Pulsed electric field generation apparatus, apparatus and related methods

Abstract

The invention provides a pulsed electric field generation device, equipment and a related method, and relates to the technical field of medical instruments. The pulse electric field generating device comprises a first pulse generating circuit used for generating a first polarity pulse; the second pulse generation circuit is used for generating a second polarity pulse; the first pulse generating circuit and the second pulse generating circuit are both connected to the applying pieces, and in the working state, the first polarity pulse and the second polarity pulse are both applied to any applying piece in the at least one applying piece; the first polarity pulse and the second polarity pulse are synchronously generated and have opposite polarities. Therefore, the requirements of elements in the device on high voltage resistance and insulativity can be reduced, and the overall cost is reduced.

Description

Technical Field

[0001] The present disclosure relates to the field of medical device technology, and in particular to a pulse electric field generating device, equipment and related methods. Background Art

[0002] Irreversible electroporation (IRE) is a tumor ablation technique used to treat malignant tumors, and has a relatively clear therapeutic effect in the treatment of locally advanced pancreatic cancer. This technology uses high-voltage short-pulse direct current penetration technology to change the transmembrane potential to increase cell membrane permeability, resulting in the formation of nanoscale irreversible electroporation in the lipid bilayer structure of the cell membrane, which more accurately induces apoptosis of cells in the ablation area.

[0003] In the related art, a method of continuously outputting multiple unipolar pulses is usually adopted. In order to achieve a certain electric field strength, this method has relatively high requirements on the voltage peak of the device, and thus puts forward higher requirements on the high voltage resistance, insulation and power supply voltage of the components of the entire device, and the overall cost of the device is relatively high. Summary of the invention

[0004] In view of this, the present disclosure provides a pulse electric field generating device, equipment and related methods to solve the problems of high requirements for high voltage resistance and insulation of components in devices of related technologies and high costs.

[0005] In the first aspect, a pulse electric field generating device is provided, comprising: a first pulse generating circuit for generating a first polarity pulse; a second pulse generating circuit for generating a second polarity pulse; at least one application member, the first pulse generating circuit and the second pulse generating circuit are both connected to the application member, and in a working state, the first polarity pulse and the second polarity pulse are both applied to any one of the at least one application member; the first polarity pulse and the second polarity pulse are generated synchronously and have opposite polarities.

[0006] In a second aspect, a pulse electric field generating device is provided, comprising: a first pulse generating circuit for generating a first polarity pulse; a second pulse generating circuit for generating a second polarity pulse; at least two application members, the first pulse generating circuit and the second pulse generating circuit are respectively connected to at least one application member, for outputting a first polarity pulse and a second polarity pulse; wherein the first polarity pulse and the second polarity pulse are generated synchronously and have opposite polarities.

[0007] In some embodiments, any two application members that respectively apply pulses of different polarities constitute an application member group, and at least two electric field action areas are formed within a preset range of the application member group.

[0008] In some embodiments, in the applicator group, at least one applicator has at least two pulse application zones.

[0009] In some embodiments, the applicator group includes a first applicator and a second applicator, the first applicator includes a first pulse application zone and a second pulse application zone, and the second applicator includes a third pulse application zone and a fourth pulse application zone.

[0010] In some embodiments, the first pulse application zone is connected to the first pulse generating circuit for outputting a first polarity pulse generated by the first pulse generating circuit, the third pulse application zone is connected to the second pulse generating circuit for outputting a second polarity pulse generated by the second pulse generating circuit, and the voltage of the second pulse application zone and the fourth pulse application zone is zero.

[0011] In some embodiments, the first pulse application zone and the third pulse application zone are connected to the first pulse generating circuit for outputting the first polarity pulse generated by the first pulse generating circuit, and the second pulse application zone and the fourth pulse application zone are connected to the second pulse generating circuit for outputting the second polarity pulse generated by the second pulse generating circuit.

[0012] In some embodiments, the first pulse application zone and the third pulse application zone are connected to the first pulse generating circuit for outputting the first polarity pulse generated by the first pulse generating circuit, the second pulse application zone is connected to the second pulse generating circuit for outputting the second polarity pulse generated by the second pulse generating circuit, and the voltage of the fourth pulse application zone is zero.

[0013] In some embodiments, the first pulse generating circuit includes: a first pulse generating module and a second pulse generating module, the first pulse generating module is used to generate a first electric pulse, the second pulse generating module is used to generate a second electric pulse, wherein the pulse parameters of the first electric pulse and the second electric pulse are different; the second pulse generating circuit includes: a third pulse generating module and a fourth pulse generating module, the third pulse generating module is used to generate a third electric pulse, the fourth pulse generating module is used to generate a fourth electric pulse, wherein the pulse parameters of the third electric pulse and the fourth electric pulse are different.

[0014] In some embodiments, the pulse parameters include at least one of pulse amplitude and pulse width.

[0015] In some embodiments, the first electric pulse and the third electric pulse have equal pulse amplitude and pulse width, opposite polarity, and are generated synchronously; and the second electric pulse and the fourth electric pulse have equal pulse amplitude and pulse width, opposite polarity, and are generated synchronously.

[0016] In some embodiments, the pulse amplitude of the first electric pulse is greater than the pulse amplitude of the second electric pulse, and the pulse width of the first electric pulse is less than the pulse width of the second electric pulse.

[0017] In some embodiments, the pulse width of the first electric pulse is in nanosecond order, and the pulse amplitude is 6000V-8000V; the pulse width of the second electric pulse is in microsecond order, and the pulse amplitude is 1000V-5000V.

[0018] In some embodiments, each application element is connected to at least one of the first pulse generating circuit and the second pulse generating circuit.

[0019] In a third aspect, a pulse electric field generating device is provided, comprising: the pulse electric field generating device provided in the first aspect or the second aspect; and a control module, which is respectively connected to the first pulse generating circuit and the second pulse generating circuit in the pulse electric field generating device, and is used to generate a control signal; wherein the control signal is at least used to control the first pulse generating circuit and the second pulse generating circuit to synchronously generate a first polarity pulse and a second polarity pulse with opposite polarities, so that the first polarity pulse and the second polarity pulse are synchronously applied to the application member in the pulse electric field generating device.

[0020] In some embodiments, the pulse electric field generating device further comprises a switching module for switching the first polarity pulse and the second polarity pulse to be transmitted to different application members.

[0021] In a fourth aspect, a pulse synchronization method is provided, which is applied to the pulse electric field generating device provided in the third aspect, and the method includes: obtaining input information; generating a control signal based on the input information; based on the control signal, synchronously controlling the first pulse generating circuit in the pulse electric field generating device to generate a first polarity pulse, and the second pulse generating circuit in the pulse electric field generating device to generate a second polarity pulse; wherein the first polarity pulse and the second polarity pulse are generated synchronously and have opposite polarities.

[0022] In a fifth aspect, a pulse electric field generating method is provided, which is applied to the pulse electric field generating device provided in the first aspect or the second aspect. The method comprises: obtaining a control signal; based on the control signal, controlling the pulse electric field generating device to generate a plurality of combined pulses; wherein each combined pulse comprises a first polarity pulse and a second polarity pulse, the first polarity pulse and the second polarity pulse are generated synchronously, and have opposite polarities.

[0023] In some embodiments, the control signal includes a first control signal and a second control signal. Based on the control signal, controlling the pulse electric field generating device to generate a plurality of combined pulses includes: based on the first control signal, controlling the pulse electric field generating device to generate a plurality of first combined pulses; based on the second control signal, controlling the pulse electric field generating device to generate a plurality of second combined pulses; wherein the pulse parameters of the first combined pulse and the second combined pulse are different.

[0024] In some embodiments, the control signal includes a first control signal and a second control signal. Based on the control signal, the pulse electric field generating device is controlled to generate a plurality of combination pulses, including: based on the first control signal, the pulse electric field generating device is controlled to generate a first combination pulse; based on the second control signal, the pulse electric field generating device is controlled to generate a second combination pulse; the above steps are repeated until the sum of the number of the first combination pulse and the second combination pulse reaches a preset value; wherein the pulse parameters of the first combination pulse and the second combination pulse are different.

[0025] In a sixth aspect, a pulse application method is provided, which is applied to the pulse electric field generating device provided in the second aspect, and the method includes: setting at least two application members in the pulse electric field generating device at the target position; selecting any two application members from the at least two application members; synchronously applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two application members; wherein the first polarity pulse and the second polarity pulse are generated synchronously and have opposite polarities.

[0026] In some embodiments, any two applicators include a first applicator and a second applicator, the first applicator includes a first pulse application area and a second pulse application area, and the second applicator includes a third pulse application area and a fourth pulse application area. Synchronously applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applicators includes: applying the first polarity pulse to the first pulse application area; applying the second polarity pulse to the third pulse application area; wherein the voltage of the second pulse application area and the fourth pulse application area is zero.

[0027] In some embodiments, any two applicators include a first applicator and a second applicator, the first applicator includes a first pulse application area and a second pulse application area, and the second applicator includes a third pulse application area and a fourth pulse application area. Synchronously applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applicators includes: applying the first polarity pulse and the second polarity pulse to the first pulse application area and the second pulse application area respectively; applying the first polarity pulse or the second polarity pulse to the third pulse application area; wherein the voltage of the fourth pulse application area is zero.

[0028] In some embodiments, any two applicators include a first applicator and a second applicator, the first applicator includes a first pulse application area and a second pulse application area, and the second applicator includes a third pulse application area and a fourth pulse application area. Synchronously applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applicators includes: synchronously applying the first polarity pulse to the first pulse application area and the third pulse application area; synchronously applying the second polarity pulse to the second pulse application area and the fourth pulse application area.

[0029] In the pulse electric field generating device provided by the present disclosure, the first polarity pulse and the second polarity pulse are synchronously applied to the applying member, so that the electric field strength of the generated electric field action area can reach the sum of the pulse amplitudes of the first polarity pulse and the second polarity pulse. In order to generate the same electric field strength as the device in the related art, the embodiment of the present disclosure only requires half of the power supply voltage in the related art; the requirements for the high voltage resistance and insulation of the components in the device can also be reduced by half, reducing the overall cost of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1a The figure shows a time waveform diagram of a pulse voltage provided by the related art.

[0031] Figure 1b The figure shows another time waveform of a pulse voltage provided by the related art.

[0032] Figure 1c The figure shows a time waveform diagram of another pulse voltage provided by the related art.

[0033] Figure 1d Shown is a schematic structural diagram of a pulse electric field generating device provided by the related art.

[0034] Figure 2a Shown is a schematic structural diagram of a pulse electric field generating device provided in an embodiment of the present disclosure.

[0035] Figure 2b Shown is a schematic structural diagram of another pulse electric field generating device provided in an embodiment of the present disclosure.

[0036] Figure 2c Shown is a schematic structural diagram of an application member provided in an embodiment of the present disclosure.

[0037] Figure 3 Shown is a time waveform diagram of a pulse voltage provided by an embodiment of the present disclosure.

[0038] Figure 4 Shown is a schematic structural diagram of another application member provided in an embodiment of the present disclosure.

[0039] Figure 5 Shown is a schematic diagram of an electric field action area provided in an embodiment of the present disclosure.

[0040] Figure 6a Shown is a schematic diagram of another electric field action area provided in an embodiment of the present disclosure.

[0041] Figure 6b Shown Figure 6a A schematic diagram of another electric field action region in the illustrated embodiment.

[0042] Figure 7aShown is a schematic diagram of another electric field action area provided in an embodiment of the present disclosure.

[0043] Figure 7b Shown Figure 7a A schematic diagram of another electric field action region in the illustrated embodiment.

[0044] Figure 8 Shown is a schematic structural diagram of another pulse electric field generating device provided in an embodiment of the present disclosure.

[0045] Fig. 9 Shown is a schematic structural diagram of a pulse electric field generating device provided in an embodiment of the present disclosure.

[0046] Fig.10 The figure is a flow chart of a pulse synchronization method provided in an embodiment of the present disclosure.

[0047] Fig.11 Shown is a flow chart of a pulse electric field generating method provided in an embodiment of the present disclosure.

[0048] Fig.12 The figure is a flow chart of a further implementation method of controlling a pulse electric field generating device to generate a plurality of combined pulses based on a control signal provided by an embodiment of the present disclosure.

[0049] Fig.13 Shown is a time waveform diagram of another pulse voltage provided in an embodiment of the present disclosure.

[0050] Fig.14 The figure is a flow chart of another further implementation method of controlling a pulse electric field generating device to generate a plurality of combined pulses based on a control signal provided by an embodiment of the present disclosure.

[0051] Fig.15 Shown is a time waveform diagram of another pulse voltage provided by an embodiment of the present disclosure.

[0052] Fig.16 Shown is a flow chart of a pulse application method provided in an embodiment of the present disclosure. DETAILED DESCRIPTION

[0053] The following will be combined with the drawings in the embodiments of the present disclosure to clearly and completely describe the technical solutions in the embodiments of the present disclosure. Obviously, the described embodiments are only part of the embodiments of the present disclosure, not all of the embodiments. Based on the embodiments in the present disclosure, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present disclosure.

[0054] As mentioned above, there are usually three ways to generate pulse electric fields in the related art. Figure 1aAs shown in the figure, method 1 is: first output a positive polarity pulse, and after a certain pulse delay, output a negative polarity pulse, thereby outputting bipolar pulses alternately. Figure 1b As shown in FIG. 2 , method 2 is: outputting multiple unipolar pulses at a certain pulse interval delay. Figure 1c As shown, method 3 is: after outputting multiple pulses according to the above method 1, reducing the pulse amplitude and increasing the pulse width, and continuing to output multiple pulses according to the above method 1.

[0055] The above three methods all have relatively high requirements for the voltage peak of the device, and thus put forward higher requirements for the high voltage resistance, insulation and power supply voltage of the components of the entire device, and the overall cost of the device is relatively high.

[0056] In view of this, the present disclosure provides a pulse electric field generating device, including: a first pulse generating circuit for generating a first polarity pulse; a second pulse generating circuit for generating a second polarity pulse; at least one application member, the first pulse generating circuit and the second pulse generating circuit are both connected to the application member, and in a working state, the first polarity pulse and the second polarity pulse are both applied to any one of the at least one application member; the first polarity pulse and the second polarity pulse are generated synchronously and have opposite polarities. In this way, the requirements of the device for high voltage resistance and insulation can be reduced, and the overall cost can be reduced. In this way, the power supply voltage requirement of the device can be reduced, and then the requirements of the components in the device for high voltage resistance and insulation can be reduced, so as to reduce the overall cost.

[0057] The pulse electric field generating device provided by the present disclosure will be described in detail below with reference to the accompanying drawings and embodiments.

[0058] Figure 2a FIG. 1 is a schematic diagram of the structure of a pulse electric field generating device provided by an embodiment of the present disclosure. Figure 2a As shown, the pulse electric field generating device includes: a first pulse generating circuit 210, a second pulse generating circuit 220 and at least one applying member 230. The applying member 230 is connected to the first pulse generating circuit 210 and the second pulse generating circuit 220 respectively.

[0059] The first pulse generating circuit 210 is used to generate a first polarity pulse, and the second pulse generating circuit 220 is used to generate a second polarity pulse. At least two pulse application areas are provided on the application member 230, at least one of the at least two pulse application areas applies a first polarity pulse, and at least one of the other pulse application areas applies a second polarity pulse. If there are pulse application areas to which the first polarity pulse or the second polarity pulse is not applied, they can be grounded. Insulation is provided between each pulse application area to avoid short circuit. When the first polarity pulse and the second polarity pulse are generated synchronously and applied synchronously to one application member 230, at least one electric field action area can be generated between the pulse application areas on the application member 230.

[0060] Continue to refer Figure 2a The application member 230 includes a first pulse application area 2311 and a second pulse application area 2312, wherein the first pulse application area 2311 applies a first polarity pulse, and the second pulse application area 2312 applies a second polarity pulse. An electric field action area can be generated between the first pulse application area 2311 and the second pulse application area 2312. The electric field strength of the electric field action area is equal to the sum of the pulse amplitudes of the first polarity pulse and the second polarity pulse. In order to generate the same electric field strength as the device in the related art, the embodiment of the present disclosure only requires half of the power supply voltage in the related art; the requirements for high voltage resistance and insulation of the components in the device can also be reduced by half, reducing the overall cost of the device.

[0061] The following is an introduction to a pulse electric field generating device in the related art. Figure 1d As shown, the device includes a pulse generating circuit 110 for providing positive and negative polarity pulses, and two electrode needles 120. Each electrode needle is provided with a pulse applying region 121, the pulse applying region of one electrode needle is used to apply a positive polarity pulse, and the pulse applying region of the other electrode needle is used to apply a negative polarity pulse. Figure 1d Although the device shown can also generate an electric field action area and its power supply voltage requirement can be reduced accordingly, compared with the device in the present disclosure, the embodiment of the present disclosure can achieve the effect using only one application member, which improves the ease of use of the device in the present disclosure and reduces its difficulty of use.

[0062] Continue to refer to Figure 2a , the specific structures of the first pulse generating circuit 210 and the second pulse generating circuit 220 are introduced in detail.

[0063] Specifically, the first pulse generating circuit 210 includes: a first power supply 211, and a first pulse generating module 212 connected to the first power supply 211. The first pulse generating module 212 further includes a plurality of first pulse generating units 2121 connected in parallel. The first power supply 211 provides electric energy to the first pulse generating module 212, and the first pulse generating module 212 stores the electric energy in the plurality of first pulse generating units 2121 respectively. The first pulse generating units 2121 release energy in sequence according to the control signal to form a first polarity pulse.

[0064] The second pulse generating circuit 220 includes: a third power supply 221, and a third pulse generating module 222 connected to the third power supply 221. The third pulse generating module 222 further includes a plurality of third pulse generating units 2221 connected in parallel. The third power supply 221 provides electric energy to the third pulse generating module 222, and the third pulse generating module 222 stores the electric energy in the plurality of third pulse generating units 2221 respectively. The third pulse generating units 2221 release energy in sequence according to the control signal to form a second polarity pulse.

[0065] In response to the same control signal, the first pulse generating module 212 and the third pulse generating module 222 release energy synchronously, so that the first polarity pulse and the second polarity pulse are generated synchronously. For example, the control signal can be generated by a control module in the pulse electric field generating device, or by an external control system, and the present disclosure does not make specific restrictions on this.

[0066] Based on the above method, the time waveform of the pulse voltage generated by the pulse electric field generating device is as follows: Figure 3 As shown. The first polarity pulse matches the second polarity pulse, that is, the first polarity pulse and the second polarity pulse have equal pulse amplitudes, equal pulse widths, and opposite polarities. The pulse amplitudes, pulse widths, and inter-pulse delays of the first polarity pulse and the second polarity pulse can be set according to actual conditions. Exemplarily, the pulse amplitudes of the first polarity pulse and the second polarity pulse can be 1000V to 20000V, the pulse widths can be nanoseconds or 100 nanoseconds, and the inter-pulse delays can be 100 nanoseconds to 1 millisecond.

[0067] Multiple continuously generated first polarity pulses together form a pulse sequence, and multiple continuously generated second polarity pulses together form another pulse sequence; there is no phase difference between the two pulse sequences, and each first polarity pulse can find a second polarity pulse generated synchronously with it. Next, a first polarity pulse and a second polarity pulse generated synchronously are combined into a combined pulse, so the two pulse sequences together form a combined pulse sequence with positive and negative amplitudes.

[0068] Next, another pulse electric field generating device provided by an embodiment of the present disclosure is introduced. The device of this embodiment generates at least two electric field action areas through the interaction of two application members, further expanding the ablation force and ablation range.

[0069] like Figure 2b As shown, the pulse electric field generating device includes: a first pulse generating circuit 210 , a second pulse generating circuit 220 and at least two applying members 230 .

[0070] The first pulse generating circuit 210 and the second pulse generating circuit 220 are respectively connected to at least one application element 230 , so that the application element 230 outputs a first polarity pulse and / or a second polarity pulse.

[0071] Among the at least two application members 230, any two application members 230 that respectively apply pulses of different polarities constitute an application member group, and the two application members in an application member group puncture the target load (such as biological tissue, tumor, etc.) together to conduct the pulse generated by the pulse electric field generating device to the target load. It can be understood that Figure 2a The number of application members and the connection method shown are schematic. The structure and Figure 2a The structures shown are similar, and the multiple groups of application members are all connected to the first pulse generating circuit 210 and / or the second pulse generating circuit 220, and the repeated parts are not repeated.

[0072] For example, if the first pulse generating circuit 210 is connected to n application elements in total, and the second pulse generating circuit 220 is connected to m application elements in total, then the m+n application elements can form n×m application element groups, and each application element group can independently apply synchronously generated first polarity pulses and second polarity pulses, where m and n are positive integers.

[0073] The first polarity pulse generated by the first pulse generating circuit 210 is opposite in polarity to the second polarity pulse generated by the second pulse generating circuit 220. Exemplarily, the first polarity pulse may be a positive polarity pulse, and correspondingly, the second polarity pulse may be a negative polarity pulse; or, the first polarity pulse may be a negative polarity pulse, and correspondingly, the second polarity pulse may be a positive polarity pulse, and the present disclosure does not impose any specific limitation on this. When the first polarity pulse and the second polarity pulse are synchronously applied to a group of applicators, the pulse application areas of the two applicators may be respectively set, so that at least two electric field action areas can be simultaneously formed within a preset range of the applicator group to expand the ablation intensity and ablation range.

[0074] A method for setting the pulse application area in the application component group is introduced below.

[0075] In some embodiments, in the application member group, at least one application member has at least two pulse application zones. Figure 2c As shown, one application member group includes a first application member 231 and a second application member 232; the first application member 231 includes a first pulse application area 2311 and a second pulse application area 2312, and the two pulse application areas are insulated from each other; the second application member 232 includes a third pulse application area 2321. In this embodiment, when the first polarity pulse or the second polarity pulse is synchronously applied to the application member group, at least two electric field action areas can be generated between the three pulse application areas.

[0076] As a possible implementation, the first pulse application area 2311 and the second pulse application area 2312 simultaneously apply a first polarity pulse, and the third pulse application area 2321 simultaneously applies a second polarity pulse. At this time, there is a potential difference between the first pulse application area 2311 and the third pulse application area 2321, so an electric field action area can be generated; similarly, an electric field action area can also be generated between the second pulse application area 2312 and the third pulse application area 2321.

[0077] As another possible implementation, the first pulse application area 2311 applies a first polarity pulse, the second pulse application area 2312 is grounded, and the third pulse application area 2321 applies a second polarity pulse. At this time, an electric field action area can be generated between the first pulse application area 2311 and the third pulse application area 2321. At the same time, since the second pulse application area 2312 is grounded, its voltage is 0V; an electric field action area can also be generated between the first pulse application area 2311 and the second pulse application area 2312, and between the second pulse application area 2312 and the third pulse application area 2321, but the electric field strength of the two is less than the electric field strength between the first pulse application area 2311 and the third pulse application area 2321.

[0078] For example, continue to refer to Figure 2c , the voltage of the first polarity pulse is +1500V, and the voltage of the second polarity pulse is -1500V; at this time, the electric field strength between the first pulse application area 2311 and the second pulse application area 2312 is 0V, +1500V; the electric field strength between the second pulse application area 2312 and the third pulse application area 2321 is -1500V, 0V; and the electric field strength between the first pulse application area 2311 and the third pulse application area 2321 is -1500V, +1500V, under the same conditions, its electric field strength is equivalent to the electric field strength of 0V, +3000V in the related art. In the figure, the electric field action area with the largest electric field strength is represented by gray.

[0079] Through the above settings, the pulse electric field generating device provided by the embodiment of the present disclosure can form multiple electric field action zones, thereby expanding the ablation force and ablation range. In addition, the first polarity pulse and the second polarity pulse are synchronously applied to the application member, so that the electric field strength of at least one electric field action zone can reach the sum of the pulse amplitudes of the first polarity pulse and the second polarity pulse. In order to generate the same electric field strength as the device in the related art, the embodiment of the present disclosure only requires half of the power supply voltage in the related art; the requirements for the high voltage resistance and insulation of the components in the device can also be reduced by half, reducing the overall cost of the device.

[0080] The above describes a situation in which two application members in a group of application members output a first polarity pulse and a second polarity pulse respectively. Of course, each application member can also output a first polarity pulse and a second polarity pulse at the same time. Specifically, each application member can be connected to at least one of the first pulse generating circuit and the second pulse generating circuit, so that each application member can apply a first polarity pulse and / or a second polarity pulse. Based on this flexible connection method, the following introduces several other ways to set the pulse application area in the application member group.

[0081] Figure 4 FIG. 2 is a schematic diagram of the structure of another application member provided in an embodiment of the present disclosure. Figure 4 As shown, a group of application members includes a first application member 231 and a second application member 232. The first application member 231 includes a first pulse application area 2311 and a second pulse application area 2312, and the second application member 232 includes a third pulse application area 2321 and a fourth pulse application area 2322.

[0082] Among them, the materials of the first pulse application area 2311, the second pulse application area 2312, the third pulse application area 2321 and the fourth pulse application area 2322 are conductive materials; the materials of the remaining surfaces of the first application member 231 and the second application member 232 except the pulse application area are insulating materials to ensure the safety of the user.

[0083] Through this arrangement, one applicator can simultaneously apply a first polarity pulse and a second polarity pulse. Therefore, by separately setting the pulses applied to multiple application areas, multiple electric field action areas can be simultaneously formed in a group of applicators, further expanding the ablation force and ablation range.

[0084] The following describes a specific setting method for pulses applied to multiple pulse application areas in a group of application members.

[0085] In some embodiments, the first application member 231 is connected to the first pulse generating circuit 210, and the second application member 232 is connected to the second pulse generating circuit 220. The first pulse application area 2311 of the first application member 231 outputs the first polarity pulse generated by the first pulse generating circuit 210; the third pulse application area 2321 of the second application member 232 outputs the second polarity pulse generated by the second pulse generating circuit 220; the first polarity pulse and the second polarity pulse are generated synchronously and synchronously applied to the first pulse application area 2311 and the third pulse application area 2321; the second pulse application area 2312 and the fourth pulse application area 2322 do not apply pulses, and the voltages of the two application areas are both zero. The voltage of the pulse application area being zero can be achieved by grounding the pulse application area.

[0086] The application method in the above embodiment can generate five electric field action areas with different electric field strengths. Figure 5 As shown, the first polarity pulse is an electric pulse of +1500V, and the second polarity pulse is an electric pulse of -1500V; an electric field action zone is generated between the first pulse application zone 2311 and the third pulse application zone 2321, and the electric field strength of this electric field action zone is the largest, which is -1500V, +1500V (the electric field action zone with the largest electric field strength is represented by gray in the figure); an electric field action zone is formed between the first pulse application zone 2311 and the second pulse application zone 2312, between the first pulse application zone 2311 and the fourth pulse application zone 2322, between the third pulse application zone 2321 and the second pulse application zone 2312, and between the third pulse application zone 2321 and the fourth pulse application zone 2322, respectively, and the electric field strength of these four electric field action zones is smaller than the electric field strength between the first pulse application zone 2311 and the third pulse application zone 2321.

[0087] The pulse electric field generating device provided in the embodiment of the present disclosure can generate five electric field action zones, and there is an electric field action zone with the greatest electric field intensity, so that the ablation intensity and ablation range are significantly improved.

[0088] Several other implementations are introduced below. Although the connection methods between the circuit and the application member and the pulses applied in the pulse application area are different in various implementations, multiple electric field action areas with different electric field strengths can be formed.

[0089] In some embodiments, the first application member 231 and the second application member 232 are both connected to the first pulse generating circuit 210, and the second application member 232 is also connected to the second pulse generating circuit 220. The first pulse applying area 2311 and the third pulse applying area 2321 output the first polarity pulse generated by the first pulse generating circuit 210; the second pulse applying area 2312 outputs the second polarity pulse generated by the second pulse generating circuit 220; the first polarity pulse and the second polarity pulse are generated synchronously and synchronously applied to the first pulse applying area 2311, the third pulse applying area 2321 and the fourth pulse applying area 2322; the fourth pulse applying area 2322 does not apply a pulse, and its voltage is zero.

[0090] The application method in the above embodiment can generate five electric field action areas with different electric field strengths. Figure 6a As shown, the first polarity pulse is an electric pulse of +1500V, and the second polarity pulse is an electric pulse of -1500V; an electric field action zone is formed between the first pulse application zone 2311 and the second pulse application zone 2312, and between the second pulse application zone 2312 and the third pulse application zone 2321, respectively, and the electric field intensities of these two electric field action zones are the largest; an electric field action zone is formed between the first pulse application zone 2311 and the fourth pulse application zone 2322, between the second pulse application zone 2312 and the fourth pulse application zone 2322, and between the third pulse application zone 2321 and the fourth pulse application zone 2322, respectively.

[0091] Therefore, the pulse electric field generating device provided in the embodiment of the present disclosure can generate five electric field action areas, and there are two electric field action areas with the largest electric field strength, and the ablation intensity and ablation range are significantly improved.

[0092] In other embodiments, the above connection method can also realize the following pulse application method to generate four electric field action areas. Figure 6b As shown, the first pulse application area 2311 and the third pulse application area 2321 output the +1500V electric pulse generated by the first pulse generating circuit 210, and the second pulse application area 2312 and the fourth pulse application area 2322 do not apply pulses, and the voltages of the two application areas are both zero. At this time, an electric field action area is formed between the first pulse application area 2311 and the second pulse application area 2312, between the first pulse application area 2311 and the fourth pulse application area 2322, between the second pulse application area 2312 and the third pulse application area 2321, and between the third pulse application area 2321 and the fourth pulse application area 2322, and the electric field strengths are the same, both 0V and +1500V.

[0093] In some embodiments, the first application member 231 and the second application member 232 are both connected to the first pulse generating circuit 210, and at the same time, the first application member 231 and the second application member 232 are also connected to the second pulse generating circuit 220. The first pulse application area 2311 and the third pulse application area 2321 output the first polarity pulse generated by the first pulse generating circuit 210; the second pulse application area 2312 and the fourth pulse application area 2322 output the second polarity pulse generated by the second pulse generating circuit 220; the first polarity pulse and the second polarity pulse are synchronously generated and synchronously applied to the first pulse application area 2311, the second pulse application area 2312, the third pulse application area 2321 and the fourth pulse application area 2322.

[0094] The application method in the above embodiment can generate four electric field action areas. Figure 7a As shown, the first polarity pulse is an electric pulse of +1500V, and the second polarity pulse is an electric pulse of -1500V; an electric field action zone is formed between the first pulse application zone 2311 and the second pulse application zone 2312, between the first pulse application zone 2311 and the fourth pulse application zone 2322, between the second pulse application zone 2312 and the third pulse application zone 2321, and between the third pulse application zone 2321 and the fourth pulse application zone 2322, respectively. The electric field strengths of these four electric field action zones are the same, both -1500V and +1500V.

[0095] In other embodiments, the above connection method can also realize the following pulse application method to generate four electric field action areas. Figure 7b As shown, the first pulse application area 2311 and the fourth pulse application area 2322 output the +1500V electric pulse generated by the first pulse generating circuit 210; the second pulse application area 2312 and the third pulse application area 2321 output the -1500V electric pulse generated by the second pulse generating circuit 220. At this time, an electric field action area is formed between the first pulse application area 2311 and the second pulse application area 2312, between the first pulse application area 2311 and the third pulse application area 2321, between the second pulse application area 2312 and the fourth pulse application area 2322, and between the third pulse application area 2321 and the fourth pulse application area 2322, respectively, and the electric field strength is the same, both -1500V and +1500V. The pulse electric field generating devices in the above two embodiments can generate four electric field action areas, and the electric field strength of these four electric field action areas is equivalent to the maximum electric field strength in other implementations, and the ablation intensity and ablation range are significantly improved.

[0096] It is understandable that the above embodiments only introduce the case where one or two pulse application areas are set on the application member. Based on the same inventive concept, multiple pulse application areas can also be set on the same application member, and the number of electric field action areas generated will also increase accordingly. At the same time, the pulses applied to each pulse application area can also be flexibly set, and the present disclosure does not impose specific restrictions on this.

[0097] Similarly, the above embodiment also only introduces a specific implementation method of applying the first polarity pulse and the second polarity pulse to a group of application members. Based on the same inventive concept, each application member of the device can be connected to at least one of the first pulse generating circuit and the second pulse generating circuit. In this case, each application member of the device can apply the first polarity pulse and / or the second polarity pulse.

[0098] When the first polarity pulse and the second polarity pulse are generated at the same time and synchronously transmitted to the application member, any two application members to which pulses of different polarities are applied can constitute an application member group, and at least two electric field action areas can be formed within a preset range of the application member group. Therefore, multiple electric field action areas of different ranges can be obtained by switching the first polarity pulse and the second polarity pulse generated by the first pulse generating circuit and the second pulse generating circuit and transmitting them to different application members.

[0099] Figure 8 FIG. 2 is a schematic diagram of the structure of another pulse electric field generating device provided by an embodiment of the present disclosure. Figure 8 As shown, the pulse electric field generating device of this embodiment is Figure 2b The pulse electric field generating device shown is partially the same, and the differences are as follows. In addition to the first power supply 211 and the first pulse generating module 212, the first pulse generating circuit 210 also includes: a second power supply 213, and a second pulse generating module 214 connected to the second power supply 213. Among them, the second pulse generating module 214 includes a plurality of second pulse generating units 2141 connected in parallel. The second power supply 213 provides electrical energy to the second pulse generating module 214, and the second pulse generating module 214 stores the electrical energy in the plurality of second pulse generating units 2141 respectively. The second pulse generating units 2141 release energy in sequence according to the control signal to form a first polarity pulse.

[0100] The first polarity pulse generated by the second pulse generation module 214 has different pulse parameters from the first polarity pulse generated by the first pulse generation module 212. Therefore, the first polarity pulse generated by the first pulse generation module 212 is referred to as the first electrical pulse, and the first polarity pulse generated by the second pulse generation module 214 is referred to as the second electrical pulse.

[0101] In addition to the third power supply 221 and the third pulse generating module 222, the second pulse generating circuit 220 further includes: a fourth power supply 223, and a fourth pulse generating module 224 connected to the fourth power supply 223. The fourth pulse generating module 224 further includes a plurality of fourth pulse generating units 2241 connected in parallel. The fourth power supply 223 provides electric energy to the fourth pulse generating module 224, and the fourth pulse generating module 224 stores the electric energy in the plurality of fourth pulse generating units 2241 respectively. The fourth pulse generating units 2241 release energy in sequence according to the control signal to form a second polarity pulse.

[0102] The second polarity pulse generated by the fourth pulse generating module 224 has different pulse parameters from the second polarity pulse generated by the third pulse generating module 222. Therefore, the second polarity pulse generated by the third pulse generating module 222 is referred to as the third electrical pulse, and the second polarity pulse generated by the fourth pulse generating module 224 is referred to as the fourth electrical pulse.

[0103] In some embodiments, the first power source 211 and the second power source 213 can be configured as one power source, and the third power source 221 and the fourth power source 223 can be configured as one power source to reduce the complexity of the device structure and the power supply circuit.

[0104] The pulse electric field generating device provided in the embodiment of the present disclosure can respectively generate a first electric pulse, a second electric pulse, a third electric pulse and a fourth electric pulse with different pulse parameters. By changing their pulse parameters, the pulse electric field generating device can flexibly adapt to various usage scenarios.

[0105] In some embodiments, the pulse parameters include at least one of pulse amplitude and pulse width. By adjusting the pulse amplitude and / or pulse width of the pulse, the pulse characteristics can be changed. Exemplarily, an electrical pulse with a high pulse amplitude and a narrow pulse width has a higher ablation intensity and a smaller ablation area than an electrical pulse with a low pulse amplitude and a wide pulse width.

[0106] The pulse electric field generating device provided in the embodiment of the present disclosure is capable of generating two groups of combined pulses with different pulse amplitudes and / or pulse widths, which cooperate with each other to obtain a better ablation effect.

[0107] In some embodiments, the first electric pulse and the third electric pulse have equal pulse amplitude and pulse width, opposite polarity, and are generated synchronously; correspondingly, the second electric pulse and the fourth electric pulse have equal pulse amplitude and pulse width, opposite polarity, and are generated synchronously.

[0108] Exemplarily, the second electric pulse is a positive polarity pulse, and the fourth electric pulse is a negative polarity pulse. Moreover, the pulse amplitudes of the two can be 1000V to 5000V, the pulse width can be microseconds or 100 microseconds, and the delay between pulses can be 1 microsecond to 1 millisecond.

[0109] The disclosed embodiment can generate two groups of combined pulses with different pulse amplitudes and pulse widths. The first electric pulse and the third electric pulse are referred to as first combined pulses, and the second electric pulse and the fourth electric pulse are referred to as second combined pulses.

[0110] In some embodiments, the pulse amplitude of the first electric pulse is greater than the pulse amplitude of the second electric pulse, and the pulse width of the first electric pulse is less than the pulse width of the second electric pulse. Correspondingly, the pulse amplitude of the third electric pulse is greater than the pulse amplitude of the fourth electric pulse, and the pulse width of the third electric pulse is less than the pulse width of the fourth electric pulse.

[0111] As a preferred embodiment, the pulse width of the first electric pulse and the third electric pulse is in nanosecond order, and the pulse amplitude is 6000V-8000V, and the pulse width of the second electric pulse and the fourth electric pulse is in microsecond order, and the pulse amplitude is 1000V-5000V.

[0112] The first combination pulse is a nanosecond pulse. When the nanosecond pulse acts on tumor cells, it has a higher ablation rate, but the ablation area is small. The second combination pulse is a microsecond pulse. When the microsecond pulse acts on tumor cells, it has a larger ablation area, but the ablation rate for tumor cells, especially malignant tumor cells with higher distortion, is low. Therefore, the combination of microsecond pulses and nanosecond pulses can significantly improve the ablation effect of tumor cells.

[0113] In addition to using nanosecond pulse-induced reversible electroporation to ablate tumor cells, microsecond pulses can be applied in synergy during the duration of irreversible electroporation induced by nanosecond pulses, thereby using the perforation of the cell membrane to allow the electric field of the microsecond pulse to penetrate into the cell and further induce cell apoptosis, achieving better ablation effects than single nanosecond pulses or microsecond pulses.

[0114] In some embodiments, microsecond pulses can be replaced by millisecond pulses, which also have the characteristics of large ablation area and low ablation rate.

[0115] Based on the same inventive concept, a pulse electric field generating device is also provided in the embodiment of the present disclosure, and the device includes a pulse electric field generating device and a control module. Specifically, the pulse electric field generating device includes a first pulse generating circuit, a second pulse generating circuit and at least two application members. The control module is respectively connected to the first pulse generating circuit and the second pulse generating circuit for generating a control signal.

[0116] The control signal can control the first pulse generating circuit to generate a first polarity pulse; at the same time, in response to the same control signal, the second pulse generating circuit synchronously generates a second polarity pulse. The first polarity pulse and the second polarity pulse are synchronously applied to the application member in the pulse electric field generating device.

[0117] In some other embodiments, the first pulse generating circuit includes a first pulse generating module and a second pulse generating module; the second pulse generating circuit includes a third pulse generating module and a fourth pulse generating module. Accordingly, the control module can generate a first control signal and / or a second control signal. The first control signal is used to control the first pulse generating module and the third pulse generating module to synchronously generate the first electrical pulse and the third electrical pulse. The second control signal is used to control the second pulse generating module and the fourth pulse generating module to synchronously generate the second electrical pulse and the fourth electrical pulse.

[0118] Exemplarily, the control module includes a host computer (host + display), a program control module, etc. The control signal can be automatically generated based on a preset setting, or can be generated according to information input by a user, wherein the input information may include pulse amplitude, pulse width, delay between pulses, and the order of applying two combined pulses, etc.

[0119] The pulse electric field generating device provided in the embodiment of the present disclosure can control the pulse electric field generating device to generate the first combined pulse and / or the second combined pulse through the control module. It can be understood that since the principle of solving the problem in the embodiment of the device is similar to that in the above-mentioned device embodiment, the implementation of the embodiment of the device can refer to the implementation of the above-mentioned device embodiment, and the repeated parts will not be repeated.

[0120] When applying pulses using the device of the embodiment of the present disclosure, it is best to have only one application component group in the state of applying pulses at the same time, otherwise the problem of electric field disorder is likely to occur. Therefore, in a preferred embodiment, pulses are applied to one application component group first, and then pulses are applied to the other application component group.

[0121] To implement the above solution, the pulse electric field generating device may further include a switching module. The switching module is capable of switching the first polarity pulse and the second polarity pulse to different application members. Through the switching module, the device provided by the embodiment of the present disclosure can act on multiple targets to improve its treatment efficiency and reduce treatment costs.

[0122] In some embodiments, the pulse electric field generating device also includes a power supply module and a human-computer interaction module. The power supply module is used to supply power to the first power supply, the second power supply, the third power supply and the fourth power supply, as well as other modules of the device. Exemplarily, the power supply module includes a high-voltage power supply, a power filter, an isolation transformer, an auxiliary power supply module, an energy storage module, etc. The human-computer interaction module includes a display, a foot switch, an emergency stop switch and various interfaces. The display is used to display the operating status of the device to improve the user experience; the foot switch and the emergency stop switch are used to control the start and stop of the device to further ensure the personal safety of the user.

[0123] Fig. 9 FIG. 1 is a schematic diagram of the structure of a pulse electric field generating device provided by an embodiment of the present disclosure. Fig. 9 As shown, the pulse electric field generating device includes a host computer 910, a program control module 920, a pulse generating circuit 930, a switching module 940, and a power supply and energy storage module 950. The host computer 910 and the program control module 920 are connected to each other by optical fiber communication, and together they constitute a control module; the program control module 920 is connected to the emergency stop switch 960, the foot switch 970, and the signal line interface 980; the pulse generating circuit 930 includes a first pulse generating circuit and a second pulse generating circuit; the switching module 940 is connected to the treatment output interface 990, and the treatment output interface 990 is further connected to at least two application members; the power supply and energy storage module 950 provides energy for the program control module 920, the switching module 940, and the pulse generating circuit 930. The electric energy of the power supply and energy storage module 950 comes from the power supply system, and the power supply system includes the national power grid or a private power supply network, or a battery, etc. As shown Fig. 9 As shown, the power supply system not only supplies power to the power supply and energy storage module 950 , but also supplies power to the host computer 910 .

[0124] Based on the same inventive concept, a pulse synchronization method is also provided in the embodiment of the present disclosure, which is applied to the pulse electric field generating device provided in the embodiment of the present disclosure, and more specifically, can be applied to the control module in the pulse electric field generating device. Since the principle of solving the problem in the embodiment of the method is similar to that in the above-mentioned device embodiment and equipment embodiment, the implementation of the embodiment of the method can refer to the implementation of the above-mentioned device embodiment and equipment embodiment, and the repeated parts will not be repeated.

[0125] Fig.10 FIG. 1 is a flow chart of a pulse synchronization method provided by an embodiment of the present disclosure, such as Fig.10 As shown, the pulse synchronization method provided by the embodiment of the present disclosure includes the following steps.

[0126] S1010, obtaining input information.

[0127] The input information may be information such as pulse parameters and specific pulse application methods input by the user in the host computer.

[0128] S1020, generating a control signal based on the input information.

[0129] The control module in the device generates corresponding control signals based on the input information.

[0130] For example, the input information indicates that the user wants the device to generate a combined pulse with a pulse amplitude of 10,000 V and a pulse width of nanoseconds. In response to the acquired input information, the control module generates a corresponding control signal, which can control the pulse electric field generating device to generate a combined pulse with a pulse amplitude of 10,000 V and a pulse width of nanoseconds.

[0131] Alternatively, the input information indicates that the user wants the device to generate a combined pulse with a pulse amplitude of 3000V and a pulse width of microseconds. In response to the acquired input information, the control module generates a corresponding control signal, which can control the pulse electric field generating device to generate a combined pulse with a pulse amplitude of 3000V and a pulse width of microseconds.

[0132] S1030, based on the control signal, synchronously control the first pulse generating circuit in the pulse electric field generating device to generate a first polarity pulse, and the second pulse generating circuit in the pulse electric field generating device to generate a second polarity pulse.

[0133] Specifically, based on the control signal, the first pulse generating circuit generates a first polarity pulse; at the same time, in response to the same control signal, the second pulse generating circuit synchronously generates a second polarity pulse. The first polarity pulse and the second polarity pulse are synchronously applied to at least two application members to form at least two electric field action areas within a preset range of any two application members to which different polarity pulses are applied.

[0134] In some other embodiments, the first pulse generating circuit includes a first pulse generating module and a second pulse generating module; the second pulse generating circuit includes a third pulse generating module and a fourth pulse generating module. The control signal further includes a first control signal and / or a second control signal. The first control signal is used to control the first pulse generating module and the third pulse generating module to synchronously generate the first electrical pulse and the third electrical pulse; the second control signal is used to control the second pulse generating module and the fourth pulse generating module to synchronously generate the second electrical pulse and the fourth electrical pulse.

[0135] In this embodiment, first, based on the first control signal, the first pulse generating module generates the first electrical pulse; in response to the same control signal, the third pulse generating module simultaneously generates the third electrical pulse. Therefore, the first electrical pulse and the third electrical pulse can be generated synchronously.

[0136] Next, based on the second control signal, the second pulse generating module generates a second electrical pulse, and in response to the same control signal, the fourth pulse generating module simultaneously generates a fourth electrical pulse. Therefore, the second electrical pulse and the fourth electrical pulse can be generated synchronously.

[0137] In the above method, the first control signal or the second control signal may be generated based on the input information alone, or the first control signal and the second control signal may be generated based on the input information, which is specifically determined by the content of the input information or the setting of the device.

[0138] Based on the same inventive concept, a pulse electric field generating method is also provided in the embodiment of the present disclosure, which is applied to the pulse electric field generating device or pulse electric field generating equipment provided in the embodiment of the present disclosure. Since the principle of solving the problem in the embodiment of the method is similar to that in the above-mentioned device embodiment and equipment embodiment, the implementation of the embodiment of the method can refer to the implementation of the above-mentioned device embodiment and equipment embodiment, and the repeated parts will not be repeated.

[0139] Fig.11 FIG. 1 is a flow chart of a pulse electric field generating method provided by an embodiment of the present disclosure, such as Fig.11 As shown, the pulse electric field generating method provided by the embodiment of the present disclosure includes the following steps.

[0140] S1110, obtaining a control signal.

[0141] The control signal can be automatically generated based on a preset setting, or can be generated based on information input by a user. Each control signal is generated at intervals so that a certain time interval exists between the generated pulses.

[0142] S1120, based on the control signal, controlling the pulse electric field generating device to generate a plurality of combined pulses.

[0143] Specifically, in response to the same control signal, the first pulse generating circuit and the second pulse generating circuit synchronously generate a first polarity pulse and a second polarity pulse with opposite polarities, which together form a combined pulse. The first polarity pulse and the second polarity pulse are synchronously applied to at least two applying members to form at least two electric field action areas.

[0144] In some embodiments, the control signal is continuously generated at intervals. Based on the continuously generated control signal, the first pulse generating circuit generates a first polarity pulse, and the second pulse generating circuit generates a second polarity pulse. That is, the control signal controls the first pulse generating circuit and the second pulse generating circuit to synchronously generate a plurality of first polarity pulses and a plurality of second polarity pulses, and the time waveform of the pulse voltage is as shown in FIG. Figure 3 shown.

[0145] In some embodiments, the control signal includes a first control signal and a second control signal, wherein the pulse parameters represented by the first control signal and the second control signal are different, and therefore, the pulse parameters of the first combined pulse generated based on the first control signal are different from the pulse parameters of the second combined pulse generated based on the second control signal.

[0146] Therefore, a variety of different waveform pulse sequences can be generated by control signals. The following introduces several specific implementations of pulse generation methods to generate pulse sequences with different waveforms. Of course, the implementations in the embodiments of the present disclosure are only exemplary, and the control signals can be specifically set according to actual conditions.

[0147] In some embodiments, the first control signal and the second control signal are generated alternately. For example, a first control signal may be generated first, a second control signal may be generated second, and then a first control signal may be generated again, and multiple control signals may be generated in this manner; wherein there is an inter-pulse delay between each control signal. Alternatively, a second control signal may be generated first, and then a first control signal may be generated, and multiple control signals may be generated in a cycle, and the present disclosure does not impose any specific limitation on this.

[0148] Accordingly, if Fig.12 As shown, in the above method, based on the control signal, controlling the pulse electric field generating device to generate a plurality of combined pulses includes:

[0149] S1210: Based on the first control signal, control the pulse electric field generating device to generate a first combined pulse.

[0150] Based on the first control signal, the first pulse generating circuit and the second pulse generating circuit in the device synchronously generate the first electrical pulse and the third electrical pulse, and the first electrical pulse and the third electrical pulse together constitute a first combined pulse.

[0151] S1220: Based on the second control signal, control the pulse electric field generating device to generate a second combined pulse.

[0152] After a certain inter-pulse delay, based on the second control signal, the second pulse generating circuit and the fourth pulse generating circuit synchronously generate a second electrical pulse and a fourth electrical pulse, and the second electrical pulse and the fourth electrical pulse together constitute a second combined pulse.

[0153] S1230: Repeat the above steps until the sum of the number of the first combination pulses and the number of the second combination pulses reaches a preset value.

[0154] The first control signal and the second control signal are generated alternately, and the first combination pulse and the second combination pulse respectively controlled by the first control signal and the second control signal are also generated alternately until the sum of the number of the first combination pulse and the second combination pulse reaches a preset value. The preset value can be determined according to actual conditions.

[0155] Exemplarily, the first control signal controls the first pulse generating circuit to generate a first electric pulse with a voltage of +6000V, and controls the second pulse generating circuit to generate a third electric pulse with a voltage of -6000V, and the first electric pulse and the third electric pulse are synchronously delivered to at least one group of application members; after a certain interval, the second control signal controls the first pulse generating circuit to generate a second electric pulse with a voltage of +1500V, and controls the second pulse generating circuit to generate a fourth electric pulse with a voltage of -1500V, and the second electric pulse and the fourth electric pulse are synchronously delivered to the same application member; the time waveform of the pulse voltage is shown as follows. Fig.13 shown.

[0156] Through the above method, a combination pulse of two pulse parameters is generated, and the two combination pulses are generated alternately and act synergistically to obtain a better ablation effect.

[0157] In other embodiments, Fig.14 As shown, in the above method, based on the control signal, controlling the pulse electric field generating device to generate a plurality of combined pulses includes:

[0158] S1410, based on the first control signal, controlling the pulse electric field generating device to generate a plurality of first combination pulses.

[0159] S1420, based on the second control signal, controlling the pulse electric field generating device to generate a plurality of second combined pulses.

[0160] That is to say, a plurality of first combination pulses may be output continuously first, and then a plurality of second combination pulses may be output continuously after a certain delay, wherein the pulse parameters of the first combination pulse and the second combination pulse are different. For example, the pulse amplitude of the first combination pulse is greater than the pulse amplitude of the second combination pulse, and the pulse width of the first combination pulse is less than the pulse width of the second combination pulse. The time waveform of the obtained pulse voltage is as follows: Fig.15 Alternatively, multiple second combination pulses may be output continuously first, and then multiple first combination pulses may be output continuously after a certain delay, and the present disclosure does not impose any specific limitation on this.

[0161] Exemplarily, 10 to 200 first combination pulses may be generated first, and then 10 to 400 second combination pulses may be generated; wherein the time interval between the last first combination pulse and the first second combination pulse is 100 microseconds to hundreds of milliseconds. As a preferred embodiment, 10 to 100 first combination pulses may be generated first, and then 100 to 200 second combination pulses may be generated to obtain a better ablation effect.

[0162] Based on the same inventive concept, a pulse application method is also provided in the embodiment of the present disclosure, which is applied to the pulse electric field generating device or pulse electric field generating equipment provided in the embodiment of the present disclosure. Since the principle of solving the problem in the embodiment of the method is similar to that in the above-mentioned device embodiment and equipment embodiment, the implementation of the embodiment of the method can refer to the implementation of the above-mentioned device embodiment and equipment embodiment, and the repeated parts will not be repeated.

[0163] Fig.16 FIG. 1 is a flow chart of a pulse application method provided by an embodiment of the present disclosure, such as Fig.16 As shown, the pulse application method provided by the embodiment of the present disclosure includes the following steps.

[0164] S1610, setting at least two applicators in the pulse electric field generating device at the target position.

[0165] The target position refers to the range of the electric field action area that the user expects the pulse electric field generator to generate. For example, the target position may refer to the area near the tumor cells. When the pulse electric field generator is working, the generated electric field action area can cover all or most of the tumor cells.

[0166] S1620, select any two application members from at least two application members.

[0167] Any two selected application members constitute an application member group. At least one application member in the application member group has two pulse application areas for outputting synchronously generated first polarity pulses and second polarity pulses.

[0168] S1630, synchronously applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applying members.

[0169] When the first polarity pulse and the second polarity pulse are synchronously applied to a group of applicators, the specific application methods of the two applicators can be set respectively so that at least two electric field action areas can be simultaneously formed within the preset range of the applicator group to expand the ablation force and ablation range.

[0170] The following describes several specific implementations of pulse application methods to generate electric field action zones with different ranges and ablation strengths. In some embodiments, the above-mentioned application member group includes a first application member and a second application member; the first application member includes a first pulse application zone and a second pulse application zone, and the second application member includes a third pulse application zone and a fourth pulse application zone.

[0171] The method of synchronously applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two application members includes: applying the first polarity pulse to the first pulse application area; applying the second polarity pulse to the third pulse application area; and at the same time, the voltage of the second pulse application area and the fourth pulse application area is 0V. The electric field action area generated by the method of this embodiment is as follows: Figure 5 shown.

[0172] In other embodiments, the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device are synchronously applied to any two application members, including: applying the first polarity pulse and the second polarity pulse to the first pulse application area and the second pulse application area respectively; applying the first polarity pulse or the second polarity pulse to the third pulse application area; and at the same time, the voltage of the fourth pulse application area is 0V. The electric field action area generated by the method of this embodiment is as follows: Figure 6a shown.

[0173] In some other embodiments, the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device are synchronously applied to any two application members, including: synchronously applying the first polarity pulse to the first pulse application area and the third pulse application area; synchronously applying the second polarity pulse to the second pulse application area and the fourth pulse application area. The electric field action area generated by the method of this embodiment is as follows: Figure 7a shown.

[0174] Compared with the single electric field action area in the related art, the pulse application method provided by the embodiment of the present disclosure has a larger ablation range and a stronger ablation force. At the same time, compared with the method of alternately outputting the first polarity pulse and the second polarity pulse, or sequentially outputting the unipolar pulse in the related art, the method of the embodiment of the present disclosure can directly reduce the voltage value requirement by half, and the high voltage resistance and insulation requirements of the system components can also be reduced by half, thereby reducing the overall cost of the device.

[0175] Those skilled in the art will appreciate that aspects of the present disclosure may be implemented as systems, methods or program products. When the program product is run on a terminal device such as a pulse electric field generator or a host computer, the program code is used to enable the terminal device to execute the steps of various exemplary embodiments of the present disclosure described in the above method embodiment section of this specification.

[0176] Those skilled in the art will readily appreciate other embodiments of the present disclosure after considering the specification and practicing the invention disclosed herein. The present disclosure is intended to cover any variations, uses or adaptations of the present disclosure, which follow the general principles of the present disclosure and include common knowledge or customary techniques in the art that are not disclosed in the present disclosure. The description and examples are intended to be exemplary only, and the true scope and spirit of the present disclosure are indicated by the appended claims.

Claims

1. A pulse electric field generating device, characterized in that: include: A first pulse generating circuit, used for generating a first polarity pulse; A second pulse generating circuit, used for generating a second polarity pulse; At least one application member, the first pulse generating circuit and the second pulse generating circuit are both connected to the application member, and in a working state, the first polarity pulse and the second polarity pulse are both applied to any one of the at least one application member; The first polarity pulse and the second polarity pulse are generated synchronously and have opposite polarities.

2. A pulse electric field generating device, characterized in that: include: A first pulse generating circuit, used for generating a first polarity pulse; A second pulse generating circuit, used for generating a second polarity pulse; At least two applying members, the first pulse generating circuit and the second pulse generating circuit are respectively connected to at least one applying member, for outputting a first polarity pulse and a second polarity pulse; The first polarity pulse and the second polarity pulse are generated synchronously and have opposite polarities.

3. The pulse electric field generating device according to claim 2, characterized in that: Any two application members that respectively apply pulses of different polarities constitute an application member group, and at least two electric field action areas are formed within a preset range of the application member group.

4. The pulse electric field generating device according to claim 3, characterized in that: In the group of application elements, at least one application element has at least two pulse application zones.

5. The pulse electric field generating device according to claim 3, characterized in that: The application member group includes a first application member and a second application member, the first application member includes a first pulse application area and a second pulse application area, and the second application member includes a third pulse application area and a fourth pulse application area.

6. The pulse electric field generating device according to claim 5, characterized in that: The first pulse application area is connected to the first pulse generating circuit, and is used to output the first polarity pulse generated by the first pulse generating circuit. The third pulse application area is connected to the second pulse generating circuit, and is used to output the second polarity pulse generated by the second pulse generating circuit. Moreover, the voltage of the second pulse application area and the fourth pulse application area is zero.

7. The pulse electric field generating device according to claim 5, characterized in that: The first pulse application area and the third pulse application area are connected to the first pulse generating circuit for outputting the first polarity pulse generated by the first pulse generating circuit, and the second pulse application area and the fourth pulse application area are connected to the second pulse generating circuit for outputting the second polarity pulse generated by the second pulse generating circuit.

8. The pulse electric field generating device according to claim 5, characterized in that: The first pulse application area and the third pulse application area are connected to the first pulse generating circuit for outputting the first polarity pulse generated by the first pulse generating circuit, the second pulse application area is connected to the second pulse generating circuit for outputting the second polarity pulse generated by the second pulse generating circuit, and the voltage of the fourth pulse application area is zero.

9. The pulse electric field generating device according to claim 2, characterized in that: The first pulse generating circuit comprises: a first pulse generating module and a second pulse generating module, the first pulse generating module is used to generate a first electric pulse, and the second pulse generating module is used to generate a second electric pulse, wherein the pulse parameters of the first electric pulse and the second electric pulse are different; The second pulse generating circuit includes: a third pulse generating module and a fourth pulse generating module, the third pulse generating module is used to generate a third electrical pulse, and the fourth pulse generating module is used to generate a fourth electrical pulse, wherein the pulse parameters of the third electrical pulse and the fourth electrical pulse are different.

10. The pulse electric field generating device according to claim 9, characterized in that: The pulse parameters include at least one of a pulse amplitude and a pulse width.

11. The pulse electric field generating device according to claim 9, characterized in that: The first electric pulse and the third electric pulse have equal pulse amplitude and pulse width, opposite polarity, and are generated synchronously; and, The second electric pulse and the fourth electric pulse have equal pulse amplitudes and pulse widths, opposite polarities, and are generated synchronously.

12. The pulse electric field generating device according to claim 9, characterized in that: The pulse amplitude of the first electric pulse is greater than the pulse amplitude of the second electric pulse, and the pulse width of the first electric pulse is smaller than the pulse width of the second electric pulse.

13. The pulse electric field generating device according to claim 9, characterized in that: The pulse width of the first electric pulse is in nanosecond order, and the pulse amplitude is 6000V-8000V; the pulse width of the second electric pulse is in microsecond order, and the pulse amplitude is 1000V-5000V.

14. The pulse electric field generating device according to claim 2, characterized in that: Each of the applying elements is connected to at least one of the first pulse generating circuit and the second pulse generating circuit.

15. A pulse electric field generating device, characterized in that: include: The pulse electric field generating device according to any one of claims 1 to 14; as well as A control module, connected to the first pulse generating circuit and the second pulse generating circuit in the pulse electric field generating device, respectively, for generating a control signal; Wherein, the control signal is at least used to control the first pulse generating circuit and the second pulse generating circuit to synchronously generate a first polarity pulse and a second polarity pulse with opposite polarities, so that the first polarity pulse and the second polarity pulse are synchronously applied to the application element in the pulse electric field generating device.

16. The pulse electric field generating device according to claim 15, characterized in that: The invention also includes a switching module for switching the first polarity pulse and the second polarity pulse to be transmitted to different application members.

17. A pulse synchronization method, characterized in that: Applied to the pulse electric field generating device of claim 15, the method comprises: Get input information; generating a control signal based on the input information; Based on the control signal, synchronously controlling a first pulse generating circuit in the pulse electric field generating device to generate a first polarity pulse, and a second pulse generating circuit in the pulse electric field generating device to generate a second polarity pulse; The first polarity pulse and the second polarity pulse are generated synchronously and have opposite polarities.

18. A method for generating a pulse electric field, characterized in that: A pulse electric field generating device as claimed in any one of claims 1 to 14; The method comprises: Get control signal; Based on the control signal, controlling the pulse electric field generating device to generate a plurality of combined pulses; Each combined pulse includes a first polarity pulse and a second polarity pulse, the first polarity pulse and the second polarity pulse are generated synchronously and have opposite polarities.

19. The pulse electric field generating method according to claim 18, characterized in that: The control signal includes a first control signal and a second control signal, and based on the control signal, controlling the pulse electric field generating device to generate a plurality of combined pulses includes: Based on the first control signal, controlling the pulse electric field generating device to generate a plurality of first combined pulses; Based on the second control signal, controlling the pulse electric field generating device to generate a plurality of second combined pulses; The pulse parameters of the first combined pulse and the second combined pulse are different.

20. The pulse electric field generating method according to claim 18, characterized in that: The control signal includes a first control signal and a second control signal, and based on the control signal, controlling the pulse electric field generating device to generate a plurality of combined pulses includes: Based on the first control signal, controlling the pulse electric field generating device to generate a first combined pulse; Based on the second control signal, controlling the pulse electric field generating device to generate a second combined pulse; Repeat the above steps until the sum of the number of the first combined pulses and the number of the second combined pulses reaches a preset value; The pulse parameters of the first combined pulse and the second combined pulse are different.

21. A pulse application method, characterized in that: A pulse electric field generating device as claimed in any one of claims 2 to 14; The method comprises: placing at least two application members in the pulse electric field generating device at a target position; Selecting any two application members from the at least two application members; Synchronously applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applying members; The first polarity pulse and the second polarity pulse are generated synchronously and have opposite polarities.

22. The pulse application method according to claim 21, characterized in that: The any two application members include a first application member and a second application member, the first application member includes a first pulse application area and a second pulse application area, and the second application member includes a third pulse application area and a fourth pulse application area; The step of synchronously applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applying members comprises: applying the first polarity pulse to the first pulse application area; applying the second polarity pulse to the third pulse application area; Wherein, the voltages of the second pulse application area and the fourth pulse application area are zero.

23. The pulse application method according to claim 21, characterized in that: The any two application members include a first application member and a second application member, the first application member includes a first pulse application area and a second pulse application area, and the second application member includes a third pulse application area and a fourth pulse application area; The step of synchronously applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applying members comprises: applying the first polarity pulse and the second polarity pulse to the first pulse application area and the second pulse application area respectively; applying the first polarity pulse or the second polarity pulse to the third pulse applying area; Wherein, the voltage of the fourth pulse application area is zero.

24. The pulse application method according to claim 21, characterized in that: The any two application members include a first application member and a second application member, the first application member includes a first pulse application area and a second pulse application area, and the second application member includes a third pulse application area and a fourth pulse application area; The step of synchronously applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applying members comprises: applying the first polarity pulse synchronously to the first pulse application area and the third pulse application area; The second polarity pulse is synchronously applied to the second pulse application area and the fourth pulse application area.

Images