39results about How to "Reduce activity" patented technology

Methods and formulations for inducing substantially safer local anesthesia in a patient are provided. The methods comprise administering, to a patient in need thereof, a substrate containing a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material to safely obtain a reversible nerve blockade when implanted or injected in a patient.

The present invention pertains to methods for treatment of inflammatory and cell proliferation disorders, such as cancer, by administering an agent that reduces atrial natriuretic peptide receptor-A (NPR-A) activity. In one aspect, the invention concerns a method for treatment of inflammatory and cell proliferation disorders, such as cancer, by administration of an effective amount of natriuretic hormone peptide (NP), or a polynucleotide encoding NP and an operably-linked promoter sequence. In another aspect, the present invention includes a pharmaceutical composition comprising an agent that reduces the activity of atrial natriuretic peptide receptor-A (NPR-A), and an anti-cancer agent. In another aspect, the present invention further concerns a method for identifying an agent useful for treating an inflammatory or cell proliferation disorder, comprising determining whether the agent reduces the activity of atrial natriuretic peptide receptor-A (NPR-A).

A system, method, and memory controller are provided that alters a memory command stream to a hardware memory. Data is written to the hardware memory and, after the data is stored in the memory, error correction code is received from the memory. Bit errors are identified based upon the error correction code that was received. The memory command stream is then altered based upon the number of bit errors that were identified. In one embodiment, altering the memory command stream includes adjusting a memory refresh rate, while in another embodiment, altering the memory command stream includes adjusting a memory usage delay.

The present invention concerns compositions and methods for the treatment of disorders characterized by the over-expression of an LIV-1. More specifically, the compositions include DNA and amino acid sequences of an LIV-1, antibodies to an LIV-1, and methods for the treatment of a mammal susceptible to or diagnosed with cancer wherein an LIV-1 is overexpressed.

A method for assessing prognosis in a subject having a breast tumor comprises determining the level of expression of at least one Notch receptor gene, Notch ligand gene or Notch signaling target gene. A method of treating a subject suffering from a breast tumor associated with increased Notch signaling comprises administering to the subject an effective amount of an inhibitor of Notch signaling.

The present invention provides methods for inhibiting ocular angiogenesis, vascular leakage, and / or edema. The methods comprise administering to a subject an agent comprising a caveolin scaffolding domain. The present invention further encompasses methods of treating and / or preventing ophthalmic conditions that are associated with ocular angiogenesis, vascular leakage, or edema.

Provided are a modified diphenylmethane diisocyanate (MDI) biuret curing agent and preparation method thereof, the curing agent being prepared by reacting dibasic alcohol, water and MDI in an organic solvent. The preparation method includes the steps of: firstly, using the dibasic alcohol to modify a part of MDI, dividing the metered water into multiple parts, and adding the water by multiple times; after adding the first part of water, reacting firstly under 70-100° C., then heating up to 120-140° C. for reaction; secondly, lowering the temperature to 70-100° C., adding the second part of water; and repeating the above processes until all the metered water is added, to produce the MDI curing agent with partial biuret structure. The curing agent is mainly used as the curing agent of polyurethane coating and adhesive agent, and has a higher NCO percentage and a slower curing speed than that of common MDI prepolymer curing agents.

The invention discloses whitening essence. The whitening essence is prepared from a component A, a component B, a component C and a component D; on the basis of the weight percent of the whitening essence, the component A comprises tremella fuciformis extracts, lavender hydrolat, glycerin, nicotinamide, aloe extracts, organic calophyllum inophyllum kernel oil, butanediol, raspberryketone glucosideand vitamin E, the component B comprises polyacrylate cross-linked polymer-6, ethylhexyl methoxycinnamate, carbomer, sodium hyaluronate and deionized water, the component C comprises triethanolamine,and the component D comprises hexanediol, p-hydroxyacetophenone and flavors. The whitening essence can effectively inhibit formation of melanin and repair skin and is safe and free of stimulation. The invention further discloses a preparation method of the whitening essence. The technology is simple, the production efficiency is high, the environment is not polluted, and no toxicity or stimulation exists.

The invention concerns an isolated complex comprising an HIV or HTLV protein and a human protein. Corresponding nucleic acids, vectors, host cells, host organisms, compositions, kits, medical uses, diagnostic uses, and methods of screening agents are also contemplated. Disclosed are 212 interactions between 19 retroviral proteins and 131 human proteins.

A novel technique for improving ability for secretory production of a multimeric protein of a coryneform bacterium is provided, and thereby a method for secretory production of a multimeric protein is provided. A multimeric protein is produced by secretory production utilizing a coryneform bacterium having an ability to produce a multimeric protein by secretory production and modified so that expression of a gene coding for a metallopeptidase is increased as an expression host.

The present invention concerns a method for treating and / or preventing a disease in a subject comprising the step of administrating an effective amount of a compound of formula I to a subject in need thereof.

An optogenetic system and method for preventing or halting seizures. The system and method use a sensor for monitoring the activity of a neural network containing a group of target neurons, and generating an input signal indicative of said activity, the target neurons being excitatory neurons. Excitatory stimulation is delivered in the form of an optical signal by an optical stimulator to the target neurons, the optical signal being determined based on the input signal, to reduce the overall activity of the target neurons.

The present invention relates to a cosmetic composition comprising guacatonga extract (Casearia silvestris), aroeira extract (Schinus tere-binthifolius raddi) and cosmetically acceptable adjuvants, for preventing and / or treating signs of skin aging. It further relates to the use of guagatonga extract (Casearia silvestris) and aroeira extract (Schinus terebinthifolius raddi) in the preparation of a cosmetic composition for preventing and / or treating signs of skin aging, as well as the use of this composition for simultaneously increasing tropoelastin, increasing the lysyl exidase (LOX) enzyme and reducing the activity of elastase in the dermis. The invention relates to a method of preventing and / or treating signs of skin aging, which comprises applying said cosmetic composition to the skin. Finally, the invention relates to a method of preparing said composition according to the present invention.

The present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronary artery disease in a subject with a metabolic disorder, as well as methods of reducing hepatic glucose production in a subject. Such methods include, but are not limited to, the administration to the subject of inhibitors or activators of CaMKII, IP3Rs, calcineurin, p38, MK2 / 3, HDAC4, Dach1, Dach2, or any combination thereof. The invention also provides methods of identifying a compound that inhibits the activity of CaMKII, IP3Rs, calcineurin, p38, MK2 / 3, HDAC4, Dach1 or Dach2, or reduces the activity and / or activation of CaMKII, IP3Rs, calcineurin, p38, MK2 / 3, HDAC4, Dach1 or Dach, or activates CaMKII, IP3Rs, calcineurin, p38, MK2 / 3, HDAC4, Dach1 or Dach2.

This invention provides derivatives of dodecapeptide ISSIKEKYPSHS which interfere with binding of calbindin to inositol monophosphatase, and their use in treating mood disorders.

Reagents that regulate human asparagine-hydroxylase and reagents which bind to human asparagine-hydroxylase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to cardio-vascular disorders, anaemia, cancer, inflammatory diseases, fibrotic disorders, and CNS disorders.

The invention relates, in part, to methods and compounds that are useful to modulate hair growth in mammals. The invention, in part, also includes nucleic acids, polypeptides, and genetic constructs that may be used to diagnose and treat hair growth disorders, for screening for compounds that modulate hair growth, and for selecting treatment regimens for subjects with hair loss disorders or hair growth conditions. The invention in some aspects also includes kits that may include polypeptides and / or nucleic acids for diagnosis of hair growth disorders and / or for the modulation of hair growth in subjects.

The invention discloses a field multifunctional insect detaining and collecting test tube device. One end of an insect detaining tube is open, the other end of the insect detaining tube and the top end of an insect storage tube are in threaded connection, and the bottom end of the insect storage tube, a ventilating screen and a generator are in threaded connection. An opening and closing baffle is arranged in the insect detaining tube, the ventilating screen is arranged at the joint of the insect storage tube and the generator, a ventilating screen hole plate is arranged on the ventilating screen, small screen holes are formed in the plate, and cotton is placed in the generator. The device has the advantages that all the parts are convenient to detach and replace; re-escape of insects is effectively avoided; drop resistance is achieved, and it is avoided that the appearance integrity of small insects is damaged due to the fact that plastic materials generate static; the insects in the tube can be paralyzed through alcohol gas to be in a coma, the active degree of the insects is reduced, limb damage and deficiency caused by space competition fight among the insects are reduced, DNA of insect specimens saved after alcohol fumigation is not prone to degradation, molecular relevant experiments can be carried out, and meanwhile later insect shape classification work is also promoted.

An application of a radiofrequency catheter ablation system to treatment of essential hypertension. The treatment process is under ultrasonic guidance, an electrode needle is made to penetrate into target tissue of a patient, electrification is conducted to start ablation, the needle is withdrawn or made to penetrate into the other side of the target tissue for target ablation after reaching ablation temperature and duration time, and overall ablation treatment is completed. The system can treat a secondary center for regulating the activity of a whole-body sympathetic system to reduce its activity, thus, the blood pressure level of a patient can be reduced, and fewer kinds and smaller dosage of antihypertensive drugs taken or ceased altogether. By treating the secondary center, the activity of the whole-body sympathetic system, insulin resistance and whole-body fibrosis is reduced, and other diseases characterized in activity abnormity of the sympathetic system might be treated too.

The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human insulin to result in insulin proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

A stable aqueous composition containing follicle-stimulating hormone, which comprises follicle-stimulating hormone and histidine as a stabilizing agent.

The present disclosure relates to monoclonal anti-LINE-1 ORF2 protein endonuclease domain antibody, and fragments and derivatives that bind the LINE-1 ORF2 protein endonuclease domain and inhibit its activity.

The invention relates to a cleaning liquid with effects of mite clearing and skin repairing, and a preparation method thereof, wherein the raw materials comprise, by weight, 65-75 parts of distilled water, 15-25 parts of propylene glycol, 1-3 parts of glycerin, 1-3 parts of a Gentiana scabra Bunge extract, 0.5-1.5 parts of a Zanthoxylum schinifolium Sieb. et Zucc extract, 0.25-0.75 part of a Salvia japonica plant active peptide, and 0.25-0.75 part of a lavender plant active peptide. According to the present invention, the cleaning liquid can kill bacteria and mites, has effects of skin compacting and psychological emotion regulating, and maintains the clean skin, wherein the effect is long and lasting; and the preparation method only needs the raw material mixing in a step-by-step manner,such that the process is easy to control, and the method is suitable for large-scale production.

The present invention features improved methods of identifying patients having cancer (e.g., melanoma, adenocarcinoma, lung, cervical, liver or breast cancer) using biomarkers (e.g., PDE3A, SLFN12) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., DNMDP, zardaverine, and anagrelide).

The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide containing cyclic compounds of Formula (1) to Formula (5) and the enantiomers, diastereomers, tautomers, / V-oxides, solvates and pharmaceutically acceptable salts thereof.

The invention discloses a CMOS protective layer structure, which is formed on a metal layer of a CMOS and comprises a first protective layer and a second protective layer, wherein the first protectivelayer is formed on the metal layer in a deposition mode and has a first thickness; the second protective layer is formed on the first protective layer in a deposition mode, and the thickness of the second protective layer is a second thickness; the first protective layer and the second protective layer are nitride layers formed by deposition of different materials, the second thickness is largerthan the first thickness, and the temperature required for deposition of the first protective layer is lower than the temperature required for deposition of the second protective layer. After the method is used for the CMOS metal process, the defect of bumps formed by metal precipitation can be avoided, the uniformity and the stability of the CMOS can be improved, and the yield can be further improved.

The invention discloses a device for storing bulk cigarettes through automatic-control low-temperature freshness preservation and moisture preservation. The device comprises a cigarette storage barrel, wherein the cigarette storage barrel comprises a storage device outer barrel and a storage device inner barrel; a heat insulation layer is arranged between the storage device outer barrel and the storage device inner barrel; a temperature detection probe is arranged on a barrel wall of the storage device inner barrel; and a filter screen, a cool air distribution plate, an annular support hoop, an airtight door, a cool air circulating fan, an electronic cooling circuit, an electronic cooling circuit hot and cold end diaphragm, a cooling fan, a temperature control display module, a cooling fansafety screen and a base are sequentially arranged on the bottom part of the storage device inner barrel from top to bottom. According to the device for storing the bulk cigarettes through automatic-control low-temperature freshness preservation and moisture preservation provided by the invention, the cigarettes can be preserved with freshness, moisture and fragrance at low temperature, the fragrance and the moisture of the cigarettes are prevented from being lost at low temperature, the active level of microorganisms and bacteria is reduced under the low-temperature state of the cigarettes,the generation of mildews and worms on the cigarettes is reduced, and the pleasant feeling during a cigarette smoking process is improved.

The invention provides a method for preparing a lithium ion battery pack, and the method comprises the following steps: carrying out vacuum drying on a plurality of assembled lithium ion batteries, injecting part of electrolyte, carrying out constant-current charging to a first preset voltage, and carrying out constant-voltage charging at the first preset voltage until the charging current is lower than a cut-off current, performing constant-current charging on the battery to a charging cut-off voltage, measuring the surface temperature of the battery, and recording the charging electric quantity of the battery voltage rising from the first preset voltage to the charging cut-off voltage for the first time; determining to inject a first supplementary electrolyte or a second supplementary electrolyte according to the temperature value; recording the charging electric quantity of the battery voltage rising from the first preset voltage to the charging cut-off voltage for the second time, and recording the capacity of each battery; and assembling the batteries of which the difference percentage of the charging constants and the capacity difference percentage are within preset values into one group to form a battery pack. The battery pack prepared by the method disclosed by the invention is high in service life performance and good in consistency between single batteries.

Methods and compositions are provided for increasing muscle hypertrophy, e.g., through the administration of novel combinations of natural products that inhibit SIRT1.