Intelligent DYG selenoprotein NMN composite gradient anti-aging supplement product and intelligent wearable equipment health management system

Abstract

The invention discloses an intelligent DYG selenoprotein NMN composite gradient anti-aging supplement product and an intelligent wearable equipment health management system, and a comprehensive and scientific anti-aging and intelligent health management system is constructed by integrating DYG selenoprotein, NMN and other core anti-aging components, combining various nutrients and traditional Chinese medicine components and integrating the traditional Chinese medicine massage and movement concepts. According to the scheme, through the synergistic effect of the composite components, the antioxidant capacity of the body is remarkably enhanced, damage of free radicals to cells is effectively reduced, and therefore the senescence process is delayed. Meanwhile, the application of the intelligent wearable device enables health management to be more personalized and accurate, and customized anti-aging strategies and health suggestions are provided by monitoring user health data in real time. In addition, health and longevity are promoted through multiple ways of adjusting energy metabolism, improving cardiovascular health, enhancing immunity and the like, and the life quality of the user is comprehensively improved. The combination of traditional Chinese medicine massage and exercise is not only beneficial to body health, but also capable of relieving psychological pressure and improving the overall happiness. On the whole, the anti-aging effect is remarkably improved, the disease prevention ability of the user is enhanced, and the healthy, longevity and vigor life experience is brought to the user.

Description

Technical Field

[0001] The present invention relates to a product with anti-aging and life-extending functions and a preparation method thereof, covering different dosage forms such as powders, drinks, tablets and capsules, belonging to the field of food, beverage and medical health technology, specifically a smart DYG selenoprotein NMN composite gradient anti-aging supplement product and a smart wearable device health management system. Background Art

[0002] In the field of anti-aging, NMN, as an important dietary supplement, can increase the level of NAD+ in the body, activate the longevity protein Sirtuins, promote cell repair and regeneration, and delay aging, and has attracted much attention.

[0003] The production efficiency is low and the raw material cost is high, making it difficult to adapt to the needs of large-scale production.

[0004] The technology is difficult and the cost is relatively high.

[0005] Long-term intake may put the nerves in an excited state, thereby affecting sleep quality and causing insomnia or restless sleep.

[0006] Long-term excessive intake may lead to malnutrition and have adverse effects on overall health.

[0007] In severe cases, there may even be more serious allergic symptoms such as difficulty breathing.

[0008] After entering the human body, NMN may participate in cell metabolism, causing an increase in the level of sex hormones in the body, resulting in changes such as enhanced sexual function and vigorous hair growth, affecting the endocrine system.

[0009] Long-term and excessive intake may increase the burden on the liver and kidneys, causing damage to liver and kidney function.

[0010] Long-term use of NMN may also cause adverse reactions such as dizziness, hypoglycemia, acne, and inflammation. Summary of the invention

[0011] In order to make up for the shortcomings of existing anti-aging technologies, the present invention introduces core anti-aging substances DYG selenoprotein, NMN and nutrients, and combines them with Chinese medicine ingredients, combines Chinese medicine massage and exercise, and constructs a comprehensive solution for gradient anti-aging and intelligent health management, which is committed to effectively solving the public health problems brought about by human aging.

[0012] Anti-aging and life-extending substances 1. DYG selenoprotein, characteristics: Selenoprotein characteristics: It is a protein containing selenium. Selenium is a component of a variety of selenoenzymes and selenoproteins, which have the function of removing free radicals in the body. Anti-aging mechanism: Selenoprotein, as a strong antioxidant, can remove free radicals in the body, protect cells from oxidative damage, and delay aging. At the same time, selenoprotein is also involved in the synthesis of phosphatidylethanolamine, and has functions such as PE regulation and anti-oxidation.

[0013] 2. NMN Features: NMN Features: β-nicotinamide mononucleotide is a precursor of NAD+, which exists naturally in living cells and various organisms. Anti-aging mechanism: NMN activates the longevity protein Sirtuins by increasing the level of NAD+ in the body, promoting cell repair and regeneration, and delaying aging. NAD+ plays an important role in cell energy metabolism and DNA repair. Increasing its level can enhance cell function and fight aging.

[0014] 3. Chitosan, Characteristics: Chitosan Characteristics: Natural high molecular weight polysaccharide, with good biocompatibility and biodegradability. Anti-aging mechanism: Chitosan forms a protective film on the skin surface, reduces water loss, improves moisturizing ability, and moisturizes the skin. It also has antibacterial effects, inhibits the growth of bacteria and fungi, improves skin condition, and delays skin aging.

[0015] 4. VC, Characteristics: VC Characteristics: Water-soluble vitamin, with multiple functions such as anti-oxidation, anti-inflammatory, and skin protection. Anti-aging mechanism: VC can reduce the damage of oxidative stress to cells by removing free radicals, and delay aging. It can also promote collagen synthesis, enhance skin elasticity, and improve skin condition.

[0016] 5. VE, Characteristics: VE Characteristics: Fat-soluble vitamin, with multiple functions such as anti-oxidation, anti-inflammatory, and promotion of sex hormone secretion. Anti-aging mechanism: VE protects cells from oxidative damage and delays aging by removing free radicals. It can also promote sex hormone secretion, increase testosterone levels, and prevent aging.

[0017] 6. Zinc protein, characteristics: Zinc protein characteristics: Protein containing zinc, zinc is one of the essential trace elements for the human body, and participates in the formation of the active center of multiple enzymes. The strong antibacterial protein derived from the complex with selenoprotein has significant antibacterial effect and therapeutic effect on prostate diseases. Anti-aging mechanism: Zinc protein improves the enzyme activity of the body, enhances the ability to scavenge free radicals, protects the structure and function of biological membranes, delays cell aging, and prolongs cell life through antioxidant effects.

[0018] 7. Composite effect: When selenoprotein, NMN, chitosan, VC, VE and zinc protein are combined, they can play a synergistic role and significantly enhance the anti-aging effect. As strong antioxidants, selenoprotein and NMN can jointly remove free radicals in the body and protect cells from oxidative damage. The skin protection effect of chitosan combined with the antioxidant effect of VC and VE can improve skin condition and delay skin aging. The antioxidant effect of zinc protein and the cell repair and regeneration effect of NMN promote each other to maintain cell health and fight aging. The composite substance can also enhance the body's immunity, enhance disease resistance and delay the aging process from many aspects.

[0019] 8. Chaga polysaccharide: Chaga is a fungus with multiple biological activities. Its polysaccharide components have antioxidant, anti-inflammatory, and immunomodulatory effects. Combining with NMN may enhance the function of the immune system and further resist aging.

[0020] 9. Pterostilbene: A natural polyphenol compound with powerful antioxidant and anti-inflammatory effects. When used in combination with NMN, it may reduce the damage to cells caused by oxidative stress and inflammation and slow down the aging process.

[0021] 10. Notoginseng saponins: Notoginseng is a traditional Chinese medicinal material. Its saponins have the effects of promoting blood circulation and removing blood stasis, improving microcirculation, etc. When combined with NMN, it may improve blood circulation, promote cell metabolism, and enhance anti-aging effects.

[0022] 11. Epimedium saponin: Epimedium is a Chinese herbal medicine for tonifying kidney and strengthening Yang. Its saponin components have biological activities such as antioxidant and immunomodulatory. When used in combination with NMN, it may improve body functions and enhance anti-aging effects.

[0023] 12. Astragaloside IV: Astragalus is a commonly used Chinese herbal medicine, which has the effects of invigorating qi and strengthening the exterior, promoting diuresis and reducing swelling. Its glycoside IV has biological activities such as antioxidant and anti-inflammatory, and when combined with NMN, it may enhance the body's immunity and resist aging.

[0024] 13. Ginsenoside: One of the main active ingredients of ginseng, it has multiple biological activities such as antioxidant, anti-inflammatory, and immune regulation.

[0025] Antioxidant effect: Ginsenosides are similar to human NMN and have antioxidant capacity, which can reduce the damage of free radicals to cells. It can increase the activity of antioxidant enzymes, such as SOD, GSH-Px, etc., and enhance the cell antioxidant defense system. When used in combination with NMN, it can further enhance the antioxidant effect and reduce oxidative stress damage.

[0026] Regulate energy metabolism: Ginsenosides can regulate cellular energy metabolism, improve mitochondrial function, promote mitochondrial biosynthesis, increase the number and activity of mitochondria, and improve the energy production capacity of cells. Working together with NMN, it can further improve the level of cellular energy metabolism and enhance cell vitality and function.

[0027] Regulate immune function: Ginsenosides can regulate immune function and enhance the body's immunity. They promote the proliferation and activity of immune cells and improve the ability to identify and eliminate pathogens. When used in combination with NMN, it helps maintain the balance of the immune system, improve resistance, and reduce disease damage.

[0028] 14. Astragalus polysaccharide: One of the main active ingredients of Astragalus, it has multiple biological activities such as antioxidant, immunomodulatory, and cell proliferation promotion. Antioxidant effect: Astragalus polysaccharide has antioxidant effects, can scavenge free radicals, and reduce oxidative stress damage. It improves the activity of antioxidant enzymes such as SOD, GSH-Px, etc., and enhances the cellular antioxidant defense system. When used in combination with NMN, it can further enhance the antioxidant effect and protect cells from oxidative damage. Regulate immune function: Astragalus polysaccharide can regulate immune function and enhance the body's immunity. It promotes the proliferation and activity of immune cells and improves the ability to identify and eliminate pathogens. When used in combination with NMN, it helps maintain the balance of the immune system and improves resistance. Promote cell proliferation: Astragalus polysaccharide can promote cell proliferation, including the proliferation and differentiation of stem cells. It can stimulate cell growth and repair and promote tissue regeneration. When used in combination with NMN, it may help maintain cell vitality and function and delay the aging process.

[0029] 15. Ganoderma lucidum polysaccharide: Ganoderma lucidum polysaccharide is one of the main active ingredients of Ganoderma lucidum. Ganoderma lucidum polysaccharide has a variety of biological activities, including antioxidant, immunomodulatory, and anti-tumor effects. Antioxidant effect: Ganoderma lucidum polysaccharide has antioxidant effects, which can scavenge free radicals and reduce the damage of oxidative stress to cells. It can increase the activity of antioxidant enzymes, such as SOD, GSH-Px, etc., and enhance the antioxidant defense system of cells. When used in combination with NMN, it may further enhance the antioxidant effect and protect cells from oxidative damage. Regulate immune function: Ganoderma lucidum polysaccharide can regulate immune function and enhance the body's immunity. It can promote the proliferation and activity of immune cells and improve the ability of immune cells to recognize and eliminate pathogens. When used in combination with NMN, it may help maintain the balance of the immune system and improve the body's resistance. Regulate metabolism: Ganoderma lucidum polysaccharide can regulate cell metabolism, including sugar metabolism, lipid metabolism, etc. It can promote the uptake and utilization of glucose by cells and lower blood sugar levels; at the same time, it can inhibit the differentiation of adipocytes and lipid accumulation, and lower blood lipid levels. When used in combination with NMN, it may help maintain the metabolic balance of cells and prevent the occurrence of metabolic diseases.

[0030] Efficacy and mechanism of action of NMN and DYG selenoprotein complex 1. Basic effects and mechanisms of action of NMN and selenoprotein Efficacy and mechanism of action of NMN: NMN (β-nicotinamide mononucleotide) is a precursor of NAD+ (nicotinamide adenine dinucleotide). It plays a variety of biological activities by converting into NAD+ in the body. NAD+ is a key coenzyme for various biochemical reactions in cells and participates in life activities such as energy metabolism, DNA repair, and gene expression regulation. NMN helps improve energy metabolism, anti-aging, and protect cardiovascular health by increasing NAD+ levels.

[0031] Efficacy and mechanism of action of selenoprotein: Selenoprotein is a type of protein containing selenium, which has multiple biological activities such as anti-oxidation, anti-inflammatory, and immune regulation. Selenoprotein plays an important role in maintaining human health by scavenging free radicals, reducing oxidative stress damage, and regulating the activity and function of immune cells.

[0032] 2. Synergistic mechanism of NMN and selenoprotein complex Antioxidant synergy: Both NMN and selenoprotein have antioxidant effects. The combination may produce a stronger antioxidant synergistic effect, more effectively remove free radicals in the body, and reduce the damage to cells caused by oxidative stress. Anti-inflammatory and immunomodulatory synergy: NMN and selenoprotein may also have synergistic effects in anti-inflammatory and immunomodulatory aspects. By regulating the activity and function of immune cells and reducing the release of inflammatory factors, the complex may more effectively reduce the inflammatory response in the body and maintain the balance of the immune system. Energy metabolism and cell protection synergy: NMN helps improve energy metabolism and protect cell health by increasing NAD+ levels; while selenoprotein reduces cell damage through antioxidant and anti-inflammatory effects. The combination of the two may produce synergistic effects in these aspects and more effectively promote cell health and functional recovery.

[0033] 3. Metabolic pathway of NMN and DYG selenoprotein complex in vivo Metabolic pathway of NMN: After NMN enters the body, it is converted into NAD+ through a series of biotransformation processes and participates in a variety of biochemical reactions.

[0034] Metabolic pathway of selenoprotein: The metabolic process of selenoprotein in the body involves multiple links such as absorption, transport, utilization and excretion of selenium. Selenoprotein plays an important role in maintaining human health through its specific biological activity.

[0035] Complex metabolic pathway: After NMN is combined with selenoprotein, the metabolic pathway in the body is affected by the interaction between the two. The complex produces a synergistic biological effect by affecting each other's metabolic processes.

[0036] 4. Effects of NMN and selenoprotein complexes on specific health problems Effects on cardiovascular health: Since both NMN and selenoproteins have the effect of protecting cardiovascular health, the complex may have potential effects on the prevention and treatment of cardiovascular disease. By improving energy metabolism and reducing oxidative stress and inflammatory responses, the complex may help reduce the risk of cardiovascular disease.

[0037] Anti-aging effects: NMN has significant anti-aging effects, while DYG selenoproteins maintain cell health through antioxidant and anti-inflammatory effects. Therefore, the complex may have a positive impact on the anti-aging process and delay the onset of aging symptoms.

[0038] Impact on other health problems: In addition to cardiovascular health and anti-aging, NMN and DYG selenoprotein complex may also have potential effects on other health problems such as immune system diseases and nervous system diseases.

[0039] Biological effects of NMN combined with selenoprotein 1. Basic biological effects of NMN and selenoproteins Biological effects of NMN: NMN (β-nicotinamide mononucleotide) is a precursor of NAD+ (nicotinamide adenine dinucleotide). It exerts various biological effects by converting into NAD+ in the body. NAD+ is a key coenzyme for various biochemical reactions in cells and participates in life activities such as energy metabolism, DNA repair, and gene expression regulation. Therefore, NMN has potential biological effects such as improving energy metabolism, anti-aging, and protecting cardiovascular health.

[0040] Biological effects of DYG selenoprotein: DYG selenoprotein is a type of protein containing selenium, which has multiple biological effects such as anti-oxidation, anti-inflammatory, and immune regulation. DYG selenoprotein plays an important role in maintaining human health by scavenging free radicals, reducing oxidative stress damage, and regulating the activity and function of immune cells.

[0041] 2. Potential biological effects of NMN combined with DYG selenoprotein Synergistic antioxidant effect: Both NMN and DYG selenoprotein have antioxidant effects. The combination may produce a stronger synergistic antioxidant effect, more effectively eliminate free radicals in the body, and reduce the damage of oxidative stress to cells.

[0042] Enhanced immune regulation: DYG selenoprotein has a significant effect in regulating immunity, while NMN may indirectly enhance the function of the immune system by improving energy metabolism and reducing inflammatory responses. Therefore, the combination may produce a stronger immune regulation effect.

[0043] Comprehensive health benefits: In addition to the potential biological effects mentioned above, NMN and DYG selenoprotein complex may also have a positive impact on improving sleep quality and improving physical endurance.

[0044] 3. Metabolism and mechanism of action of NMN and DYG selenoprotein complex in vivo Metabolic pathway: After NMN enters the body, it is converted into NAD+ through a series of biotransformation processes and participates in a variety of biochemical reactions. DYG selenoprotein plays an important role in maintaining human health through its specific biological activity. The metabolic pathway of the two after compounding may be affected by each other's interaction, producing biological effects different from those of a single component.

[0045] Mechanism of action: NMN and DYG selenoprotein complex may produce comprehensive health benefits to organisms through multiple mechanisms such as synergistic antioxidant, anti-inflammatory, and immune regulation.

[0046] Theoretical basis and clinical trials of compound mechanism Antioxidant synergy: Both NMN and DYG selenoprotein have antioxidant effects, but their mechanisms of action are different. NMN indirectly enhances the antioxidant capacity of cells by increasing NAD+ levels, while DYG selenoprotein directly removes free radicals and protects cell structures. The combination of the two produces an antioxidant synergistic effect, jointly resisting the damage of oxidative stress to cells.

[0047] Immunomodulation and cell repair: NMN can activate the Sirtuins family of longevity proteins and participate in the process of immune regulation and cell repair; while DYG selenoprotein also affects the activity and function of immune cells. The combined NMN and DYG selenoprotein may synergistically regulate immune responses through different pathways and promote cell repair and regeneration.

[0048] Synergistic effect: Based on theoretical foundations and clinical trials, NMN and DYG selenoprotein complex has stronger antioxidant, anti-inflammatory and immunomodulatory effects. This synergistic effect helps delay aging, improve metabolic health, enhance immunity, etc.

[0049] Mechanism of action 1. Synergistic antioxidant effect. Mechanism: NMN indirectly enhances the antioxidant capacity of cells by increasing the level of NAD+ in the body. NAD+ is an important coenzyme for a variety of antioxidant enzymes and is involved in the scavenging of free radicals and other oxidative stress products. DYG selenoprotein is a type of protein with direct antioxidant activity that can scavenge free radicals and protect cells from oxidative damage. When NMN is combined with DYG selenoprotein, the two may synergistically exert antioxidant effects and further enhance the antioxidant defense system of cells.

[0050] 2. Enhance immune regulation function. Mechanism: NMN activates the Sirtuins and other longevity protein families by increasing NAD+ levels. These proteins play an important role in regulating immune cell functions and inflammatory responses. DYG selenoprotein is also involved in the immune cell regulation process and can affect the proliferation, differentiation and function of immune cells. The compounded NMN and DYG selenoprotein may synergistically enhance the body's immunity and improve the ability to resist diseases through different pathways.

[0051] 3. Promote cell repair and regeneration Mechanism: NMN promotes DNA repair and cell energy metabolism by increasing NAD+ levels, providing the necessary energy and material support for cell repair and regeneration. DYG selenoprotein may directly participate in cell repair and regeneration by regulating processes such as cell cycle and apoptosis. The combined NMN and DYG selenoprotein may further optimize the cell repair and regeneration process through synergistic effects.

[0052] Other synergies Energy metabolism regulation: Both NMN and DYG selenoprotein may participate in regulating the energy metabolism of cells. After compounding, the two may synergistically optimize the energy metabolism of cells and improve energy utilization efficiency.

[0053] Anti-inflammatory effect: DYG selenoprotein has anti-inflammatory effects and can reduce the damage to cells caused by inflammatory reactions. NMN may indirectly enhance the anti-inflammatory ability of cells by increasing NAD+ levels. The compounded NMN and DYG selenoprotein may have a stronger anti-inflammatory effect and help alleviate the symptoms of inflammation-related diseases.

[0054] The medical scientific principles of DYG selenoprotein and NMN combination in anti-aging and life extension 1. Increased NAD+ levels and cellular energy metabolism. The complexity of the intracellular NAD+ metabolic network and its multi-dimensional metabolic regulation: The role of NAD+ in cells is far more than just a simple coenzyme for energy metabolism. In terms of calcium signal regulation, increased levels can affect the release and uptake of intracellular calcium ions. Calcium ions play a key role in physiological processes such as cell excitability and muscle contraction. For example, in cardiomyocytes, an appropriate calcium ion concentration is essential for the normal contraction of the heart. When NAD+ levels increase, the normal function of cardiomyocytes can be maintained by regulating the dynamic balance of calcium ions, which has a positive effect on the overall function of the heart.

[0055] Circadian rhythm regulation mechanism: The biological clock mechanism in cells is closely related to energy metabolism, and the restoration of NAD+ levels can regulate the expression of biological clock-related genes. This allows the metabolic activities of cells to be better synchronized with the circadian rhythm, thereby optimizing the overall function of the cells. Taking liver cells as an example, their metabolic activities vary at different times of the day, adapting to the circadian rhythm. When NAD+ levels are increased through supplementation, it can promote liver cells to carry out specific metabolic activities at the right time, such as detoxification metabolism at night, thereby improving the overall metabolic efficiency of the liver.

[0056] The precision of NMN transport mechanism Tissue-specific distribution and absorption: NMN enters cells mainly through specific transporters, and the expression levels and activities of these transporters in different tissue cells vary. In metabolically active organs such as the liver and kidneys, the expression of NMN transporters is relatively high, allowing these organs to more efficiently take up NMN and convert it into NAD+ to meet the needs of high-energy metabolism. For example, during strenuous exercise or high-intensity metabolic states, the kidneys require more energy to maintain their normal filtration and excretion functions. At this time, higher levels of NMN transporter expression can prompt kidney cells to take up NMN more efficiently and convert it into NAD+, thereby providing support for the high-energy metabolism of the kidneys.

[0057] Profound improvements in mitochondrial function Mitochondrial respiratory chain and energy production: Mitochondria are the "energy factories" of cells, and NAD+ plays a key role in electron transfer in complex I of the mitochondrial respiratory chain. When NMN supplements to increase NAD+ levels, the electron transfer efficiency of the mitochondrial respiratory chain is improved, which not only increases ATP production but also reduces electron leakage. Taking muscle cells as an example, a large amount of energy is required during exercise. The efficient electron transfer of the mitochondrial respiratory chain can provide muscle cells with sufficient ATP to maintain muscle contraction and motor function.

[0058] Antioxidant mechanism: Electron leakage can lead to the production of reactive oxygen species (ROS), and excessive ROS can cause oxidative damage to the mitochondria themselves and other components in the cell. NMN indirectly plays an antioxidant role by improving mitochondrial function. For example, in nerve cells, oxidative stress is one of the important factors leading to neurodegenerative diseases. After NMN increases the level of NAD+, it reduces the ROS produced by mitochondrial electron leakage, which can protect nerve cells from oxidative damage, and is of great significance for the prevention and relief of neurodegenerative diseases.

[0059] 2. Antioxidant effect and cell protection of DYG selenoproteins, details of the enzymatic mechanism of DYG selenoprotein antioxidants: The role of glutathione peroxidase: Take glutathione peroxidase (GSH-Px) as an example, it is an important antioxidant enzyme in the DYG selenoprotein family. GSH-Px can use glutathione (GSH) to reduce hydrogen peroxide (H2O2) to water, and oxidize GSH to oxidized glutathione (GSSG). Then, under the action of glutathione reductase, GSSG can be reduced to GSH again. This cycle can continuously and effectively remove hydrogen peroxide from cells. For example, in liver cells, the activity of GSH-Px is essential for maintaining the normal metabolism and function of liver cells. When liver cells are subjected to oxidative stress, GSH-Px can quickly remove hydrogen peroxide and protect liver cells from oxidative damage.

[0060] Special role of selenocysteine ​​residues: The selenocysteine ​​residues in DYG selenoprotein are located in the active center of the enzyme. Its special chemical structure enables it to effectively catalyze redox reactions. Its binding to the substrate is highly specific and can accurately identify and remove free radicals, which is essential for maintaining redox balance in cells. For example, in retinal cells, the presence of selenocysteine ​​residues enables DYG selenoprotein to effectively remove free radicals generated by light, protect retinal cells from oxidative damage, and maintain the normal function of the retina.

[0061] Regulation of intracellular redox signaling pathways Regulation of the thioredoxin system: The antioxidant effect of DYG selenoprotein is not just a simple scavenging of free radicals. It can also regulate the redox signaling pathways within cells. For example, by regulating the thioredoxin (Trx) system within cells, DYG selenoprotein can affect processes such as cell proliferation, differentiation, and apoptosis. When cells are under oxidative stress, DYG selenoprotein can activate the Trx system, causing it to interact with related transcription factors and regulate the expression of antioxidant genes, thereby enhancing the cell's antioxidant defense capabilities. Taking stem cells as an example, DYG selenoprotein can affect the proliferation and differentiation of stem cells by regulating the Trx system, providing support for tissue repair and regeneration.

[0062] Regulation of antioxidant gene expression: DYG selenoprotein regulation of redox signaling pathways can lead to enhanced expression of antioxidant genes. For example, in skin cells, DYG selenoprotein can regulate the expression of antioxidant genes, improve the antioxidant capacity of skin cells, reduce the damage of ultraviolet radiation to the skin, and help prevent skin aging and skin cancer.

[0063] Protection of intracellular membrane structure, damage to membrane structure by free radicals: Free radicals have a strong destructive effect on cell membrane structures, such as cell membranes, mitochondrial membranes and endoplasmic reticulum membranes. DYG selenoprotein can prevent lipid peroxidation by removing free radicals near the membrane. Lipid peroxidation can cause changes in membrane fluidity and damage to membrane protein function, which in turn affects the cell's material transport, signal transduction and other functions. For example, in red blood cells, the integrity of the cell membrane is essential for maintaining the normal morphology and function of red blood cells. DYG selenoprotein can protect the red blood cell membrane from the attack of free radicals and prevent the occurrence of red blood cell rupture and hemolysis. Maintaining the stability of the intracellular and extracellular environment: The protection of membrane structure by DYG selenoprotein helps maintain the stability of the intracellular and extracellular environment and ensure the normal physiological function of the cell. For example, in kidney cells, the integrity of the cell membrane is essential for maintaining the normal filtration function of the kidney. DYG selenoprotein protects the kidney cell membrane, prevents macromolecules such as proteins from leaking into the urine, and maintains the normal metabolism and excretion function of the kidney.

[0064] 3. Synergistic activation of longevity proteins Sirtuins Molecular details of Sirtuins substrate recognition and deacetylation reaction, substrate recognition and enzymatic reaction mechanism: Sirtuins recognize substrates through their specific domains. They are able to recognize acetylated lysine residues on substrate proteins and then use NAD+ as a coenzyme for deacetylation reactions. This process involves complex enzyme-substrate binding kinetics and chemical reaction mechanisms. For example, Sirtuin 1 (SIRT1) mainly acts on histones and many non-histone substrates to regulate gene transcription through deacetylation. In the chromatin structure of cells, deacetylation of histones by SIRT1 can change the compactness of chromatin, thereby affecting the transcriptional activity of genes.

[0065] Regulation of gene transcription: SIRT1 deacetylation of histones can make the chromatin structure more compact and inhibit the transcription of certain genes, such as genes related to inflammatory response, thereby reducing the damage of chronic inflammation to cells. For example, in immune cells, SIRT1 activity can regulate the expression of inflammatory factors, reduce chronic inflammatory response, and protect cells from inflammatory damage.

[0066] DYG selenoproteins protect sirtuins and regulate their signaling Antioxidant protection and structural maintenance: In cells, the activity of Sirtuins is affected by the microenvironment in which they are located. The antioxidant effect of DYG selenoprotein can remove free radicals around Sirtuins to prevent oxidative damage. Sirtuins are protected spatially to maintain their normal structure and function. For example, in neuronal cells, Sirtuins are essential for maintaining the survival and function of neurons. DYG selenoprotein protects Sirtuins from oxidative damage by removing free radicals, helping to maintain the normal metabolism and signal transduction function of neurons.

[0067] Signal pathway regulation and activity influence: DYG selenoprotein may indirectly affect the activity of Sirtuins by regulating intracellular signal pathways, such as the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway plays a key role in cell stress response and proliferation. The regulation of this pathway by DYG selenoprotein may change the stress state in cells, thereby providing a favorable environment for the normal function of Sirtuins. For example, in cancer cells, abnormal activation of the MAPK pathway often leads to uncontrolled cell proliferation. DYG selenoprotein can affect the activity of Sirtuins by regulating the MAPK pathway, thereby regulating the metabolism and proliferation of cancer cells, providing new ideas for the treatment of cancer.

[0068] Synergistic inhibition of senescence-associated secretory phenotype (SASP), negative effects and inhibition mechanisms of SASP: During cell senescence, senescent cells will secrete a variety of inflammatory factors, growth factors, and proteases, which will promote the aging of surrounding cells and the inflammatory response of tissues. The synergistic effect of NMN and DYG selenoproteins can inhibit the production of SASP by activating Sirtuins and reducing oxidative stress. For example, in aged skin tissue, inflammatory factors secreted by senescent cells can lead to skin inflammation and accelerated aging. The synergistic effect of NMN and DYG selenoproteins can inhibit SASP, reduce the secretion of inflammatory factors, and delay the process of skin aging. Regulation of inflammatory factor secretion: SIRT1 can reduce the secretion of inflammatory factors by regulating the nuclear factor-κB (NF-κB) signaling pathway, thereby delaying the process of cell aging and tissue aging. For example, in the pathogenesis of arthritis, the activation of the NF-κB signaling pathway leads to the massive secretion of inflammatory factors, causing joint inflammation and damage. The synergistic effect of NMN and DYG selenoprotein can activate SIRT1, regulate the NF-κB signaling pathway, reduce the secretion of inflammatory factors, and relieve the symptoms of arthritis.

[0069] 4. Comprehensive anti-aging mechanism, multi-level regulation of gene expression: Regulation at the transcriptional level: The combined action of NMN and DYG selenoproteins can regulate gene expression at the transcriptional level. The activation of Sirtuins can lead to changes in histone modifications, thereby affecting the accessibility of genes. For example, SIRT1 can deacetylate certain aging-related genes, such as the p53 gene, regulate its transcriptional activity, and inhibit the expression of cell cycle arrest and apoptosis-related genes. In cancer cells, mutations in the p53 gene often lead to uncontrolled cell proliferation and inhibition of apoptosis. NMN and DYG selenoproteins may have an inhibitory effect on the growth of cancer cells by activating SIRT1 and regulating the transcriptional activity of the p53 gene. Regulatory mechanism at the post-transcriptional level: At the post-transcriptional level, NMN and DYG selenoproteins may affect gene expression by regulating the expression of microRNA (miRNA). miRNA can complementarily pair with mRNA, inhibit the translation of mRNA or promote its degradation. They can regulate the expression of many genes related to cell metabolism, anti-oxidation, and cell survival. For example, some miRNAs can regulate the expression of antioxidant enzyme genes and enhance the antioxidant capacity of cells. NMN and DYG selenoproteins may further enhance the antioxidant defense mechanism of cells by regulating the expression of these miRNAs. Protective effect at the translation level: At the translation level, the antioxidant effect of DYG selenoprotein can protect the structure and function of ribosomes. Ribosomes are the site of protein synthesis, and oxidative stress can damage ribosomes, affecting the accuracy and efficiency of protein synthesis. By protecting ribosomes, DYG selenoproteins help maintain the normal translation process and ensure the synthesis of various functional proteins in cells. For example, in muscle cells, protein synthesis is essential for muscle growth and repair. The antioxidant effect of DYG selenoprotein can protect ribosomes, ensuring that muscle cells can synthesize enough protein to maintain the normal function of muscles.

[0070] Enhancement of DNA repair mechanism, regulation of DNA repair by Sirtuins: DNA damage in cells is one of the important causes of aging and many diseases. The complex of NMN and DYG selenoprotein can enhance the DNA repair mechanism. On the one hand, the activation of Sirtuins can regulate the activity of DNA repair-related proteins, such as SIRT6, which can promote the repair of DNA double-strand breaks. For example, in stem cells, the integrity of DNA is essential for maintaining the pluripotency and self-renewal ability of stem cells. The activation of SIRT6 can promote the repair of DNA double-strand breaks in stem cells and maintain the normal function of stem cells. Antioxidant environment and DNA repair: On the other hand, the antioxidant effect of DYG selenoprotein can reduce the damage of free radicals to DNA and provide a relatively stable intracellular environment for DNA repair. For example, under ultraviolet radiation, the DNA of skin cells is easily damaged. The antioxidant effect of DYG selenoprotein can reduce the free radicals generated by ultraviolet radiation, protect the DNA of skin cells, and provide a favorable environment for DNA repair, which helps prevent the occurrence of skin cancer. Systemic improvement of metabolic status: Regulatory effect of multiple metabolic pathways: In terms of overall metabolism, the combination of NMN and DYG selenoprotein can regulate multiple metabolic pathways such as sugar metabolism, lipid metabolism, and amino acid metabolism. For example, NMN can activate AMP-activated protein kinase (AMPK) after increasing NAD+ levels. AMPK is an energy sensor in cells. It can regulate metabolic processes such as fatty acid oxidation and glucose uptake, and improve metabolic syndrome. By reducing oxidative stress, DYG selenoprotein can also prevent lipid peroxidation and the formation of glycation end products, which interfere with normal metabolic signals and lead to metabolic disorders. Improvement of metabolic syndrome and health effects: In patients with metabolic syndrome, abnormal sugar metabolism and lipid metabolism often lead to symptoms such as insulin resistance and hyperlipidemia. The combined effect of NMN and DYG selenoprotein can improve the symptoms of metabolic syndrome by regulating multiple metabolic pathways. For example, by activating AMPK, fatty acid oxidation and glucose uptake are promoted, blood sugar and blood lipid levels are lowered, and insulin sensitivity is improved, thereby reducing the harm of metabolic syndrome to the body.

[0071] For the dosage safety evaluation of 99% pure NMN 500mg and 90% pure DYG selenoprotein 200μg for heart failure patients, we can analyze it from the following aspects: Safety Assessment 1. Safety of NMN: According to existing studies, based on multiple animal experiments and preliminary human clinical trials, NMN is generally safe when taken in moderation. For example, studies have shown that a single oral dose of up to 500 mg of NMN is safe and can be effectively metabolized by healthy adult males (source: research published in authoritative medical journals). Dosage considerations: The dose mentioned in this case is 500 mg of 99% pure NMN per day, which is within the safety range of existing studies. 2. Safety of DYG selenoprotein: Recommended intake: According to the recommendations of the World Health Organization (WHO) and the Department of Medicine (IOM) of the National Academy of Sciences of the United States, the recommended daily intake of selenium for adults is 55-400 μg (source: authoritative health institutions). Dosage considerations: The dose of DYG selenoprotein mentioned in this case is 200 μg of 90% purity per day, which is far below the upper limit of the recommended intake when converted to selenium content. 3. Safety of the complex: Comprehensive evaluation: Based on the safety data of the individual components, it can be preliminarily inferred that the complex is safe when taken in moderation. Basis for dose selection: Based on existing research: The choice of dose should be based on the safety and efficacy data of existing studies. Since there are few studies directly on the complex of NMN and DYG selenoprotein, the choice of dose can rely more on the research results of the individual components. Individualized considerations: The specific condition and physical condition of patients with heart failure may vary, so the choice of dose should take into account individual factors and be carried out under the guidance of professional medical personnel. Scientific rationality: Synergistic effect: Both NMN and DYG selenoprotein have biological activities such as antioxidant and anti-inflammatory. In theory, they can produce synergistic effects after compounding, further enhancing the therapeutic effect on patients with heart failure.

[0072] The mechanism and scientific principle of acupoint meridian massage and anti-aging and life extension From the perspective of traditional Chinese medicine, acupoint massage and meridian massage are closely related to anti-aging and life extension. The following will explain the mechanism of action and scientific principles: 1. Mechanism of action: regulating and unblocking meridians. Meridian system: Chinese medicine believes that there is a meridian system in the human body, which is the channel for the circulation of qi and blood, connecting the internal organs and all parts of the body. The unobstructed meridians are essential for good health. Massage effect: Through acupoint massage and meridian massage, the meridians can be stimulated, the circulation of qi and blood can be promoted, and the blockages and stagnation in the meridians can be regulated and unblocked, thereby restoring the normal function of the meridians. Promoting the circulation of qi and blood: Qi and blood theory: Chinese medicine believes that qi and blood are the material basis of human life activities. Sufficient qi and blood and smooth circulation are important signs of good health. Massage effect: Massage can directly act on meridians and acupoints, promote the circulation of qi and blood, enable qi and blood to reach various parts of the body, and nourish the internal organs, tendons, bones and skin. Adjust the function of internal organs: Internal organ relationship: Chinese medicine believes that internal organs are the core of human life activities. The normal function of internal organs is directly related to the health and life span of the body. Massage conditioning: Through acupoint massage and meridian massage, the functional state of internal organs can be adjusted to keep them coordinated and balanced. For example, massaging the liver meridian can soothe the liver and regulate qi, while massaging the kidney meridian can nourish the kidney and replenish essence. Enhance disease resistance: Immune regulation: Massage can stimulate the body's immune system and enhance disease resistance. By promoting the circulation of qi and blood and regulating the functions of internal organs, massage can improve the body's overall resistance and reduce the occurrence of diseases. Psychological effects: Massage can also relieve psychological stress and anxiety and improve mental health. A good mental state helps to enhance disease resistance and promote physical health and longevity.

[0073] 2. Scientific principles: Qi and blood balance principle: Traditional Chinese medicine believes that the balance of qi and blood is the basis of physical health. Through acupoint massage and meridian massage, the circulation of qi and blood can be regulated to keep it in a balanced state. The balance of qi and blood helps to maintain the normal physiological functions of the body and delay the aging process. Yin and Yang balance principle: Yin and Yang balance is an important part of traditional Chinese medicine theory. Through massage, the yin and yang state of the body can be adjusted to keep it relatively balanced. The balance of yin and yang helps to maintain the body's stable state, enhance disease resistance, and promote physical health and longevity. Holistic concept principle: Traditional Chinese medicine emphasizes the holistic concept and believes that the human body is an organic whole. Acupoint massage and meridian massage can affect the circulation of qi and blood and the function of internal organs throughout the body by acting on specific parts of the body (acupoints and meridians). This holistic regulation effect helps to enhance the body's self-regulation and repair ability, and has positive significance for anti-aging and prolonging life. Acupoint massage and meridian massage have a significant positive effect on anti-aging and prolonging life through multiple mechanisms and action principles such as regulating and dredging meridians, promoting the circulation of qi and blood, adjusting the function of internal organs, and enhancing disease resistance. These action mechanisms and scientific principles reflect the unique charm and wisdom of traditional Chinese medicine science.

[0074] The mechanism and scientific principle of exercise and anti-aging to extend life From the perspective of Chinese medicine, there is a close relationship between exercise and anti-aging and life extension. The following is a detailed explanation of the mechanism and scientific principles of exercise and anti-aging and life extension: Mechanism of action: Regulate Qi and blood: Chinese medicine believes that Qi and blood are the material basis of human life activities. Exercise can promote the generation and circulation of Qi and blood, making Qi and blood more abundant, thereby nourishing the internal organs, bones and skin of the whole body and delaying the aging process. Clear the meridians: Meridians are the channels for the circulation of Qi and blood. Exercise can stimulate the meridians and keep them unobstructed. Unobstructed meridians help the smooth circulation of Qi and blood, thereby maintaining the normal physiological functions of the body. Strengthen physical fitness: Exercise can enhance the function of the internal organs of the human body and improve physical fitness. Through exercise, cardiopulmonary function is strengthened, muscle strength is improved, and bone density is increased, thereby enhancing the overall resistance of the human body. Regulate emotions: Chinese medicine believes that emotions are closely related to the function of internal organs. Exercise can regulate emotions, relieve negative emotions such as stress, anxiety and depression, thereby maintaining mental health, helping to resist aging and prolong life.

[0075] Scientific principle: The principle of yin and yang balance. Chinese medicine believes that the balance of yin and yang is the basis for maintaining human life activities. Exercise can promote the balance of yin and yang and keep the human body in a relatively stable state. When yin and yang are balanced, the physiological functions of the human body can be normally exerted, thereby delaying the aging process. Holistic concept principle: Chinese medicine emphasizes the holistic concept and believes that the human body is an organic whole. Exercise produces a holistic regulatory effect by acting on various parts and organs of the body. This holistic regulatory effect helps to enhance the body's self-regulation and repair capabilities, and has positive significance for anti-aging and prolonging life.

[0076] Life lies in movement principle: Chinese medicine believes that life lies in movement. Appropriate exercise can promote the circulation of qi and blood, dredge meridians, enhance physical fitness, regulate emotions, etc., thereby maintaining the normal physiological functions of the body. When the body remains healthy, the aging process is naturally delayed. There is a close relationship between exercise and anti-aging and life extension. Through mechanisms and principles such as harmonizing qi and blood, dredging meridians, enhancing physical fitness, and regulating emotions, exercise helps maintain the body's healthy state, thereby delaying the aging process and prolonging life. Therefore, in daily life, we should actively participate in appropriate exercise to promote physical and mental health and longevity.

[0077] 1. A smart DYG selenoprotein NMN compound gradient anti-aging supplement product and smart wearable device health management system Its features include: 1. Smart health management system and solution module, 2. Smart DYG DYG selenoprotein NMN compound gradient anti-aging supplement product module, 3. Smart wearable device and patch module, 4. Smart DYG selenoprotein NMN compound gradient anti-aging supplement formula, massage formula, sports formula module, 5. Product product module, 6. Preparation process module.

[0078] 2. Smart health management system and solution module Including: intelligent health management system, an anti-aging auxiliary system based on intelligent wearable devices. It is characterized by: Intelligent diagnosis and assessment module: Use biometric technology combined with basic user information to establish and update personal health records, integrate multi-source data for multi-dimensional health data analysis, and use machine learning algorithms to conduct in-depth mining of health data to identify potential health risks and provide personalized health advice and warnings.

[0079] Gradient anti-aging comprehensive strategy system: Instant response intelligent antioxidant protection submodule: The core ingredients include DYG selenoprotein, NMN (β-nicotinamide mononucleotide), superoxide dismutase (SOD), glutathione peroxidase (GPx), coenzyme Q10, and resveratrol. It uses intelligent nano-carrier technology, combines high-efficiency antioxidants with intelligent activity regulation mechanisms, and the carrier is made of biocompatible and degradable materials. It can accurately and timely release antioxidants according to individual oxidative stress levels, effectively remove free radicals, and protect cells from oxidative damage.

[0080] Medium-speed conditioning natural plant essence and nutritional complex sub-module: The core ingredients are DYG selenoprotein, improved longevity herbal formula (green tea extract, epimedium saponin, notoginseng saponin, ganoderma lucidum polysaccharide), D-flavonoids, curcumin, Omega-3 fatty acids, vitamin D, coenzyme NAD+. Ultrafine grinding and controlled release technology are used to improve the bioavailability of plant active ingredients and nutrients. Combined with the user's physiological age, genetic characteristics and living habits, the formula ratio is dynamically adjusted to achieve personalized conditioning.

[0081] Long-lasting nourishment personalized nutrition intelligent regulation submodule: The core ingredients include customized complex vitamins (including vitamins A, C, E, B group, etc.), essential trace elements (zinc, selenium, iron, magnesium), Omega-3 fatty acids, advanced antioxidant complexes (β-carotene, astaxanthin, vitamin E), DYG selenoprotein, ginsenosides, and astragalus polysaccharides. Based on a personalized nutrition assessment model, using precision medical-grade 3D printing technology, combined with real-time health monitoring data and daily habits, dynamic customization of exclusive nutrition supplementation plans ensures accurate nutrient supplementation to meet individual anti-aging needs.

[0082] Continuous monitoring and intelligent feedback system: Wearable devices monitor the user's oxidative stress status, cell aging indicators (such as telomere length, NAD + level), skin health and overall physiological function in real time, and the data is uploaded to the cloud for analysis in real time. Using AI algorithms, combined with the user's historical health records, current living environment and real-time data, the anti-aging plan is dynamically optimized, and personalized health advice, early warnings and online linkage services with professional medical institutions are provided through mobile applications or intelligent voice assistants.

[0083] Health promotion and community interaction platform: Provide comprehensive health management services, including health record management, risk assessment, personalized health plan formulation and implementation supervision, regularly release scientific anti-aging knowledge, and enhance users' health awareness and self-management ability. Build a user community, encourage sharing of anti-aging experiences, success stories and life experiences, set up health challenge tasks and reward mechanisms, stimulate users' enthusiasm for participation, and jointly explore the way to anti-aging.

[0084] This comprehensive anti-aging strategy system deeply integrates natural plant essences, nutrients and advanced technologies through scientific proportions and intelligent regulation, providing users with comprehensive and personalized anti-aging solutions to help achieve the goal of health and longevity.

[0085] 3. The smart wearable device and patch module include: a smart wearable device anti-aging system, an anti-aging auxiliary system based on a smart wearable device. It is characterized by comprising: a smart wearable device: Real-time monitoring and data analysis: Integrates advanced biosensors to monitor the user's body's oxidative stress level, cell aging indicators (such as NAD+ levels, telomere length, etc.) and overall physiological function parameters in real time. When elevated oxidative stress levels or abnormal cell aging indicators are detected, the intelligent algorithm immediately triggers a response mechanism.

[0086] Intelligent regulation and precise care: Built-in micro-precision temperature control elements, based on the analysis results of intelligent algorithms, accurately control the temperature and heat the anti-aging drug patches or skin care products attached to the skin to optimize their absorption effect. At the same time, the micro-pulse generator provides precise pulse signals and energy to open the skin channels and promote the efficient penetration and absorption of anti-aging drugs, nutrients or other active ingredients.

[0087] High-performance processing and personalized strategies: Equipped with a high-performance microprocessor, it runs intelligent algorithms to process sensor data and dynamically adjust anti-aging strategies based on the user's physiological age, genetic characteristics, living habits, etc. The intelligent algorithm can also optimize the use of drug patches based on the user's real-time health status and feedback to ensure the maximum anti-aging effect.

[0088] Interactive interface and user experience: Equipped with a high-definition small display screen, it supports touch or voice interaction, allowing users to view information such as oxidative stress levels, cell aging indicators, and anti-aging progress. It provides personalized health advice, anti-aging solutions, and life tips to enhance users' sense of participation and experience.

[0089] Technical details: The biosensor uses electrochemical or optical principles to monitor the key anti-aging indicators in the user's body with high precision. The micro-temperature control element has a precise temperature control function to ensure that the drug patch or skin care product is effective at the optimal temperature. The intelligent processor is a high-performance microprocessor that supports complex algorithm operations to achieve real-time data processing and dynamic adjustment of strategies. The display screen and interactive module are miniaturized for easy wear and provide an intuitive and easy-to-use interactive interface.

[0090] This smart wearable anti-aging system provides users with a full range of high-efficiency anti-aging solutions through real-time monitoring, intelligent regulation and precise care, combined with personalized anti-aging strategies, helping to maintain youthful vitality and health.

[0091] Software design modules, including a functional module for developing real-time monitoring algorithms to analyze sensor data to accurately determine the user's pulse threshold, an intelligent response mechanism module that automatically triggers the heating element and drug release when blood pressure / heart rate / NAD+ levels exceed preset thresholds, a personalized anti-aging program module that adjusts the drug patch formula and heating parameters based on the user's personal information (such as age, gender, weight, eating habits, etc.), a safety monitoring module that implements overheating protection to ensure the safety of the heating process, and a user education and feedback system module that provides usage tutorials, pulse threshold interpretation and anti-aging effect evaluation and collects user feedback to optimize services; Advanced technology integration module, including the nanotechnology module that uses nano-nano crystal introduction instrument and electrospinning technology to improve the absorption effect and fit of drug patches, the electromagnetic microneedle technology module that combines microneedle and electromagnetic microfluidic technology to promote the absorption of drug ingredients deep into the skin, and the bioluminescence therapy module that uses light of a specific wavelength to activate the vitality of skin cells to assist the drug in taking effect; The pharmacokinetic and pharmacodynamic optimization module includes a transdermal technology module that optimizes the lipid solubility, molecular size and shape of drug patches to promote passive diffusion, a precise temperature control module that uses intelligent algorithms to accurately control the heating temperature to ensure maximum enzyme activity without inactivation, and a pharmacodynamic evaluation module that continuously monitors anti-aging effects and adjusts drug release rate and heating parameters.

[0092] 4. Smart DYG selenoprotein NMN compound gradient anti-aging supplement formula, massage formula, sports formula module It is characterized by comprising: a DYG selenoprotein NMN compound gradient anti-aging supplement mother formula, a sub-formula, an anti-aging and longevity acupoint meridian massage formula, and an anti-aging and longevity exercise formula. DYG selenoprotein NMN complex gradient anti-aging supplement master formula: composed of DYG selenoprotein, NMN, zinc protein, chitosan, VC, VE, ginseng, chaga polysaccharide, pterostilbene, notoginseng saponin, icariin, ginsenoside, astragalus polysaccharide, ganoderma lucidum polysaccharide, D-flavonoids, curcumin, Omega-3 fatty acids, vitamin D, coenzyme NAD+, superoxide dismutase (SOD), glutathione peroxidase (GPx), green tea extract, iron, magnesium, Omega-3 fatty acids, complex vitamin group (including vitamin A, C, E, B group, etc.), advanced antioxidant complex (β-carotene, astaxanthin, vitamin E), superoxide dismutase (SOD), glutathione peroxidase (GPx), Imperata root extract, honey, and the formula ratio range is shown in Table 1.

[0093] Table 1:

[0094] The sub-formulas and grand-formulas that can be matched according to the range of substances listed in Formula Table 1 are not listed one by one in the claims. However, these sub-formulas and grand-formulas are not limited to the contents listed in the claims. The sub-formulas and grand-formulas created from the parent formula according to actual needs together constitute an indispensable part of the present invention.

[0095] Anti-aging and longevity acupuncture point meridian massage formula In the exploration of anti-aging and life extension, acupoint meridian massage is an effective natural therapy. By precisely stimulating specific acupoints and meridians, we can promote the smooth flow of qi and blood, regulate the function of internal organs, thereby strengthening the body and delaying aging. The following is a massage formula that combines multiple key acupoints and is closely related to anti-aging and life extension.

[0096] 1. Core Acupuncture Points Zusanli: Located on the outside of the calf, it is a key acupoint for strengthening the body, helping to enhance immunity and fight aging. Sanyinjiao: Located on the inside of the calf, it is the intersection of the three Yin meridians of the liver, spleen, and kidney. It can regulate endocrine and help fight aging. Guanyuan: Located on the midline of the abdomen, it is the place where the vital energy gathers. Massaging this point can strengthen the foundation and improve physical fitness. Qihai: Also located in the abdomen, it is the sea of ​​qi, which helps to replenish the vital energy and improve the condition of qi deficiency. Baihui: Located in the center of the top of the head, it can wake up the brain, improve the mental state, and enhance memory. Hegu: Located on the back of the hand, it is the depression between the first and second metacarpal bones. It has the effects of dispelling cold, dredge the meridians and relieve pain, and calm the nerves. It has a positive effect on fighting aging and improving physical vitality.

[0097] 2. Acupuncture points for specific organs Brain: Baihui acupoint: awakens the brain and improves cognitive function. Fengchi acupoint: dispels wind and clears heat, relieves brain fatigue. Temple: clears the liver and improves eyesight, relieves head pressure. Heart: Neiguan acupoint: protects the heart, relieves palpitations and chest tightness. Shenmen acupoint: replenishes heart qi, calms the mind, and improves sleep. Tanzhong acupoint: regulates qi and widens the chest, improves heart function. Blood vessels: Xuehai acupoint: activates blood circulation and removes blood stasis, keeps blood vessels unobstructed. Jiquan acupoint: regulates heart and blood vessel functions, prevents cardiovascular diseases. Liver: Taichong acupoint: soothes the liver and regulates qi, relieves liver qi stagnation, and improves mood. Ganshu acupoint: regulates liver function, promotes detoxification, and protects liver health. Kidney: Taixi acupoint: nourishes yin and benefits the kidney, strengthens the waist and knees, and improves kidney function. Shenshu acupoint: replenishes the kidney and consolidates essence, and enhances the kidney's function of storing essence. Lung: Taiyuan acupoint: regulates lung qi, improves respiratory function, and enhances lung resistance. Feishu acupoint: clears the lungs and relieves cough, prevents and treats lung diseases. Pancreatic islet (indirect regulation): Acupoints such as Sanyinjiao and Zusanli have the function of regulating endocrine, which may indirectly benefit the function of pancreatic islet and help stabilize blood sugar.

[0098] 3. Massage methods and precautions Massage intensity: moderate, to produce a sore and swollen feeling, avoid too heavy or too light, so as not to damage the skin or acupoints. Massage time: 3-5 minutes for each acupoint massage, meridian massage can be adjusted appropriately according to the length, the total duration is recommended not to exceed 30 minutes, so as not to cause fatigue due to excessive stimulation. Note: Although acupoint massage is good for health, if you have a serious illness or physical discomfort, please seek medical attention in time. Acupoint massage cannot replace regular medical treatment and should be used as an auxiliary therapy. By insisting on massaging the above-mentioned acupoints and meridians, we can promote the health of the body more comprehensively, delay the aging process, and enjoy a more fulfilling and beautiful life. At the same time, combined with a healthy lifestyle, a balanced diet and moderate exercise, we will have a more solid foundation for anti-aging and prolonging life. Anti-aging and longevity exercise formula To design an anti-aging and longevity exercise formula, it is necessary to comprehensively consider the type, intensity, frequency and duration of exercise, and at the same time combine the principles of Chinese medicine science to ensure that exercise can harmonize qi and blood, dredge meridians, enhance physical fitness and regulate emotions. The following is an anti-aging and life-extending exercise formula based on these principles: 1. Type of exercise, aerobic exercise: such as jogging, brisk walking, swimming, cycling, etc., which helps to promote cardiopulmonary function, accelerate blood circulation, and harmonize qi and blood. Strength training: such as weightlifting, push-ups, sit-ups, yoga, etc., can enhance muscle strength, improve bone density, and enhance physical fitness. Flexibility training: such as stretching, yoga, Tai Chi, etc., can help to dredge the meridians, increase body flexibility, and reduce sports injuries. Balance training: such as Tai Chi, standing, etc., can improve body balance ability and prevent falls, especially suitable for middle-aged and elderly people. 2. Exercise intensity, moderate intensity: moderate intensity should be maintained during exercise, so as to produce slight sweating and shortness of breath, and avoid excessive fatigue. Personalized adjustment: adjust the exercise intensity according to personal physique and health status. Beginners should start with low intensity and gradually increase the intensity. 3. Exercise frequency, at least 3-5 times a week: ensure that there are enough exercises per week to maintain the body's exercise state and health benefits. Even distribution: Evenly distribute exercise on several days a week to avoid continuous high-intensity exercise that causes physical fatigue. 4. Duration, 30-60 minutes each time: The duration of each exercise should be controlled between 30-60 minutes, including warm-up, formal exercise and stretching and relaxation. Gradually increase: Beginners can start with a shorter time and gradually increase the exercise time to achieve the best exercise effect. 5. Special precautions, warm-up and stretching: Adequate warm-up and stretching should be performed before and after each exercise to prevent sports injuries. Diet and rest: Maintain a balanced diet and adequate rest to provide the body with sufficient nutrition and recovery time. Perseverance: Anti-aging and prolonging life is a long-term process that requires persistent exercise. Consult professional advice: Before starting a new exercise plan, it is recommended to consult a doctor or a professional fitness coach to ensure the safety and effectiveness of the exercise.By combining aerobic exercise, strength training, flexibility training and balance training, maintaining moderate exercise intensity, frequency and duration, and paying special attention to aspects such as warm-up, stretching, diet and rest, an effective anti-aging and life-extending exercise formula can be designed.

[0099] DYG selenoprotein NMN compound gradient anti-aging supplement sub-formulas: including powder formula, drink formula, patch formula, tablet formula, and capsule formula.

[0100] The powder formula comprises (by weight percentage): DYG selenoprotein 10% - 20%, NMN microcapsule 10% - 30%, D flavonoids 0.5% - 1.5%, curcumin 0.3% - 0.7%, ginsenosides (traditional Chinese medicine ingredients) 2% - 5%, chitosan 3% - 5%, complex vitamins (including vitamins A, C, E, B group, etc.) 10% - 20%, complex trace elements 1% - 2%, Omega - 3 fatty acids 5% - 10%, astragalus polysaccharides (traditional Chinese medicine ingredients) 5% - 10%, magnesium 1% - 3%, glutathione peroxidase (GPx) 5% - 10%; the preferred ratio is: DYG selenoprotein 10%, NMN microcapsule 30%, D flavonoids 1.5%, curcumin 0.3%, ginsenosides (traditional Chinese medicine ingredients) 2%, chitosan 5%, complex vitamins (including vitamins A, C, E, B group, etc.) family, etc.) 10%, complex trace elements 1%, Omega-3 fatty acids 5%, Astragalus polysaccharide (traditional Chinese medicine ingredient) 5%, Magnesium 1%, Glutathione peroxidase (GPx) 5%.

[0101] The beverage formula comprises (by weight percentage): DYG selenoprotein 3% - 5%, coenzyme NAD+ 1% - 2%, D flavonoids 0.5% - 1.5%, curcumin 0.3% - 0.7%, chitosan 3%-5%, complex vitamins 0.5% - 1.5%, complex trace elements 1% - 2%, Imperata root extract 3% - 9%, honey 2% - 5%, sodium citrate 0.2% - 0.4%. The preferred ratio is: DYG selenoprotein 4%, coenzyme NAD+ 1.5%, D flavonoids 1%, curcumin 0.5%, chitosan 5%, complex vitamins 1%, complex trace elements 1.5%, Imperata root extract 6%, honey 3%, and sodium citrate 0.3%.

[0102] The patch formula includes DYG selenoprotein 5% - 10%, NMN microcapsules 10% - 20%, zinc 0.5% - 3%, curcumin 1% - 3%, chitosan 10% - 30%, multivitamins 5% - 15%, pharmaceutical excipients 10% - 15%, and gelatin 5% - 10%, sodium alginate 3% - 7%, menthol 1% - 3%, propylene glycol 5% - 10%, hyaluronic acid (hyaluronic acid) 1% -3%, urea 1% - 2%, thermosensitive polymer 5% - 15% / thermosensitive liposome 5% - 10% / thermoresponsive nanomaterial 8% -18%. The preferred ratio is: DYG Selenoprotein 25%, NMN microcapsule 7.5%, zinc 1.75%, curcumin 2%, multivitamins 10%, pharmaceutical excipients (total) 12.5% ​​(including gelatin 7.5%, sodium alginate 5%, menthol 2%, propylene glycol 7.5%, hyaluronic acid (hyaluronic acid) 2%, urea 1.5%), thermosensitive materials (total) 31% (including thermosensitive polymer 10%, thermosensitive liposome 7.5%, thermoresponsive nanomaterials 13.5%); Tablet formula, including DYG selenoprotein 10%, NMM microcapsule 25%, zinc protein 1%, VC 5%, Chaga polysaccharide (traditional Chinese medicine ingredient) 2%, notoginseng saponin (traditional Chinese medicine ingredient) 3%, ginsenoside (traditional Chinese medicine ingredient) 4%, chitosan 5%, pharmaceutical excipients 12% (including microcrystalline cellulose 4%, hydroxypropyl methylcellulose 3%, cross-linked carboxymethyl cellulose sodium 3%, magnesium stearate 1%, silicon dioxide 1%); Capsule formula, including DYG selenoprotein 20%, DYG selenoprotein 10%, NMM microcapsule 25%, zinc protein 1%, VC5%, Chaga polysaccharide (traditional Chinese medicine ingredient) 2%, Panax notoginseng saponin (traditional Chinese medicine ingredient) 3%, ginsenoside (traditional Chinese medicine ingredient) 4%, chitosan 5%, chitosan 5%, garlic seed powder 5%, pharmaceutical excipients 19% (including gelatin capsule shell 10%, magnesium stearate 3%, microcrystalline cellulose 3%, cross-linked sodium carboxymethyl cellulose 3%).

[0103] In addition to the core ingredients DYG selenoprotein and NMN, which are required for any segmented formula, in the personalized segmented formula, other nutrients are combined with at least one or more, and Chinese medicine ingredients are combined with at least one or more, so as to be suitable for people with different physiques and different diseases. For example, the formula for heart failure patients with neutral physique: DYG selenoprotein, NMN, can be combined with VC, Omega-3 fatty acids, ginsenosides, notoginseng saponins and astragalus polysaccharides (the combination is shown in Table 1), which can maximize the synergistic function of nutrients and Chinese medicine ingredients.

[0104] 5. Product module It is characterized by including: smart wearable device products: the smart wearable device products are electronic devices that can be worn on different parts of the human body, including but not limited to bracelets, watches, pocket watches (a small clock worn on the chest), anklets, waist rings, neck rings, gloves, shoes, socks, hats, hand accessories (such as rings, bracelets, etc.) and clothing wearable devices (such as smart clothes, smart backpacks, etc.).

[0105] Patch products: Patch products are products that are directly attached to human skin to deliver drugs or health care ingredients, including but not limited to hand patches, abdominal patches, head patches, back patches, foot patches and patches suitable for other parts of the human body (such as shoulders, knees, etc.).

[0106] Beverage products: Beverage products are liquid products for people to drink directly, including but not limited to water drinks (such as mineral water), tea drinks (such as green tea, black tea, oolong tea, etc.), nutritional drinks (such as vitamin drinks, mineral drinks), milk drinks (such as pure milk, flavored milk), protein drinks (such as soy milk, plant protein drinks) and drinks suitable for anti-aging functions.

[0107] Food and drug products: The food and drug products include two categories: food and drug, specifically covering powders, tablets (such as vitamin tablets, mineral tablets, etc.), capsules (such as soft capsules, hard capsules, etc.), solid beverages (such as instant coffee, protein powder, milk powder, soy milk powder, tea powder, etc.), oral liquids (such as oral solutions, oral suspensions, etc.), chewing gum and other forms of products. Such products are mainly used to supplement the nutrients needed by the human body, regulate physiological functions or treat diseases while resisting aging.

[0108] Note: The above classification and feature descriptions are intended to clarify the scope and characteristics of each product category. The possibility of adding new products or refining existing product categories in the future based on market demand and technological development is not excluded.

[0109] 6. Preparation process module A preparation process of a DYG selenoprotein NMN composite anti-aging supplement product, characterized by comprising: Powder preparation process: raw material selection and pretreatment - precise blending control - unified raw material processing and extract optimization, all raw materials are uniformly screened through a 200-mesh sieve - quantitative - low-temperature vacuum high-speed mixing preparation - aseptic filling bottles / bags.

[0110] Beverage preparation process: Beverage preparation process A: During the pretreatment of raw materials, key raw materials such as DYG selenoprotein pass through a 120-mesh sieve; the efficient blending strategy is to dissolve sodium citrate in distilled water, then add all the pretreated raw materials at one time, control the temperature of the mixed solution to 75±5℃, and keep warm for 15 minutes; the homogenization pressure is set to 25MPa, and high-temperature instantaneous sterilization at 118℃ is used for 8 minutes; filling is carried out under a sterile environment, using PET bottles or sterile aluminum foil bags, combined with nitrogen filling technology.

[0111] Beverage preparation process B: When pre-treating raw materials, modern extraction technology (such as ultrasonic extraction or supercritical CO2 extraction) is used to replace traditional processing methods for the kudzu flower soup for awakening. After crushing, the raw materials are sieved through a 100-mesh sieve, and other raw materials (DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD+ and vitamins) are uniformly sieved through an 80-mesh sieve; when preparing, sodium citrate is dissolved in distilled water, and the kudzu flower soup for awakening extract and other raw materials are added in turn, and the mixed solution is heated to 70-80℃ for 15-20 minutes; the homogenization pressure is adjusted to 25MPa, the homogenization times are 1, and a high-efficiency homogenizer is used; the sterilization temperature is adjusted to 115-120℃, the sterilization time is 10 minutes, and high-temperature instantaneous sterilization technology is used; filling is carried out under strict aseptic conditions, and packaging materials that meet food safety standards (such as PET bottles or sterile aluminum foil bags) are selected.

[0112] Tablet preparation process: Tablet preparation process A: During the innovation of raw material pretreatment, ultrasonic + microwave dual-mode extraction was used for Gehua Jiexing Decoction, combined with vacuum drying to obtain the extract powder, and all raw materials passed through a 200-mesh sieve; fluidized bed one-step granulation was adopted, combined with vacuum drying and microwave-assisted drying; tableting parameters were customized according to the characteristics of the raw materials, and sustained-release film coating was used.

[0113] Tablet preparation process B: During the pretreatment of raw materials, modern extraction technology (such as ultrasonic extraction, microwave extraction or supercritical CO2 extraction) is used to replace the traditional water decoction method for Gehua Jiexing Decoction. After concentration, spray drying or vacuum drying is used to obtain the extract powder. The raw materials (DYG selenoprotein, coenzyme NAD+, etc.) are uniformly sieved through a 100-mesh sieve, and the medicinal excipients are processed in advance; a one-step granulation method (such as fluidized bed granulation) is used to optimize the mixing conditions; vacuum drying or microwave drying is used, and the granules are sieved through a 20-mesh sieve after being granulated; the tablet press parameters are adjusted according to the raw material characteristics and tablet requirements, and online monitoring equipment is introduced; suitable coating materials are selected according to the tablet characteristics and requirements, and efficient coating equipment and technology are used (coating is optional).

[0114] Capsule preparation process: Capsule preparation process A: During the unified processing of raw materials and the optimization of extracts, all raw materials are uniformly sieved through a 200-mesh sieve, and spray drying is combined to obtain a stable extract; an efficient mixing and filling machine is used to achieve the integration of raw material mixing and capsule filling, and real-time monitoring; automated polishing equipment is used to ensure the smooth surface of the capsule, and aluminum-plastic blister packaging or sealed bottles are selected. Capsule preparation process B: During the raw material pretreatment, all raw materials are uniformly sieved through a 100-mesh sieve, and vacuum drying or spray drying is used to obtain a stable extract powder; an integrated device with mixing and filling functions is used, and online monitoring equipment is introduced to ensure consistent quality; automated polishing equipment is used (optional); appropriate packaging materials (such as aluminum-plastic blister packaging, bottles, etc.) are selected according to product characteristics and needs, the packaging environment is strictly controlled, and packaging with good sealing performance is used.

[0115] Patch preparation process: Patch preparation process C: Raw material preparation: According to the patch formula, DYG selenoprotein, NMN microcapsules, zinc, curcumin, multivitamins, and pharmaceutical excipients such as gelatin, sodium alginate, menthol, propylene glycol, hyaluronic acid (hyaluronic acid), urea, thermosensitive polymers (or thermosensitive liposomes, thermoresponsive nanomaterials) are accurately weighed. Inspect the raw materials to ensure that their quality meets the requirements and the purity and activity of the active ingredients meet the specified standards. Matrix preparation: Add gelatin and sodium alginate to an appropriate amount of distilled water, stir and dissolve at a certain temperature (e.g., 50-60°C) to form a uniform gelatinous matrix. Then, menthol, propylene glycol, hyaluronic acid (hyaluronic acid), urea, etc. are added to the matrix in turn, and continue to stir evenly to fully mix the ingredients. Addition of active ingredients: Slowly add active ingredients such as DYG selenoprotein and coenzyme NAD + to the above matrix, stirring while adding to ensure that the active ingredients are evenly dispersed. For thermosensitive polymers (or thermosensitive liposomes, thermoresponsive nanomaterials), appropriate methods are used to add them according to their characteristics, such as encapsulating thermosensitive liposomes through microencapsulation technology and then adding them to the matrix to ensure their stability and effectiveness. Mixing and homogenization: Add the remaining ingredients such as curcumin, multivitamins, and Chinese herbal extracts to the mixture, stir evenly, and then use a homogenizer to homogenize the mixture to make the material more delicate and uniform, thereby improving the quality of the patch. The homogenization pressure can be set to 15-20MPa, and the number of homogenizations is 2-3 times. Molding and drying: Pour the homogenized material into the mold to form a uniform sheet, and then dry it under appropriate temperature (such as 40-50℃) and humidity conditions to remove moisture and obtain a preliminarily formed patch. The drying time depends on the thickness of the patch and the drying conditions, and is generally 12-24 hours. Cutting and packaging: Cut the dried patch according to the specified size, and then use sealed packaging materials to package it to prevent the patch from being contaminated and affected by moisture. Packaged patches should be subject to quality inspection, including appearance inspection, drug content determination, viscosity test, etc., to ensure that the patches meet quality standards.

[0116] Patch preparation process D: Raw material pretreatment: The active ingredients such as DYG selenoprotein are micronized to make their particle size meet certain requirements (such as less than 10μm) to improve their dispersibility and bioavailability. The Chinese medicine extract is refined using advanced extraction technology (such as supercritical fluid extraction combined with macroporous resin adsorption) to improve the content and purity of the active ingredients. The pharmaceutical excipients such as gelatin and sodium alginate are crushed and sieved to make their particle size uniform. Solution preparation: Dissolve gelatin and sodium alginate in an appropriate amount of distilled water, heat to a certain temperature (such as 40-50℃), stir evenly to form a glue solution. Then dissolve propylene glycol, menthol, urea, etc. in an appropriate amount of water, add them to the glue solution, continue to stir evenly, disperse the thermosensitive polymer (or thermosensitive liposome, thermoresponsive nanomaterial) in a specific solvent, use ultrasonic treatment or high-speed stirring to make it evenly dispersed, and then slowly add it to the above mixed solution. Active ingredient mixing: Add DYG selenoprotein, coenzyme NAD+, zinc, curcumin, multivitamins, Chinese herbal extracts and other active ingredients to the above solution in a certain order, stirring while adding to ensure that the active ingredients are evenly dispersed. A combination of low-speed stirring and ultrasonic-assisted dispersion can be used to improve the mixing effect. Degassing and coating: Degas the mixed solution to remove bubbles in it to prevent bubbles from affecting the quality during the patch forming process. Then evenly coat the solution on the pre-prepared backing material, and the coating thickness should be uniform. An automatic coating machine can be used for coating operations to control the coating speed and thickness. Drying and curing: Dry the patch coated with the drug solution at a certain temperature (such as 30-40℃) and humidity conditions to gradually evaporate the solvent and form a solid patch with the drug and excipients. For patches containing heat-sensitive materials, the temperature should be controlled according to the characteristics of the heat-sensitive material during the drying process to achieve an appropriate curing state. The drying time depends on the thickness of the patch and the drying conditions, and is generally 8-16 hours. Cutting and packaging: Cut the dried and solidified patch into the specified size, apply the anti-sticking layer, and then seal and package. The packaging material should have good barrier properties to prevent the patch from being affected by the external environment. Perform quality inspection on the packaged patch, including the appearance, content, viscosity, release and other indicators to ensure that the quality of the patch meets the requirements.

[0117] Smart wearable device preparation process: Overall design and component selection: Biosensor selection and integration: Select electrochemical or optical pulse sensors with high sensitivity and accuracy to ensure real-time monitoring of the user's pulse threshold; the sensor needs to be miniaturized so that it can be embedded in wearable devices while maintaining good biocompatibility and stability. Micro pulse sensing electronic switch and pulse generator: Design a micro pulse sensing electronic switch that matches the sensor to ensure rapid response when the pulse threshold exceeds the standard; integrate a micro pulse generator to provide precise pulse signals and energy to assist drug absorption. Micro heating element: Select a micro heating element with precise temperature control function to ensure safe and effective heating of the drug patch; the heating element needs to be connected to an intelligent processor to achieve intelligent temperature control. Intelligent processor and algorithm: Equipped with a high-performance microprocessor, it runs an intelligent algorithm to process sensor data, control heating elements and pulse generators; the algorithm needs to adjust the anti-aging strategy based on user information (such as weight, gender, drinking habits, etc.) to achieve a personalized anti-aging solution. Display and interactive module: A small, high-resolution display should be configured to support touch or voice interaction. The display should be able to clearly display information such as pulse threshold values ​​and anti-aging progress for easy viewing by users.

[0118] Preparation process flow: Sensor and electronic component assembly: Assemble and weld the selected biosensors, micro pulse sensing electronic switches, micro heating elements, micro pulse generators and other electronic components; ensure that the connection between the components is reliable and there is no short circuit or open circuit. Intelligent processor and software burning: Connect the high-performance microprocessor with the assembled electronic components; burn the intelligent algorithm into the microprocessor to ensure that the algorithm can operate normally and process sensor data. Display and interactive module integration: Connect the small display screen with the microprocessor to ensure the normal display function; integrate touch or voice interaction modules to facilitate user interaction with the device. Device shell design and manufacturing: Design an ergonomic device shell to ensure that it is comfortable to wear and easy to operate; use suitable materials (such as silicone, plastic, etc.) to manufacture the shell, and perform waterproof and dustproof treatment. Assembly and testing: Install the assembled electronic components, intelligent processor, display screen and other components into the shell; conduct comprehensive functional tests to ensure that the device can work properly and meet the design requirements. Calibration and debugging: Calibrate the pulse threshold monitoring function of the device to ensure the accuracy of the measurement results; adjust the intelligent algorithm and the temperature control strategy of the heating element according to the test results to optimize the anti-aging effect. Packaging and factory inspection: Pack the device and attach accessories such as the instruction manual and warranty card; conduct factory inspection to ensure that each device meets the quality standards and meets the needs of users. Quality control and after-sales service: Establish a strict quality control system to monitor and inspect every link in the production process; provide comprehensive after-sales service to promptly solve problems encountered by users during use; regularly maintain and upgrade the equipment to ensure that the equipment always maintains the best performance.

[0119] Explanation of each claim: In each claim according to claims 1-6, the functions and interrelationships of each system and module, the specific efficacy of each component and the specific functions, principles and mechanisms of each component have been described in detail in the invention content of the specification and are not listed repeatedly in the claims, but constitute an indispensable part of the present invention.

[0120] Beneficial effects of the present invention: The present invention integrates core anti-aging ingredients such as DYG selenoprotein and NMN, combines multiple nutrients and Chinese medicine ingredients, and incorporates the concepts of Chinese massage and exercise to build a comprehensive and scientific anti-aging and intelligent health management system. Through the synergistic effect of the composite ingredients, the solution significantly enhances the body's antioxidant capacity, effectively reduces the damage of free radicals to cells, and thus delays the aging process. At the same time, the application of smart wearable devices makes health management more personalized and accurate, and provides customized anti-aging strategies and health recommendations by real-time monitoring of user health data.

[0121] In addition, the present invention also promotes health and longevity through multiple ways such as regulating energy metabolism, improving cardiovascular health, and enhancing immunity, thereby comprehensively improving the quality of life of users. The combination of Chinese medicine massage and exercise not only contributes to physical health, but also relieves psychological pressure and improves overall well-being. Overall, the present invention not only significantly improves the anti-aging effect, but also enhances the user's ability to prevent diseases, bringing users a healthier, longer and more vibrant life experience. BRIEF DESCRIPTION OF THE DRAWINGS

[0122] Figure 1 A medical science schematic diagram showing the combination of DYG selenoprotein and NMN in anti-aging and life extension; Figure 2 The module of the intelligent DYG selenoprotein NMN compound gradient anti-aging supplement formula, massage formula, and sports formula is shown, including: the DYG selenoprotein NMN compound gradient anti-aging supplement mother formula, sub-formula and the anti-aging and longevity acupoint meridian massage formula, and the anti-aging and longevity sports formula composition structure diagram; Figure 3 A schematic diagram of the master formula of DYG selenoprotein NMN compound gradient anti-aging supplement is shown; Figure 4 It shows the mechanism of action of acupoint meridian massage for anti-aging and longevity and the scientific principle diagram of traditional Chinese medicine; Figure 5 Shows a schematic diagram of the structure of the anti-aging and longevity acupoint meridian massage formula; Figure 6 It shows the mechanism and scientific principle of exercise and anti-aging and longevity; Figure 7 A schematic diagram of the structure of an anti-aging and longevity sports formula is shown. DETAILED DESCRIPTION Example

[0123] 1. A smart DYG selenoprotein NMN compound gradient anti-aging supplement product and smart wearable device health management system Its features include: 1. Smart health management system and solution module, 2. Smart DYG selenoprotein NMN compound gradient anti-aging supplement product module, 3. Smart wearable device and patch module, 4. Smart DYG selenoprotein NMN compound gradient anti-aging supplement formula, massage formula, sports formula module, 5. Product product module, 6. Preparation process module.

Claims

1. A smart DYG selenoprotein NMN composite gradient anti-aging supplement product and smart wearable device health management system, Features include:

1. Smart health management system and solution module, 2. Smart DYG selenoprotein NMN compound gradient anti-aging supplement product module, 3. Smart wearable device and patch module, 4. Smart DYG selenoprotein NMN compound gradient anti-aging supplement formula, massage formula, sports formula module, 5. Product module, 6. Preparation process module.

2. The smart health management system and solution module according to claim 1, comprising: Intelligent health management system, an anti-aging auxiliary system based on intelligent wearable devices. It is characterized by: Intelligent diagnosis and assessment module: Use biometric technology combined with basic user information to establish and update personal health records, integrate multi-source data for multi-dimensional health data analysis, and use machine learning algorithms to conduct in-depth mining of health data to identify potential health risks and provide personalized health advice and warnings; Gradient anti-aging comprehensive strategy system: Instant Response Intelligent Antioxidant Protection Submodule: The core ingredients include DYG selenoprotein, NMN (β-nicotinamide mononucleotide), superoxide dismutase (SOD), glutathione peroxidase (GPx), coenzyme Q10, and resveratrol; it uses intelligent nano-carrier technology, combines high-efficiency antioxidants with intelligent activity regulation mechanisms, and the carrier is made of biocompatible and degradable materials. It can accurately and timely release antioxidants according to individual oxidative stress levels, effectively remove free radicals, and protect cells from oxidative damage; Medium-speed conditioning natural plant essence and nutritional complex sub-module: core ingredients include DYG selenoprotein and improved longevity herbal formula (green tea extract, icariin, notoginseng saponin, ganoderma lucidum polysaccharide), D-flavonoids, curcumin, omega-3 fatty acids, vitamin D, coenzyme NAD+. Ultrafine grinding and controlled release technology are used to enhance the production of plant active ingredients and nutrients. The system dynamically adjusts the formula ratio based on the user's physiological age, genetic characteristics and living habits to achieve personalized conditioning; long-term nourishing personalized nutrition intelligent regulation submodule: the core ingredients include customized complex vitamin groups (including vitamins A, C, E, B group, etc.), essential trace elements (zinc, selenium, iron, magnesium), Omega-3 fatty acids, advanced antioxidant complexes (β-carotene, astaxanthin, vitamin E), DYG selenoprotein, ginsenosides, and astragalus polysaccharides. Based on a personalized nutrition assessment model, using precision medical-grade 3D printing technology, combined with real-time health monitoring data and daily habits, it dynamically customizes exclusive nutrition supplement plans to ensure accurate nutrient supplementation and meet individual anti-aging needs; Continuous monitoring and intelligent feedback system: Wearable devices monitor the user's oxidative stress status, cell aging indicators (such as telomere length, NAD+ level), skin health status and overall physiological function in real time, and the data is uploaded to the cloud for analysis in real time. Using AI algorithms, combined with the user's historical health records, current living environment and real-time data, dynamically optimize anti-aging plans, and provide personalized health advice, warnings and online linkage services with professional medical institutions through mobile applications or smart voice assistants; Health promotion and community interaction platform: Provide comprehensive health management services, including health record management, risk assessment, personalized health plan formulation and implementation supervision, regularly publish scientific anti-aging knowledge, and enhance users' health awareness and self-management capabilities; build user communities, encourage sharing of anti-aging experiences, success stories and life experiences, establish health challenge tasks and reward mechanisms, stimulate user participation enthusiasm, and jointly explore anti-aging methods; This comprehensive anti-aging strategy system deeply integrates natural plant essences, nutrients and advanced technologies through scientific proportions and intelligent regulation, providing users with comprehensive and personalized anti-aging solutions to help achieve the goal of health and longevity.

3. The smart wearable device and patch module according to claims 1-2, comprising: The anti-aging system of smart wearable devices is an anti-aging auxiliary system based on smart wearable devices. It is characterized by including: Smart Wearable Devices Real-time monitoring and data analysis: Integrates advanced biosensors to monitor the user's body's oxidative stress level, cell aging indicators (such as NAD+ levels, telomere length, etc.) and overall physiological function parameters in real time. When elevated oxidative stress levels or abnormal cell aging indicators are detected, the intelligent algorithm immediately triggers a response mechanism; Intelligent regulation and precise care: Built-in micro-precision temperature control elements can precisely control the temperature and heat the anti-aging drug patches or skin care products attached to the skin according to the analysis results of the intelligent algorithm to optimize their absorption effect. At the same time, the micro-pulse generator provides precise pulse signals and energy to open the skin channels and promote the efficient penetration and absorption of anti-aging drugs, nutrients or other active ingredients. High-performance processing and personalized strategies: Equipped with a high-performance microprocessor, it runs intelligent algorithms to process sensor data and dynamically adjust anti-aging strategies based on the user's physiological age, genetic characteristics, living habits and other information. The intelligent algorithm can also optimize the use of drug patches based on the user's real-time health status and feedback to ensure the maximum anti-aging effect; Interactive interface and user experience: Equipped with a high-definition small display screen, supporting touch or voice interaction, it is convenient for users to view information such as oxidative stress levels, cell aging indicators, anti-aging progress, etc. It provides personalized health advice, anti-aging solutions and life tips to enhance users' sense of participation and experience; Technical details: The biosensor uses electrochemical or optical principles to monitor the key anti-aging indicators in the user's body with high precision; the micro-temperature control element has a precise temperature control function to ensure that the drug patch or skin care product is effective at the optimal temperature; the intelligent processor is a high-performance microprocessor that supports complex algorithm operations to achieve real-time data processing and dynamic adjustment of strategies; the display screen and interactive module are miniaturized for easy wear, while providing an intuitive and easy-to-use interactive interface; This smart wearable device anti-aging system provides users with a comprehensive and efficient anti-aging solution through real-time monitoring, intelligent regulation and precise care, combined with personalized anti-aging strategies, to help maintain youthful vitality and health. Software design modules, including a functional module for developing a real-time monitoring algorithm to analyze sensor data to accurately determine the user's pulse threshold, an intelligent response mechanism module that automatically triggers the heating element and drug release when the blood pressure / heart rate / NAD+ level exceeds a preset threshold, a personalized anti-aging program module that adjusts the drug patch formula and heating parameters according to the user's personal information (such as age, gender, weight, eating habits, etc.), a safety monitoring module that implements overheating protection to ensure the safety of the heating process, and a user education and feedback system module that provides usage tutorials, pulse threshold interpretation and anti-aging effect evaluation and collects user feedback to optimize services; Advanced technology integration module, including the nanotechnology module that uses nano-nano crystal introduction instrument and electrospinning technology to improve the absorption effect and fit of drug patches, the electromagnetic microneedle technology module that combines microneedle and electromagnetic microfluidic technology to promote the absorption of drug ingredients deep into the skin, and the bioluminescence therapy module that uses light of a specific wavelength to activate the vitality of skin cells to assist the drug in taking effect; The pharmacokinetic and pharmacodynamic optimization module includes a transdermal technology module that optimizes the lipid solubility, molecular size and shape of drug patches to promote passive diffusion, a precise temperature control module that uses intelligent algorithms to accurately control the heating temperature to ensure maximum enzyme activity without inactivation, and a pharmacodynamic evaluation module that continuously monitors anti-aging effects and adjusts drug release rate and heating parameters.

4. The smart DYG selenoprotein NMN composite gradient anti-aging supplement formula, massage formula, and exercise formula module according to claims 1-3, characterized in that: include: DYG selenoprotein NMN compound gradient anti-aging supplement consists of a master formula, a sub-formula, an anti-aging and longevity acupoint meridian massage formula, and an anti-aging and longevity exercise formula; DYG selenoprotein NMN complex gradient anti-aging supplement mother formula: composed of DYG selenoprotein, NMN, zinc protein, chitosan, VC, VE, ginseng, chaga polysaccharide, pterostilbene, notoginseng saponin, icariin, ginsenoside, astragalus polysaccharide, ganoderma lucidum polysaccharide, D-flavonoids, curcumin, Omega-3 fatty acids, vitamin D, coenzyme NAD+, superoxide dismutase (SOD), glutathione peroxidase (GPx), green tea extract, iron, magnesium, Omega-3 fatty acids, complex vitamin group (including vitamin A, C, E, B group, etc.), advanced antioxidant complex (β-carotene, astaxanthin, vitamin E), superoxide dismutase (SOD), glutathione peroxidase (GPx), Imperata root extract, honey, the formula ratio range is shown in Table 1: Table 1 The sub-formulas and grand-formulas that can be matched according to the range of substances listed in Formula Table 1 are not listed one by one in the claims. However, these sub-formulas and grand-formulas are not limited to the contents listed in the claims. The sub-formulas and grand-formulas created from the parent formula according to actual needs together constitute an indispensable part of the present invention; Anti-aging and longevity acupuncture point meridian massage formula In the exploration of anti-aging and life extension, acupoint meridian massage is an effective natural therapy. By precisely stimulating specific acupoints and meridians, we can promote the smooth flow of qi and blood, regulate the functions of internal organs, thereby strengthening the body and delaying aging. The following is a massage formula that combines multiple key acupoints and is closely related to anti-aging and life extension; 1. Core Acupuncture Points Zusanli: Located on the outside of the calf, it is a key acupoint for strengthening the body, helping to enhance immunity and fight aging; Sanyinjiao: Located on the inner side of the calf, it is the intersection of the three Yin meridians of the liver, spleen and kidney. It can regulate endocrine and help anti-aging. Guanyuan: Located on the midline of the abdomen, it is the place where the vital energy gathers. Massaging this point can strengthen the body and improve physical fitness. Qihai: Also located in the abdomen, it is the sea of ​​qi, which helps to replenish vital energy and improve qi deficiency; Baihui: Located in the center of the top of the head, it can awaken the brain, improve mental state and enhance memory; Hegu: Located on the back of the hand, it is the depression between the first and second metacarpal bones. It has the effects of dispelling cold, dredge meridians and relieve pain, calm the nerves and tranquilize the mind. It has a positive effect on anti-aging and improving physical vitality.

2. Acupuncture points for specific organs: Baihui acupoint: awakens the brain and improves cognitive function; Fengchi acupoint: dispels wind and heat, relieves brain fatigue; Temple: Clears the liver and improves eyesight, relieves head pressure; heart: Neiguan acupoint: protects the heart, relieves palpitations and chest tightness; Shenmen acupoint: replenishes heart qi, calms the mind, and improves sleep; Tanzhong point: regulates qi and expands the chest, improving heart function; Blood vessel: Xuehai Point: promotes blood circulation and removes blood stasis, keeping blood vessels unobstructed; Jiquan Point: regulates heart and blood vessel functions and prevents cardiovascular diseases; Liver: Taichong acupoint: soothes the liver and regulates qi, relieves liver qi stagnation, and improves mood; Liver Shu Point: regulates liver function, promotes detoxification, and protects liver health; kidney: Taixi acupoint: nourishes yin and benefits the kidney, strengthens the waist and knees, and improves kidney function; Shenshu acupoint: nourishes the kidney and consolidates essence, and enhances the kidney's function of storing essence; lung: Taiyuan point: regulates lung qi, improves respiratory function, and enhances lung resistance; Feishu point: clears the lungs and relieves cough, prevents and treats lung diseases; Islets of Langerhans (indirect regulation): Acupuncture points such as Sanyinjiao and Zusanli that have endocrine regulating functions may indirectly benefit pancreatic islet function and help stabilize blood sugar.

3. Massage methods and precautions Massage intensity: moderate, to produce a sore and swollen feeling, avoid being too heavy or too light to avoid damaging the skin or acupoints; Massage time: Massage each acupoint for 3-5 minutes. The meridian massage can be adjusted appropriately according to the length. The total duration is recommended not to exceed 30 minutes to avoid excessive stimulation and fatigue. Note: Although acupoint massage is beneficial to health, if you have a serious illness or feel unwell, please seek medical attention immediately; acupoint massage cannot replace regular medical treatment and should be used as an auxiliary therapy; By insisting on massaging the above-mentioned acupuncture points and meridians, we can promote the health of the body more comprehensively, delay the aging process, and enjoy a more fulfilling and beautiful life; at the same time, combined with a healthy lifestyle, a balanced diet and moderate exercise, we will have a more solid foundation for anti-aging and prolonging life; Anti-aging and longevity sports formula To design an anti-aging and life-extending exercise formula, it is necessary to comprehensively consider the type, intensity, frequency and duration of exercise, and combine the principles of Chinese medicine science to ensure that exercise can harmonize qi and blood, dredge meridians, strengthen physical fitness and regulate emotions; the following is an anti-aging and life-extending exercise formula based on these principles:

1. Type of exercise Aerobic exercise: such as jogging, brisk walking, swimming, cycling, etc., helps to promote cardiopulmonary function, accelerate blood circulation, and harmonize qi and blood; Strength training: such as weightlifting, push-ups, sit-ups, yoga, etc., can enhance muscle strength, increase bone density, and enhance physical fitness; Flexibility training: such as stretching, yoga, Tai Chi, etc., which helps to dredge the meridians, increase body flexibility, and reduce sports injuries; Balance training: such as Tai Chi and standing posture, which can improve body balance and prevent falls, and are especially suitable for middle-aged and elderly people; 2. Exercise Intensity Moderate intensity: When exercising, you should maintain a moderate intensity to produce slight sweating and shortness of breath, and avoid excessive fatigue; Personalized adjustment: Adjust the intensity of exercise according to your personal physique and health status. Beginners should start with low intensity and gradually increase the intensity; 3. Exercise frequency At least 3-5 times a week: Ensure you get enough exercise each week to maintain your body's movement and health benefits; Even distribution: Evenly distribute exercise on several days a week to avoid continuous high-intensity exercise that may cause physical fatigue; 4. Duration 30-60 minutes each time: Each exercise session should last between 30 and 60 minutes, including warm-up, formal exercise, and stretching and relaxation; Gradually increase: Beginners can start with a shorter period of time and gradually increase the exercise time to achieve the best exercise effect; 5. Special Notes Warm up and stretch: Perform adequate warm up and stretching before and after each exercise to prevent sports injuries; Diet and rest: Maintain a balanced diet and adequate rest to provide the body with adequate nutrition and recovery time; Perseverance: Anti-aging and extending life span is a long-term process that requires persistent exercise; Consult professional advice: Before starting a new exercise program, it is recommended to consult a doctor or professional fitness trainer to ensure the safety and effectiveness of the exercise; By combining aerobic exercise, strength training, flexibility training and balance training, maintaining moderate exercise intensity, frequency and duration, and paying special attention to warm-up, stretching, diet and rest, an effective anti-aging and life-extending exercise formula can be designed; DYG selenoprotein NMN compound gradient anti-aging supplement sub-formula: including powder formula, drink formula, patch formula, tablet formula, capsule formula; The powder formula includes (by weight): DYG selenoprotein 10%-20%, NMN microcapsule 10%-30%, D flavonoids 0.5%-1.5%, curcumin 0.3%-0.7%, ginsenoside (traditional Chinese medicine ingredient) 2%-5%, chitosan 3%-5%, complex vitamin group (including vitamin A, C, E, B group, etc.) 10%-20%, complex trace elements 1%-2%, Omega-3 fatty acids 5%-10%, astragalus polysaccharide (traditional Chinese medicine ingredient) 5%-10%, magnesium 1%-3%, glutathione peroxidase (GPx) 5%-10%; the preferred ratio is: DYG selenoprotein 10%, NMN microcapsule 30%, D flavonoids 1.5%, curcumin 0.3%, ginsenoside (traditional Chinese medicine ingredient) 2%, chitosan 5%, complex vitamin group (including vitamin A, C, E, B group, etc.) 10%, complex trace elements 1%, Omega-3 fatty acids 5%, astragalus polysaccharide (traditional Chinese medicine ingredient) 5%, magnesium 1%, glutathione peroxidase (GPx) 5%; The beverage formula comprises (by weight percentage): DYG selenoprotein 3%-5%, coenzyme NAD+1%-2%, D flavonoids 0.5%-1.5%, curcumin 0.3%-0.7%, chitosan 3%-5%, complex vitamins 0.5%-1.5%, complex trace elements 1%-2%, Imperata root extract 3%-9%, honey 2%-5%, sodium citrate 0.2%-0.4%, and the preferred ratio is: DYG selenoprotein 4%, coenzyme NAD+1.5%, D flavonoids 1%, curcumin 0.5%, chitosan 5%, complex vitamins 1%, complex trace elements 1.5%, Imperata root extract 6%, honey 3%, sodium citrate 0.3%; The patch formula contains DYG selenoprotein 5%-10%, NMN microcapsules 10%-20%, zinc 0.5%-3%, curcumin 1%-3%, chitosan 10%-30%, multivitamins 5%-15%, pharmaceutical excipients 10%-15%, as well as gelatin 5%-10%, sodium alginate 3%-7%, menthol 1%-3%, propylene glycol 5%-10%, hyaluronic acid 1%-3%, urea 1%-2%, thermosensitive polymer 5%-15% / thermosensitive liposome 5%-10% / thermoresponsive nanomaterials 8%-18%, The preferred ratio is: DYG selenoprotein 25%, NMN microcapsule 7.5%, zinc 1.75%, curcumin 2%, multivitamin 10%, pharmaceutical excipients (total) 12.5% ​​(including gelatin 7.5%, sodium alginate 5%, menthol 2%, propylene glycol 7.5%, hyaluronic acid (hyaluronic acid) 2%, urea 1.5%), thermosensitive materials (total) 31% (including thermosensitive polymer 10%, thermosensitive liposome 7.5%, thermoresponsive nanomaterial 13.5%); Tablet formula, including DYG selenoprotein 10%, NMM microcapsule 25%, zinc protein 1%, VC 5%, Chaga polysaccharide (traditional Chinese medicine ingredient) 2%, notoginseng saponin (traditional Chinese medicine ingredient) 3%, ginsenoside (traditional Chinese medicine ingredient) 4%, chitosan 5%, pharmaceutical excipients 12% (including microcrystalline cellulose 4%, hydroxypropyl methylcellulose 3%, cross-linked sodium carboxymethyl cellulose 3%, magnesium stearate 1%, silicon dioxide 1%); Capsule formula, including DYG selenoprotein 20%, DYG selenoprotein 10%, NMM microcapsule 25%, zinc protein 1%, VC 5%, Chaga polysaccharide (traditional Chinese medicine ingredient) 2%, Panax notoginseng saponin (traditional Chinese medicine ingredient) 3%, ginsenoside (traditional Chinese medicine ingredient) 4%, Chitosan 5%, chitosan 5%, garlic seed powder 5%, pharmaceutical excipients 19% (including gelatin capsule shell 10%, magnesium stearate 3%, microcrystalline cellulose 3%, cross-linked sodium carboxymethyl cellulose 3%); In addition to the core ingredients DYG selenoprotein and NMN, which are required for any segmented formula, in the personalized segmented formula, other nutrients are combined with at least one or more, and Chinese medicine ingredients are combined with at least one or more, so as to be suitable for people with different constitutions and different diseases. For example, the formula for heart failure patients with neutral constitution: DYG selenoprotein, NMN, can be combined with VC, Omega-3 fatty acids, ginsenosides, notoginseng saponins and astragalus polysaccharides (the combination is shown in Table 1), so as to maximize the synergistic function of nutrients and Chinese medicine ingredients; The subdivided formulations that can be combined according to the material range listed in Formulation Table 1 are not listed one by one in the claims, but constitute an indispensable part of the present invention.

5. The product module according to claims 1-4, characterized in that: include: Smart wearable device products: The smart wearable device products are electronic devices that can be worn on different parts of the human body, including but not limited to bracelets, watches, pocket watches (a small clock worn on the chest), anklets, waist rings, neck rings, gloves, shoes, socks, hats, hand accessories (such as rings, bracelets, etc.) and clothing wearable devices (such as smart clothes, smart backpacks, etc.); Patch products: The patch products are products that are directly attached to the human skin to deliver drugs or health care ingredients, including but not limited to hand patches, abdominal patches, head patches, back patches, foot patches and patches suitable for other parts of the human body (such as shoulders, knees, etc.) The patch made; Beverage products: Beverage products are liquid products for direct drinking, including but not limited to water drinks (such as mineral water), tea drinks (such as green tea, black tea, oolong tea, etc.), nutritional drinks (such as vitamin drinks, mineral drinks), milk drinks (such as pure milk, flavored milk), protein drinks (such as soy milk, plant protein drinks) and drinks suitable for anti-aging functions; Food and drug products: The food and drug products include two categories: food and drug, specifically covering products in the form of powders, tablets (such as vitamin tablets, mineral tablets, etc.), capsules (such as soft capsules, hard capsules, etc.), solid beverages (such as instant coffee, protein powder, milk powder, soy milk powder, tea powder, etc.), oral liquids (such as oral solutions, oral suspensions, etc.), chewing gum, etc.; such products are mainly used to supplement the nutrients needed by the human body, regulate physiological functions or treat diseases while resisting aging; Note: The above classification and feature descriptions are intended to clarify the scope and characteristics of each product category. The possibility of adding new products or refining existing product categories in the future based on market demand and technological development is not excluded.

6. The preparation process module according to claims 1-5, characterized in that: A preparation process of a DYG selenoprotein NMN composite anti-aging supplement product, comprising: Powder preparation process: raw material selection and pretreatment - precise blending control - unified raw material processing and extract optimization - all raw materials are uniformly screened through a 200-mesh sieve - quantitative - low-temperature vacuum high-speed mixing preparation - aseptic filling bottles / bags; Beverage preparation process: Beverage preparation process A: During the raw material pretreatment, key raw materials such as DYG selenoprotein pass through a 120-mesh sieve; the efficient blending strategy is to dissolve sodium citrate in distilled water, add all pretreated raw materials at once, control the temperature of the mixed solution to 75±5℃, and keep warm for 15 minutes; the homogenization pressure is set to 25MPa, and high-temperature instant sterilization is adopted at 118℃ for 8 minutes; filling is carried out under a sterile environment, using PET bottles or sterile aluminum foil bags, combined with nitrogen filling technology; Beverage preparation process B: When pre-treating raw materials, modern extraction technology (such as ultrasonic extraction or supercritical CO2 extraction) is used to replace the traditional processing method for the kudzu flower awakening soup. After crushing, it is sieved through a 100-mesh sieve. Other raw materials (DYG selenoprotein, alcohol dehydrogenase, alcohol dealdehydease, coenzyme NAD+ and vitamins) are uniformly sieved through an 80-mesh sieve. When preparing, sodium citrate is dissolved in distilled water. Add the extract of Gehua Jiexing Decoction and other raw materials in sequence, heat the mixed solution to 70-80℃, and keep it warm for 15-20 minutes; adjust the homogenization pressure to 25MPa, homogenize once, and use a high-efficiency homogenizer; adjust the sterilization temperature to 115-120℃, sterilize for 10 minutes, and use high-temperature instantaneous sterilization technology; fill under strict aseptic conditions, and use packaging materials that meet food safety standards (such as PET bottles or sterile aluminum foil bags); Tablet preparation process: Tablet preparation process A: In the innovation of raw material pretreatment, the Gehua Jiexing Decoction adopts ultrasonic + microwave dual-mode extraction, combined with vacuum drying to obtain the extract powder, and all raw materials pass through a 200-mesh sieve; fluidized bed one-step granulation is adopted, combined with vacuum drying and microwave-assisted drying; tableting parameters are customized according to the characteristics of the raw materials, and sustained-release film coating is adopted; Tablet preparation process B: During the pretreatment of raw materials, modern extraction technology (such as ultrasonic extraction, microwave extraction or supercritical CO2 extraction) is used to replace the traditional water decoction method for Gehua Jiexing Decoction. After concentration, spray drying or vacuum drying is used to obtain the extract powder. The raw materials (DYG selenoprotein, coenzyme NAD+, etc.) are uniformly sieved through a 100-mesh sieve, and the pharmaceutical excipients are processed in advance; a one-step granulation method (such as fluidized bed granulation) is used to optimize the mixing conditions; vacuum drying or microwave drying is used, and the granules are sieved through a 20-mesh sieve after being granulated; the tablet press parameters are adjusted according to the raw material characteristics and tablet requirements, and online monitoring equipment is introduced; suitable coating materials are selected according to the tablet characteristics and requirements, and efficient coating equipment and technology are used (coating is optional); Capsule preparation process: Capsule preparation process A: When all raw materials are uniformly processed and the extract is optimized, all raw materials are uniformly screened with a 200-mesh sieve, and spray drying is combined to obtain a stable extract; an efficient mixing and filling machine is used to achieve the integration of raw material mixing and capsule filling, and real-time monitoring; automated polishing equipment is used to ensure the smooth surface of the capsule, and aluminum-plastic blister packaging or sealed bottles are selected; Capsule preparation process B: During raw material pretreatment, all raw materials are uniformly screened with a 100-mesh sieve, and vacuum drying or spray drying is used to obtain a stable extract powder; an integrated device with mixing and filling functions is used, and online monitoring equipment is introduced to ensure consistent quality; automated polishing equipment is used (optional); appropriate packaging materials (such as aluminum-plastic blister packaging, bottle packaging, etc.) are selected according to product characteristics and needs, the packaging environment is strictly controlled, and a packaging form with good sealing performance is used; Patch preparation process: Patch preparation process C: Raw material preparation: accurately weigh DYG selenoprotein, NMN microcapsules, zinc, curcumin, multivitamins, and pharmaceutical excipients such as gelatin, sodium alginate, menthol, propylene glycol, hyaluronic acid, urea, thermosensitive polymers (or thermosensitive liposomes, thermoresponsive nanomaterials) according to the patch formula; inspect the raw materials to ensure that their quality meets the requirements, and the purity and activity of the active ingredients should meet the specified standards; Preparation of matrix: add gelatin and sodium alginate into an appropriate amount of distilled water, stir and dissolve at a certain temperature (e.g., 50-60°C) to form a uniform gelatinous matrix; then, add menthol, propylene glycol, hyaluronic acid (hyaluronic acid), urea, etc. into the matrix in sequence, continue to stir evenly, and fully mix the ingredients; Adding active ingredients: slowly add DYG selenoprotein, coenzyme NAD+ and other active ingredients to the above-mentioned matrix, stirring while adding to ensure that the active ingredients are evenly dispersed; for thermosensitive polymers (or thermosensitive liposomes, thermoresponsive nanomaterials), use appropriate methods to add them according to their characteristics, such as encapsulating thermosensitive liposomes through microencapsulation technology and then adding them to the matrix to ensure their stability and effectiveness; mixing and homogenizing: add remaining ingredients such as curcumin, multivitamins, and Chinese medicine extracts to the mixture, stir evenly, and use a homogenizer to homogenize the mixture to make the material more delicate and uniform, thereby improving the quality of the patch; the homogenization pressure can be set to 15-20M Pa, homogenization times are 2-3 times; molding and drying: pour the homogenized material into the mold to form a uniform sheet, and then dry it under appropriate temperature (such as 40-50°C) and humidity conditions to remove moisture and obtain a preliminarily formed patch; the drying time depends on the thickness of the patch and the drying conditions, generally 12-24 hours; cutting and packaging: cut the dried patch according to the specified size, and then use sealed packaging materials to package it to prevent the patch from being contaminated and affected by moisture; the packaged patch should be quality inspected, including appearance inspection, drug content determination, viscosity test, etc., to ensure that the patch meets the quality standards; Patch preparation process D: Raw material pretreatment: Micronize active ingredients such as DYG selenoprotein to a certain particle size (such as less than 10 μm) to improve their dispersibility and bioavailability; use advanced extraction technology (such as supercritical fluid extraction combined with macroporous resin adsorption) to refine Chinese herbal extracts to increase the content and purity of active ingredients; grind and sieve pharmaceutical excipients such as gelatin and sodium alginate to make their particle size uniform; Solution preparation: dissolve gelatin and sodium alginate in an appropriate amount of distilled water, heat to a certain temperature (such as 40-50°C), stir evenly to form a glue solution; then dissolve propylene glycol, menthol, urea, etc. in an appropriate amount of water, add them to the glue solution, continue to stir evenly, disperse the thermosensitive polymer (or thermosensitive liposome, thermoresponsive nanomaterial) in a specific solvent, use ultrasonic treatment or high-speed stirring to make it evenly dispersed, and then slowly add it to the above mixed solution; Active ingredient mixing: Add DYG selenoprotein, coenzyme NAD+, zinc, curcumin, multivitamins, Chinese herbal extracts and other active ingredients to the above solution in a certain order, stirring while adding to ensure that the active ingredients are evenly dispersed; a combination of low-speed stirring and ultrasonic-assisted dispersion can be used to improve the mixing effect; Degassing and coating: Degas the mixed solution to remove bubbles in it to prevent bubbles from affecting the quality during the patch molding process; then evenly coat the solution on the pre-prepared backing material, and the coating thickness should be uniform; an automatic coating machine can be used for coating operations to control the coating speed and thickness; Drying and curing: Dry the patch coated with drug solution at a certain temperature (such as 30-40°C) and humidity to make the solvent evaporate gradually, and the drug and excipients form a solid patch; for patches containing heat-sensitive materials, the temperature should be controlled according to the characteristics of the heat-sensitive materials during the drying process to achieve an appropriate curing state; the drying time depends on the thickness of the patch and the drying conditions, generally 8-16 hours; Cutting and packaging: Cut the dried and solidified patch into the specified size, apply the anti-sticking layer, and then seal and package. The packaging material should have good barrier properties to prevent the patch from being affected by the external environment. Perform quality inspection on the packaged patch, including the appearance, content, viscosity, release rate and other indicators to ensure that the quality of the patch meets the requirements. Smart wearable device manufacturing process: overall design and component selection: Biosensor selection and integration: Select highly sensitive and accurate electrochemical or optical pulse sensors to ensure real-time monitoring of the user's pulse threshold. The sensors need to be miniaturized so that they can be embedded in wearable devices while maintaining good biocompatibility and stability. Micro pulse sensing electronic switch and pulse generator: Design a micro pulse sensing electronic switch that matches the sensor to ensure rapid response when the pulse threshold exceeds the standard; integrate a micro pulse generator to provide precise pulse signals and energy to assist drug absorption; Micro heating element: Use micro heating elements with precise temperature control function to ensure safe and effective heating of drug patches; the heating element needs to be connected to an intelligent processor to achieve intelligent temperature control; Intelligent processor and algorithm: Equipped with a high-performance microprocessor, running intelligent algorithms to process sensor data, control heating elements and pulse generators; the algorithm needs to adjust the anti-aging strategy based on user information (such as weight, gender, drinking habits, etc.) to achieve a personalized anti-aging plan; Display and interactive module: A small, high-resolution display screen is used to support touch or voice interaction. The display screen must be able to clearly display information such as pulse threshold value and anti-aging progress for easy viewing by users. Preparation process: Sensor and electronic component assembly: Assemble and weld the selected biosensors, micro pulse sensing electronic switches, micro heating elements, micro pulse generators and other electronic components; ensure that the connection between the components is reliable without short circuit or open circuit; Intelligent processor and software burning: Connect the high-performance microprocessor with the assembled electronic components; burn the intelligent algorithm into the microprocessor to ensure that the algorithm can run normally and process sensor data; Integration of display and interaction module: Connecting a small display to a microprocessor to ensure normal display function; integrating touch or voice interaction modules to facilitate user interaction with the device; Design and manufacture of equipment shell: Design an ergonomic equipment shell to ensure that it is comfortable to wear and easy to operate; use suitable materials (such as silicone, plastic, etc.) to manufacture the shell, and make it waterproof and dustproof; Assembly and testing: Install the assembled electronic components, intelligent processors, display screens and other parts into the housing; conduct comprehensive functional tests to ensure that the equipment can work properly and meet the design requirements; Calibration and debugging: Calibrate the pulse threshold monitoring function of the device to ensure the accuracy of the measurement results; adjust the intelligent algorithm and the temperature control strategy of the heating element according to the test results to optimize the anti-aging effect; Packaging and factory inspection: Pack the equipment and attach accessories such as instruction manual and warranty card; conduct factory inspection to ensure that each equipment meets quality standards and meets user needs; Quality control and after-sales service: Establish a strict quality control system to monitor and inspect every link in the production process; provide comprehensive after-sales service to promptly resolve problems encountered by users during use; regularly maintain and upgrade equipment to ensure that the equipment always maintains optimal performance.

7. The description of each claim according to claims 1 to 6 According to the claims 1-6, the functions and interrelationships of each system and module, the specific efficacy of each component and the specific functions, principles and mechanisms of each component have been described in detail in the invention content of the specification and are not listed repeatedly in the claims, but constitute an indispensable part of the present invention.

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