Immunohistochemical staining instrument

Abstract

The utility model relates to the field of medical instruments, in particular to an immunohistochemical staining instrument which comprises a staining instrument shell, a reagent shelf is arranged in the staining instrument shell, the reagent shelf is connected with the staining instrument shell through a restraining assembly, and the reagent shelf is assembled and disassembled through the restraining assembly. A piece baking mechanism is further arranged on the lower portion in the stainer shell, and the piece baking mechanism is connected with the stainer shell through a pull-out structure. The technical effects of quickly pasting slide tissues and preventing the tissues from falling off from the slide can be realized through the slide baking mechanism; the technical effect of dyeing multiple groups of slides at the same time is achieved through a plurality of slide slots formed in the reagent shelf. The arrangement of the constraint assembly solves the technical problems of stability and disassembly of the reagent shelf. The device is reasonable in design, simple in structure, convenient to operate and high in practicability.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to an immunohistochemical staining instrument. Background Art

[0002] Immunohistochemical staining refers to the use of fluorescent or colorable chemicals on antibodies to detect the presence of target antigens in cells or tissues using the specific binding reaction between antigens and antibodies in immunology. This method can not only be used to measure the amount of antigen expression, but also to observe the location of antigen expression. Any substance that can be bound by antibodies, that is, antigenic substances including proteins, nucleic acids, polysaccharides, pathogens, etc. can be detected. The advantages of immunohistochemistry are specificity, sensitivity, simplicity, speed and low cost, so it is widely used in hospitals, usually by screening cancer through specific tumor markers. Immunohistochemical staining is a very important method for basic research, prevention and diagnosis.

[0003] After searching, a Chinese patent application with publication number CN 219842236 U discloses an immunohistochemical staining instrument, including a staining instrument housing, a reagent rack, a gear and a locking rod, wherein a glass slide slot is provided on the outer wall of the staining instrument housing, a glass slide locking button is provided on the outer wall, a system liquid bottle is provided inside, a waste liquid interface is connected to the outer wall, and a reagent placement groove is provided on the outer wall; the reagent rack is arranged in the reagent placement groove, and reagent slots for holding reagent bottles are evenly provided on the top, a rack is fixed on the rear wall, and the rack can be fixed in the reagent placement groove and can also be removed from the reagent placement groove; the gear is meshed with the rack, and a rotating shaft is fixed in the middle; the locking rod locks the gear and can fix or remove the reagent rack, an annular mounting groove is provided on the inner wall of the reagent slot, and an elastic ring is fixed in the annular mounting groove, which can facilitate the fixing and removal of the reagent rack, making the reagent placement simpler and more convenient.

[0004] When placing the reagent rack in the present application, the rack at the front end of the reagent rack meshes with the gear to drive the gear to rotate, so that the locking rod coincides with the locking hole on the gear to fix the reagent rack. However, there is a problem that it is impossible to ensure that the reagent rack is fully inserted into the reagent slot. Utility Model Content

[0005] When placing the reagent rack in the above-mentioned prior art, the rack at the front end of the reagent rack is meshed with the gear to drive the gear to rotate, so that the locking rod coincides with the locking hole on the gear to fix the reagent rack. However, there is a technical problem that it is impossible to ensure that the reagent rack is fully inserted into the reagent slot.

[0006] Technical idea: Based on the problems of the existing technology, this application provides a new type of immunohistochemical staining instrument. By setting up a pull-out structure for baking the slide, it is easy to place and quickly stick the slide, and prevent the tissue from falling off the slide; through the detachable connection of the reagent rack, on the one hand, it can fix the reagent rack, and on the other hand, it is convenient to take out and put in the reagents and perform staining operations.

[0007] In order to achieve the above purpose, the technical solution adopted by the utility model is:

[0008] The present application provides an immunohistochemical staining instrument, comprising a staining instrument housing, wherein a reagent rack is arranged in the staining instrument housing, and the reagent rack is connected to the staining instrument housing via a restraint component, and the reagent rack is installed and disassembled via the restraint component.

[0009] Specifically, the housing of the dyeing instrument is a hollow rectangular parallelepiped structure.

[0010] Furthermore, the constraint assembly includes two L-shaped rods, which are respectively threadedly connected to the sockets arranged at both ends of the reagent rack, and the bottom ends of the L-shaped rods are rotatably connected to the staining instrument housing.

[0011] In detail, a plurality of glass slide slots are arranged at intervals on the reagent rack, and a plurality of ribs are vertically arranged in the glass slide slots.

[0012] In detail, the glass slide slot is a rectangular hollow structure, and the ribs divide the glass slide slot into a plurality of partitions, which is convenient for fixing the glass slides and realizing simultaneous staining of multiple groups of glass slides.

[0013] In the above technical solution, a baking sheet mechanism is further provided at the lower inner part of the dyeing instrument housing, and the baking sheet mechanism is connected to the dyeing instrument housing via a pull-out structure.

[0014] As an example, the housing of the staining instrument is divided into two parts by a partition, a reagent rack is provided at the upper end, and a baking mechanism is provided at the lower end.

[0015] Furthermore, the sheet baking mechanism comprises a drawer box and springs arranged on both sides of the drawer box, the ends of the springs are connected to clamping sheets, and a baking lamp is arranged on the top of the drawer box.

[0016] It should be noted that long clips are provided on both sides of the drawer box, and the clips are slidably matched with the slide grooves provided on the housing of the dyeing instrument.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] 1. The utility model provides a baking lamp in the housing of the staining instrument, so as to facilitate rapid patching and prevent the tissue from falling off the glass slide; by providing a drawer box and springs on both sides of the drawer box, and the ends of the springs are connected to clamping pieces, so as to achieve the technical effect of conveniently taking and placing the baked tissue and clamping and fixing the tissue during the baking process; the setting of the spring facilitates the adjustment of the size of the clamping spacing, so as to adapt to the technical effect of clamping glass slides of different sizes.

[0019] 2. The utility model is provided with a plurality of glass slide slots on the reagent rack, which is convenient for containing various dye solutions and reagents and realizing process-based operation. A plurality of ribs are vertically arranged on opposite sides of the glass slide slot to divide the glass slide slot into a plurality of partitions, which is convenient for fixing the glass slides and realizing the technical effect of staining multiple groups of glass slides at the same time.

[0020] 3. The utility model realizes the installation and disassembly of the reagent rack by providing two L-shaped rods which are respectively threadedly connected to the sockets at both ends of the reagent rack, and the two L-shaped rods are rotatably connected to the housing of the staining instrument, thereby improving the stability of the reagent rack and facilitating the removal of the reagent rack. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0022] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0023] Figure 2 This is a diagram of the drawer box of the utility model in an open state;

[0024] Figure 3 For this utility model Figure 1 Sectional view;

[0025] Figure 4 This is a schematic diagram of the support assembly of the utility model;

[0026] Figure 5 This is a schematic diagram of the structure of the reagent rack of the utility model;

[0027] In the figure: 1. Staining instrument housing; 11. Partition; 12. Slide; 2. Slide baking mechanism; 21. Pull-out box; 22. Slide baking lamp; 23. Card bar; 24. Spring; 25. Clamping piece; 3. Reagent rack; 31. Slide slot; 32. Rib; 33. Socket; 4. Support assembly; 41. Support frame; 42. Engaging notch; 5. Constraint assembly; 51. L-shaped rod. DETAILED DESCRIPTION

[0028] In order to enable those skilled in the art to better understand the technical solution of the present invention, the technical solution of the present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0029] In the description of the present invention, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "front end", "back end", "inside", "outside", etc. indicate directions or positional relationships based on the directions or positional relationships shown in the accompanying drawings. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction. Therefore, they should not be understood as limitations on the present invention.

[0030] In the description of this application, it should also be noted that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0031] The inventors have found that the reagent rack of the existing immunohistochemical staining instrument is fixed to the instrument, and the reagent rack cannot be moved or taken out, which makes the reagent placement steps complicated and troublesome, and it is inconvenient to clean the reagent rack.

[0032] Based on the above findings, the present application provides an immunohistochemistry staining instrument, including a staining instrument housing 1, wherein a reagent rack 3 is disposed in the staining instrument housing 1, and the reagent rack 3 is connected to the staining instrument housing 1 via a constraint component 5, and the reagent rack 3 is installed and disassembled via the constraint component 5. Embodiment 1

[0033] Reference Figure 1-5 As shown, the present application provides an immunohistochemical staining instrument, including a staining instrument housing 1, wherein a reagent rack 3 is disposed in the staining instrument housing 1, and the reagent rack 3 is connected to the staining instrument housing 1 via a restraint component 5, and the reagent rack 3 is installed and disassembled via the restraint component 5.

[0034] In the above technical solution, the staining instrument housing 1 is a rectangular hollow structure with an open upper end, which is convenient for tissue processing, staining and observation.

[0035] Furthermore, a plurality of glass slide slots 31 are arranged at intervals on the reagent rack 3 , and a plurality of ribs 32 are vertically arranged on opposite sides of the glass slide slots 31 .

[0036] Specifically, the reagent rack 3 is in the shape of a polygonal long strip in the horizontal direction and a rectangular parallelepiped structure in the vertical direction.

[0037] More specifically, the slide slot 31 is a hollow rectangular parallelepiped structure with an open upper end.

[0038] It should be noted that the ribs 32 divide the glass slide slot 31 into a plurality of partitions, which is convenient for fixing the glass slides and realizing the simultaneous staining of multiple groups of glass slides.

[0039] Furthermore, the constraint assembly 5 includes two L-shaped rods 51 , which are respectively threadedly connected to the sockets 33 arranged at both ends of the reagent rack 3 , and the bottom ends of the L-shaped rods 51 are rotatably connected to the staining instrument housing 1 .

[0040] In the specific process, the slide slot 31 containing the dye and reagent is placed into the staining instrument housing 1, and the L-shaped rod 51 is rotated so that the L-shaped rod 51 and the socket 33 on the reagent rack 3 can be threadedly matched to adjust and fix the position of the reagent rack 3, so that the reagent rack 3 is in a stable state.

[0041] Furthermore, when the reagent rack 3 needs to be disassembled and taken out, the L-shaped rod 51 is pulled out so that the L-shaped rod 51 drives the reagent rack 3 to be taken out from the staining instrument housing 1 . Embodiment 2

[0042] Based on Example 1, refer to Figure 2-3 As shown, in order to achieve the technical effect of rapid sticking and preventing the tissue from falling off the glass slide, a pull-out baking mechanism 2 is provided at the bottom of the staining instrument housing 1.

[0043] In the above technical solution, the baking mechanism 2 is connected to the dyeing instrument housing 1 via a pull-out structure.

[0044] Specifically, the dyeing apparatus housing 1 separates the baking mechanism 2 through a partition 11 .

[0045] Furthermore, the sheet baking mechanism 2 includes a drawer box 21 and springs 24 arranged on both sides of the drawer box 21 , the ends of the springs 24 are connected to clamping pieces 25 , and a baking lamp 22 is arranged on the top of the drawer box 21 .

[0046] It should be noted that the baking lamp 22 is a prior art and the inventor has not made any improvements.

[0047] In more detail, long strips of clamping strips 23 are respectively provided on both sides of the drawer box 21 , and the clamping strips 23 are slidably matched with the slide grooves 12 provided on the dyeing instrument housing 1 .

[0048] In order to facilitate opening of the drawer box 21 , a handle is provided on the front side of the drawer box 21 .

[0049] According to the technical solution, a support assembly 4 is further provided inside the staining instrument housing 1 , and the support assembly 4 includes a support frame 41 and a snap-fitting notch 42 provided on the support frame 41 and matched with the slide slot 31 .

[0050] In detail, the support frame 41 is fixedly connected to the inner wall of the staining instrument housing 1, and the engaging notch 42 is a square structure, which can realize the insertion and engagement of the glass slide slot 31, and achieve the technical effect of limiting support and detachability of the glass slide slot 31.

[0051] Specific application cases

[0052] Immunohistochemistry staining is a relatively cutting-edge examination method. It is performed on the basis of pathological examination. It can classify tumor diseases and determine the early, middle and late stages of the tumor. It will have certain guiding significance for the formulation of treatment plans.

[0053] In clinical practice, after taking the diseased tissue and making pathological sections, some special chemicals can be used for corresponding staining treatment, which can quantitatively display the situation of carcinoembryonic antigen in the diseased tissue. This examination can not only see the specific nature of the diseased tissue, but also clarify the source of the diseased tissue. Usually after immunohistochemical treatment, specific classification of tumor diseases can be made, and the progression of the disease can be determined. After regular treatment, immunohistochemical examinations can also be performed to observe the effect of treatment. For patients with atypical symptoms, immunohistochemical staining examinations are usually performed.

[0054] Through immunohistochemical staining examination, a detailed diagnosis can often be made in a timely manner. It is currently widely used. This examination can not only make a diagnosis in a timely manner, but also be used to distinguish different neoplastic diseases, which will be of great help in the treatment of tumors.

[0055] When an immunohistochemical staining instrument of the present application is performing a staining inspection process for diseased tissue, the dye solution and reagents required for the tissue treatment and staining process are respectively loaded into the glass slide slot 31 set on the reagent rack 3, and the glass slide slot 31 containing the dye solution and reagent is placed into the engaging notch 42 on the support frame 41. By rotating the L-shaped plug rod 51, the L-shaped plug rod 51 and the socket 33 on the reagent rack 3 are threadedly matched to achieve adjustment and fixation of the position of the reagent rack 3, so that the reagent rack 3 is in a stable state.

[0056] The pull-out box 21 is pulled out from the staining instrument housing 1 by the handle on the pull-out box 21, and the tissue slide that needs to be stained and tested is further placed on the pull-out box 21, and the slide tissue is clamped and fixed by the clamping piece 25, and then the pull-out box 21 is pushed into the staining instrument housing 1, and then the baking lamp 22 is turned on to bake the slide tissue, thereby achieving the technical effect of rapid bonding and preventing the tissue from falling off the slide.

[0057] The baked slide tissue is taken out and placed in the slide slot 31 for treatment with dye and reagents. The slide slot 31 is divided into a plurality of partitions by a plurality of ribs 32 vertically arranged on opposite sides of the slide slot 31, so as to facilitate fixing the slides and achieve the technical effect of staining multiple groups of slides at the same time.

[0058] When the reagent rack 3 needs to be disassembled and taken out after the staining is completed, the L-shaped rod 51 is pulled out so that the L-shaped rod 51 drives the reagent rack 3 to be taken out from the staining instrument housing 1 .

[0059] In summary, although the embodiments of the present invention have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and purpose of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. An immunohistochemical staining instrument, comprising a staining instrument housing (1), characterized in that: A reagent rack (3) is arranged in the staining instrument housing (1); the reagent rack (3) is connected to the staining instrument housing (1) via a restraining component (5); and the reagent rack (3) is installed and removed via the restraining component (5); The restraining assembly (5) comprises two L-shaped rods (51), the two L-shaped rods (51) being threadedly connected to the sockets (33) arranged at both ends of the reagent rack (3), and the bottom ends of the L-shaped rods (51) are rotatably connected to the staining instrument housing (1); The reagent rack (3) is provided with a plurality of glass slide slots (31) at intervals, and a plurality of ribs (32) are vertically arranged in the glass slide slots (31); A sheet baking mechanism (2) is also provided in the lower part of the dyeing device housing (1), and the sheet baking mechanism (2) is connected to the dyeing device housing (1) via a pull-out structure; The sheet baking mechanism (2) comprises a drawer box (21) and springs (24) arranged on both sides of the drawer box (21), the ends of the springs (24) being connected to clamping sheets (25), and a baking lamp (22) being arranged on the top of the drawer box (21).

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