Detection device for acridinium ester antibody labeled sample

Abstract

The utility model discloses a detection device for acridinium ester antibody labeled samples, which comprises a box body, a filling block is fixedly connected in the box body, an anti-precipitation mechanism is arranged on the filling block, the anti-precipitation mechanism comprises a placing groove arranged on the filling block, a bottom plate is arranged in the placing groove, a bottom box is welded on the bottom plate, and the bottom box is connected with the filling block. A driving motor is welded to the outer surface of the bottom box, the output end of the driving motor is connected with a driving shaft rod through a bolt, one end of the driving shaft rod is fixedly connected with a first bevel gear, a rotating shaft rod is movably connected into the bottom cavity, and the top end of the rotating shaft rod is fixedly connected with a test tube rack. The driving motor enables the first bevel gear to synchronously rotate along with the driving shaft rod, the rotating shaft rod rotates in the bottom cavity through meshing of the first bevel gear and the second bevel gear, the rotating shaft rod rotates to drive a test tube on the test tube rack to rotate in the placing groove, compared with standing, the problem of precipitation of a substance to be detected is effectively avoided, and the effectiveness of a detection result is guaranteed.

Description

Technical Field

[0001] The utility model relates to the technical field related to acridinium ester antibody labeling detection, and in particular to a detection device for acridinium ester antibody labeled samples. Background Art

[0002] Acridinium ester is a compound with strong fluorescent properties. The special functional groups in its molecular structure enable it to covalently bind to biomacromolecules such as proteins and nucleic acids. This binding is not only stable, but also can maintain the biological activity of biomacromolecules, providing convenience for subsequent biological experiments. In addition, the fluorescent properties of acridinium ester enable it to achieve high-sensitivity signal detection in a variety of detection systems. Acridinium ester markers have special groups that produce luminescence in their chemical structure, and directly participate in the luminescence reaction during luminescent immunoassay. Usually, this type of substance has no background luminescence and can be used to detect low-concentration or trace-concentration samples in the reaction. It is a type of luminescent agent with high luminescence efficiency. Acridinium ester I, II molecules and acridinium amide III can all bind to antibodies (or antigens) to generate labeled antibodies with strong chemiluminescence activity and high immune response specificity.

[0003] At present, the existing acridinium ester antibody-labeled samples need to be stored in test tubes when being tested. However, since the detection device detects the acridinium ester antibody-labeled samples in batches, the acridinium ester antibody-labeled samples to be tested later are left in the test tube for a long time, resulting in precipitation of the acridinium ester antibody-labeled samples in the test tube, which affects the test results. Utility Model Content

[0004] In view of the shortcomings of the prior art, the utility model proposes a detection device for acridinium ester antibody labeled samples to solve the problems raised in the above background technology.

[0005] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0006] A detection device for acridinium ester antibody labeled samples, comprising a box body, one side of the box body is connected to a cover plate by a hinge, a detector is arranged on one end inside the box body, a filling block is fixedly connected to one end inside the box body away from the detector, an anti-precipitation mechanism is arranged on the filling block, the anti-precipitation mechanism comprises a placement groove arranged on the filling block, the bottom end of the placement groove is connected to a bottom plate by a damping spring, a bottom box is welded on the bottom plate, a bottom cavity is arranged inside the bottom box, a drive motor is fixedly connected on the outer surface of the bottom box, an output end of the drive motor is connected to a drive shaft by a bolt, an end of the drive shaft away from the drive motor extends into the bottom cavity and is fixedly connected to a bevel gear, a rotating shaft is movably connected in the bottom cavity, the top end of the rotating shaft extends to the outside of the bottom box and is fixedly connected to a test tube rack, and a clamping mechanism is arranged on the test tube rack.

[0007] Furthermore, in order to stabilize the test tube on the test tube rack, the clamping mechanism includes test tube grooves equidistantly arranged on the test tube rack, a fixing groove is arranged on the inner surface of the test tube groove, clamping springs are symmetrically welded on both ends of the fixing groove, and one end of the clamping spring is fixedly connected to a clamping plate.

[0008] Furthermore, in order to prevent the test substance in the test tube from settling, a vibration base is welded on the center of the bottom end of the base plate, a vibration motor is fixedly connected to the vibration base, and the output end of the vibration motor is connected to the eccentric wheel through bolts.

[0009] Furthermore, in order to make the rotating shaft rotate with the driving shaft, a second bevel gear is fixedly connected to the rotating shaft, and the second bevel gear is meshed with the first bevel gear.

[0010] Furthermore, in order to facilitate personnel control, a controller is provided on one end of the filling block away from the placement slot, and the controller is electrically connected to the driving motor and the vibration motor.

[0011] Furthermore, in order to increase the friction between the clamping plate and the test tube, an anti-slip pad is fixedly connected to the outer surface of the clamping plate.

[0012] Furthermore, in order to facilitate carrying the box, a handle is fixedly connected to the other side of the outer surface of the box.

[0013] Beneficial effects of the utility model:

[0014] 1. The controller controls the driving motor to work, and the driving motor causes the driving shaft to rotate in the bottom cavity, thereby causing the bevel gear 1 to rotate synchronously with the driving shaft. The bevel gear 1 is meshed with the bevel gear 2, so that the rotating shaft rotates in the bottom cavity. The rotation of the rotating shaft drives the test tube on the test tube rack to rotate in the placement slot. Compared with standing still, it effectively avoids the problem of precipitation of the substance to be tested and ensures the validity of the test result.

[0015] 2. The controller controls the vibration motor to work, and the vibration motor drives the eccentric wheel to rotate. The rotation of the eccentric wheel causes the vibration base to vibrate. The vibration of the vibration base causes the test tube rack to vibrate and cooperate with the drive motor to further avoid precipitation of the acridinium ester antibody labeled sample in the test tube.

[0016] 3. By placing the test tube in the test tube slot, under the elastic action of the clamping spring, the clamping plate is driven to clamp the test tube in the test tube slot. The setting of the anti-slip pad effectively increases the friction between the clamping plate and the test tube, thereby fixing the test tube in the test tube slot, further preventing the test tube from falling during rotation, thereby affecting the detection of the acridinium ester antibody labeled sample. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Other features, objects and advantages of the present invention will become more apparent by reading the detailed description of non-limiting embodiments with reference to the following drawings:

[0018] Figure 1 It is a structural schematic diagram of a detection device for acridinium ester antibody labeled samples according to an embodiment of the utility model;

[0019] Figure 2 It is a side cross-sectional view of a detection device for acridinium ester antibody labeled samples according to an embodiment of the utility model;

[0020] Figure 3 It is an enlarged view of point A in the figure;

[0021] Figure 4 It is a cross-sectional view of a bottom box in a detection device for acridinium ester antibody-labeled samples according to an embodiment of the utility model;

[0022] Figure 5 It is a partial cross-sectional view of a test tube rack in a detection device for acridinium ester antibody-labeled samples according to an embodiment of the utility model;

[0023] Figure 6 yes Figure 5 Enlarged view of point B in the middle.

[0024] In the figure:

[0025] 1. Box body; 2. Hinge; 3. Cover plate; 4. Handle; 5. Detector; 6. Filling block; 7. Controller; 8. Placement slot; 9. Shock-absorbing spring; 10. Bottom plate; 11. Vibration base; 12. Vibration motor; 13. Eccentric wheel; 14. Bottom box; 15. Drive motor; 16. Drive shaft; 17. Bevel gear 1; 18. Bottom cavity; 19. Rotating shaft; 20. Bevel gear 2; 21. Test tube rack; 22. Test tube slot; 23. Fixed slot; 24. Clamping spring; 25. Clamping plate; 26. Anti-slip pad. DETAILED DESCRIPTION

[0026] In order to make the technical means, creative features, objectives and effects achieved by the present invention clearly understood, the present invention is further described below in conjunction with specific implementation methods.

[0027] See also Figure 1 , Figure 2 and Figure 4The utility model provides a technical solution: a detection device for acridinium ester antibody labeled samples, comprising a box 1 for carrying the device, one side of the outer surface of the box 1 is connected to a cover plate 3 by a hinge 2, a handle 4 is fixedly connected to the other side of the outer surface of the box 1, a lock body is provided between the box 1 and the cover plate 3, the lock body is fixedly installed on the outer surfaces of the box 1 and the cover plate 3, a detector 5 is provided at one end inside the box 1, and a filling block 6 is fixedly connected to the end of the box 1 away from the detector 5. The setting of the filling block 6 can prevent the detector 5 from colliding with the box 1 during the transportation of the box 1. Collision, thereby causing damage to the detector 5, an anti-precipitation mechanism is provided on the filling block 6, the anti-precipitation mechanism includes a square placement groove 8 opened on the filling block 6, a controller 7 is provided on the end of the filling block 6 away from the placement groove 8, the controller 7 is electrically connected to the power supply, the bottom end of the placement groove 8 is connected to the bottom plate 10 through a damping spring 9, the number of the damping springs 9 is four, the damping springs 9 have a certain elasticity, and a damper is provided at the center of the damping spring 9, the damper is fixedly installed on the bottom end of the placement groove 8, a cylindrical bottom box 14 is welded on the bottom plate 10, a bottom cavity 18 is opened inside the bottom box 14, and the bottom box 14 A drive motor 15 is fixedly connected to the outer surface, the drive motor 15 is electrically connected to the controller 7, and the power supply provides the required electric energy. The output end of the drive motor 15 is connected to the drive shaft 16 by a bolt, and the end of the drive shaft 16 away from the drive motor 15 extends into the bottom cavity 18 and is fixedly connected to the bevel gear 17. The drive shaft 16 is connected to the bottom box 14 through a bearing, and the bottom cavity 18 is connected to the rotating shaft 19 through a bearing. In order to make the rotating shaft 19 rotate with the drive shaft 16, a bevel gear 20 is fixedly connected to the rotating shaft 19, and the bevel gear 20 is connected to the bevel gear 17. The top of the rotating shaft 19 extends to the outside of the bottom box 14 and is fixedly connected to the test tube rack 21. The controller 7 controls the driving motor 15 to work. The driving motor 15 causes the driving shaft 16 to rotate in the bottom cavity 18, and then the bevel gear 1 17 rotates synchronously with the driving shaft 16. The bevel gear 1 17 is meshed with the bevel gear 2 20, so that the rotating shaft 19 rotates in the bottom cavity 18. The rotation of the rotating shaft 19 drives the test tube on the test tube rack 21 to rotate in the placement slot 8. Compared with standing still, the problem of precipitation of the substance to be tested is effectively avoided, thereby ensuring the validity of the test result.

[0028] See also Figure 1-Figure 3In order to prevent the precipitation of the material in the test tube, a vibration base 11 is welded on the center of the bottom end of the bottom plate 10, and a vibration motor 12 is fixedly connected to the vibration base 11. The vibration motor 12 is electrically connected to the controller 7, and the power supply provides the required power. The output end of the vibration motor 12 is connected to the eccentric wheel 13 through a bolt. The controller 7 controls the vibration motor 12 to work, and the vibration motor 12 drives the eccentric wheel 13 to rotate. The rotation of the eccentric wheel 13 causes the vibration base 11 to vibrate, and the vibration of the vibration base 11 causes the test tube rack 21 to vibrate accordingly, and cooperates with the driving motor 15 to further avoid precipitation of the acridinium ester antibody labeled sample in the test tube. The damping spring 9 and the damper are set to offset the vibration force of the vibration motor 12 on the box 1.

[0029] See also Figure 1 , Figure 2 and Figure 4-Figure 6 In order to stabilize the test tube on the test tube rack 21, a clamping mechanism is provided on the test tube rack 21, and the clamping mechanism includes test tube grooves 22 equidistantly arranged on the test tube rack 21, and square fixing grooves 23 are arranged on the inner surface of the test tube grooves 22. Clamping springs 24 are symmetrically welded on both ends of the fixing grooves 23. The clamping springs 24 have a certain elasticity, and one end of the clamping springs 24 is fixedly connected with a clamping plate 25. In order to increase the friction between the clamping plate 25 and the test tube, an anti-skid pad 26 is fixedly attached to the outer surface of the clamping plate 25. By placing the test tube in the test tube groove 22, under the elastic action of the clamping springs 24, the clamping plate 25 is driven to clamp the test tube in the test tube groove 22. The setting of the anti-skid pad 26 effectively increases the friction between the clamping plate 25 and the test tube, thereby fixing the test tube in the test tube groove 22, further preventing the test tube from falling during the rotation process, thereby affecting the detection of the acridinium ester antibody labeled sample.

[0030] Working principle:

[0031] In actual use, first, the box 1 is moved to a designated position and the cover 3 is opened. Next, a portion of the acridinium ester antibody labeled sample is placed on the detector 5 for detection, and another portion of the acridinium ester antibody labeled sample is inserted into the test tube slot 22. At this time, under the elastic action of the clamping spring 24, the clamping plate 25 is driven to clamp the test tube in the test tube slot 22. The provision of the anti-slip pad 26 effectively increases the friction between the clamping plate 25 and the test tube, thereby fixing the test tube in the test tube slot 22. Then, the controller 7 controls the drive motor 15 to work, and the drive motor 15 causes the drive shaft 16 to rotate in the bottom cavity 18, thereby causing the bevel gear 17 to rotate with the drive shaft. 16 rotates synchronously, and the bevel gear 1 17 is meshed with the bevel gear 2 20, so that the rotating shaft 19 rotates in the bottom cavity 18. The rotation of the rotating shaft 19 drives the test tube on the test tube rack 21 to rotate in the placement groove 8. At the same time, the controller 7 controls the vibration motor 12 to work, and the vibration motor 12 drives the eccentric wheel 13 to rotate. The rotation of the eccentric wheel 13 causes the vibration base 11 to vibrate, and the vibration of the vibration base 11 causes the test tube rack 21 to vibrate accordingly, and cooperates with the drive motor 15 to further avoid precipitation of the acridinium ester antibody labeled sample in the test tube. Compared with standing, the problem of precipitation of the substance to be tested is effectively avoided, and the validity of the test result is guaranteed.

[0032] Although this specification is described in accordance with the implementation modes, not every implementation mode includes only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A detection device for acridinium ester antibody labeled samples, comprising a housing (1), characterized in that: One side of the box body (1) is connected to the cover plate (3) via a hinge (2); a detector (5) is provided at one end of the box body (1); a filling block (6) is fixedly connected to the end of the box body (1) away from the detector (5); an anti-sedimentation mechanism is provided on the filling block (6); the anti-sedimentation mechanism comprises a placement groove (8) provided on the filling block (6); the bottom end of the placement groove (8) is connected to the bottom plate (10) via a damping spring (9); a bottom box (14) is welded to the bottom plate (10); a bottom cavity ( The bottom box (14) is provided with a driving motor (15) fixedly connected on its outer surface, the output end of the driving motor (15) is connected to a driving shaft (16) by means of a bolt, one end of the driving shaft (16) away from the driving motor (15) extends into the bottom cavity (18) and is fixedly connected to a bevel gear (17), a rotating shaft (19) is movably connected in the bottom cavity (18), the top end of the rotating shaft (19) extends to the outside of the bottom box (14) and is fixedly connected to a test tube rack (21), and a clamping mechanism is provided on the test tube rack (21).

2. The detection device for acridinium ester antibody labeled samples according to claim 1, characterized in that: The clamping mechanism comprises test tube grooves (22) arranged at equal distances on the test tube rack (21), a fixing groove (23) being arranged on the inner surface of the test tube groove (22), clamping springs (24) being symmetrically welded at both ends of the fixing groove (23), and a clamping plate (25) being fixedly connected to one end of the clamping spring (24).

3. The detection device for acridinium ester antibody labeled samples according to claim 1, characterized in that: A vibration base (11) is welded at the center of the bottom end of the base plate (10), a vibration motor (12) is fixedly connected to the vibration base (11), and the output end of the vibration motor (12) is connected to an eccentric wheel (13) via bolts.

4. The detection device for acridinium ester antibody labeled samples according to claim 1, characterized in that: The rotating shaft (19) is fixedly connected with a second bevel gear (20), and the second bevel gear (20) is meshed with the first bevel gear (17).

5. The detection device for acridinium ester antibody labeled samples according to claim 1, characterized in that: A controller (7) is provided on one end of the filling block (6) away from the placement groove (8), and the controller (7) is electrically connected to the driving motor (15) and the vibration motor (12).

6. The detection device for acridinium ester antibody labeled samples according to claim 2, characterized in that: An anti-slip pad (26) is fixedly connected to the outer surface of the clamping plate (25).

7. The detection device for acridinium ester antibody labeled samples according to claim 1, characterized in that: A handle (4) is fixedly connected to the other side of the outer surface of the box body (1).

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