CMCS-CuO NPs antibacterial latex and application of CMCS-CuO NPs antibacterial latex in clinical imbedded artificial pipeline base material

By blending CMCS-CuO NPs antibacterial materials with natural latex to prepare antibacterial latex, the problem of easily causing infection after being left in the human body is solved, and the effective antibacterial effect on common urinary tract pathogens is achieved, and good biosafety and histocompatibility are shown.

CN119633180APending Publication Date: 2025-03-18SHANXI MEDICAL UNIV
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Patent Information

Application Number
CN202411855582.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-17
Publication Date
2025-03-18

AI Technical Summary

Technical Problem

Existing catheters or ureteral stent tubes are easily induce infection after being left in the human body. It is mainly due to the formation of biofilms on the surface. Traditional antibiotics are difficult to effectively kill bacteria and easily lead to bacterial resistance.

Method used

Antibacterial latex is prepared by blending CMCS-CuO NPs antibacterial materials with medical natural latex. Carboxymethyl chitosan composite nano-copper oxide (CMCS-CuO NPs) is generated by reaction under hydrothermal conditions, and blending it with natural latex to form antibacterial latex.

Benefits of technology

This antibacterial latex has a 100.0% antibacterial rate on bacteria such as Staphylococcus aureus, Staphylococcus epidermis, and the antibacterial rate on Enterococcus faecalis reaches 99.8%, effectively inhibiting bacterial growth, reducing biofilm formation, and reducing the incidence of urinary tract infection. At the same time, there is no obvious difference in cytotoxicity and good histocompatibility.

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Abstract

The invention belongs to the technical field of medical material preparation, and provides CMCS-CuO NPs antibacterial latex and application thereof in a clinical implantable artificial pipeline base material in order to solve the problem that existing catheter or ureteral stent and other pipes implanted into a human body are prone to causing human body infection. The preparation method comprises the following steps: reacting carboxymethyl chitosan with copper sulfate under a hydrothermal condition to obtain a carboxymethyl chitosan composite nano copper oxide CMCS-CuO NPs antibacterial material, and then preparing the CMCS-CuO NPs antibacterial latex from the carboxymethyl chitosan composite nano copper oxide CMCS-CuO NPs antibacterial material and medical natural latex by adopting a blending method. The CMCS-CuO NPs antibacterial latex prepared by the invention is simple in process and low in cost, has an antibacterial effect on six common pathogenic bacteria in the urinary system, is high in biological safety, and can be further used as a base material to develop a novel antibacterial catheter, a ureteral stent tube and the like to be clinically used for helping to solve related infection problems.
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