Mediators of hedgehog signaling pathways, compositions and uses related thereto

Abstract

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g.,to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Description

[0001] This application is a divisional application of the parent application with application number 02818679.6. The application date of the parent application is July 29, 2002; the title of the invention is "Hedgehog signal transduction pathway mediator, its related composition and application". Background of the invention [0002] Schema formation is the activity by which embryonic cells form different tissues arranged in an orderly space. Physiological complexity in higher organisms arises during embryogenesis through the interplay of the cell's own lineage and signals external to the cell. Inducible interactions are essential for embryonic patterning in vertebrate development, from the earliest establishment of body plans, to patterning of organ systems and generation of distinct cell types during tissue differentiation (Davidson, E., (1990 ) Development 108:365-389; Gurdon, J.B., (1992) Cell 68:185-199; Jessell, T.M. et al., (1992) Cell 68:257-270). The effects ...

AI Technical Summary

Problems solved by technology

It is more likely that this causes secondary signaling leading to the synthesis of parathyroid hormone-related protein (PTHrP) in the periarticular perichondrium

Images