The invention discloses a self-interference elimination method of a full duplex system. Each full duplex node comprises a symbol modulator, a sending module, a receiving module and two antennae, wherein the data of the multiple continuous time slots are collected for algebraic operation so as to eliminate self-interference by virtue of the receiving module of the node, after a converted receiving signal is obtained, the signal is demodulated by virtue of a maximum likelihood method. The sending module can send a symbol by virtue of a method of a constellation point of a rotating symbol modulator, a demodulation mistake of an inherent mode during a process of demodulating the converted receiving signal is avoided. The self-interference elimination method not only can be used in a common full duplex system, but also can be used in an airspace modulation full duplex system, the self-interference is eliminated by virtue of the self-interference elimination method, and the estimation of a self-interference communication channel is not carried out; the signal-to-noise ratio is improved, the equipment cost is lowered, the communication efficiency is improved, and the self-interference elimination method has great economic value for a communication equipment manufacturer and a communication operator.