Portable magnetic pen

Abstract

The utility model discloses a portable magnetic pen which comprises a shell with an outlet, a pen core, a miniature magnet and a stirring sleeve. The miniature magnet is fixed at one end of the refill; the stirring sleeve is sleeved at the outlet of the shell; the refill is arranged in the shell in a telescopic mode, and the end, provided with the miniature magnet, of the refill faces an outlet of the shell. The portable magnetic pen disclosed by the utility model is simple in structure, does not need a power supply so as to reduce the manufacturing cost, is small and exquisite in design, is easy to operate and carry, and can be suitable for various scenes.

Description

Technical Field

[0001] The utility model belongs to the technical field of magnetic bead separation, in particular to a portable magnetic pen. Background Art

[0002] The technology of using superparamagnetic magnetic microparticles to separate biomolecules in solution has been widely used in the biomedical field, such as separation of proteins, immunoassays, gene sequencing, antibodies and nucleic acids. Compared with commonly used separation methods such as precipitation, centrifugation, ion exchange and various chromatography methods, magnetic separation technology is convenient and fast, requires simple equipment and has high extraction efficiency.

[0003] The operating principle is that after adding magnetic bead microparticles into a test tube containing the sample liquid to be separated, in the absence of magnetic force, the magnetic bead microparticles can be distributed in the solution and fully combined with the sample to be separated after stirring or oscillating; adding a magnetic separation device to the test tube applies an external magnetic field to the solution, and under the action of the external magnetic field, the magnetic bead microparticles combined with the separation sample are enriched from the solution, thereby achieving sample separation.

[0004] The commonly used magnetic separation equipment on the market now is generally a large automatic extraction (separation) instrument, which is large in size, complicated to assemble and bulky, and is therefore not conducive to carrying and using at any time. Utility Model Content

[0005] The utility model aims to provide a portable magnetic pen.

[0006] The utility model provides a portable magnetic pen, comprising a shell (102) provided with an outlet (105), a pen core, a micro magnet (501) and a stirring sleeve; the micro magnet (501) is fixed to one end of the pen core; the stirring sleeve is arranged at the outlet (105) of the shell (102); the pen core is telescopically arranged in the shell (102), and one end of the pen core provided with the micro magnet (501) faces the outlet (105) of the shell (102).

[0007] Preferably, the pen core comprises a first column (201) and a first protrusion (204); the first protrusion (204) is fixed on a side close to the top of the first column (201), and the side wall of the shell (102) is provided with a first slot hole (103) and a second slot hole (104); the first slot hole (103) is vertically opened at a position close to the top of the shell (102); the second slot hole (104) is arranged at a position close to the bottom of the first slot hole (103) and is connected to the first slot hole (103); the first protrusion (204) is slidably arranged at the first slot hole (103) and protrudes outward from the first slot hole (103).

[0008] Preferably, the portable magnetic pen provided by the utility model further comprises a spring (301); the cross section of the first column (201) is T-shaped; the inner wall of the shell (102) is provided with a protrusion (106); the spring (301) is sleeved on the first column (201); one end of the spring (301) is in contact with the top of the first column (201), and the other end is in contact with the protrusion (106).

[0009] Preferably, the pen core further comprises a second column (203); one end of the second column (203) is fixed to the bottom of the first column (201); and the micro magnet (501) is fixed to the bottom of the second column (203).

[0010] Preferably, the bottom of the second column (203) is in a concave shape.

[0011] Preferably, the pen core further comprises two ejector rods (202); the two ejector rods (202) are both fixed at the bottom of the first column (201) and are symmetrically arranged on both sides of the second column (203).

[0012] Preferably, the stirring sleeve comprises a sleeve body (401) and a clamping piece (402) fixed on the top of the sleeve body (401); the shape of the outlet (105) of the housing (102) is conical; and the clamping piece (402) is sleeved at the outlet (105).

[0013] Preferably, the portable magnetic pen provided by the utility model further comprises a cap (101) matching the shell (102); the cap (101) is detachably connected to the shell (102).

[0014] Compared with the prior art, the portable magnetic pen provided by the utility model has the following beneficial effects:

[0015] 1. The design structure is simple, no power supply is required, and the cost is reduced.

[0016] 2. Compact design, easy to operate and carry, suitable for a variety of scenarios.

[0017] 3. The magnetic field can directly enter the sample liquid to be separated for separation operation, which improves the separation speed and achieves the purpose of instant transfer of magnetic bead microparticles. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 A schematic diagram of the structure of the portable magnetic pen provided by the utility model;

[0019] Figure 2 A schematic diagram of the front view structure of the pen refill provided by an embodiment of the utility model;

[0020] Figure 3 A schematic diagram of the side view structure of the pen refill provided by an embodiment of the utility model;

[0021] Figure 4 This is a schematic diagram of the structure of the housing provided by an embodiment of the utility model. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all of the embodiments. Based on the embodiment of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0023] like Figure 1-Figure 4 As shown, the portable magnetic pen provided in this embodiment includes a shell 102 provided with an outlet 105, a pen core, a micro magnet 501 and a stirring sleeve; the micro magnet 501 is fixed at one end of the pen core; the stirring sleeve is arranged at the outlet 105 of the shell 102; the pen core is retractably arranged in the shell 102, and one end of the pen core provided with the micro magnet 501 is facing the outlet 105 of the shell 102. Those skilled in the art can understand that the pen core is slid out of the outlet 105 of the housing 102, so that the micro magnet 501 at the end of the pen core extends out of the housing 102 and falls into the stirring sleeve. At this time, the magnetic pen with the stirring sleeve at one end can be put into the test tube containing the sample liquid to be separated. Under the action of the magnetic field, the magnetic beads in the sample to be separated are quickly adsorbed at the bottom of the stirring sleeve. After the adsorption of the magnetic beads, the end of the magnetic pen with the stirring sleeve is taken out from the liquid of the sample to be separated, and after transferring to the test tube of the next process, the pen core is retracted into the housing 102. Since the stirring sleeve does not contain a magnet, due to the withdrawal of the magnetic field, the magnetic beads are quickly dispersed under the slight stirring of the magnetic pen, thereby realizing the separation and transfer of the sample. The device has a simple structure, does not require a power supply, thereby reducing the cost, and is compact, easy to operate and carry, and can be applied to a variety of scenarios.

[0024] Furthermore, the pen core includes a first column 201 and a first protrusion 204; the first protrusion 204 is fixed on a side close to the top of the first column 201, and the side wall of the shell 102 is provided with a first slot 103 and a second slot 104; the first slot 103 is vertically opened at a position close to the top of the shell 102; the second slot 104 is arranged at a position close to the bottom of the first slot 103 and is connected to the first slot 103; the first protrusion 204 is slidably arranged at the first slot 103 and protrudes outward from the first slot 103. Those skilled in the art will appreciate that the operator can push and pull the first protrusion 204 to drive the pen core to slide outward from the outlet 105. After the first protrusion 204 slides downward, the operator can move the first protrusion 204 to the second slot 104 to fix the pen core in the working position. After the magnetic beads are transferred, the first protrusion 204 is moved from the second slot 104 to the first slot 103 to push the first protrusion 204 upward to the initial position, thereby retracting the micro magnet 501 into the housing 102.

[0025] Furthermore, the portable magnetic pen provided in this embodiment further includes a spring 301; the cross section of the first column 201 is T-shaped; the inner wall of the housing 102 is provided with a protrusion 106; the spring 301 is sleeved on the first column 201; one end of the spring 301 abuts against the top of the first column 201, and the other end abuts against the protrusion 106. Those skilled in the art can understand that the spring 301 can realize the pen core to rebound to the initial position by itself.

[0026] Furthermore, the pen core further comprises a second column 203 ; one end of the second column 203 is fixed to the bottom of the first column 201 ; and the micro magnet 501 is fixed to the bottom of the second column 203 .

[0027] Furthermore, the bottom of the second column 203 is in a concave shape. Those skilled in the art will appreciate that the concave portion is used to embed a micro magnet.

[0028] Furthermore, the pen core also includes two ejector rods 202; the two ejector rods 202 are fixed at the bottom of the first column 201 and symmetrically arranged on both sides of the second column 203. Those skilled in the art can understand that, because the second slot 104 is arranged at the bottom of the first slot 103, after the first protrusion 204 is pushed back to the first slot 103, the staff can continue to press down the first protrusion 204, driving the first column 201 to continue to slide downward, thereby ejecting the two ejector rods 202 from the outlet 105, so that the stirring sleeve can be withdrawn from the bottom of the housing 102. At this time, the staff releases the first protrusion 204, and under the action of the spring 301, the pen core rebounds to the initial position.

[0029] Further, the stirring sleeve includes a sleeve body 401 and a clamping member 402 fixed on the top of the sleeve body 401; the shape of the outlet 105 of the housing 102 is conical; the clamping member 402 is sleeved on the outlet 105. Those skilled in the art can understand that the clamping member 402 is a common technical means in the field and is not described here. After the ejector rod 202 extends from the outlet 105, it abuts against the clamping member 402, and the clamping member 402 is withdrawn from the housing 102 by pressing down the pen core.

[0030] Furthermore, the portable magnetic pen provided in this embodiment further includes a cap 101 matching the housing 102; the cap 101 is detachably connected to the housing 102. Those skilled in the art will appreciate that the cap 101 and the housing 102 are detachably connected, which makes it easy to replace the components in the housing 102, thereby increasing the service life of the magnetic pen.

[0031] Principle: First, take a new stirring sleeve and connect it to the magnetic pen and fix it. Use the principle of aperture friction to fix the stirring sleeve. Then push the first protrusion 204 downward along the first slot 103 to the second slot 104 at the working position and fix it. The pen core drives the second column 203 and the micro magnet 501 downward to push out of the magnetic pen housing 102 and enter the stirring sleeve. At this time, the end of the magnetic pen with the stirring sleeve can be put into the test tube containing the sample liquid to be separated. Under the action of the magnetic field, the magnetic bead microparticles in the sample to be separated are quickly adsorbed on the bottom of the stirring sleeve. After the magnetic bead microparticles are adsorbed, take the end of the magnetic pen with the stirring sleeve out of the liquid of the sample to be separated and transfer it to the test tube of the next process. At this time, separate the first protrusion 204 from the second slot 104 at the working position. Push it to the reset point of the refill sliding groove, that is, the top of the first slot 103, and the refill drives the micro magnet 501 upward and sends it back to the inside of the magnetic pen shell 102. After completion, the stirring sleeve does not contain a magnet. Due to the withdrawal of the magnetic field, the magnetic bead microparticles are quickly dispersed under the slight stirring of the magnetic pen, thereby realizing the separation and transfer of the sample. Finally, after the end of the magnetic pen with the stirring sleeve is removed from the test tube, the first protrusion 204 is pushed and slides from the reset point of the refill sliding groove to the point where the refill sliding groove ejects the stirring sleeve. The ejection rod 202 is used to push onto the tightening part of the stirring sleeve, and the stirring sleeve is withdrawn from the connection at the shell 102 and discarded. Then the first protrusion 204 is released, and the reaction force of the spring 301 is used to restore the refill to its initial position. At this point, the entire separation and transfer work is completed.

[0032] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the utility model, rather than to limit it. Although the utility model has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the utility model.

Claims

1. A portable magnetic pen, It is characterized in that The invention comprises a shell (102) provided with an outlet (105), a pen core, a micro magnet (501) and a stirring sleeve; the micro magnet (501) is fixed to one end of the pen core; the stirring sleeve is arranged at the outlet (105) of the shell (102); the pen core is telescopically arranged in the shell (102), and one end of the pen core provided with the micro magnet (501) faces the outlet (105) of the shell (102).

2. The portable magnetic pen as claimed in claim 1, It is characterized in that The pen core comprises a first column (201) and a first protrusion (204); the first protrusion (204) is fixed on a side close to the top of the first column (201), and the side wall of the shell (102) is provided with a first slot hole (103) and a second slot hole (104); the first slot hole (103) is vertically opened at a position close to the top of the shell (102); the second slot hole (104) is arranged at a position close to the bottom of the first slot hole (103) and is connected to the first slot hole (103); the first protrusion (204) is slidably arranged at the first slot hole (103) and protrudes outward from the first slot hole (103).

3. The portable magnetic pen as claimed in claim 2, It is characterized in that It also includes a spring (301); the cross-section of the first column (201) is T-shaped; the inner wall of the shell (102) is provided with a protrusion (106); the spring (301) is sleeved on the first column (201); one end of the spring (301) is in contact with the top of the first column (201), and the other end is in contact with the protrusion (106).

4. The portable magnetic pen as claimed in claim 3, It is characterized in that The pen core further comprises a second column (203); one end of the second column (203) is fixed to the bottom of the first column (201); and the micro magnet (501) is fixed to the bottom of the second column (203).

5. The portable magnetic pen as claimed in claim 4, It is characterized in that The bottom of the second column (203) is in a concave shape.

6. The portable magnetic pen as claimed in claim 5, It is characterized in that The pen core further comprises two ejector rods (202); the two ejector rods (202) are both fixed at the bottom of the first column (201) and are symmetrically arranged on both sides of the second column (203).

7. The portable magnetic pen as claimed in claim 6, It is characterized in that The stirring sleeve comprises a sleeve body (401) and a clamping piece (402) fixed on the top of the sleeve body (401); the shape of the outlet (105) of the housing (102) is conical; and the clamping piece (402) is sleeved on the outlet (105).

8. The portable magnetic pen as claimed in claim 7, It is characterized in that It also comprises a cover cap (101) matching the outer shell (102); the cover cap (101) is detachably connected to the outer shell (102).

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