Tablet anti-counterfeiting method based on afterglow effect

Abstract

The invention discloses a tablet anti-counterfeiting method based on the afterglow effect, and relates to the technical field of tablet anti-counterfeiting, the tablet anti-counterfeiting method based on the afterglow effect comprises the following steps: S1, preparing anti-counterfeiting ink: adding povidone K30 and sodium carboxymethyl cellulose into ethanol, and mixing the povidone K30, the sodium carboxymethyl cellulose and the ethanol into paste to prepare the anti-counterfeiting ink; s2, preparing a tablet with an anti-counterfeiting pattern: uniformly spraying the anti-counterfeiting ink on the tablet, drying at 40-60 DEG C for 5-10 minutes, and volatilizing ethanol in the anti-counterfeiting ink to form the tablet with the anti-counterfeiting pattern; s3, detecting the anti-counterfeiting tablet; s4, processing the afterglow image: the anti-forgery ink has a good afterglow effect visible to naked eyes due to the special phosphorescence characteristic of the anti-forgery ink; the components of the anti-forgery ink are all edible pharmaceutic adjuvants, so that the anti-forgery ink has no toxic effect; the characteristics of unique optical characteristics of afterglow effect, high identification degree, difficulty in imitation and good safety and stability are utilized, so that the anti-counterfeiting reliability of the medicine is enhanced.

Description

Technical Field

[0001] The invention relates to the field of tablet anti-counterfeiting technology, in particular to a tablet anti-counterfeiting method based on afterglow effect. Background Art

[0002] Existing drug anti-counterfeiting methods mainly focus on drug packaging anti-counterfeiting, query system anti-counterfeiting, and drug appearance and shape anti-counterfeiting. These methods have the following problems: packaging anti-counterfeiting is easy to imitate, consumers are not aware of the query system and the system is easy to crack, and the anti-counterfeiting of drug appearance and properties is highly subjective and difficult to quantify, so it is not applicable to all drugs. The afterglow effect is that the material can continue to emit light after being excited and then stopped. Due to its unique optical properties, high recognition, difficulty in imitation, high safety, and good stability, it has received widespread attention. At present, the afterglow effect has been studied and applied in the field of materials science, but it has not been fully developed in drug anti-counterfeiting, and drug afterglow anti-counterfeiting still focuses on traditional drug anti-counterfeiting methods, such as drug packaging anti-counterfeiting is affected by the environment and storage, and the problem of unstable luminescence performance limits its large-scale promotion and application. The edible excipient sodium carboxymethyl cellulose (CMC-Na) has ultra-long organic phosphorescence characteristics and exhibits a strong afterglow effect. It exhibits an inherent stimulus response to excitation wavelength and moisture, and has a large signal-to-noise ratio, which can be used for non-destructive testing of tablets. The part of achieving anti-counterfeiting effect by combining the afterglow effect with the tablet itself is still vacant. It is urgent to develop an anti-counterfeiting method focusing on the drug itself. Therefore, we proposed a tablet anti-counterfeiting method based on the afterglow effect. Summary of the invention

[0003] In view of this, the present invention aims to address the deficiencies in the prior art, and its main purpose is to provide a tablet anti-counterfeiting method based on the afterglow effect. The anti-counterfeiting ink has a good afterglow effect visible to the naked eye due to its special phosphorescent properties; the ingredients of the anti-counterfeiting ink are all edible pharmaceutical excipients with no toxic effects; the unique optical properties of the afterglow effect, high recognition, difficulty in imitation, good safety and stability are utilized to enhance the reliability of drug anti-counterfeiting.

[0004] To achieve the above purpose, the present invention adopts the following technical solutions: A tablet anti-counterfeiting method based on afterglow effect comprises the following steps: S1. Preparing anti-counterfeiting ink: adding povidone K30 and sodium carboxymethyl cellulose to ethanol, and mixing the three into a paste to prepare anti-counterfeiting ink; S2. Preparing tablets with anti-counterfeiting patterns: preparing a mold for the anti-counterfeiting pattern, spraying the anti-counterfeiting ink evenly on the tablets, drying them at 40-60° C. for 5-10 min to evaporate the ethanol in the anti-counterfeiting ink, and forming tablets with the anti-counterfeiting pattern; S3. Detection of anti-counterfeiting tablets: Tablets with anti-counterfeiting patterns can be detected based on the afterglow effect of sodium carboxymethyl cellulose due to the phosphorescence characteristics of anti-counterfeiting ink. The afterglow video is taken using the camera function of a mobile phone during the detection process. In a dark environment, an ultraviolet lamp is set at a distance of 1-10 cm from the tablet with the anti-counterfeiting pattern. After irradiation with the ultraviolet lamp for 5-15 seconds, the afterglow image is recorded for 1-10 seconds. S4. Processing afterglow images: importing the captured afterglow video into video analysis software for frame-by-frame analysis, capturing afterglow images at different times, and representing the afterglow images at each time with the number of frames; dividing 1 second into 60 frames for processing, that is, the frame rate is 60 frames / second; capturing an afterglow image every 2 frames until the 30th frame, capturing an afterglow image every 5 frames from the 31st frame until the 70th frame, and capturing an afterglow image every 10 frames from the 71st frame until the afterglow phenomenon disappears.

[0005] As a preferred embodiment: the mass ratio of sodium carboxymethyl cellulose to povidone K30 is 3:1-10:1.

[0006] As a preferred embodiment: the mass ratio of sodium carboxymethyl cellulose to povidone K30 is 8:2.

[0007] As a preferred solution: the excitation wavelength of the ultraviolet lamp is 254nm or 365nm.

[0008] As a preferred embodiment, the ethanol has a concentration of 75%-100%.

[0009] As a preferred embodiment: the ethanol has a concentration of 100%.

[0010] As a preferred solution: in step S2, the anti-counterfeiting ink is evenly sprayed on the tablets and dried at 45° C. for 5-10 minutes.

[0011] As a preferred solution: in step S3, the ultraviolet lamp is set at a distance of 5 cm from the tablet with the anti-counterfeiting pattern.

[0012] As a preferred solution: the tablet with the anti-counterfeiting pattern is in the form of a round tablet, a flat tablet, or an irregularly shaped curved tablet.

[0013] As a preferred solution: the anti-counterfeiting ink is adhered to the surface of the tablet, the povidone K30 is used as a binder to increase the viscosity of the anti-counterfeiting ink, and sodium carboxymethyl cellulose is used as a phosphorescent material.

[0014] Compared with the prior art, the present invention has obvious advantages and beneficial effects. Specifically, it can be seen from the above technical scheme that the anti-counterfeiting ink is a solution with strong viscosity, which is conducive to adhering to the surface of the tablet; the anti-counterfeiting ink has a good afterglow effect visible to the naked eye due to its special phosphorescent properties; the components of the anti-counterfeiting ink are all edible pharmaceutical excipients with no toxic effects; the unique optical properties of the afterglow effect, high recognition, difficulty in imitation, good safety and stability are utilized to enhance the reliability of drug anti-counterfeiting; this patent prepares an anti-counterfeiting ink and sprays the ink onto the surface of the tablet. The method is simple to operate and easy to implement, and is applicable to all types of Chinese medicine tablets and different tablet shapes, without being restricted by the type of medicine and tablet shape. The method can prepare a variety of anti-counterfeiting patterns and effectively improve the anti-counterfeiting performance; the application can meet the anti-counterfeiting needs of pharmaceutical companies for different tablets.

[0015] In order to more clearly illustrate the structural features and effects of the present invention, it is described in detail below in conjunction with the accompanying drawings and specific embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is the afterglow image of the anti-counterfeiting pattern prepared with 75% ethanol solution under irradiation of 365nm ultraviolet lamp of the present invention; Figure 2 It is the afterglow image of the anti-counterfeiting pattern on the surface of the circular piece of Phellodendron chinense under the irradiation of the 254nm ultraviolet lamp of the present invention; Figure 3 It is the afterglow image of the anti-counterfeiting pattern on the surface of the round piece of cork under the irradiation of 365nm ultraviolet lamp of the present invention; Figure 4 It is the afterglow image of the anti-counterfeiting pattern on the surface of the cork flat sheet under the 254nm ultraviolet light of the present invention; Figure 5 It is the afterglow image of the anti-counterfeiting pattern on the surface of the cork flat sheet under the irradiation of the 365nm ultraviolet lamp of the present invention; Figure 6 It is the afterglow image of the anti-counterfeiting pattern on the surface of the Xiao Chaihu circular tablet under the irradiation of the 254nm ultraviolet lamp of the present invention; Figure 7 It is the afterglow image of the anti-counterfeiting pattern on the surface of the Xiao Chaihu circular tablet under the irradiation of the 365nm ultraviolet lamp of the present invention; Figure 8 It is the afterglow image of the anti-counterfeiting pattern on the surface of the Xiao Chaihu flat tablet under the irradiation of the 254nm ultraviolet lamp of the present invention; Fig. 9 It is the afterglow image of the anti-counterfeiting pattern on the surface of the Xiao Chaihu flat tablet under the irradiation of 365nm ultraviolet lamp of the present invention; Fig.10 It is the afterglow image of the flower anti-counterfeiting pattern on the surface of the special-shaped curved surface sheet under the irradiation of the 254nm ultraviolet lamp of the present invention; Fig.11It is the afterglow image of the flower anti-counterfeiting pattern on the surface of the special-shaped curved surface sheet under the irradiation of the 365nm ultraviolet lamp of the present invention; Fig.12 It is the afterglow image of the moon anti-counterfeiting pattern on the surface of the special-shaped curved surface sheet under the irradiation of the 254nm ultraviolet lamp of the present invention; Fig.13 It is the afterglow image of the moon anti-counterfeiting pattern on the surface of the special-shaped curved surface sheet under the irradiation of the 365nm ultraviolet lamp of the present invention; Fig.14 It is the afterglow image of the anti-counterfeiting pattern of the circular flat tablet of Bupleurum chinense under the irradiation of 254nm and 365nm ultraviolet lamps of the present invention; Fig.15 It is the afterglow image of the anti-counterfeiting pattern of the circular flat sheet of cork under the irradiation of 254nm and 365nm ultraviolet lamps of the present invention; Fig.16 It is the afterglow image of the anti-counterfeiting pattern of the special-shaped curved surface sheet under the irradiation of the 254m ultraviolet lamp of the present invention; Fig.17 It is the afterglow image of the special-shaped curved surface sheet without anti-counterfeiting pattern under the irradiation of 365nm ultraviolet lamp of the present invention; Fig.18 It is the afterglow image of the anti-counterfeiting pattern of the special-shaped curved surface sheet under the irradiation of the 365nm ultraviolet lamp of the present invention; Fig.19 The anti-counterfeiting patterns are prepared under different adhesive ratios of the present invention. DETAILED DESCRIPTION

[0017] The present invention Figure 1 As shown in FIG19 , a tablet anti-counterfeiting method based on the afterglow effect comprises the following steps: S1. Preparing anti-counterfeiting ink: adding polyvidone K30 (PVP K30) and sodium carboxymethyl cellulose (CMC-Na) into ethanol, and mixing the three into a paste to prepare anti-counterfeiting ink; S2. Preparing tablets with anti-counterfeiting patterns: preparing a mold for the anti-counterfeiting pattern, spraying the anti-counterfeiting ink evenly on the tablets, drying them at 40-60° C. for 5-10 min to evaporate the ethanol in the anti-counterfeiting ink, and forming tablets with the anti-counterfeiting pattern; S3. Detection of anti-counterfeiting tablets: Tablets with anti-counterfeiting patterns can be detected based on the afterglow effect of sodium carboxymethyl cellulose due to the phosphorescence characteristics of anti-counterfeiting ink. The afterglow video is taken using the camera function during the detection process. In a dark environment, a UV lamp is set at a distance of 1-10 cm from the tablet with the anti-counterfeiting pattern. After irradiation with the UV lamp for 5-15 seconds, the afterglow image is recorded for 1-10 seconds. S4. Processing afterglow images: Analyze the shot afterglow video frame by frame through video analysis software, capture afterglow images at different times, and the afterglow images at each time are expressed by frame numbers; divide 1 second into 60 frames for processing, that is, the frame rate is 60 frames / second; capture one afterglow image every 2 frames until the 30th frame, capture one afterglow image every 5 frames from the 31st frame to the 70th frame, and capture one afterglow image every 10 frames from the 71st frame until the afterglow phenomenon disappears.

[0018] Preparation of different tablet types: (1) Bupleurum chinense round tablets: Bupleurum chinense, Pinellia ternata, Scutellaria baicalensis, Codonopsis pilosula, Licorice, Ginger and Jujube are taken in a mass ratio of 29.63%, 14.78%, 11.12%, 11.12%, 11.12%, 11.12% and 11.12% respectively. The medicinal solution is extracted with water at a temperature of 100°C. The extraction is carried out in two steps. The first extraction uses 10 times the total weight of the medicinal materials for 2 h. The second extraction uses 8 times the total weight of the medicinal materials for 2 h. The filtrates are combined and concentrated to a density of 1.1 g / ml. The filtrates are spray-dried to obtain Bupleurum chinense extract powder. The Bupleurum chinense extract powder (98%), silicon dioxide (1%) and magnesium stearate (1%) are uniformly mixed in a mass ratio. The tablets are continuously pressed using an automatic rotary tablet press to obtain Bupleurum chinense round tablets with a hardness of 70±5 N.

[0019] (2) Phellodendron chinense round tablets: Phellodendron chinense slices were taken and extracted with water at a temperature of 98°C. The extraction was carried out in two steps. The first step was to use 10 times the total weight of the medicinal material for 2 h and the second step was to use 8 times the total weight of the medicinal material for 1 h. The filtrates were combined and concentrated to a density of 1.15 g / ml. The mixture was spray-dried to obtain Phellodendron chinense extract powder. The mixture was mixed evenly with Phellodendron chinense extract powder (98.7%), silicon dioxide (0.3%) and magnesium stearate (1%) according to the mass ratio and continuously pressed using a fully automatic rotary tablet press to obtain Phellodendron chinense round tablets with a hardness of 70±5 N.

[0020] (3) Special-shaped arc-shaped tablets: purchased from commercially available stomach-strengthening and digestion-promoting tablets.

[0021] The mass ratio of the sodium carboxymethyl cellulose to povidone K30 is 3:1-10:1.

[0022] The mass ratio of the sodium carboxymethyl cellulose to povidone K30 is 8:2.

[0023] The excitation wavelength of the ultraviolet lamp is 254nm or 365nm.

[0024] The ethanol has a concentration of 75%-100%.

[0025] The ethanol has a concentration of 100%.

[0026] In step S2, the anti-counterfeiting ink is evenly sprayed on the tablets and dried at 45° C. for 5-10 minutes.

[0027] In step S3, the ultraviolet lamp is set at a distance of 5 cm from the tablet with the anti-counterfeiting pattern.

[0028] The tablet with the anti-counterfeiting pattern is in the form of a round tablet, a flat tablet, or an irregularly shaped curved tablet.

[0029] The anti-counterfeiting ink adheres to the surface of the tablet, the polyvidone K30 is used as a binder to increase the viscosity of the anti-counterfeiting ink, and sodium carboxymethyl cellulose is used as a phosphorescent material.

[0030] Existing tablet anti-counterfeiting technologies are mostly used for tablet packaging numbering and printing process anti-counterfeiting. These anti-counterfeiting methods do not directly mark the tablets with anti-counterfeiting marks. Directly laser engraving the tablets is easy to be imitated and is difficult to play an effective anti-counterfeiting role.

[0031] Embodiment 1: Take 0.95g of CMC-Na, 0.05g of PVP K30, and 1.5ml of 75% ethanol solution to prepare anti-counterfeiting ink, spray it on the surface of the round flat piece of Phellodendron chinense to form a heart shape, and place it in an oven for 5 minutes to allow the ethanol solution to evaporate. The prepared tablet with anti-counterfeiting pattern is fixed with a 365nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0032] Embodiment 2: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 1.5ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the round piece of Phellodendron chinense to form a flower shape, and place it in an oven for 8 minutes to allow the ethanol solution to evaporate. The prepared tablet with an anti-counterfeiting pattern is fixed with a 254nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0033] Embodiment 3: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 1.5ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the round piece of Phellodendron chinense to form a flower shape, and place it in an oven for 8 minutes to allow the ethanol solution to evaporate. The prepared tablet with an anti-counterfeiting pattern is fixed with a 365nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0034] Embodiment 4: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 1.5ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the flat piece of Phellodendron to form a heart shape, and place it in an oven for 8 minutes to allow the ethanol solution to evaporate. The prepared tablet with an anti-counterfeiting pattern is fixed with a 254nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0035] Embodiment 5: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 1.5ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the cork flat sheet to form a heart shape, and place it in an oven for 8 minutes to allow the ethanol solution to evaporate. The prepared tablet with an anti-counterfeiting pattern is fixed with a 365nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0036] Embodiment 6: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 1.5ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the round tablets of Chaihu to form a heart shape, and place it in an oven for 8 minutes to allow the ethanol solution to evaporate. The prepared tablets with anti-counterfeiting patterns are fixed with a 254nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0037] Embodiment 7: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 1.5ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the round tablets of Chaihu to form a heart shape, and place it in an oven for 8 minutes to allow the ethanol solution to evaporate. The prepared tablets with anti-counterfeiting patterns are fixed with a 365nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0038] Embodiment 8: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 1.5ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the small bupleurum flat tablet to form a moon shape, and place it in an oven for 8 minutes to allow the ethanol solution to evaporate. The prepared tablet with an anti-counterfeiting pattern is fixed with a 254nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0039] Embodiment 9: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 1.5ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the small bupleurum flat tablet to form a moon shape, and place it in an oven for 8 minutes to allow the ethanol solution to evaporate. The prepared tablet with an anti-counterfeiting pattern is fixed with a 365nm fixture ultraviolet lamp at a distance of 5cm from the tablet surface. Turn on the ultraviolet lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the ultraviolet lamp, record the afterglow image for 5s.

[0040] Embodiment 10: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 3ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the special-shaped curved surface sheet to form a flower shape, and place it in an oven for 10 minutes to allow the ethanol solution to evaporate. The prepared tablet with an anti-counterfeiting pattern is fixed with a 254nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0041] Embodiment 11: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 3ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the special-shaped curved surface sheet to form a flower shape, and place it in an oven for 10 minutes to allow the ethanol solution to evaporate. The prepared tablet with an anti-counterfeiting pattern is fixed with a 365nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0042] Embodiment 12: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 3ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the special-shaped curved surface sheet to form a moon shape, and place it in an oven for 10 minutes to allow the ethanol solution to evaporate. The prepared tablet with an anti-counterfeiting pattern is fixed with a 254nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0043] Embodiment 13: Take 0.8g of CMC-Na, 0.2g of PVP K30, and 3ml of anhydrous ethanol solution to mix and prepare anti-counterfeiting ink, spray it on the surface of the special-shaped curved surface sheet to form a moon shape, and place it in an oven for 10 minutes to allow the ethanol solution to evaporate. The prepared tablet with an anti-counterfeiting pattern is fixed with a 365nm fixture UV lamp at a distance of 5cm from the tablet surface. Turn on the UV lamp and irradiate the surface of the tablet with the anti-counterfeiting pattern for 10s. After turning off the UV lamp, record the afterglow image for 5s.

[0044] Comparative Example 1: To further illustrate the beneficial effects of the present invention, first, the tablets with anti-counterfeiting patterns were irradiated with ultraviolet light to explore the afterglow effect of the anti-counterfeiting pattern. The afterglow shooting method in this comparative example is consistent with that in Examples 1 to 13. The difference between this comparative example and Examples 1 to 13 is that tablets without anti-counterfeiting patterns are used in this experiment.

[0045] Comparative Example 2: In order to further illustrate the beneficial effects of the present invention, the tablets with anti-counterfeiting patterns were first irradiated with ultraviolet light to explore the role of the adhesive in this study. The preparation method of the anti-counterfeiting pattern in this comparative example is consistent with that in Examples 1 to 13. The difference between this comparative example and Examples 1 to 13 is that povidone K30 is not added in this experiment, and the most suitable component ratio is explored.

[0046] The afterglow images of the anti-counterfeit tablets obtained from the results of Examples 1 to 13 were analyzed, and the results were as follows: Figure 1-Figure 13 Shown by: Figure 1-Figure 13It can be seen that Examples 1 to 13 all prepared tablet anti-counterfeiting images visible to the naked eye. The components of the anti-counterfeiting ink in Example 1 and Examples 2 to 13 are inconsistent. The mass ratios of CMC-Na:PVP K30 are 95:5 and 80:20, respectively, and the ethanol used is 75% ethanol and anhydrous ethanol, respectively. In the process of designing anti-counterfeiting ink, it is necessary to ensure the viscosity of the anti-counterfeiting ink and to ensure that it can be evenly sprayed on the surface of the tablet. PVP K30, as an adhesive, can increase the viscosity of the anti-counterfeiting ink, and CMC-Na, as a good phosphorescent material, has a highly sensitive humidity response. Therefore, ethanol is selected as the main solvent to disperse the anti-counterfeiting ink material into the solvent. The anti-counterfeiting ink prepared in Example 1 contains 0.95g CMC-Na and 0.05g PVP K30. The content of PVP K30 is relatively small and it is difficult to adhere directly to the surface of the tablet. Therefore, 75% ethanol is used to increase the wettability of the anti-counterfeiting ink, which sacrifices part of the phosphorescent effect while ensuring the adhesion of the anti-counterfeiting ink. The anti-counterfeiting inks prepared in other embodiments all contain 0.80g CMC-Na and 0.20g PVP K30. The PVP K30 content increases, the adhesion is enhanced, and the anti-counterfeiting ink can be dispersed into the solvent using anhydrous ethanol, so that the adhesion and phosphorescence properties of the anti-counterfeiting ink are maintained at a good level. The experimental results show that the Huangbai anti-counterfeiting tablets of Example 1 under 365nm wavelength irradiation have an afterglow effect visible to the naked eye, the duration is 1s, and the afterglow effects of Examples 3 and 5 are stronger than that of Example 1, and the afterglow image duration is 2s.

[0047] Depend on Figure 2-Figure 12 It can be seen that the tablets containing anti-counterfeiting ink have a 2s afterglow effect after being irradiated by 254nm and 365nm ultraviolet lamps. This is due to the special photophysical properties of CMC-Na. Under ambient conditions, when excited by 254nm and 365nm ultraviolet light, CMC-Na emits different colors. As the excitation wavelength increases, the color of the anti-counterfeiting ink changes from blue to yellow, and obvious afterglow effects appear at both 254nm and 365nm wavelengths.

[0048] Depend on Figure 2-Figure 13 It can be seen that the experiment uses different types of tablets to prepare anti-counterfeiting patterns, including round tablets, flat tablets, and special-shaped curved tablets, all of which can achieve anti-counterfeiting ink spraying, and the afterglow effect visible to the naked eye can be observed, and the afterglow image duration is 2s. The anti-counterfeiting ink prepared by this patent is not affected by the tablet morphology, and can effectively adhere to the surface of different types of tablets to achieve tablet anti-counterfeiting.

[0049] Depend on Figure 2-Figure 13It can be seen that the experiment sprayed anti-counterfeiting images of different shapes on each tablet, including flower-shaped, heart-shaped, and moon-shaped patterns. The anti-counterfeiting ink prepared by this patent can be evenly coated on the surface of the tablet, ensuring that the brightness of the anti-counterfeiting image on the surface of the tablet is evenly distributed, with a visual and intuitive effect. The experimental results show that the anti-counterfeiting ink prepared by this patent is not affected by the shape of the anti-counterfeiting pattern, and can be observed by the naked eye, and the afterglow image duration is 2s.

[0050] The results of comparative example 1 are analyzed. Figure 14-18 As shown: Chinese medicine Huangbai tablets and Xiao Chaihu tablets have no afterglow effect, while the special-shaped curved tablets have a weak afterglow effect. By spraying the anti-counterfeiting ink on the surface of Chinese medicine tablets, the afterglow effect of the anti-counterfeiting pattern can be observed with the naked eye, and it can be clearly distinguished from the Chinese medicine special-shaped tablets with a weak response afterglow effect. The afterglow image duration of the anti-counterfeiting image is 2s. The results show that the anti-counterfeiting ink is not affected by the type of Chinese medicine. The anti-counterfeiting ink prepared by CMC-Na is suitable for anti-counterfeiting applications of various Chinese medicine tablets.

[0051] The results of Example 2 are analyzed, and the results are as follows Fig.19 As shown in the figure: The ratio of CMC-Na to PVP K30 has a significant effect on the preparation of anti-counterfeiting patterns. When the ratio of CMC-Na: PVP K30 is 8:2, the anti-counterfeiting pattern can be sprayed on the surface of various types of tablets. When the ratio of CMC-Na: PVP K30 is 10:0, due to the poor viscosity of the anti-counterfeiting ink, after the ethanol solution is evaporated in the oven, the anti-counterfeiting ink is difficult to adhere to the surface of the tablet, resulting in the phenomenon of the anti-counterfeiting pattern falling off, such as Fig.19 As shown in the figure, the anti-counterfeiting pattern without PVP K30 cannot be attached to the tablet and will fall off with a slight touch, while the anti-counterfeiting pattern with PVP K30 can be fixed on the tablet. Figure 1 , Figure 2 , Fig.19 As shown, the experimental results show that the anti-counterfeiting ink prepared with 0.95g CMC-Na and 0.05g PVP K30 has an afterglow image of 1s, the anti-counterfeiting ink prepared with 0.80g CMC-Na and 0.20g PVP K30 has an afterglow image of 2s, and the anti-counterfeiting ink prepared with pure CMC-Na and no PVP K30 is difficult to adhere to the tablet surface. Therefore, the optimal ratio of anti-counterfeiting ink, that is, CMC-Na: PVP K30 is 8:2.

[0052] The design focus of the present invention is that the anti-counterfeiting ink is a highly viscous solution, which is conducive to adhering to the surface of the tablet; the anti-counterfeiting ink has a good afterglow effect visible to the naked eye due to its special phosphorescent properties; the components of the anti-counterfeiting ink are all edible pharmaceutical excipients with no toxic effects; the unique optical properties of the afterglow effect, high recognition, difficulty in imitation, good safety and stability are utilized to enhance the reliability of drug anti-counterfeiting; this patent prepares an anti-counterfeiting ink and sprays the ink onto the surface of the tablet. This method is simple to operate and easy to implement, and is applicable to all types of Chinese medicine tablets and different tablet shapes, without being restricted by the type of drug and tablet shape. This method can prepare a variety of anti-counterfeiting patterns and effectively improve the anti-counterfeiting performance; this application can meet the anti-counterfeiting needs of pharmaceutical companies for different tablets.

[0053] The above description is only a preferred embodiment of the present invention and does not limit the technical scope of the present invention. Therefore, any slight modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A tablet anti-counterfeiting method based on afterglow effect, characterized in that: The steps include: S1. Preparing anti-counterfeiting ink: adding povidone K30 and sodium carboxymethyl cellulose to ethanol, and mixing the three into a paste to prepare anti-counterfeiting ink; S2. Preparing tablets with anti-counterfeiting patterns: spraying the anti-counterfeiting ink evenly on the tablets, drying them at 40-60° C. for 5-10 min, volatilizing the ethanol in the anti-counterfeiting ink, and forming tablets with anti-counterfeiting patterns; S3. Detection of anti-counterfeiting tablets: Tablets with anti-counterfeiting patterns can be detected based on the afterglow effect of sodium carboxymethyl cellulose due to the phosphorescence characteristics of anti-counterfeiting ink. The afterglow video is taken using the camera function during the detection process. In a dark environment, a UV lamp is set at a distance of 1-10 cm from the tablet with the anti-counterfeiting pattern. After irradiation with the UV lamp for 5-15 seconds, the afterglow image is recorded for 1-10 seconds. S4. Processing afterglow images: Analyze the shot afterglow video frame by frame through video analysis software, capture afterglow images at different times, and the afterglow images at each time are expressed by frame numbers; divide 1 second into 60 frames for processing, that is, the frame rate is 60 frames / second; capture one afterglow image every 2 frames until the 30th frame, capture one afterglow image every 5 frames from the 31st frame to the 70th frame, and capture one afterglow image every 10 frames from the 71st frame until the afterglow phenomenon disappears.

2. A tablet anti-counterfeiting method based on afterglow effect according to claim 1, characterized in that: The mass ratio of the sodium carboxymethyl cellulose to povidone K30 is 3:1-10:

1.

3. A tablet anti-counterfeiting method based on afterglow effect according to claim 2, characterized in that: The mass ratio of the sodium carboxymethyl cellulose to povidone K30 is 8:

2.

4. The tablet anti-counterfeiting method based on afterglow effect according to claim 1, characterized in that: The excitation wavelength of the ultraviolet lamp is 254nm or 365nm.

5. The tablet anti-counterfeiting method based on afterglow effect according to claim 1, characterized in that: The ethanol has a concentration of 75%-100%.

6. The tablet anti-counterfeiting method based on afterglow effect according to claim 5, characterized in that: The ethanol has a concentration percentage of 100%.

7. The tablet anti-counterfeiting method based on afterglow effect according to claim 1, characterized in that: In step S2, the anti-counterfeiting ink is evenly sprayed on the tablets and dried at 45° C. for 5-10 minutes.

8. The tablet anti-counterfeiting method based on afterglow effect according to claim 1, characterized in that: In step S3, the ultraviolet lamp is set at a distance of 5 cm from the tablet with the anti-counterfeiting pattern.

9. The tablet anti-counterfeiting method based on afterglow effect according to claim 1, characterized in that: The tablet with the anti-counterfeiting pattern is in the form of a round tablet, a flat tablet, or an irregularly shaped curved tablet.

10. The tablet anti-counterfeiting method based on afterglow effect according to claim 1, characterized in that: The anti-counterfeiting ink adheres to the surface of the tablet, the povidone K30 is used as a binder to increase the viscosity of the anti-counterfeiting ink, and sodium carboxymethyl cellulose is used as a phosphorescent material.

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