Body membrane for analyzing and verifying characteristics of craniocerebral enhanced magnetic resonance imaging sequence

Abstract

The utility model discloses a body membrane for analyzing and verifying characteristics of a craniocerebral enhanced magnetic resonance imaging sequence. The body film comprises a bracket; the bracket comprises an upper-layer bracket, a middle-layer bracket and a lower-layer bracket; the upper-layer bracket and the middle-layer bracket are used for placing a plurality of injectors, and the injectors are filled with gadolinium preparation, gadolinium preparation stock solution and normal saline with gradient concentration; the lower-layer bracket is used for placing a spherical water film; concave grooves are formed in the upper-layer bracket and the middle-layer bracket, and the injectors are arranged in the concave grooves; and the concave grooves in the upper-layer bracket and the middle-layer bracket are arranged at equal intervals. The external model provided by the utility model can analyze and verify the imaging characteristics of different sequences of craniocerebral MRI under different gadolinium agent concentrations.

Description

Technical Field

[0001] The utility model relates to a body membrane used for analyzing and verifying the characteristics of brain enhanced magnetic resonance imaging sequences. Background Art

[0002] Compared with other commonly used clinical imaging methods, magnetic resonance imaging (MRI) has the characteristics of multi-sequence and multi-parameter imaging, and plays an important role in neuroimaging. Brain MRI has unique advantages in evaluating stroke, tumor lesions and tumor-like lesions, and provides strong imaging evidence for the diagnosis and differential diagnosis of diseases. In addition, plain and enhanced sequences of brain MRI are now routinely used in clinical practice to evaluate and characterize intracranial and meningeal metastases in tumor patients. Enhanced MRI requires the injection of exogenous gadolinium contrast agents to increase the contrast between lesions and normal brain parenchyma or meninges to achieve the purpose of clear diagnosis. For MRI sequences with different imaging characteristics, different concentrations of gadolinium have different enhancement effects. The complexity of MRI multi-parameters is behind it. With regard to the above characteristics, both radiologists and clinical oncologists can help the use of plain and enhanced MRI of the brain if they fully understand and master its theoretical basis and imaging characteristics. However, in terms of the principle of MRI imaging, it has abstract characteristics, which makes it difficult for relevant personnel to understand the characteristics of each sequence. Therefore, it is necessary to provide an in vitro model to analyze and verify the imaging characteristics of commonly used sequences of plain and enhanced MRI of the brain. Utility Model Content

[0003] The purpose of the utility model is to provide a body membrane for analyzing and verifying the characteristics of brain enhanced magnetic resonance imaging sequences, which can analyze and verify the imaging characteristics of different brain MRI sequences at different gadolinium concentrations, and improve the understanding dimension of different brain MRI sequences.

[0004] The utility model relates to plain scan and enhanced MRI of the brain, and the plain scan sequences include: T2 WI, T1 WI, T2FLAIR, DWI, T1 WI (sagittal position), and the enhanced sequences often include: T1 WI+C, 3D T1 BRAVO, 3D T2CUBE FLAIR.

[0005] The body membrane for analyzing and verifying the characteristics of brain enhanced magnetic resonance imaging sequence provided by the utility model comprises a bracket, the material of which is plastic; wherein:

[0006] The support comprises an upper support, a middle support and a lower support;

[0007] The upper support and the middle support are used to place a plurality of syringes, and the syringes are filled with gadolinium with gradient concentrations, gadolinium stock solution and physiological saline;

[0008] The specification of the syringe is preferably 5ml;

[0009] The lower support is used for placing the spherical water film.

[0010] In the body membrane of the utility model, the upper support and the middle support are provided with concave grooves, and the syringe is arranged in the concave grooves;

[0011] Preferably, the concave grooves on the upper support and the middle support are arranged at equal intervals.

[0012] In the body membrane of the utility model, 7 concave grooves are arranged on the upper support, and syringes filled with the following stock solutions are placed in sequence: gadolinium stock solution, 1 / 2 gadolinium stock solution, 1 / 4 gadolinium stock solution, 1 / 8 gadolinium stock solution, 1 / 16 gadolinium stock solution, 1 / 32 gadolinium stock solution, and 1 / 64 gadolinium stock solution;

[0013] Six concave grooves are arranged on the middle support, and syringes filled with the following stock solutions and saline are placed in sequence: 1 / 128 gadolinium stock solution, 1 / 256 gadolinium stock solution, 1 / 512 gadolinium stock solution, 1 / 1024 gadolinium stock solution, 1 / 2048 gadolinium stock solution, and saline.

[0014] In the body membrane of the utility model, the radius of the concave groove is 2 to 3 cm.

[0015] In the body membrane of the utility model, the upper support and the middle support are both in the shape of a cuboid;

[0016] The lower support is in a cubic shape, in which a spherical water film can be placed conformably;

[0017] Preferably, the length of the lower support is 18 to 20 cm, the width is 18 to 20 cm, and the height is 18 to 20 cm;

[0018] The length of the upper support and the middle support is consistent with that of the lower support, the width is 5 to 6 cm larger than that of the lower support, and the height is 3 to 5 cm.

[0019] In the body membrane of the utility model, the syringe and the spherical water membrane can be disassembled repeatedly.

[0020] When the body film of the utility model is used to verify the imaging characteristics of different sequences at different gadolinium concentrations, the verification can be performed on a 1.5T GEMRI 380 scanning platform. At the same time, in order to perform signal correction, the spherical water film of the GE MRI scanning device is preferably used.

[0021] The utility model body film has the following advantages:

[0022] 1. The body membrane of the utility model is compactly designed to meet the "three-center" principle of magnetic resonance imaging and the imaging characteristics of stably obtaining magnetic resonance signals.

[0023] 2. The grooves of the upper support and the middle support used in the body membrane of the utility model are arranged at equal intervals and stable magnetic resonance signals can also be obtained.

[0024] 3. The syringes and spherical water films placed on the upper bracket, the middle bracket and the bottom bracket are all detachable and have the characteristic of strong operability.

[0025] 4. Since the body membrane of the utility model has the characteristic of being able to detachably place syringes and water membranes of different concentration gradients, it can be used to verify and analyze the imaging characteristics of other magnetic resonance imaging sequences at different low concentrations, and can be used for teaching. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the planar structure of the body membrane of the utility model.

[0027] Figure 2 It is a schematic diagram of the three-dimensional structure of the body membrane of the utility model.

[0028] Figure 3 It is a schematic diagram of T2 WI propeller imaging in an embodiment of the present utility model.

[0029] Figure 4 It is a schematic diagram of T1 WI FLAIR imaging in an embodiment of the present utility model.

[0030] Figure 5 It is a schematic diagram of T2 FLAIR imaging in an embodiment of the present utility model.

[0031] Figure 6 It is a schematic diagram of 3D T1 BRAVO imaging in an embodiment of the present utility model.

[0032] Figure 7 It is a schematic diagram of 3D T2 CUBE FLAIR imaging in an embodiment of the present utility model.

[0033] Figure 8 Statistical comparison of the signal-to-noise ratio (SNR) of the concentration range that can be imaged by both 3D T1 BRAVO and T1 WI FLAIR in the embodiments of the present invention.

[0034] Fig. 9 Statistical comparison of SNR of the concentration range that can be imaged by both 3D T2 CUBE FLAIR and T2 WI FLAIR in the embodiments of the present invention.

[0035] Fig.10 This is the T2 WI propeller concentration signal intensity curve in the embodiment of the present utility model.

[0036] Fig.11This is the T1 WI FLAIR concentration signal intensity curve in the embodiment of the present utility model.

[0037] Fig.12 This is the T2 WI FLAIR concentration signal intensity curve in the embodiment of the present utility model.

[0038] Fig.13 This is a 3D T1 BRAVO concentration signal intensity curve in an embodiment of the present invention.

[0039] Fig.14 This is a 3D T2 CUBE FLAIR concentration signal intensity curve in an embodiment of the present invention. DETAILED DESCRIPTION

[0040] The present invention will be further described below in conjunction with the accompanying drawings, but the present invention is not limited to the following embodiments.

[0041] like Figure 1 and Figure 2 As shown, the body membrane for analyzing and verifying the characteristics of cranial magnetic resonance imaging sequences provided by the utility model includes a plastic support, wherein: the support includes an upper support 15, a middle support 16 and a lower support 17. The upper support 15 and the middle support 16 are used to place a plurality of syringes, and the syringes are filled with gradient concentrations of gadolinium solution or saline, and the specification of the syringe is preferably 5ml. The lower support 17 is used to place the spherical water film 14.

[0042] In the body membrane of the utility model, the upper support 15 and the middle support 16 are provided with concave grooves arranged at equal intervals, the radius of the concave grooves is 2 to 3 cm, and the syringe is arranged in the concave grooves. Preferably, 7 concave grooves are provided on the upper support 15, and syringes filled with the following stock solutions are placed in sequence: gadolinium stock solution 1, 1 / 2 gadolinium stock solution 2, 1 / 4 gadolinium stock solution 3, 1 / 8 gadolinium stock solution 4, 1 / 16 gadolinium stock solution 5, 1 / 32 gadolinium stock solution 6, and 1 / 64 gadolinium stock solution 7; 6 concave grooves are provided on the middle support 16, and syringes filled with the following stock solutions and normal saline are placed in sequence: 1 / 128 gadolinium stock solution 8, 1 / 256 gadolinium stock solution 9, 1 / 512 gadolinium stock solution 10, 1 / 1024 gadolinium stock solution 11, 1 / 2048 gadolinium stock solution 12, and normal saline 13.

[0043] like Figure 1 and Figure 2As shown, the upper support 15 and the middle support 16 of the body membrane of the utility model are both in the shape of a cuboid, and the lower support 17 is in the shape of a cube, in which a spherical water membrane can be placed conformably. Preferably, the length of the lower support 17 is 18 to 20 cm, the width is 18 to 20 cm, and the height is 18 to 20 cm; the length of the upper support 15 and the middle support 16 is consistent with that of the lower support 17, the width is 5 to 6 cm larger than that of the lower support, and the height is 3 to 5 cm.

[0044] In the body membrane of the utility model, the syringe and the spherical water membrane can be disassembled repeatedly.

[0045] When the body membrane of the utility model is used to verify the imaging characteristics of different sequences at different gadolinium concentrations, the body membrane is scanned using a 1.5T GE380MRI scanner, the body membrane is placed in the center of the cranial and brain dedicated channel coil, and the body membrane is imaged using plain scan T2 WI propeller, T1 WI FLAIR, T2 FLAIR, enhanced T1 WI FLAIR+C, 3D T1BRAVO, and 3D T2CUBE FLAIR sequences. The scanning conditions are shown in Table 1 below.

[0046] Table 1 1.5T GE 380MRI scanner brain MRI scan sequence parameters

[0047]

[0048] After the body membrane scan, the signal intensity of the body membrane in different sequences was measured and analyzed, and ROI was drawn on 16 5ml syringes and the water film. The ROI area on the syringe was 10mm 2 , the ROI area on the water film is 1000mm 2 The signal intensity value was taken as the average of three consecutive layers. Then, the imageable syringe (concentration gradient) was plotted as a concentration-signal intensity curve in Excel to analyze the imaging signal characteristics.

[0049] In order to illustrate that the utility model can analyze and verify the characteristics of the above-mentioned MRI scanning sequence, this embodiment uses the signal intensity after water film correction for comparative verification, and the calculation method is: the mean signal intensity of three measurements of the imageable body membrane / the signal intensity at the center of the water film. In order to compare the imaging differences between T1 WI FLAIR and 3D T1 BRAVO, as well as between T2 FLAIR and 3DT2 CUBE FLAIR, the signal-to-noise ratio (SNR) is introduced for verification, and the calculation method is: the mean signal intensity of three measurements of the imageable body membrane / the standard deviation of the background noise in the phase encoding direction, and the Paired ttest is used to test whether the difference is significant. Figure 3-Figure 7As shown, the embodiment of the present invention utilizes a 1.5TGE 380MRI scanner to perform T2 WI propeller, T1 WI FLAIR, T2 FLAIR, 3D T1 BRAVO, and 3D T2 CUBE FLAIR sequences on the body membrane of the present invention.

[0050] First, it can be found that 3D T1BRAVO can image a wider concentration range than T1 WI FLAIR and the concentration range for body membrane imaging is 4 times different. The concentrations that produce the maximum corrected signal intensity also differ by 4 times. Figure 8 It can be shown that there is no significant difference in SNR between 3DT1BRAVO and T1 WI FLAIR in the concentration range that both can image.

[0051] T2 WI FLAIR has a wider range of imaging concentrations than 3D T2 CUBE FLAIR, and the concentration range for body membrane imaging is also 4 times different. The relationship that the concentration difference that produces the maximum corrected signal intensity is 4 times different between the two can also be verified. Fig. 9 It can be shown that there is no significant difference in SNR between T2 WI FLAIR and 3D T2 CUBE within the concentration range that both can image.

[0052] The drug concentration range that can be imaged by T1 WI FLAIR and the maximum signal intensity after water film correction also differ by 4 times compared with T2 WI FLAIR. However, compared with 3D T1 BRAVO and 3D T2 CUBE FLAIR, the former has a larger concentration range that can be imaged, and the concentration difference between the two, both of which produce the maximum signal intensity after water film correction, is 32 times.

[0053] like Fig.10 , Fig.12 and Fig.14 As shown, the utility model can show that the signal intensity generated by the T2 sequence decays exponentially with the drug concentration, and a larger signal intensity can be generated at a lower drug concentration. Fig.11 and Fig.13 As shown, the body membrane of the present invention can show that the signal intensity generated by the T1 sequence is also exponentially related within a certain concentration range.

Claims

1. A body membrane for analyzing and verifying the characteristics of brain enhanced magnetic resonance imaging sequences, comprising a bracket; characterized in that: The support comprises an upper support, a middle support and a lower support; The upper support and the middle support are used to place a plurality of syringes, and the syringes are filled with gadolinium agents of gradient concentrations, gadolinium agent stock solutions and physiological saline; The lower support is used for placing the spherical water film.

2. The body film according to claim 1, characterized in that: The upper support and the middle support are provided with concave grooves, and the syringe is arranged in the concave grooves.

3. The body film according to claim 2, characterized in that: The concave grooves on the upper support and the middle support are arranged at equal intervals.

4. The body film according to claim 2 or 3, characterized in that: The upper bracket is provided with 7 concave grooves; Six concave grooves are arranged on the middle support.

5. The body film according to claim 2 or 3, characterized in that: The radius of the concave groove is 2 to 3 cm.

6. The body film according to claim 2 or 3, characterized in that: The upper support and the middle support are both in the shape of a cuboid; The lower support is in a cubic shape.

7. The body film according to claim 6, characterized in that: The lower support has a length of 18 to 20 cm, a width of 18 to 20 cm, and a height of 18 to 20 cm.

8. The body film according to claim 7, characterized in that: The length of the upper support and the middle support is consistent with that of the lower support, the width is 5 to 6 cm larger than that of the lower support, and the height is 3 to 5 cm.

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