2results about How to "Effective anti-inflammatory" patented technology

This invention discloses a near-infrared light-exciteable composite nanosheet, its preparation method, and its applications, belonging to the field of biomedical technology. The method includes the following steps: mixing epigallocatechin gallate with a Ti3C2 nanosheet dispersion, ultrasonically reacting, adding silver salt, and continuing stirring in the dark; after the reaction is complete, washing and separating to obtain MXene-EGCG@Ag composite nanosheets. The composite nanosheets provided by this invention possess near-infrared light-exciteable properties and can be used to prepare medically acceptable dosage forms such as hydrogels for the treatment of periodontitis. The preparation method provided by this invention is simple, the raw materials are readily available, and it exhibits significant antibacterial and anti-inflammatory effects, enabling further widespread application.

The present invention relates to the field of genetic engineering, protein engineering technology and its application, and discloses a novel recombinant collagen and its application, including any one of the recombinants COL17-CO-1, COL17-CO-2, COL17-CO-3 or COL17-CO-4 of the specific functional region of human type XVII collagen and the 1232-1466 region of human type III collagen, wherein the amino acid sequences of the specific functional regions in the COL17-CO-1, COL17-CO-2, COL17-CO-3 and COL17-CO-4 are SEQ ID No.2, SEQ ID No.6, SEQ ID No.8 and SEQ ID No.10, respectively. The recombinant exhibits better ability to promote cell proliferation, promotes the expression of proline hydroxylase (HYP), improves the antioxidant capacity of skin cells, improves the expression of multiple collagens in skin cells, and better reduces the expression of collagen degradation-related bases MMP-3 and MMP-9.