs, 27-33 parts of fresh fig leaves, 47-53 parts of honey, 27-33 parts of kapok flowers, 17-23 parts of tribulus terrestris and 7-13 parts of psoralea corylifolia.

3. A Chinese medicine composition for treating constipation according to claim 2, characterized in that: The invention comprises 60 parts of figs, 30 parts of fresh fig leaves, 50 parts of honey, 30 parts of kapok flowers, 20 parts of tribulus terrestris and 10 parts of psoralea corylifolia.

4. A method for preparing a Chinese medicine composition for treating constipation according to any one of claims 1 to 3, characterized in that: The steps include: Step S1: Take corresponding weight portions of fig and psoralea corylifolia, mix them evenly and grind them into fine powder; Step S2: taking corresponding weight portions of fresh fig leaves, kapok flowers and tribulus terrestris and putting them into 3-5 times the weight of cold water and decocting them for 5-10 minutes; Step S3: The decoction prepared in step S2 is evenly mixed with the fine powder prepared in step S1 to form a medicine, the honey and the medicine are mixed in a mass ratio of 3:1, and then the standard mold is installed on the pharmaceutical machinery, the honey and the medicine are decocted into a paste by the pharmaceutical machinery, and injected into the pharmaceutical machinery mold to produce honey plugs.

5. The method for preparing a Chinese medicine composition for treating constipation according to claim 4, characterized in that: The size of the honey plug is 2×3 cm.

6. Use of a Chinese medicinal composition for treating constipation as claimed in any one of claims 1 to 3 in preventing / improving / treating constipation.

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