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This invention discloses a two-component PU / SIS injectable hydrogel material and its preparation method. The preparation method includes the following steps: S1. Preparing an isocyanate-terminated aqueous polyurethane prepolymer solution; S2. Preparing an aminated SIS porous microsphere suspension; S3. Dispensing component A and component B into a dual-syringe or parallel syringe, and sterilizing them to obtain the two-component PU / SIS injectable hydrogel material. The two-component PU / SIS injectable hydrogel material prepared by this invention can be conveniently injected subcutaneously or deeply using a standard syringe, and can rapidly form a stable gel with excellent mechanical support and degradation resistance in situ. It can meet the requirements of an ideal soft tissue filler material and is expected to further broaden the application of SIS in medical aesthetic soft tissue filling and repair.