1 results about "Multidimensional liquid chromatography" patented technology

Described herein are multi-dimensional liquid chromatography (MDLC) systems and methods of performing MDLC. The MDLC systems include a valve configuration that enables modulation of a flow containing an analyte in an eluent of a first dimension liquid chromatography system such that the analyte can be captured in a fluidic circuit and subsequently provided to a second dimension liquid chromatography system. Various system embodiments are provided with small instrument size, including the option of using the same detector for both the first and second dimensions, enabling improved valve timing operations, and reduced magnitude and impact of pressure pulses. Additionally, the modulator can enable dilution of the analyte, and the use of incompatible mobile phases and mobile phase flow rates on the first and second dimensions.