Antibacterial pressure-sensitive adhesive as well as preparation method and application thereof

Abstract

The invention discloses an antibacterial pressure-sensitive adhesive and a preparation method and application thereof, the antibacterial pressure-sensitive adhesive comprises the following raw materials: an emulsifier, monomers, an initiator and water, the monomers comprise a hard monomer, a soft monomer, a functional monomer and a cross-linking agent, the emulsifier is a cationic emulsifier, and the initiator is an initiator. The emulsifier is at least one of dodecyl dimethyl benzyl ammonium chloride, didodecyl dimethyl ammonium chloride and hexadecyl trimethyl ammonium bromide. The antibacterial pressure-sensitive adhesive has the characteristics of good adhesion, easiness in stripping, no residue, no need of additional drugs, no secondary damage to wounds, good biocompatibility and good antibacterial property.

Description

Technical Field

[0001] The invention belongs to the field of medical wound hemostatic dressings, and in particular relates to an antibacterial pressure-sensitive adhesive and a preparation method and application thereof. Background Art

[0002] Medical pressure-sensitive adhesives have very high performance requirements, are non-irritating to the skin, must be able to adhere well to various types of skin, and require no adhesion residues and skin damage when detached. According to the composition, the current medical pressure-sensitive adhesives can be divided into acrylate pressure-sensitive adhesives, silicone pressure-sensitive adhesives, polyurethane pressure-sensitive adhesives and medical hot-melt pressure-sensitive adhesives. Currently, the most widely used is acrylate pressure-sensitive adhesives. Compared with other pressure-sensitive adhesives, acrylate pressure-sensitive adhesives have excellent weather resistance, heat resistance, adhesion, good biocompatibility and other advantages. According to the preparation process, acrylate medical pressure-sensitive adhesives can be divided into four categories: solvent-based, emulsion-based, hot-melt-based and radiation-cured. Emulsion-based acrylate pressure-sensitive adhesives have the advantages of low cost, environmental protection and pollution-free, simple process, and short production cycle. It has become a widely used type of pressure-sensitive adhesive in the current market, but it still has the disadvantages of poor water resistance, insufficient high temperature resistance, slow coating and drying speed, and insufficient bonding strength to polar materials. Summary of the invention

[0003] In order to solve the above technical problems, the purpose of the present invention is to provide an antibacterial pressure-sensitive adhesive with good adhesion, easy peeling, no residue, no need for additional drugs, no secondary damage to the wound, good biocompatibility and good antibacterial performance.

[0004] In order to achieve the above purpose, the technical scheme of the present invention is as follows: an antibacterial pressure-sensitive adhesive, whose raw materials include emulsifier, monomer, initiator and water, the monomer includes hard monomer, soft monomer, functional monomer and crosslinking agent, and the emulsifier is a cationic emulsifier.

[0005] The contents of the raw materials in the above technical solution are as follows by mass percentage: emulsifier 0.4-1.2wt%, hard monomer 2.5-4.5wt%, soft monomer 17.2-33.8wt%, functional monomer 0.5-1.8wt%, crosslinker 0.05-0.1wt%, initiator 0.5-2.8wt%, and the balance is water.

[0006] The emulsifier described in the above technical solution is at least one of dodecyldimethylbenzylammonium chloride, didodecyldimethylammonium chloride and hexadecyltrimethylammonium bromide.

[0007] The monomers described in the above technical solution meet at least one of the following conditions:

[0008] a: the soft monomer is at least one of isooctyl acrylate and butyl acrylate;

[0009] b: The functional monomer is β-carboxyethyl acrylate;

[0010] c: the hard monomer is methyl methacrylate;

[0011] d: The cross-linking agent is N-isobutyloxymethyl acrylamide.

[0012] The initiator in the above technical solution is 2,2'-azo(2-methylpropylimidazole) dihydrochloride.

[0013] The second object of the present invention is to provide a method for preparing the antibacterial pressure-sensitive adhesive as described above, which is simple and convenient.

[0014] In order to achieve the above object, the technical scheme of the present invention is as follows: a method for preparing the antibacterial pressure-sensitive adhesive as described above, wherein an emulsifier and a portion of water are uniformly mixed to obtain an emulsion 1, and an initiator is completely dissolved in the remaining water to obtain an initiator solution;

[0015] Add part of the monomer to the emulsion 1, mix well to obtain the emulsion 2, and heat the emulsion 2 to 60-95° C., add part of the initiator solution after the temperature of the emulsion 2 stabilizes, and mix well to obtain the emulsion 3;

[0016] The emulsion 3 is continuously stirred, and after a period of time when the emulsion 3 emits blue light, the remaining monomer and initiator solution are slowly added dropwise to the emulsion 3, and the emulsion 4 is obtained after the addition is completed;

[0017] The emulsion 4 is kept warm for a period of time, then cooled and filtered to remove impurities, the filtered material is subjected to film coating, and the obtained film sheet is dried to obtain the antibacterial pressure-sensitive adhesive.

[0018] The content of the monomers in the second emulsion in the above technical solution is 5-20wt% of the total monomers.

[0019] The content of the initiator in the emulsion 3 in the above technical solution is 20-40wt% of the total amount of the initiator.

[0020] In the above technical solution, the monomer and initiator solution are added dropwise at the same time, and the addition time is 2-6 hours.

[0021] The third object of the present invention is to provide a use of the above-mentioned antibacterial pressure-sensitive adhesive in wound hemostasis.

[0022] In order to achieve the above object, the technical scheme of the present invention is as follows: a use of the antibacterial pressure-sensitive adhesive as described above or the antibacterial pressure-sensitive adhesive prepared by the preparation method as described above as a wound hemostatic dressing or for preparing a wound hemostatic dressing.

[0023] The beneficial effects of the present invention are as follows: 1. The isooctyl acrylate and / or butyl acrylate used in the present invention as soft monomers have the advantages of good adhesion, easy peeling, no residue, etc., and can make the prepared pressure-sensitive adhesive still maintain good adhesion performance after multiple peeling and adhesion, thereby enhancing the service life of the medical pressure-sensitive adhesive. When it is used on a wound, the easy peeling performance can eliminate secondary damage to the wound, and will not cause damage to normal skin and hair;

[0024] 2. The emulsifier used in the present invention (at least one of dodecyldimethylbenzyl ammonium chloride, didodecyldimethylammonium chloride and hexadecyltrimethylammonium bromide) can improve the viscoelastic properties of the pressure-sensitive adhesive, and will not be restricted in daily use, especially in daily sports and activities. At the same time, the emulsifier used in the present invention has the properties of light resistance, acid resistance and hard water resistance, so that the prepared pressure-sensitive adhesive can maintain the advantages of stability and not easy to decompose under various environments, so that the pressure-sensitive adhesive can be used in various special environments; in addition, the emulsifier in the present invention has the characteristics of good biocompatibility and good antibacterial performance, and after the didodecyldimethylammonium chloride and hexadecyltrimethylammonium bromide are compounded, the antibacterial performance can be further enhanced, and it has broad-spectrum antibacterial properties, and exhibits good antibacterial activity against various bacteria (including Gram-positive and Gram-negative bacteria). Therefore, the pressure-sensitive adhesive prepared by the present invention does not need to add antibacterial drugs, reducing the processing steps and costs;

[0025] 3. The reagents used in the present invention are all green and environmentally friendly monomers, and the obtained products are non-toxic, odorless, and more easily accepted by the public. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 A physical picture showing the antibacterial pressure-sensitive adhesive provided in an embodiment of the present invention;

[0027] Figure 2 The fluorescence microscope pictures of the antibacterial pressure-sensitive adhesive in the cell compatibility experiment corresponding to each embodiment of the present invention are shown;

[0028] Figure 3 The graphs show the antibacterial properties of various embodiments of the present invention and commercially available antibacterial pressure-sensitive adhesives. DETAILED DESCRIPTION

[0029] The principles and features of the present invention are described below in conjunction with the accompanying drawings. The examples given are only used to explain the present invention and are not used to limit the scope of the present invention. The present invention is described in more detail by way of example with reference to the accompanying drawings in the following paragraphs. The advantages and features of the present invention will become clearer according to the following description and claims. It should be noted that the drawings are all in a very simplified form and are not in precise proportions, and are only used to conveniently and clearly assist in explaining the purpose of the embodiments of the present invention.

[0030] On the one hand, the present embodiment provides an antibacterial pressure-sensitive adhesive, wherein the raw materials include an emulsifier, a monomer, an initiator and water, wherein the monomer includes a hard monomer, a soft monomer, a functional monomer and a cross-linking agent, wherein the emulsifier is a cationic emulsifier, and the content of each raw material is as follows by mass percentage: 0.4-1.2wt% of emulsifier (can be any value among 0.4wt%, 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1wt%, 1.1wt% and 1.2wt% or a range corresponding to any two values, and if the amount of the emulsifier added is lower than the range, the latex particles are prone to collision and aggregation, resulting in poor stability of the emulsion, When the addition amount is higher than this range, the effective contact area between the emulsion and the substrate will be reduced, thereby reducing the initial adhesion), the hard monomer is 2.5-4.5wt% (it can be any value among 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt% and 4.5wt% or the range corresponding to any two values), the addition amount of the hard monomer is lower than When the amount added is within this range, the cohesive force of the pressure-sensitive adhesive will decrease, which will cause the pressure-sensitive adhesive's holding force to decrease and affect its long-term bonding performance. If the added amount is higher than this range, the pressure-sensitive adhesive will become hard, affecting its wetting performance to the substrate and thereby reducing the 180° peel strength), soft monomer 17.2-33.8wt% (can be any value or any of 17.2wt%, 18wt%, 19wt%, 20wt%, 21wt%, 22wt%, 23wt%, 24wt%, 25wt%, 26wt%, 27wt%, 28wt%, 29wt%, 30wt%, 31wt%, 32wt%, 33wt%, and 33.8wt%). The range between the two values ​​is as follows. If the amount of soft monomer added is lower than this range, the glass transition temperature of the polymer is too low, the polymer gradually hardens, the wetting performance of the emulsion to the substrate decreases, and the 180° peel strength decreases accordingly. If it is higher than this range, the glass transition temperature of the polymer will be reduced, the cohesive strength will be reduced, and the adhesive performance will be poor). The functional monomer is 0.5-1.8wt% (it can be 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1wt%, 1.1wt%, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, and 1.8wt% or any value or the corresponding range between any two values. If the amount of functional monomer added is lower than this range, it is not enough to provide enough polar groups, thereby affecting the cohesion and bonding properties of the pressure-sensitive adhesive. If it is higher than this range, it will increase the probability of demulsification, resulting in reduced adhesion and poor stability of the pressure-sensitive adhesive), crosslinking agent 0.05-0.1wt% (can be any value among 0.05wt%, 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt% and 0.1wt% or the corresponding range between any two values, the addition of crosslinking agent. If When it is lower than this range, the obtained antibacterial pressure-sensitive adhesive is insufficient to form a sufficient cross-linked structure, resulting in insufficient cohesion of the product, and if it is higher than this range, the peel strength and viscosity of the antibacterial pressure-sensitive adhesive are reduced), initiator 0.5-2.8wt% (can be 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1wt%, 1.1wt%, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt% and 2.8wt% or the corresponding range between any two values. If the amount of initiator added is lower than the range, the polymerization reaction will not be easily initiated, the reaction will not proceed normally, and the performance of the polymer will be affected. If the amount of initiator added is higher than the range, the polymerization reaction rate will be too fast and difficult to control, affecting the performance and stability of the polymer. The balance is water.

[0031] The emulsifier in the above technical solution is at least one of dodecyldimethylbenzylammonium chloride, didodecyldimethylammonium chloride and hexadecyltrimethylammonium bromide (specifically, the emulsifier can be dodecyldimethylbenzylammonium chloride, didodecyldimethylammonium chloride or hexadecyltrimethylammonium bromide, or a composite of any two of the three, or a direct reset of the three); the initiator is 2,2'-azo(2-methylpropylimidazole) dihydrochloride.

[0032] The cationic emulsifier selected in this embodiment has excellent antistatic properties, which can significantly reduce the accumulation of static electricity, and also has good dispersing and emulsifying properties, and can make immiscible liquids (such as water and oil) form stable emulsions; it has good compatibility with cationic, nonionic, and zwitterionic surfactants, and can be used with other types of surfactants to improve the emulsification effect or achieve other functions; it is very easy to be adsorbed to the surface with negative charge, which enables it to effectively stabilize the emulsion system during the emulsification process, and it also has light resistance, acid resistance, and hard water resistance, so that it can remain stable in a variety of environments and is not easy to decompose; it is degradable, environmentally friendly, and reduces the risk of environmental pollution; in addition, it has excellent antibacterial properties, and the cationic property enables it to interact with the negative charge on the bacterial cell membrane, firmly adsorbing the bacteria on the surface of the material, and further it will destroy the cell membrane, resulting in the leakage of protein in the bacteria, and ultimately leading to the death of the bacteria. It has a broad-spectrum antibacterial property and exhibits good antibacterial activity against a variety of bacteria (including Gram-positive and Gram-negative bacteria), and its effect is closely related to the length of the alkyl chain.

[0033] The monomers described in the above technical solution meet at least one of the following conditions:

[0034] a: the soft monomer is at least one of isooctyl acrylate and butyl acrylate;

[0035] b: The functional monomer is β-carboxyethyl acrylate;

[0036] c: the hard monomer is methyl methacrylate;

[0037] d: The cross-linking agent is N-isobutyloxymethyl acrylamide.

[0038] The crosslinking agent (N-isobutoxymethyl acrylamide) in this embodiment can improve the adhesion of the pressure-sensitive adhesive, increase its tensile strength, help prevent the pressure-sensitive adhesive from sticking and agglomerating during use, maintain its good performance, improve the feel, and provide a more comfortable use experience. The initiator used in this embodiment can initiate a polymerization reaction between monomer molecules to form a high molecular polymer; the soft monomers (isooctyl acrylate and butyl acrylate) in this embodiment are used as viscous monomers, have a lower glass transition temperature, and can improve the adhesion and flexibility of the pressure-sensitive adhesive; the hard monomer (methyl methacrylate) can improve the cohesion and bonding strength of the adhesive, which helps to improve the water resistance, bonding strength and transparency of the pressure-sensitive adhesive; the functional monomer (β-carboxyethyl acrylate) contains hydroxyl groups, which can increase the cohesive strength of the pressure-sensitive adhesive through hydrogen bonds and a slight network cross-linking structure, can cross-link with other monomers, promote polymerization reactions, accelerate the polymerization rate, and improve the stability of the adhesive, which can improve the bonding performance as well as water resistance, weather resistance, solvent resistance and other properties of the pressure-sensitive adhesive.

[0039] On the other hand, the present embodiment provides a method for preparing the antibacterial pressure-sensitive adhesive as described above, and the specific steps are as follows: uniformly mixing an emulsifier and a portion of water to obtain an emulsion 1, and completely dissolving an initiator in the remaining water to obtain an initiator solution;

[0040] Add part of the monomer to the emulsion 1, mix well to obtain the emulsion 2, and heat the emulsion 2 to 60-95° C. (it can be any value among 60° C., 65° C., 70° C., 75° C., 80° C., 85° C., 90° C. and 95° C. or a range corresponding to any two values), add part of the initiator solution after the temperature of the emulsion 2 is stable, mix well to obtain the emulsion 3;

[0041] The emulsion 3 is continuously stirred, and after a period of time when the emulsion 3 emits blue light, the remaining monomer and initiator solution are slowly added dropwise to the emulsion 3, and the emulsion 4 is obtained after the addition is completed;

[0042] The emulsion 4 is kept warm for a period of time, then cooled and filtered to remove impurities, the filtered material is subjected to film coating, and the obtained film sheet is dried to obtain the antibacterial pressure-sensitive adhesive.

[0043] The content of the monomer in the second emulsion in the above technical solution is 5-20wt% of the total monomer amount (it can be any value among 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, 16wt%, 17wt%, 18wt%, 19wt% and 20wt% or the range corresponding to any two values); the content of the initiator in the third emulsion is initiator The amount of the agent is 20-40wt% of the total weight of the agent (it can be any value among 20wt%, 21wt%, 22wt%, 23wt%, 24wt%, 25wt%, 26wt%, 27wt%, 28wt%, 29wt%, 30wt%, 31wt%, 32wt%, 33wt%, 34wt%, 35wt%, 36wt%, 37wt%, 38wt%, 39wt% and 40wt%, or the corresponding range between any two values).

[0044] The monomer and initiator solution in the above technical solution are added simultaneously, and the addition time is 2-6h (it can be any value among 2h, 2.5h, 3h, 3.5h, 4h, 4.5h, 5h, 5.5h and 6h or the corresponding range between any two values).

[0045] Example 1

[0046] The present embodiment provides an antibacterial pressure-sensitive adhesive, the preparation raw materials of which are as follows: the emulsifier is dodecyl dimethyl benzyl ammonium chloride (1.15 parts), the hard monomer is methyl methacrylate (4.25 parts), the soft monomer is a compound of isooctyl acrylate (28.75 parts) and butyl acrylate (2.2 parts), the functional monomer is β-carboxyethyl acrylate (1.8 parts), the cross-linking agent is N-isobutoxymethyl acrylamide (0.08 parts), the initiator is 2,2'-azo (2-methylpropylimidamide) dihydrochloride (2.65 parts), water (59.12 parts), and the total amount of the above raw materials is 100 parts; the specific preparation method comprises the following steps:

[0047] Disperse all the emulsifiers into 55.02 parts of water, stir at 300 rpm until dissolved and mixed uniformly to obtain emulsion 1, and dissolve all the initiators into the remaining 4.1 parts of water to obtain an initiator solution;

[0048] 10% of the total weight of the monomers was taken out and added to the emulsion 1, and stirred at 550 rpm for 2 hours to obtain the emulsion 2. The emulsion 2 was heated to 80° C., and after the temperature of the emulsion 2 stabilized, part of the initiator solution was added (the amount added was calculated as 25% of the total weight of the initiator based on the initiator content), and the speed was reduced to 150 rpm to obtain the emulsion 3 after stirring and mixing.

[0049] Continue stirring emulsion 3, and 10 minutes after emulsion 3 emits blue light, slowly dropwise add the remaining monomer and initiator solution to emulsion 3 for 5 hours, and obtain emulsion 4 after the dropwise addition is completed;

[0050] The emulsion 4 was kept warm for 2 hours, then cooled to room temperature and filtered to remove impurities, the filtrate was coated with a coater, and the obtained film was dried (drying temperature was 105°C, baking for 25 minutes) to obtain the antibacterial pressure-sensitive adhesive.

[0051] Example 2

[0052] Same as Example 1, except that the raw material emulsifier is hexadecyltrimethylammonium bromide (1.15 parts).

[0053] Example 3

[0054] The same as Example 1, except that the raw material emulsifier is a compound of didodecyldimethylammonium chloride (0.85 parts) and hexadecyltrimethylammonium bromide (0.3 parts).

[0055] Example 4

[0056] The same as Example 1, except that the raw material part of the emulsifier is a compound of dodecyldimethylbenzylammonium chloride (0.85 parts) and hexadecyltrimethylammonium bromide (0.3 parts).

[0057] Product effect testing

[0058] Cut a piece of the antibacterial pressure-sensitive adhesive prepared in Example 1 (size 2x5 cm, as shown in FIG. Figure 1 As shown in Figure a), Figure 1 As shown in Figures b and c, the cut antibacterial pressure-sensitive adhesive is adhered to the skin of the hand, and Figure 1 As shown in Figure d, one end of the antibacterial pressure-sensitive adhesive is adhered to the carrier, and the other end is hung with a 1000g weight. At this time, the antibacterial pressure-sensitive adhesive does not loosen from the carrier, indicating that it has good adhesion.

[0059] Biocompatibility testing

[0060] like Figure 2 As shown, the antibacterial pressure-sensitive adhesives prepared in Examples 1 to 4 were co-incubated with NIH 3T3 cells (commercially available) for 24 hours, and it was found that both grew normally, indicating that the pressure-sensitive adhesives prepared by us have good biocompatibility. Figure 2 shown.

[0061] Antimicrobial testing

[0062] The antibacterial pressure-sensitive adhesives prepared in Examples 1 to 4 and commercially available samples were incubated with Staphylococcus aureus in a culture medium at 37°C for 12 hours. 150 μL of the solution was taken out of each group and the OD value at 450 nm was measured in a 96-well plate. By comparison, it was found that Examples 1 to 4 all had obvious antibacterial properties, while the bacteria in the commercially available ordinary pressure-sensitive adhesives proliferated normally. The results are shown in FIG. Figure 3 shown.

[0063] Performance Testing

[0064] The antibacterial pressure-sensitive adhesives prepared in the above-mentioned Examples 1 to 4 were subjected to initial adhesion test (performed in accordance with the method disclosed in GB / T 4852-2002 "Test Method for Initial Adhesion of Pressure-Sensitive Adhesive Tapes"), sustained adhesion test (performed in accordance with the method disclosed in GB / T 4851-2014 "Test Method for Sustained Adhesion of Adhesive Tapes"), and peel strength test (performed in accordance with the method disclosed in GB / T 2792-2014 "Test Method for Peel Strength of Adhesive Tapes"). It was found that the initial adhesion and sustained adhesion of Examples 2 and 4 were both poor, and the peel strength was large, which may cause secondary damage to the wound. Examples 1 and 3 have good initial adhesion, sustained adhesion, and peel strength, indicating that the performance of the antibacterial pressure-sensitive adhesive prepared by using dodecyl dimethyl benzyl ammonium chloride alone as an emulsifier or by mixing didodecyl dimethyl ammonium chloride and hexadecyl trimethyl ammonium bromide as an emulsifier is better, as shown in Table 1.

[0065] Table 1 Comparison of the performance of the antibacterial pressure-sensitive adhesives obtained in Examples 1 to 4

[0066]

[0067] The above content describes the basic principle and main features of the present invention and the advantages of the present invention. It should be understood by those skilled in the art that protection scope of the present invention is not limited by the above-described embodiments. Without departing from the spirit and scope of the present invention, the present invention also has various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed for protection.

[0068] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Any ordinary technician in the industry can smoothly implement the present invention as shown in the drawings and described above. However, any equivalent changes, modifications and evolutions made by technicians familiar with the profession without departing from the scope of the technical solution of the present invention using the technical content disclosed above are all equivalent embodiments of the present invention. At the same time, any equivalent changes, modifications and evolutions made to the above embodiments based on the essential technology of the present invention are still within the protection scope of the technical solution of the present invention.

Claims

1. An antibacterial pressure-sensitive adhesive, characterized in that: The raw materials include emulsifier, monomer, initiator and water, the monomer includes hard monomer, soft monomer, functional monomer and crosslinking agent, and the emulsifier is a cationic emulsifier.

2. The antibacterial pressure-sensitive adhesive according to claim 1, characterized in that: The contents of the raw materials are as follows by mass percentage: emulsifier 0.4-1.2wt%, hard monomer 2.5-4.5wt%, soft monomer 17.2-33.8wt%, functional monomer 0.5-1.8wt%, crosslinking agent 0.05-0.1wt%, initiator 0.5-2.8wt%, and the balance is water.

3. The antibacterial pressure-sensitive adhesive according to claim 1, characterized in that: The emulsifier is at least one of dodecyldimethylbenzyl ammonium chloride, didodecyldimethylammonium chloride and hexadecyltrimethylammonium bromide.

4. The antibacterial pressure-sensitive adhesive according to claim 1, characterized in that: The monomer meets at least one of the following conditions: a: the soft monomer is at least one of isooctyl acrylate and butyl acrylate; b: The functional monomer is β-carboxyethyl acrylate; c: the hard monomer is methyl methacrylate; d: The cross-linking agent is N-isobutyloxymethyl acrylamide.

5. The antibacterial pressure-sensitive adhesive according to claim 1, characterized in that: The initiator is 2,2'-azo(2-methylpropylimidazole) dihydrochloride.

6. A method for preparing the antibacterial pressure-sensitive adhesive according to any one of claims 1 to 5, characterized in that: The emulsifier and part of the water are mixed evenly to obtain an emulsion 1, and the initiator is completely dissolved in the remaining water to obtain an initiator solution; Add part of the monomer to the emulsion 1, mix well to obtain the emulsion 2, and heat the emulsion 2 to 60-95° C., add part of the initiator solution after the temperature of the emulsion 2 stabilizes, and mix well to obtain the emulsion 3; The emulsion 3 is continuously stirred, and after a period of time when the emulsion 3 emits blue light, the remaining monomer and initiator solution are slowly added dropwise to the emulsion 3, and the emulsion 4 is obtained after the addition is completed; The emulsion 4 is kept warm for a period of time, then cooled and filtered to remove impurities, the filtered material is subjected to film coating, and the obtained film sheet is dried to obtain the antibacterial pressure-sensitive adhesive.

7. The preparation method according to claim 6, characterized in that: The content of the monomers in the second emulsion is 5-20 wt % of the total amount of the monomers.

8. The preparation method according to claim 6, characterized in that: The content of the initiator in the emulsion 3 is 20-40wt% of the total amount of the initiator.

9. The preparation method according to claim 6, characterized in that: The monomer and initiator solution are added dropwise at the same time, and the duration of the addition is 2-6 hours.

10. Use of the antibacterial pressure-sensitive adhesive according to any one of claims 1 to 5 or the antibacterial pressure-sensitive adhesive prepared by the preparation method according to any one of claims 6 to 9, characterized in that: It is used as a wound hemostatic dressing or for preparing a wound hemostatic dressing.

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