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2 results about "Duck hepatitis B virus" patented technology
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Duck hepatitis B virus, abbreviated DHBV, is part of the genus Avihepadnavirus of the Hepadnaviridae, and is the causal agent of duck hepatitis B. DHBV is a small DNA virus with a diameter of 40–45 nm. The viral envelope is made up from host cell lipid, with viral surface antigens (DHBsAg). The icosahedral nucleocapsid within, is composed of the virus core antigen (DHBcAg) and surrounds the DNA genome and viral polymerase. The viral genome is a circular double stranded DNA molecule about 3000 base pairs long. The genome has three overlapping open reading frames or ORFs...
Application of formononetin
PendingCN119488516AGood antiviral effectprevent proliferationOrganic active ingredientsDigestive systemHepatitis B immunizationMechanism of action
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of formononetin in prevention and treatment of duck hepatitis B virus. According to the invention, the anti-DHBV effect of formononetin is proved for the first time. According to the application disclosed by the invention, the formononetin is proved to have a very good antiviral effect on DHBV by virtue of research of various methods, the action mechanism of the formononetin is clarified, a foundation is laid for developing a novel drug for resisting DHBV and discussing the action mechanism of the drug, and the formononetin has a very good application prospect in the aspect of preventing and treating duck hepatitis B.
Owner:JIANGSU AGRI ANIMAL HUSBANDRY VOCATIONAL COLLEGE
Nanoparticle vaccine carrier protein with immune-enhancing effect and application thereof
An immunomodulatory nanoparticle vaccine carrier protein and its application. This invention uses duck hepatitis B virus core antigen (DHBc) as a base, fuses and expresses the SpyCatcher003 sequence to construct DHBc-SpyCatcher (DHBc-SC) virus-like particles with self-assembly capability, and efficiently expresses them in *E. coli*. When DHBc-SC virus-like particles are mixed with heterologous monomeric antigens containing SpyTag, they can spontaneously couple to form virus-like particles displaying the heterologous antigen, significantly enhancing the immunogenicity of the heterologous antigen.
Owner:SHANGHAI INSTITUTE OF INFECTIOUS DISEASE & BIOSECURITY