The invention relates to a compound topical
combination drug for treatment of
acne and a preparation method thereof. The compound topical
combination drug is characterized in that a matrix carrier of the compound
topical drug contains the following
active components (by weight percent): 0.01-2.5 percent of
retinoid acid, 0.2-10 percent of two antibacterial drugs, and 0.01-1 percent of
estrogen or1-10 percent of
spironolactone. The applied dosage forms are gel, ointment,
liniment, film,
film coating agent, sprays and the like, and the gels, the ointment, the
liniment and the
film coating agent are preferred. The preparation method comprises the following steps: dissolving the main
drug with a suitable
solvent system, adding into the matrix, adding corresponding and necessary auxiliary materials and mixing to obtain the
combination drug. The invention has the advantages that: the main
drug contains the
retinoid acid, two antibacterial drugs, and
estrogen or
spironolactone, the prescription combination is scientific so as to simultaneously play three or more therapeutic effects (adjusting the
sebaceous gland function, resisting keratinization abnormalities,
inflammation and microbe,performing like
estrogen and the like), and thereby curing the
acne more comprehensively and intensively. Humectants such as carbamide is added in the
drug so as to reduce side effects such as
skin dryness,
desquamation,
erythema and the like, and no adverse reactions such as stimulus and
allergy are caused during animal experiments. The preferred drug dosage forms have
strong coupling effect with the
skin, are easy to be applied and spread, can not pollute the clothes, and have good
patient compliance and accurate clinical
therapeutic effect.